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Volumn 35, Issue 4, 2016, Pages 645-654

EMT, cell plasticity and metastasis

Author keywords

Cancer cell plasticity; EMT; Metastasis; Partial EMT; Tumor initiating cells (TICs)

Indexed keywords

AB 16B 5; ACYLTRANSFERASE INHIBITOR; ASCRINVACUMAB; BEVACIZUMAB; CLUSTERIN; DASATINIB; ERIBULIN; ERLOTINIB; ETC 1922159; FOXY 5; GALUNISERTIB; IPAFRICEPT; MK 0752; MONOCLONAL ANTIBODY; PROTEIN INHIBITOR; TRAMETINIB; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; VORINOSTAT;

EID: 84996523823     PISSN: 01677659     EISSN: 15737233     Source Type: Journal    
DOI: 10.1007/s10555-016-9648-7     Document Type: Article
Times cited : (669)

References (62)
  • 1
    • 20744439516 scopus 로고    scopus 로고
    • The mesenchymal cell, its role in the embryo, and the remarkable signaling mechanisms that create it
    • COI: 1:CAS:528:DC%2BD2MXmtFKgsrY%3D, PID: 15937929
    • Hay, E. D. (2005). The mesenchymal cell, its role in the embryo, and the remarkable signaling mechanisms that create it. Developmental Dynamics, 233(3), 706–720.
    • (2005) Developmental Dynamics , vol.233 , Issue.3 , pp. 706-720
    • Hay, E.D.1
  • 2
    • 84894593599 scopus 로고    scopus 로고
    • Molecular mechanisms of epithelial-mesenchymal transition
    • COI: 1:CAS:528:DC%2BC2cXivFagtrY%3D, PID: 24556840
    • Lamouille, S., Xu, J., & Derynck, R. (2014). Molecular mechanisms of epithelial-mesenchymal transition. Nature Reviews. Molecular Cell Biology, 15(3), 178–196.
    • (2014) Nature Reviews. Molecular Cell Biology , vol.15 , Issue.3 , pp. 178-196
    • Lamouille, S.1    Xu, J.2    Derynck, R.3
  • 3
    • 34249289041 scopus 로고    scopus 로고
    • Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?
    • COI: 1:CAS:528:DC%2BD2sXls1Kjs70%3D, PID: 17508028
    • Peinado, H., Olmeda, D., & Cano, A. (2007). Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nature Reviews. Cancer, 7(6), 415–428.
    • (2007) Nature Reviews. Cancer , vol.7 , Issue.6 , pp. 415-428
    • Peinado, H.1    Olmeda, D.2    Cano, A.3
  • 4
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • COI: 1:CAS:528:DC%2BC3cXksFWltA%3D%3D, PID: 19945376
    • Thiery, J. P., Acloque, H., Huang, R. Y., & Nieto, M. A. (2009). Epithelial-mesenchymal transitions in development and disease. Cell, 139(5), 871–890.
    • (2009) Cell , vol.139 , Issue.5 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 5
    • 79953147370 scopus 로고    scopus 로고
    • A perspective on cancer cell metastasis
    • COI: 1:CAS:528:DC%2BC3MXjs1Cgtbo%3D, PID: 21436443
    • Chaffer, C. L., & Weinberg, R. A. (2011). A perspective on cancer cell metastasis. Science, 331(6024), 1559–1564.
    • (2011) Science , vol.331 , Issue.6024 , pp. 1559-1564
    • Chaffer, C.L.1    Weinberg, R.A.2
  • 7
    • 43049165453 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition generates cells with properties of stem cells
    • COI: 1:CAS:528:DC%2BD1cXmsVOru7w%3D, PID: 18485877
    • Mani, S. A., Guo, W., Liao, M. J., Eaton, E. N., Ayyanan, A., Zhou, A. Y., et al. (2008). The epithelial-mesenchymal transition generates cells with properties of stem cells. Cell, 133(4), 704–715.
    • (2008) Cell , vol.133 , Issue.4 , pp. 704-715
    • Mani, S.A.1    Guo, W.2    Liao, M.J.3    Eaton, E.N.4    Ayyanan, A.5    Zhou, A.Y.6
  • 8
    • 51449085561 scopus 로고    scopus 로고
    • Generation of breast cancer stem cells through epithelial-mesenchymal transition
    • PID: 18682804
    • Morel, A. P., Lievre, M., Thomas, C., Hinkal, G., Ansieau, S., & Puisieux, A. (2008). Generation of breast cancer stem cells through epithelial-mesenchymal transition. PloS One, 3(8), e2888.
    • (2008) PloS One , vol.3 , Issue.8
    • Morel, A.P.1    Lievre, M.2    Thomas, C.3    Hinkal, G.4    Ansieau, S.5    Puisieux, A.6
  • 9
    • 84865203983 scopus 로고    scopus 로고
    • A restricted cell population propagates glioblastoma growth after chemotherapy
    • COI: 1:CAS:528:DC%2BC38XhtFChu7rO, PID: 22854781
    • Chen, J., Li, Y., Yu, T. S., McKay, R. M., Burns, D. K., Kernie, S. G., et al. (2012). A restricted cell population propagates glioblastoma growth after chemotherapy. Nature, 488(7412), 522–526.
