17q21 asthma-risk variants switch CTCF binding and regulate IL-2 production by T cells

Nature Communications

Volumn 7, Issue , 2016, Pages

  Schmiedel, Benjamin Joachim ^a   Seumois, Grégory ^a   Samaniego Castruita, Daniela ^a   Cayford, Justin ^a   Schulten, Veronique ^a   Chavez, Lukas ^b   Ay, Ferhat ^a   Sette, Alessandro ^a   Peters, Bjoern ^a   Vijayanand, Pandurangan ^a,c  

^a LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY   (United States)

^b GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^c UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; INTERLEUKIN 2; TRANSCRIPTION FACTOR CTCF; CTCF PROTEIN, HUMAN; PROTEIN BINDING;

ALLELE; ASTHMA; CELLS AND CELL COMPONENTS; GENE EXPRESSION; GENETIC VARIATION; HEALTH RISK; IMMUNE SYSTEM; PROTEIN;

ALLELE; ARTICLE; ASTHMA; BINDING SITE; CD4+ T LYMPHOCYTE; CHROMOSOME 17Q; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENHANCER REGION; GENE; GENE DISRUPTION; GENE EXPRESSION; GENE LOCUS; GENETIC RISK; GENETIC VARIABILITY; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; IMMUNOREGULATION; INTRON; ORMDL3 GENE; PROMOTER REGION; SINGLE NUCLEOTIDE POLYMORPHISM; T LYMPHOCYTE; ZPBP2 GENE; B LYMPHOCYTE; BIOSYNTHESIS; CELL CULTURE; CHROMOSOME 17; GENETIC PREDISPOSITION; GENETICS; IMMUNOLOGY; METABOLISM; NUCLEOTIDE SEQUENCE; RISK FACTOR;

ASTHMA; B-LYMPHOCYTES; BASE SEQUENCE; BINDING SITES; CCCTC-BINDING FACTOR; CELLS, CULTURED; CHROMOSOMES, HUMAN, PAIR 17; ENHANCER ELEMENTS, GENETIC; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INTERLEUKIN-2; INTRONS; POLYMORPHISM, SINGLE NUCLEOTIDE; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; RISK FACTORS; T-LYMPHOCYTES;

EID: 84995611335     PISSN: None     EISSN: 20411723     Source Type: Journal    
DOI: 10.1038/ncomms13426     Document Type: Article

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