메뉴 건너뛰기




Volumn 75, Issue 18, 2015, Pages 3687-3691

Tumors and mitochondrial respiration: A neglected connection

Author keywords

[No Author keywords available]

Indexed keywords

MITOCHONDRIAL DNA;

EID: 84942872148     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-15-0491     Document Type: Review
Times cited : (120)

References (41)
  • 1
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg O. On the origin of cancer cells. Science 1956;123:309-14.
    • (1956) Science , vol.123 , pp. 309-314
    • Warburg, O.1
  • 2
    • 84901410479 scopus 로고    scopus 로고
    • Mitochondria as signaling organelles
    • Chandel NS. Mitochondria as signaling organelles. BMC Biol 2014;12:34.
    • (2014) BMC Biol , vol.12 , pp. 34
    • Chandel, N.S.1
  • 3
    • 84866665390 scopus 로고    scopus 로고
    • Mitochondria and cancer
    • Wallace DC. Mitochondria and cancer. Nat Rev Cancer 2012;12: 685-98.
    • (2012) Nat Rev Cancer , vol.12 , pp. 685-698
    • Wallace, D.C.1
  • 4
    • 84869397441 scopus 로고    scopus 로고
    • Human mitochondrial DNA: Roles of inherited and somatic mutations
    • Schon EA, DiMauro S, Hirano M. Human mitochondrial DNA: roles of inherited and somatic mutations. Nat Rev Genet 2012;13:878-90.
    • (2012) Nat Rev Genet , vol.13 , pp. 878-890
    • Schon, E.A.1    DiMauro, S.2    Hirano, M.3
  • 5
    • 77649210966 scopus 로고    scopus 로고
    • Molecular poltergeists: Mitochondrial DNA copies (numts) in sequenced nuclear genomes
    • Hazkani-Covo E, Zeller RM, Martin W. Molecular poltergeists: mitochondrial DNA copies (numts) in sequenced nuclear genomes. PLoS Genet 2010;6:e1000834.
    • (2010) PLoS Genet , vol.6 , pp. e1000834
    • Hazkani-Covo, E.1    Zeller, R.M.2    Martin, W.3
  • 6
    • 82755182650 scopus 로고    scopus 로고
    • Nuclear insertions of mitochondrial origin: Database updating and usefulness in cancer studies
    • Ramos A, Barbena E, Mateiu L, del Mar Gonzalez M, Mairal Q, Lima M, et al. Nuclear insertions of mitochondrial origin: database updating and usefulness in cancer studies. Mitochondrion 2011;11:946-53.
    • (2011) Mitochondrion , vol.11 , pp. 946-953
    • Ramos, A.1    Barbena, E.2    Mateiu, L.3    Del Mar Gonzalez, M.4    Mairal, Q.5    Lima, M.6
  • 9
    • 85060496113 scopus 로고    scopus 로고
    • Mitochondrial reactive oxygen species and cancer
    • Sullivan LB, Chandel NS. Mitochondrial reactive oxygen species and cancer. Cancer Metab 2014;2:17.
    • (2014) Cancer Metab , vol.2 , pp. 17
    • Sullivan, L.B.1    Chandel, N.S.2
  • 10
    • 0024448458 scopus 로고
    • Human cells lacking mtDNA: Repopulation with exogenous mitochondria by complementation
    • King MP, Attardi G. Human cells lacking mtDNA: repopulation with exogenous mitochondria by complementation. Science 1989;246: 500-3.
    • (1989) Science , vol.246 , pp. 500-503
    • King, M.P.1    Attardi, G.2
  • 11
    • 0026697079 scopus 로고
    • Recovery of the missing tumorigenicity in mitochondrial DNA-less HeLa cells by introduction of mitochondrial DNA from normal human cells
    • Hayashi J, Takemitsu M, Nonaka I. Recovery of the missing tumorigenicity in mitochondrial DNA-less HeLa cells by introduction of mitochondrial DNA from normal human cells. Somat Cell Mol Genet 1992;18:123-9.
    • (1992) Somat Cell Mol Genet , vol.18 , pp. 123-129
    • Hayashi, J.1    Takemitsu, M.2    Nonaka, I.3
  • 12
    • 0030728737 scopus 로고    scopus 로고
    • Diminished tumorigenic phenotype after depletion of mitochondrial DNA
    • Cavalli LR, Varella-Garcia M, Liang BC. Diminished tumorigenic phenotype after depletion of mitochondrial DNA. Cell Growth Differ 1997; 8:1189-98.
    • (1997) Cell Growth Differ , vol.8 , pp. 1189-1198
    • Cavalli, L.R.1    Varella-Garcia, M.2    Liang, B.C.3
  • 13
    • 0028107856 scopus 로고