    • (2012) Nature , vol.488 , Issue.7412 , pp. 522-526
    • Chen, J.1    Li, Y.2    Yu, T.S.3    McKay, R.M.4    Burns, D.K.5    Kernie, S.G.6
  • 10
    • 70349859809 scopus 로고    scopus 로고
    • Snail and slug mediate radioresistance and chemoresistance by antagonizing p53-mediated apoptosis and acquiring a stem-like phenotype in ovarian cancer cells
    • COI: 1:CAS:528:DC%2BD1MXhtlGnsbzO, PID: 19544473
    • Kurrey, N. K., Jalgaonkar, S. P., Joglekar, A. V., Ghanate, A. D., Chaskar, P. D., Doiphode, R. Y., et al. (2009). Snail and slug mediate radioresistance and chemoresistance by antagonizing p53-mediated apoptosis and acquiring a stem-like phenotype in ovarian cancer cells. Stem Cells, 27(9), 2059–2068.
    • (2009) Stem Cells , vol.27 , Issue.9 , pp. 2059-2068
    • Kurrey, N.K.1    Jalgaonkar, S.P.2    Joglekar, A.V.3    Ghanate, A.D.4    Chaskar, P.D.5    Doiphode, R.Y.6
  • 11
    • 68749099671 scopus 로고    scopus 로고
    • Identification of selective inhibitors of cancer stem cells by high-throughput screening
    • COI: 1:CAS:528:DC%2BD1MXhsVCjs73E, PID: 19682730
    • Gupta, P. B., Onder, T. T., Jiang, G., Tao, K., Kuperwasser, C., Weinberg, R. A., et al. (2009). Identification of selective inhibitors of cancer stem cells by high-throughput screening. Cell, 138(4), 645–659.
    • (2009) Cell , vol.138 , Issue.4 , pp. 645-659
    • Gupta, P.B.1    Onder, T.T.2    Jiang, G.3    Tao, K.4    Kuperwasser, C.5    Weinberg, R.A.6
  • 12
    • 84908149021 scopus 로고    scopus 로고
    • ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1
    • COI: 1:CAS:528:DC%2BC2cXht1GqtrnE, PID: 25086746
    • Zhang, P., Wei, Y., Wang, L., Debeb, B. G., Yuan, Y., Zhang, J., et al. (2014). ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1. Nature Cell Biology, 16(9), 864–875.
    • (2014) Nature Cell Biology , vol.16 , Issue.9 , pp. 864-875
    • Zhang, P.1    Wei, Y.2    Wang, L.3    Debeb, B.G.4    Yuan, Y.5    Zhang, J.6
  • 14
    • 85114270629 scopus 로고    scopus 로고
    • Role of EMT in metastasis and therapy resistance
    • Smith, B. N., & Bhowmick, N. A. (2016). Role of EMT in metastasis and therapy resistance. J Clin Med, 5(2).
    • (2016) J Clin Med , vol.5 , Issue.2
    • Smith, B.N.1    Bhowmick, N.A.2
  • 15
    • 84976539958 scopus 로고    scopus 로고
    • EMT: 2016
    • COI: 1:CAS:528:DC%2BC28XhtFaitLbF, PID: 27368099
    • Nieto, M. A., Huang, R. Y., Jackson, R. A., & Thiery, J. P. (2016). EMT: 2016. Cell, 166(1), 21–45.
    • (2016) Cell , vol.166 , Issue.1 , pp. 21-45
    • Nieto, M.A.1    Huang, R.Y.2    Jackson, R.A.3    Thiery, J.P.4
  • 16
    • 9244227134 scopus 로고    scopus 로고
    • Stromal fibroblasts in cancer initiation and progression
    • COI: 1:CAS:528:DC%2BD2cXpvVCjtLw%3D, PID: 15549095
    • Bhowmick, N. A., Neilson, E. G., & Moses, H. L. (2004). Stromal fibroblasts in cancer initiation and progression. Nature, 432(7015), 332–337.
    • (2004) Nature , vol.432 , Issue.7015 , pp. 332-337
    • Bhowmick, N.A.1    Neilson, E.G.2    Moses, H.L.3
  • 17
    • 79958265710 scopus 로고    scopus 로고
    • Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast
    • COI: 1:CAS:528:DC%2BC3MXnsVOkt7s%3D, PID: 21663795
    • Scheel, C., Eaton, E. N., Li, S. H., Chaffer, C. L., Reinhardt, F., Kah, K. J., et al. (2011). Paracrine and autocrine signals induce and maintain mesenchymal and stem cell states in the breast. Cell, 145(6), 926–940.
