Negative regulatory roles of ORMDL3 in the FcεRI-triggered expression of proinflammatory mediators and chemotactic response in murine mast cells

Cellular and Molecular Life Sciences

Volumn 73, Issue 6, 2016, Pages 1265-1285

  Bugajev, Viktor ^a   Halova, Ivana ^a   Draberova, Lubica ^a   Bambouskova, Monika ^a   Potuckova, Lucie ^a   Draberova, Helena ^a   Paulenda, Tomas ^a   Junyent, Sergi ^a   Draber, Petr ^a  

^a INSTITUTE OF MOLECULAR GENETICS   (Czech Republic)

Author keywords

Chemotaxis; Degranulation; Mast cell; ORMDL3 knockdown; Proinflammatory cytokines; Prostaglandin D2; RNA interference

Indexed keywords

CYCLOOXYGENASE 2; FIBRONECTIN; I KAPPA B ALPHA; INTERLEUKIN 13; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; ORMDL3 PROTEIN; OROSOMUCOID; PROSTAGLANDIN D2; PROTEIN KINASE B; SERINE; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; CYTOKINE; IMMUNOGLOBULIN E RECEPTOR; MEMBRANE PROTEIN; MESSENGER RNA; ORMDL3 PROTEIN, MOUSE;

ANIMAL CELL; ANTIGEN FUNCTION; ARTICLE; CELL ACTIVATION; CELL ADHESION; CELL SPREADING; CHEMOTAXIS; CONTROLLED STUDY; CYTOKINE RELEASE; DOWN REGULATION; ENZYME PHOSPHORYLATION; GENE TRANSLOCATION; MAST CELL; MAST CELL DEGRANULATION; MOUSE; NONHUMAN; PASSIVE SKIN ANAPHYLAXIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; BAGG ALBINO MOUSE; CELL CULTURE; CYTOLOGY; DEGRANULATION; GENETICS; IMMUNOLOGY; METABOLISM;

ANIMALS; CELL DEGRANULATION; CELLS, CULTURED; CHEMOTAXIS; CYTOKINES; DOWN-REGULATION; MAST CELLS; MEMBRANE PROTEINS; MICE; MICE, INBRED BALB C; RECEPTORS, IGE; RNA, MESSENGER; UP-REGULATION;

EID: 84958811543     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-015-2047-3     Document Type: Article

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