    • Tumor-forming ability in athymic nude mice of human cell lines devoid of mitochondrial DNA
    • Morais R, Zinkewich-Peotti K, Parent M, Wang H, Babai F, Zollinger M. Tumor-forming ability in athymic nude mice of human cell lines devoid of mitochondrial DNA. Cancer Res 1994;54:3889-96.
    • (1994) Cancer Res , vol.54 , pp. 3889-3896
    • Morais, R.1    Zinkewich-Peotti, K.2    Parent, M.3    Wang, H.4    Babai, F.5    Zollinger, M.6
  • 14
    • 84920560830 scopus 로고    scopus 로고
    • Mitochondrial genome acquisition restores respiratory function and tumorigenic potential of cancer cells without mitochondrial DNA
    • Tan AS, Baty JW, Dong LF, Bezawork-Geleta A, Endaya B, Goodwin J, et al. Mitochondrial genome acquisition restores respiratory function and tumorigenic potential of cancer cells without mitochondrial DNA. Cell Metab 2015;21:81-94.
    • (2015) Cell Metab , vol.21 , pp. 81-94
    • Tan, A.S.1    Baty, J.W.2    Dong, L.F.3    Bezawork-Geleta, A.4    Endaya, B.5    Goodwin, J.6
  • 15
    • 84920616812 scopus 로고    scopus 로고
    • PGC-1alpha mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis
    • 1-15
    • LeBleu VS, O'Connell JT, Gonzalez Herrera KN, Wikman H, Pantel K, Haigis MC, et al. PGC-1alpha mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis. Nat Cell Biol 2014;16:992-1003, 1-15.
    • (2014) Nat Cell Biol , vol.16 , pp. 992-1003
    • LeBleu, V.S.1    O'Connell, J.T.2    Gonzalez Herrera, K.N.3    Wikman, H.4    Pantel, K.5    Haigis, M.C.6
  • 16
    • 84911861458 scopus 로고    scopus 로고
    • Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function
    • Viale A, Pettazzoni P, Lyssiotis CA, Ying H, Sanchez N, MarchesiniM, et al. Oncogene ablation-resistant pancreatic cancer cells depend on mitochondrial function. Nature 2014;514:628-32.
    • (2014) Nature , vol.514 , pp. 628-632
    • Viale, A.1    Pettazzoni, P.2    Lyssiotis, C.A.3    Ying, H.4    Sanchez, N.5    Marchesini, M.6
  • 17
    • 84860321700 scopus 로고    scopus 로고
    • Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism
    • Ying H, Kimmelman AC, Lyssiotis CA, Hua S, Chu GC, Fletcher- Sananikone E, et al. Oncogenic Kras maintains pancreatic tumors through regulation of anabolic glucose metabolism. Cell 2012;149: 656-70.
    • (2012) Cell , vol.149 , pp. 656-670
    • Ying, H.1    Kimmelman, A.C.2    Lyssiotis, C.A.3    Hua, S.4    Chu, G.C.5    Fletcher-Sananikone, E.6
  • 18
    • 84863012865 scopus 로고    scopus 로고
    • Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice
    • Collins MA, Bednar F, Zhang Y, Brisset JC, Galban S, Galban CJ, et al. Oncogenic Kras is required for both the initiation and maintenance of pancreatic cancer in mice. J Clin Invest 2012;122:639-53.
    • (2012) J Clin Invest , vol.122 , pp. 639-653
    • Collins, M.A.1    Bednar, F.2    Zhang, Y.3    Brisset, J.C.4    Galban, S.5    Galban, C.J.6
  • 19
    • 84903984143 scopus 로고    scopus 로고
    • Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer
    • Kapoor A, Yao W, Ying H, Hua S, Liewen A, Wang Q, et al. Yap1 activation enables bypass of oncogenic Kras addiction in pancreatic cancer. Cell 2014;158:185-97.
    • (2014) Cell , vol.158 , pp. 185-197
    • Kapoor, A.1    Yao, W.2    Ying, H.3    Hua, S.4    Liewen, A.5    Wang, Q.6
  • 20
    • 84875143073 scopus 로고    scopus 로고
    • BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells
    • Lagadinou ED, Sach A, Callahan K, Rossi RM, Neering SJ, Minhajuddin M, et al. BCL-2 inhibition targets oxidative phosphorylation and selectively eradicates quiescent human leukemia stem cells. Cell Stem Cell 2013; 12:329-41.
    • (2013) Cell Stem Cell , vol.12 , pp. 329-341
    • Lagadinou, E.D.1    Sach, A.2    Callahan, K.3    Rossi, R.M.4    Neering, S.J.5    Minhajuddin, M.6
  • 21