    • (2011) Cell , vol.145 , Issue.6 , pp. 926-940
    • Scheel, C.1    Eaton, E.N.2    Li, S.H.3    Chaffer, C.L.4    Reinhardt, F.5    Kah, K.J.6
  • 18
    • 84905493203 scopus 로고    scopus 로고
    • Concise review: breast cancer stem cells: regulatory networks, stem cell niches, and disease relevance
    • COI: 1:CAS:528:DC%2BC2cXhslylurnM, PID: 24904174
    • Guo, W. (2014). Concise review: breast cancer stem cells: regulatory networks, stem cell niches, and disease relevance. Stem Cells Transl Med, 3(8), 942–948.
    • (2014) Stem Cells Transl Med , vol.3 , Issue.8 , pp. 942-948
    • Guo, W.1
  • 19
    • 73049110243 scopus 로고    scopus 로고
    • The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs
    • COI: 1:CAS:528:DC%2BD1MXhsV2gsLnM, PID: 19935649
    • Wellner, U., Schubert, J., Burk, U. C., Schmalhofer, O., Zhu, F., Sonntag, A., et al. (2009). The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs. Nature Cell Biology, 11(12), 1487–1495.
    • (2009) Nature Cell Biology , vol.11 , Issue.12 , pp. 1487-1495
    • Wellner, U.1    Schubert, J.2    Burk, U.C.3    Schmalhofer, O.4    Zhu, F.5    Sonntag, A.6
  • 20
    • 84855729906 scopus 로고    scopus 로고
    • A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition
    • COI: 1:CAS:528:DC%2BC3MXhsVeit7jP, PID: 22024162
    • Kim, N. H., Kim, H. S., Li, X. Y., Lee, I., Choi, H. S., Kang, S. E., et al. (2011). A p53/miRNA-34 axis regulates Snail1-dependent cancer cell epithelial-mesenchymal transition. The Journal of Cell Biology, 195(3), 417–433.
    • (2011) The Journal of Cell Biology , vol.195 , Issue.3 , pp. 417-433
    • Kim, N.H.1    Kim, H.S.2    Li, X.Y.3    Lee, I.4    Choi, H.S.5    Kang, S.E.6
  • 21
    • 84055184850 scopus 로고    scopus 로고
    • miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions
    • COI: 1:CAS:528:DC%2BC38XhvVKlurg%3D, PID: 22134354
    • Siemens, H., Jackstadt, R., Hunten, S., Kaller, M., Menssen, A., Gotz, U., et al. (2011). miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions. Cell Cycle, 10(24), 4256–4271.
    • (2011) Cell Cycle , vol.10 , Issue.24 , pp. 4256-4271
    • Siemens, H.1    Jackstadt, R.2    Hunten, S.3    Kaller, M.4    Menssen, A.5    Gotz, U.6
  • 22
    • 84879983245 scopus 로고    scopus 로고
    • Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity
    • COI: 1:CAS:528:DC%2BC3sXhtVGrtb3P, PID: 23827675
    • Chaffer, C. L., Marjanovic, N. D., Lee, T., Bell, G., Kleer, C. G., Reinhardt, F., et al. (2013). Poised chromatin at the ZEB1 promoter enables breast cancer cell plasticity and enhances tumorigenicity. Cell, 154(1), 61–74.
    • (2013) Cell , vol.154 , Issue.1 , pp. 61-74
    • Chaffer, C.L.1    Marjanovic, N.D.2    Lee, T.3    Bell, G.4    Kleer, C.G.5    Reinhardt, F.6
  • 23
    • 0242499448 scopus 로고    scopus 로고
    • Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer
    • COI: 1:CAS:528:DC%2BD3sXotVWkt78%3D, PID: 14557817
    • Siegel, P. M., & Massague, J. (2003). Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer. Nature Reviews. Cancer, 3(11), 807–821.
    • (2003) Nature Reviews. Cancer , vol.3 , Issue.11 , pp. 807-821
    • Siegel, P.M.1    Massague, J.2
  • 24
    • 0029662049 scopus 로고    scopus 로고
    • TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells
    • COI: 1:CAS:528:DyaK28Xmt1KnurY%3D
    • Oft, M., Peli, J., Rudaz, C., Schwarz, H., Beug, H., & Reichmann, E. (1996). TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells. Genes & Development, 10(19), 2462–2477.
    • (1996) Genes & Development , vol.10 , Issue.19 , pp. 2462-2477
    • Oft, M.1    Peli, J.2    Rudaz, C.3    Schwarz, H.4    Beug, H.5    Reichmann, E.6
  • 25
    • 84953242016 scopus 로고    scopus 로고
    • ShcA protects against epithelial-mesenchymal transition through compartmentalized inhibition of TGF-beta-induced Smad activation
    • PID: 26680585
    • Muthusamy, B. P., Budi, E. H., Katsuno, Y., Lee, M. K., Smith, S. M., Mirza, A. M., et al. (2015). ShcA protects against epithelial-mesenchymal transition through compartmentalized inhibition of TGF-beta-induced Smad activation. PLoS Biology, 13(12), e1002325.
