Large-Scale Gene Expression Profiling Platform for Identification of Context-Dependent Drug Responses in Multicellular Tumor Spheroids

Cell Chemical Biology

Volumn 23, Issue 11, 2016, Pages 1428-1438

  Senkowski, Wojciech ^a   Jarvius, Malin ^a   Rubin, Jenny ^a   Lengqvist, Johan ^b   Gustafsson, Mats G ^a   Nygren, Peter ^a   Kultima, Kim ^a   Larsson, Rolf ^a   Fryknäs, Mårten ^a  

^a UPPSALA UNIVERSITY   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

Author keywords

3D culture; gene expression profiling; high throughput screening; L1000; mevalonate pathway; mitochondria; OXPHOS; spheroids; statins; transcriptomics

Indexed keywords

MEVALONIC ACID; ANTINEOPLASTIC AGENT; TRANSCRIPTOME;

ARTICLE; CANCER CELL; CONTROLLED STUDY; DRUG RESPONSE; DRUG SCREENING; GENE EXPRESSION PROFILING; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; MULTICELLULAR SPHEROID; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; TREATMENT RESPONSE; TUMOR SPHEROID; UPREGULATION; CELL CULTURE TECHNIQUE; DRUG EFFECTS; GENETICS; METABOLISM; NEOPLASMS; PROCEDURES; SIGNAL TRANSDUCTION; TUMOR CELL CULTURE; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; DRUG SCREENING ASSAYS, ANTITUMOR; GENE EXPRESSION PROFILING; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; MEVALONIC ACID; NEOPLASMS; OXIDATIVE PHOSPHORYLATION; SIGNAL TRANSDUCTION; SPHEROIDS, CELLULAR; TRANSCRIPTOME; TUMOR CELLS, CULTURED;

EID: 84995785853     PISSN: 24519456     EISSN: 24519448     Source Type: Journal    
DOI: 10.1016/j.chembiol.2016.09.013     Document Type: Article

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