    • 81255192118 scopus 로고    scopus 로고
    • Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia
    • Skrtic M, Sriskanthadevan S, Jhas B, Gebbia M, Wang X, Wang Z, et al. Inhibition of mitochondrial translation as a therapeutic strategy for human acute myeloid leukemia. Cancer Cell 2011;20:674-88.
    • (2011) Cancer Cell , vol.20 , pp. 674-688
    • Skrtic, M.1    Sriskanthadevan, S.2    Jhas, B.3    Gebbia, M.4    Wang, X.5    Wang, Z.6
  • 23
    • 84876448550 scopus 로고    scopus 로고
    • PGC1alpha expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress
    • Vazquez F, Lim JH, Chim H, Bhalla K, Girnun G, Pierce K, et al. PGC1alpha expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress. Cancer Cell 2013;23:287-301.
    • (2013) Cancer Cell , vol.23 , pp. 287-301
    • Vazquez, F.1    Lim, J.H.2    Chim, H.3    Bhalla, K.4    Girnun, G.5    Pierce, K.6
  • 25
    • 78249250559 scopus 로고    scopus 로고
    • Phenotypic heterogeneity among tumorigenic melanoma cells from patients that is reversible and not hierarchically organized
    • Quintana E, Shackleton M, Foster HR, Fullen DR, Sabel MS, Johnson TM, et al. Phenotypic heterogeneity among tumorigenic melanoma cells from patients that is reversible and not hierarchically organized. Cancer Cell 2010;18:510-23.
    • (2010) Cancer Cell , vol.18 , pp. 510-523
    • Quintana, E.1    Shackleton, M.2    Foster, H.R.3    Fullen, D.R.4    Sabel, M.S.5    Johnson, T.M.6
  • 27
    • 77952502408 scopus 로고    scopus 로고
    • A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth
    • Roesch A, Fukunaga-Kalabis M, Schmidt EC, Zabierowski SE, Brafford PA, Vultur A, et al. A temporarily distinct subpopulation of slow-cycling melanoma cells is required for continuous tumor growth. Cell 2010;141: 583-94.
    • (2010) Cell , vol.141 , pp. 583-594
    • Roesch, A.1    Fukunaga-Kalabis, M.2    Schmidt, E.C.3    Zabierowski, S.E.4    Brafford, P.A.5    Vultur, A.6
  • 28
    • 84878959237 scopus 로고    scopus 로고
    • Overcoming intrinsic multidrug resistance in melanoma by blocking the mitochondrial respiratory chain of slow-cycling JARID1B(high) cells
    • Roesch A, Vultur A, Bogeski I, Wang H, Zimmermann KM, Speicher D, et al. Overcoming intrinsic multidrug resistance in melanoma by blocking the mitochondrial respiratory chain of slow-cycling JARID1B(high) cells. Cancer Cell 2013;23:811-25.
    • (2013) Cancer Cell , vol.23 , pp. 811-825
    • Roesch, A.1    Vultur, A.2    Bogeski, I.3    Wang, H.4    Zimmermann, K.M.5    Speicher, D.6
  • 29
    • 77949901183 scopus 로고    scopus 로고
    • Cell respiration under hypoxia: Facts and artefacts in mitochondrial oxygen kinetics
    • Scandurra FM,Gnaiger E. Cell respiration under hypoxia: facts and artefacts in mitochondrial oxygen kinetics. Adv Exp Med Biol 2010;662:7-25.
    • (2010) Adv Exp Med Biol , vol.662 , pp. 7-25
    • Scandurra, F.M.1    Gnaiger, E.2
  • 30
    • 84862917865 scopus 로고    scopus 로고
    • Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone
    • Kobayashi A, Okuda H, Xing F, Pandey PR, Watabe M, Hirota S, et al. Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone. J Exp Med 2011;208:2641-55.
    • (2011) J Exp Med , vol.208 , pp. 2641-2655
    • Kobayashi, A.1    Okuda, H.2    Xing, F.3    Pandey, P.R.4    Watabe, M.5    Hirota, S.6
  • 31
    • 0035172910 scopus 로고    scopus 로고
    • Urokinase receptor and fibronectin regulate the ERK(MAPK) to p38(MAPK) activity ratios that determine carcinoma cell proliferation or dormancy in vivo
    • Aguirre-Ghiso JA, Liu D, Mignatti A, Kovalski K, Ossowski L. Urokinase receptor and fibronectin regulate the ERK(MAPK) to p38(MAPK) activity ratios that determine carcinoma cell proliferation or dormancy in vivo. Mol Biol Cell 2001;12:863-79.
    • (2001) Mol Biol Cell , vol.12 , pp. 863-879