    • (2015) PLoS Biology , vol.13 , Issue.12
    • Muthusamy, B.P.1    Budi, E.H.2    Katsuno, Y.3    Lee, M.K.4    Smith, S.M.5    Mirza, A.M.6
  • 26
    • 79955954699 scopus 로고    scopus 로고
    • An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition
    • COI: 1:CAS:528:DC%2BC3MXntFSjt7s%3D, PID: 21411626
    • Gregory, P. A., Bracken, C. P., Smith, E., Bert, A. G., Wright, J. A., Roslan, S., et al. (2011). An autocrine TGF-beta/ZEB/miR-200 signaling network regulates establishment and maintenance of epithelial-mesenchymal transition. Molecular Biology of the Cell, 22(10), 1686–1698.
    • (2011) Molecular Biology of the Cell , vol.22 , Issue.10 , pp. 1686-1698
    • Gregory, P.A.1    Bracken, C.P.2    Smith, E.3    Bert, A.G.4    Wright, J.A.5    Roslan, S.6
  • 27
    • 0033559946 scopus 로고    scopus 로고
    • Lysis of tumor cells by natural killer cells in mice is impeded by platelets
    • COI: 1:CAS:528:DyaK1MXhvFehtbo%3D, PID: 10096562
    • Nieswandt, B., Hafner, M., Echtenacher, B., & Männel, D. N. (1999). Lysis of tumor cells by natural killer cells in mice is impeded by platelets. Cancer Research, 59(6), 1295.
    • (1999) Cancer Research , vol.59 , Issue.6 , pp. 1295
    • Nieswandt, B.1    Hafner, M.2    Echtenacher, B.3    Männel, D.N.4
  • 28
    • 0037092984 scopus 로고    scopus 로고
    • Multiple roles for platelet GPIIb/IIIa and alphavbeta3 integrins in tumor growth, angiogenesis, and metastasis
    • COI: 1:CAS:528:DC%2BD38XjvFaktLg%3D, PID: 12019160
    • Trikha, M., Zhou, Z., Timar, J., Raso, E., Kennel, M., Emmell, E., et al. (2002). Multiple roles for platelet GPIIb/IIIa and alphavbeta3 integrins in tumor growth, angiogenesis, and metastasis. Cancer Research, 62(10), 2824–2833.
    • (2002) Cancer Research , vol.62 , Issue.10 , pp. 2824-2833
    • Trikha, M.1    Zhou, Z.2    Timar, J.3    Raso, E.4    Kennel, M.5    Emmell, E.6
  • 29
    • 81255205399 scopus 로고    scopus 로고
    • Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis
    • COI: 1:CAS:528:DC%2BC3MXhsFSktLnJ, PID: 22094253
    • Labelle, M., Begum, S., & Hynes, R. O. (2011). Direct signaling between platelets and cancer cells induces an epithelial-mesenchymal-like transition and promotes metastasis. Cancer Cell, 20(5), 576–590.
    • (2011) Cancer Cell , vol.20 , Issue.5 , pp. 576-590
    • Labelle, M.1    Begum, S.2    Hynes, R.O.3
  • 30
    • 28644432204 scopus 로고    scopus 로고
    • VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche
    • COI: 1:CAS:528:DC%2BD2MXht1ynsrnL, PID: 16341007
    • Kaplan, R. N., Riba, R. D., Zacharoulis, S., Bramley, A. H., Vincent, L., Costa, C., et al. (2005). VEGFR1-positive haematopoietic bone marrow progenitors initiate the pre-metastatic niche. Nature, 438(7069), 820–827.
    • (2005) Nature , vol.438 , Issue.7069 , pp. 820-827
    • Kaplan, R.N.1    Riba, R.D.2    Zacharoulis, S.3    Bramley, A.H.4    Vincent, L.5    Costa, C.6
  • 31
    • 33751504690 scopus 로고    scopus 로고
    • Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis
    • COI: 1:CAS:528:DC%2BD28Xht1Kju7rL, PID: 17128264
    • Hiratsuka, S., Watanabe, A., Aburatani, H., & Maru, Y. (2006). Tumour-mediated upregulation of chemoattractants and recruitment of myeloid cells predetermines lung metastasis. Nature Cell Biology, 8(12), 1369–1375.
    • (2006) Nature Cell Biology , vol.8 , Issue.12 , pp. 1369-1375
    • Hiratsuka, S.1    Watanabe, A.2    Aburatani, H.3    Maru, Y.4
  • 32
    • 79952070774 scopus 로고    scopus 로고
    • The secreted factors responsible for pre-metastatic niche formation: old sayings and new thoughts
    • COI: 1:CAS:528:DC%2BC3MXjs1Crtbs%3D, PID: 21251983
    • Peinado, H., Lavotshkin, S., & Lyden, D. (2011). The secreted factors responsible for pre-metastatic niche formation: old sayings and new thoughts. Seminars in Cancer Biology, 21(2), 139–146.
