Constitutive expression of CCR7 directs effector CD8 T cells into the splenic white pulp and impairs functional activity

Journal of Immunology

Volumn 173, Issue 5, 2004, Pages 3013-3019

  Unsoeld, Heike ^a   Voehringer, David ^a   Krautwald, Stefan ^b   Pircher, Hanspeter ^a  

^a UNIVERSITY OF FREIBURG   (Germany)

^b UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; CHEMOKINE RECEPTOR CCR7;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; BLOOD; BREEDING; CELLULAR DISTRIBUTION; CLEARANCE; CONTROLLED STUDY; DELAYED HYPERSENSITIVITY; DOWN REGULATION; EFFECTOR CELL; IMMUNITY; IMMUNOREGULATION; IMMUNOSTIMULATION; LYMPHOCYTE MIGRATION; LYMPHOCYTE PROLIFERATION; LYMPHOCYTIC CHORIOMENINGITIS VIRUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPLEEN; T LYMPHOCYTE; TRANSGENE; TRANSGENIC MOUSE; VIRUS INFECTION; WILD TYPE;

EID: 4344718400     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.173.5.3013     Document Type: Article

References (29)

1. Butcher, E. C., M. Williams, K. Youngman, L. Rott, and M. Briskin. 1999. Lymphocyte trafficking and regional immunity. Adv. Immunol. 72:209.
2. Cyster, J. G. 1999. Chemokines and cell migration in secondary lymphoid organs. Science 286:2098.
3. Lyons, A. B., and C. R. Parish. 1995. Are murine marginal-zone macrophages the splenic white pulp analog of high endothelial venules? Eur. J. Immunol. 25:3165.
4. Cyster, J. G., and C. C. Goodnow. 1995. Pertussis toxin inhibits migration of B and T lymphocytes into splenic white pulp cords. J. Exp. Med. 182:581.
5. Lo, C. G., T. T. Lu, and J. G. Cyster. 2003. Integrin-dependence of lymphocyte entry into the splenic white pulp. J. Exp. Med. 197:353.
6. Van Ewijk, W., and P. Nieuwenhuis. 1985. Compartments, domains and migration pathways of lymphoid cells in the splenic pulp. Experientia 41:199.
7. Forster, R., A. Schubel, D. Breitfeld, E. Kremmer, I. Renner-Muller, E. Wolf, and M. Lipp. 1999. CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell 99:23.
8. Sallusto, F., D. Lenig, R. Forster, M. Lipp, and A. Lanzavecchia. 1999. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature 401:708.
9. Potsch, C., D. Vohringer, and H. Pircher. 1999. Distinct migration patterns of naive and effector CD8 T cells in the spleen: correlation with CCR7 receptor expression and chemokine reactivity. Eur. J. Immunol. 29:3562.
10. Masopust, D., V. Vezys, A. L. Marzo, and L. Lefrancois. 2001. Preferential localization of effector memory cells in nonlymphoid tissue. Science 291:2413.
11. Reinhardt, R. L., A. Khoruts, R. Merica, T. Zell, and M. K. Jenkins. 2001. Visualizing the generation of memory CD4 T cells in the whole body. Nature 410:101.
12. Kim, C. H., L. Rott, E. J. Kunkel, M. C. Genovese, D. P. Andrew, L. Wu, and E. C. Butcher. 2001. Rules of chemokine receptor association with T cell polarization in vivo. J. Clin. Invest. 108:1331.
13. - memory T cells do not differ in immediate effector cell function. J. Immunol. 169:638.
14. + T cells express functional CCR7. J. Immunol. 168:5441.
15. - memory cells in humans defined by HLA and CC chemokine ligand 19 tetramers. J. Immunol. 170:2461.
16. Wherry, E. J., V. Teichgraber, T. C. Becker, D. Masopust, S. M. Kaech, R. Antia, U. H. von Andrian, and R. Ahmed. 2003. Lineage relationship and protective immunity of memory CD8 T cell subsets. Nat. Immunol. 4:225.
17. Matloubian, M., A. David, S. Engel, J. E. Ryan, and J. G. Cyster. 2000. A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo. Nat. Immunol. 1:298.
18. Pircher, H., K. Burki, R. Lang, H. Hengartner, and R. M. Zinkernagel. 1989. Tolerance induction in double specific T-cell receptor transgenic mice varies with antigen. Nature 342:559.
19. Pircher, H., T. W. Mak, R. Lang, W. Ballhausen, E. Ruedi, H. Hengartner, R. M. Zinkernagel, and K. Burki. 1989. T cell tolerance to MIsa encoded antigens in T cell receptor V β8.1 chain transgenic mice. EMBO J. 8:719.
20. Battegay, M., S. Cooper, A. Althage, J. Banziger, H. Hengartner, and R. M. Zinkernagel. 1991. Quantification of lymphocytic choriomeningitis virus with an immunological focus assay in 24- or 96-well plates. [Published errata appear in 1991 J. Virol. Methods 35:115 and 1992 J. Virol. Methods 38:263.] J. Virol. Methods 33:191.
21. Battegay, M., S. Cooper, A. Althage, J. Banziger, H. Hengartner, and R. M. Zinkernagel. 1991. Quantification of lymphocytic choriomeningitis virus with an immunological focus assay in 24- or 96-well plates. [Published errata appear in 1991 J. Virol. Methods 35:115 and 1992 J. Virol. Methods 38:263.] J. Virol. Methods 33:191.
22. Battegay, M., S. Cooper, A. Althage, J. Banziger, H. Hengartner, and R. M. Zinkernagel. 1991. Quantification of lymphocytic choriomeningitis virus with an immunological focus assay in 24- or 96-well plates. [Published errata appear in 1991 J. Virol. Methods 35:115 and 1992 J. Virol. Methods 38:263.] J. Virol. Methods 33:191.
23. Hany, M., S. Oehen, M. Schulz, H. Hengartner, M. Mackett, D. H. Bishop, H. Overton, and R. M. Zinkernagel. 1989. Anti-viral protection and prevention of lymphocytic choriomeningitis or of the local footpad swelling reaction in mice by immunization with vaccinia-recombinant virus expressing LCMV-WE nucleo-protein or glycoprotein. Eur. J. Immunol. 19:417.
24. Bradley, L. M., S. R. Watson, and S. L. Swain. 1994. Entry of naive CD4 T cells into peripheral lymph nodes requires L-selectin. J. Exp. Med. 180:2401.
25. Steeber, D. A., N. E. Green, S. Sato, and T. F. Tedder. 1996. Lymphocyte migration in L-selectin-deficient mice: altered subset migration and aging of the immune system. J. Immunol. 157:1096.
26. Mackay, C. R., W. L. Marston, and L. Dudler. 1990. Naive and memory T cells show distinct pathways of lymphocyte recirculation. J. Exp. Med. 171:801.
27. Lepault, F., M. C. Gagnerault, C. Faveeuw, and C. Boitard. 1994. Recirculation, phenotype and functions of lymphocytes in mice treated with monoclonal antibody MEL-14. Eur. J. Immunol. 24:3106.
28. Tang, M. L., D. A. Steeber, X. Q. Zhang, and T. F. Tedder. 1998. Intrinsic differences in L-selectin expression levels affect T and B lymphocyte subset-specific recirculation pathways. J. Immunol. 160:5113.
29. Nolte, M. A., A. Hamann, G. Kraal, and R. E. Mebius. 2002. The strict regulation of lymphocyte migration to splenic white pulp does not involve common homing receptors. Immunology 106:299.