    • Aguirre-Ghiso, J.A.1    Liu, D.2    Mignatti, A.3    Kovalski, K.4    Ossowski, L.5
  • 32
    • 0002460807 scopus 로고    scopus 로고
    • Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling
    • Aguirre Ghiso JA, Kovalski K, Ossowski L. Tumor dormancy induced by downregulation of urokinase receptor in human carcinoma involves integrin and MAPK signaling. J Cell Biol 1999;147:89-104.
    • (1999) J Cell Biol , vol.147 , pp. 89-104
    • Aguirre Ghiso, J.A.1    Kovalski, K.2    Ossowski, L.3
  • 34
    • 67651003108 scopus 로고    scopus 로고
    • Computational identification of a p38SAPK-regulated transcription factor network required for tumor cell quiescence
    • Adam AP, George A, Schewe D, Bragado P, Iglesias BV, Ranganathan AC, et al. Computational identification of a p38SAPK-regulated transcription factor network required for tumor cell quiescence. Cancer Res 2009;69: 5664-72.
    • (2009) Cancer Res , vol.69 , pp. 5664-5672
    • Adam, A.P.1    George, A.2    Schewe, D.3    Bragado, P.4    Iglesias, B.V.5    Ranganathan, A.C.6
  • 36
    • 21244477127 scopus 로고    scopus 로고
    • Exercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathway
    • Akimoto T, Pohnert SC, Li P, Zhang M, Gumbs C, Rosenberg PB, et al. Exercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathway. J Biol Chem 2005;280:19587-93.
    • (2005) J Biol Chem , vol.280 , pp. 19587-19593
    • Akimoto, T.1    Pohnert, S.C.2    Li, P.3    Zhang, M.4    Gumbs, C.5    Rosenberg, P.B.6
  • 37
    • 18244399631 scopus 로고    scopus 로고
    • Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1
    • Puigserver P, Rhee J, Lin J, Wu Z, Yoon JC, Zhang CY, et al. Cytokine stimulation of energy expenditure through p38 MAP kinase activation of PPARgamma coactivator-1. Mol Cell 2001;8:971-82.
    • (2001) Mol Cell , vol.8 , pp. 971-982
    • Puigserver, P.1    Rhee, J.2    Lin, J.3    Wu, Z.4    Yoon, J.C.5    Zhang, C.Y.6
  • 38
    • 34548512239 scopus 로고    scopus 로고
    • Intramolecular control of protein stability, subnuclear compartmentalization, and coactivator function of peroxisome proliferatoractivated receptor gamma coactivator 1alpha
    • Sano M, Tokudome S, Shimizu N, Yoshikawa N, Ogawa C, Shirakawa K, et al. Intramolecular control of protein stability, subnuclear compartmentalization, and coactivator function of peroxisome proliferatoractivated receptor gamma coactivator 1alpha. J Biol Chem 2007;282: 25970-80.
    • (2007) J Biol Chem , vol.282 , pp. 25970-25980
    • Sano, M.1    Tokudome, S.2    Shimizu, N.3    Yoshikawa, N.4    Ogawa, C.5    Shirakawa, K.6
  • 39
    • 10744222588 scopus 로고    scopus 로고
    • Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: Modulation by p38 MAPK
    • Fan M, Rhee J, St-Pierre J, Handschin C, Puigserver P, Lin J, et al. Suppression of mitochondrial respiration through recruitment of p160 myb binding protein to PGC-1alpha: modulation by p38 MAPK. Genes Dev 2004;18:278-89.
    • (2004) Genes Dev , vol.18 , pp. 278-289
    • Fan, M.1    Rhee, J.2    St-Pierre, J.3    Handschin, C.4    Puigserver, P.5    Lin, J.6
  • 40
    • 84919489013 scopus 로고    scopus 로고
    • Is reliance on mitochondrial respiration a "chink in the armor" of therapy-resistant cancer?
    • Wolf DA. Is reliance on mitochondrial respiration a "chink in the armor" of therapy-resistant cancer? Cancer Cell 2014;26:788-95.
    • (2014) Cancer Cell , vol.26 , pp. 788-795
    • Wolf, D.A.1
  • 41
    • 84927133194 scopus 로고    scopus 로고
    • Targeting mitochondria metabolism for cancer therapy
    • Weinberg SE, Chandel NS. Targeting mitochondria metabolism for cancer therapy. Nat Chem Biol 2015;11:9-15.
    • (2015) Nat Chem Biol , vol.11 , pp. 9-15
    • Weinberg, S.E.1    Chandel, N.S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.