    • (2011) Seminars in Cancer Biology , vol.21 , Issue.2 , pp. 139-146
    • Peinado, H.1    Lavotshkin, S.2    Lyden, D.3
  • 33
    • 59149083102 scopus 로고    scopus 로고
    • Membrane microvesicles as actors in the establishment of a favorable prostatic tumoral niche: a role for activated fibroblasts and CX3CL1-CX3CR1 axis
    • COI: 1:CAS:528:DC%2BD1MXhtFOksbg%3D, PID: 19155311
    • Castellana, D., Zobairi, F., Martinez, M. C., Panaro, M. A., Mitolo, V., Freyssinet, J. M., et al. (2009). Membrane microvesicles as actors in the establishment of a favorable prostatic tumoral niche: a role for activated fibroblasts and CX3CL1-CX3CR1 axis. Cancer Research, 69(3), 785–793.
    • (2009) Cancer Research , vol.69 , Issue.3 , pp. 785-793
    • Castellana, D.1    Zobairi, F.2    Martinez, M.C.3    Panaro, M.A.4    Mitolo, V.5    Freyssinet, J.M.6
  • 34
    • 84895914531 scopus 로고    scopus 로고
    • Lysyl oxidase-like 2 (LOXL2) and E47 EMT factor: novel partners in E-cadherin repression and early metastasis colonization
    • COI: 1:CAS:528:DC%2BC2cXktlGmtrk%3D, PID: 24632622
    • Canesin, G., Cuevas, E. P., Santos, V., Lopez-Menendez, C., Moreno-Bueno, G., Huang, Y., et al. (2015). Lysyl oxidase-like 2 (LOXL2) and E47 EMT factor: novel partners in E-cadherin repression and early metastasis colonization. Oncogene, 34(8), 951–964.
    • (2015) Oncogene , vol.34 , Issue.8 , pp. 951-964
    • Canesin, G.1    Cuevas, E.P.2    Santos, V.3    Lopez-Menendez, C.4    Moreno-Bueno, G.5    Huang, Y.6
  • 35
    • 52649162338 scopus 로고    scopus 로고
    • Circulating tumor cells and bone marrow micrometastasis
    • COI: 1:CAS:528:DC%2BD1cXpslKgtr4%3D, PID: 18698019
    • Alix-Panabieres, C., Riethdorf, S., & Pantel, K. (2008). Circulating tumor cells and bone marrow micrometastasis. Clinical Cancer Research, 14(16), 5013–5021.
    • (2008) Clinical Cancer Research , vol.14 , Issue.16 , pp. 5013-5021
    • Alix-Panabieres, C.1    Riethdorf, S.2    Pantel, K.3
  • 36
    • 84867984708 scopus 로고    scopus 로고
    • Mesenchymal-epithelial transition (MET) as a mechanism for metastatic colonisation in breast cancer
    • COI: 1:CAS:528:DC%2BC38XhsFSqsrrL, PID: 22729277
    • Gunasinghe, N. P., Wells, A., Thompson, E. W., & Hugo, H. J. (2012). Mesenchymal-epithelial transition (MET) as a mechanism for metastatic colonisation in breast cancer. Cancer Metastasis Reviews, 31(3–4), 469–478.
    • (2012) Cancer Metastasis Reviews , vol.31 , Issue.3-4 , pp. 469-478
    • Gunasinghe, N.P.1    Wells, A.2    Thompson, E.W.3    Hugo, H.J.4
  • 37
    • 84890192124 scopus 로고    scopus 로고
    • TGF-beta-Id1 signaling opposes Twist1 and promotes metastatic colonization via a mesenchymal-to-epithelial transition
    • COI: 1:CAS:528:DC%2BC3sXhvFylurbP, PID: 24332369
    • Stankic, M., Pavlovic, S., Chin, Y., Brogi, E., Padua, D., Norton, L., et al. (2013). TGF-beta-Id1 signaling opposes Twist1 and promotes metastatic colonization via a mesenchymal-to-epithelial transition. Cell Reports, 5(5), 1228–1242.
    • (2013) Cell Reports , vol.5 , Issue.5 , pp. 1228-1242
    • Stankic, M.1    Pavlovic, S.2    Chin, Y.3    Brogi, E.4    Padua, D.5    Norton, L.6
  • 38
    • 30944450821 scopus 로고    scopus 로고
    • Phenotypic evaluation of the basal-like subtype of invasive breast carcinoma
    • COI: 1:CAS:528:DC%2BD28Xlt1eqtw%3D%3D, PID: 16341146
    • Livasy, C. A., Karaca, G., Nanda, R., Tretiakova, M. S., Olopade, O. I., Moore, D. T., et al. (2006). Phenotypic evaluation of the basal-like subtype of invasive breast carcinoma. Modern Pathology, 19(2), 264–271.
    • (2006) Modern Pathology , vol.19 , Issue.2 , pp. 264-271
    • Livasy, C.A.1    Karaca, G.2    Nanda, R.3    Tretiakova, M.S.4    Olopade, O.I.5    Moore, D.T.6
  • 39
    • 33644695272 scopus 로고    scopus 로고
    • Morphological and immunophenotypic analysis of breast carcinomas with basal and myoepithelial differentiation
    • COI: 1:CAS:528:DC%2BD28XislCqt78%3D, PID: 16429394
    • Rakha, E. A., Putti, T. C., Abd El-Rehim, D. M., Paish, C., Green, A. R., Powe, D. G., et al. (2006). Morphological and immunophenotypic analysis of breast carcinomas with basal and myoepithelial differentiation. The Journal of Pathology, 208(4), 495–506.
    • (2006) The Journal of Pathology , vol.208 , Issue.4 , pp. 495-506
    • Rakha, E.A.1    Putti, T.C.2    Abd El-Rehim, D.M.3    Paish, C.4    Green, A.R.5    Powe, D.G.6
  • 40
    • 84865217666 scopus 로고    scopus 로고
    • A dynamic in vivo model of epithelial-to-mesenchymal transitions in circulating tumor cells and metastases of breast cancer
    • COI: 1:CAS:528:DC%2BC3MXhsFeitLvK, PID: 22120722
    • Bonnomet, A., Syne, L., Brysse, A., Feyereisen, E., Thompson, E. W., Noel, A., et al. (2012). A dynamic in vivo model of epithelial-to-mesenchymal transitions in circulating tumor cells and metastases of breast cancer. Oncogene, 31(33), 3741–3753.
    • (2012) Oncogene , vol.31 , Issue.33 , pp. 3741-3753
    • Bonnomet, A.1    Syne, L.2    Brysse, A.3    Feyereisen, E.4    Thompson, E.W.5    Noel, A.6
  • 41
    • 84920942890 scopus 로고    scopus 로고
    • Stem-cell-like properties and epithelial plasticity arise as stable traits after transient Twist1 activation
    • COI: 1:CAS:528:DC%2BC2MXntVaitg%3D%3D, PID: 25578726
    • Schmidt, J. M., Panzilius, E., Bartsch, H. S., Irmler, M., Beckers, J., Kari, V., et al. (2015). Stem-cell-like properties and epithelial plasticity arise as stable traits after transient Twist1 activation. Cell Reports, 10(2), 131–139.
    • (2015) Cell Reports , vol.10 , Issue.2 , pp. 131-139
    • Schmidt, J.M.1    Panzilius, E.2    Bartsch, H.S.3    Irmler, M.4    Beckers, J.5    Kari, V.6
  • 42
    • 84909606776 scopus 로고    scopus 로고
    • Transient SNAIL1 expression is necessary for metastatic competence in breast cancer
    • COI: 1:CAS:528:DC%2BC2cXhvVGjtbzP, PID: 25164016
    • Tran, H. D., Luitel, K., Kim, M., Zhang, K., Longmore, G. D., & Tran, D. D. (2014). Transient SNAIL1 expression is necessary for metastatic competence in breast cancer. Cancer Research, 74(21), 6330–6340.
    • (2014) Cancer Research , vol.74 , Issue.21 , pp. 6330-6340
    • Tran, H.D.1    Luitel, K.2    Kim, M.3    Zhang, K.4    Longmore, G.D.5    Tran, D.D.6
  • 43
    • 84870845421 scopus 로고    scopus 로고
    • Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis
    • COI: 1:CAS:528:DC%2BC38XhslKqsLjL, PID: 23201165
    • Tsai, J. H., Donaher, J. L., Murphy, D. A., Chau, S., & Yang, J. (2012). Spatiotemporal regulation of epithelial-mesenchymal transition is essential for squamous cell carcinoma metastasis. Cancer Cell, 22(6), 725–736.
    • (2012) Cancer Cell , vol.22 , Issue.6 , pp. 725-736
    • Tsai, J.H.1    Donaher, J.L.2    Murphy, D.A.3    Chau, S.4    Yang, J.5
  • 44
    • 33845809125 scopus 로고    scopus 로고
    • Mesenchymal-to-epithelial transition facilitates bladder cancer metastasis: role of fibroblast growth factor receptor-2
    • COI: 1:CAS:528:DC%2BD28Xht1KnsL%2FE, PID: 17145872
    • Chaffer, C. L., Brennan, J. P., Slavin, J. L., Blick, T., Thompson, E. W., & Williams, E. D. (2006). Mesenchymal-to-epithelial transition facilitates bladder cancer metastasis: role of fibroblast growth factor receptor-2. Cancer Research, 66(23), 11271–11278.
    • (2006) Cancer Research , vol.66 , Issue.23 , pp. 11271-11278
    • Chaffer, C.L.1    Brennan, J.P.2    Slavin, J.L.3    Blick, T.4    Thompson, E.W.5    Williams, E.D.6
  • 45
    • 84941243013 scopus 로고    scopus 로고
    • Distinct EMT programs control normal mammary stem cells and tumour-initiating cells
    • COI: 1:CAS:528:DC%2BC2MXhsVCis77I, PID: 26331542
    • Ye, X., Tam, W. L., Shibue, T., Kaygusuz, Y., Reinhardt, F., Ng Eaton, E., et al. (2015). Distinct EMT programs control normal mammary stem cells and tumour-initiating cells. Nature, 525(7568), 256–260.
    • (2015) Nature , vol.525 , Issue.7568 , pp. 256-260
    • Ye, X.1    Tam, W.L.2    Shibue, T.3    Kaygusuz, Y.4    Reinhardt, F.5    Ng Eaton, E.6
  • 46
    • 77956230322 scopus 로고    scopus 로고
    • The ZEB/miR-200 feedback loop--a motor of cellular plasticity in development and cancer?
    • COI: 1:CAS:528:DC%2BC3cXhtVaisL%2FM, PID: 20706219
    • Brabletz, S., & Brabletz, T. (2010). The ZEB/miR-200 feedback loop--a motor of cellular plasticity in development and cancer? EMBO Reports, 11(9), 670–677.
    • (2010) EMBO Reports , vol.11 , Issue.9 , pp. 670-677
    • Brabletz, S.1    Brabletz, T.2
  • 47
    • 84945566252 scopus 로고    scopus 로고
    • Epithelial-mesenchymal plasticity: a central regulator of cancer progression
    • COI: 1:CAS:528:DC%2BC2MXhs1Sht7vN, PID: 26437589
    • Ye, X., & Weinberg, R. A. (2015). Epithelial-mesenchymal plasticity: a central regulator of cancer progression. Trends in Cell Biology, 25(11), 675–686.
    • (2015) Trends in Cell Biology , vol.25 , Issue.11 , pp. 675-686
    • Ye, X.1    Weinberg, R.A.2
  • 48
    • 84873050284 scopus 로고    scopus 로고
    • Regulatory networks defining EMT during cancer initiation and progression
    • COI: 1:CAS:528:DC%2BC3sXht1GlsLk%3D, PID: 23344542
    • De Craene, B., & Berx, G. (2013). Regulatory networks defining EMT during cancer initiation and progression. Nature Reviews. Cancer, 13(2), 97–110.
    • (2013) Nature Reviews. Cancer , vol.13 , Issue.2 , pp. 97-110
    • De Craene, B.1    Berx, G.2
  • 50
    • 84964560527 scopus 로고    scopus 로고
    • In vivo visualization and characterization of epithelial-mesenchymal transition in breast tumors
    • COI: 1:CAS:528:DC%2BC28XmtVahtb8%3D, PID: 26893478
    • Zhao, Z., Zhu, X., Cui, K., Mancuso, J., Federley, R., Fischer, K., et al. (2016). In vivo visualization and characterization of epithelial-mesenchymal transition in breast tumors. Cancer Research, 76(8), 2094–2104.
    • (2016) Cancer Research , vol.76 , Issue.8 , pp. 2094-2104
    • Zhao, Z.1    Zhu, X.2    Cui, K.3    Mancuso, J.4    Federley, R.5    Fischer, K.6
  • 51
    • 84905489718 scopus 로고    scopus 로고
    • Therapeutic delivery of miR-200c enhances radiosensitivity in lung cancer
    • COI: 1:CAS:528:DC%2BC2cXpvVSgur8%3D, PID: 24791940
    • Cortez, M. A., Valdecanas, D., Zhang, X., Zhan, Y., Bhardwaj, V., Calin, G. A., et al. (2014). Therapeutic delivery of miR-200c enhances radiosensitivity in lung cancer. Molecular Therapy, 22(8), 1494–1503.
    • (2014) Molecular Therapy , vol.22 , Issue.8 , pp. 1494-1503
    • Cortez, M.A.1    Valdecanas, D.2    Zhang, X.3    Zhan, Y.4    Bhardwaj, V.5    Calin, G.A.6
  • 52
    • 84948753065 scopus 로고    scopus 로고
    • Overcoming multidrug resistance in cancer stem cells
    • Moitra, K. (2015). Overcoming multidrug resistance in cancer stem cells. BioMed Research International, 2015.
    • (2015) BioMed Research International , pp. 2015
    • Moitra, K.1
  • 54
    • 84960441572 scopus 로고    scopus 로고
    • Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability. Science
    • Pattabiraman, D. R., Bierie, B., Kober, K. I., Thiru, P., Krall, J. A., Zill, C., et al. (2016). Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability. Science, 351(6277) aad3680.
    • (2016) 351(6277) aad3680
    • Pattabiraman, D.R.1    Bierie, B.2    Kober, K.I.3    Thiru, P.4    Krall, J.A.5    Zill, C.6
  • 55
    • 84984596113 scopus 로고    scopus 로고
    • HER2 expression identifies dynamic functional states within circulating breast cancer cells
    • COI: 1:CAS:528:DC%2BC28XhsVamtrjI, PID: 27556950
    • Jordan, N. V., Bardia, A., Wittner, B. S., Benes, C., Ligorio, M., Zheng, Y., et al. (2016). HER2 expression identifies dynamic functional states within circulating breast cancer cells. Nature, 537(7618), 102–106.
    • (2016) Nature , vol.537 , Issue.7618 , pp. 102-106
    • Jordan, N.V.1    Bardia, A.2    Wittner, B.S.3    Benes, C.4    Ligorio, M.5    Zheng, Y.6
  • 57
    • 84911164671 scopus 로고    scopus 로고
    • Eribulin mesylate reduces tumor microenvironment abnormality by vascular remodeling in preclinical human breast cancer models
    • COI: 1:CAS:528:DC%2BC2cXhslyltLjO, PID: 25060424
    • Funahashi, Y., Okamoto, K., Adachi, Y., Semba, T., Uesugi, M., Ozawa, Y., et al. (2014). Eribulin mesylate reduces tumor microenvironment abnormality by vascular remodeling in preclinical human breast cancer models. Cancer Science, 105(10), 1334–1342.
    • (2014) Cancer Science , vol.105 , Issue.10 , pp. 1334-1342
    • Funahashi, Y.1    Okamoto, K.2    Adachi, Y.3    Semba, T.4    Uesugi, M.5    Ozawa, Y.6
  • 58
    • 84896489562 scopus 로고    scopus 로고
    • Eribulin mesilate suppresses experimental metastasis of breast cancer cells by reversing phenotype from epithelial-mesenchymal transition (EMT) to mesenchymal-epithelial transition (MET) states
    • COI: 1:CAS:528:DC%2BC2cXjsVCrtrY%3D, PID: 24569463
    • Yoshida, T., Ozawa, Y., Kimura, T., Sato, Y., Kuznetsov, G., Xu, S., et al. (2014). Eribulin mesilate suppresses experimental metastasis of breast cancer cells by reversing phenotype from epithelial-mesenchymal transition (EMT) to mesenchymal-epithelial transition (MET) states. British Journal of Cancer, 110(6), 1497–1505.
    • (2014) British Journal of Cancer , vol.110 , Issue.6 , pp. 1497-1505
    • Yoshida, T.1    Ozawa, Y.2    Kimura, T.3    Sato, Y.4    Kuznetsov, G.5    Xu, S.6
  • 59
    • 84867586066 scopus 로고    scopus 로고
    • Tumor-derived secretory clusterin induces epithelial-mesenchymal transition and facilitates hepatocellular carcinoma metastasis
    • COI: 1:CAS:528:DC%2BC38Xhs1Kjs7%2FL
    • Wang, C., Jiang, K., Kang, X., Gao, D., Sun, C., Li, Y., et al. (2012). Tumor-derived secretory clusterin induces epithelial-mesenchymal transition and facilitates hepatocellular carcinoma metastasis. The International Journal of Biochemistry & Cell Biology, 44(12), 2308–2320.
    • (2012) The International Journal of Biochemistry & Cell Biology , vol.44 , Issue.12 , pp. 2308-2320
    • Wang, C.1    Jiang, K.2    Kang, X.3    Gao, D.4    Sun, C.5    Li, Y.6
  • 60
    • 85008381285 scopus 로고    scopus 로고
    • Abstract 1467: AB-16B5, a therapeutic monoclonal antibody against human clusterin that blocks the epithelial-to-mesenchymal transition
    • [10.1158/1538-7445.AM10-1467]
    • Tremblay, G., Malouin, M., Grothe, S., Kalbakji, A., Roy, S., Pagé, M., et al. (2010). Abstract 1467: AB-16B5, a therapeutic monoclonal antibody against human clusterin that blocks the epithelial-to-mesenchymal transition. Cancer Research, 70(8 Supplement), 1467 [10.1158/1538-7445.AM10-1467].
    • (2010) Cancer Research , vol.70 , pp. 1467
    • Tremblay, G.1    Malouin, M.2    Grothe, S.3    Kalbakji, A.4    Roy, S.5    Pagé, M.6
  • 61
    • 85008320646 scopus 로고    scopus 로고
    • Abstract LB-297: the EMT inhibitor AB-16B5 interacts with specific isoforms of secreted clusterin. Cancer Research, 72(8 Supplement) LB-297
    • Tremblay, G. B., Viau, E., & Filion, M. (2012). Abstract LB-297: the EMT inhibitor AB-16B5 interacts with specific isoforms of secreted clusterin. Cancer Research, 72(8 Supplement) LB-297. [10.1158/1538-7445.AM2012-LB-297].
    • (2012) [10.1158/1538-7445.AM2012-LB-297]
    • Tremblay, G.B.1    Viau, E.2    Filion, M.3
  • 62
    • 84962822024 scopus 로고    scopus 로고
    • Abstract 2505; a first-in-human phase 1 study of anticancer stem cell agent OMP-54F28 (FZD8-Fc), decoy receptor for WNT ligands, in patients with advanced solid tumors
    • Jimeno, A., Gordon, M. S., Chugh, R., Messersmith, W. A., Mendelson, D. S., Dupont, J., et al. (2014). Abstract 2505; a first-in-human phase 1 study of anticancer stem cell agent OMP-54F28 (FZD8-Fc), decoy receptor for WNT ligands, in patients with advanced solid tumors. Journal of Clinical Oncology, 32, 5s.
    • (2014) Journal of Clinical Oncology , vol.32 , pp. 5s
    • Jimeno, A.1    Gordon, M.S.2    Chugh, R.3    Messersmith, W.A.4    Mendelson, D.S.5    Dupont, J.6


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