Rac2 modulates atherosclerotic calcification by regulating macrophage interleukin-1β production

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 37, Issue 2, 2017, Pages 328-340

  Ceneri, Nicolle ^a,c   Zhao, Lina ^a,c   Young, Bryan D ^a   Healy, Abigail ^a,b,c,d   Coskun, Suleyman ^a   Vasavada, Hema ^a   Yarovinsky, Timur O ^a   Ike, Kenneth ^a   Pardi, Ruggero ^e   Qin, Lingfen ^a,c   Qiin, Li ^a   Tellides, George ^a   Hirschi, Karen ^a   Meadows, Judith ^a,c   Soufer, Robert ^a,c   Chun, Hyung J ^a   Sadeghi, Mehran M ^a,c   Bender, Jeffrey R ^a,c   Morrison, Alan R ^a,b,c,d  

^a VA CONNECTICUT HEALTHCARE SYSTEM   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d BROWN UNIVERSITY   (United States)

^e VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

Author keywords

atherosclerosis; biomarkers; coronary artery disease; inflammation; macrophages

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; AFIMOXIFENE; ALKALINE PHOSPHATASE; APOLIPOPROTEIN E; CALCIUM; CHOLESTEROL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; INTERLEUKIN 1ALPHA; INTERLEUKIN 1BETA; LOW DENSITY LIPOPROTEIN; MSH HOMEOBOX 2 PROTEIN; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; PROTEIN; RAC1 PROTEIN; RAC2 PROTEIN; SRY RELATED HMG BOX 9 PROTEIN; TRANSCRIPTION FACTOR OSTERIX; TRANSCRIPTION FACTOR RUNX2; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; AUTACOID; IL1B PROTEIN, HUMAN; IL1B PROTEIN, MOUSE; NEUROPEPTIDE; RAC PROTEIN; RAC1 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ATHEROSCLEROSIS; ARTICLE; ATHEROGENESIS; ATHEROSCLEROTIC CALCIFICATION; ATHEROSCLEROTIC PLAQUE; BLOOD VESSEL CALCIFICATION; BONE DEVELOPMENT; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DISEASE ASSOCIATION; ENZYME INHIBITION; HEART DEATH; HUMAN; HUMAN TISSUE; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; TRIACYLGLYCEROL BLOOD LEVEL; VASCULAR SMOOTH MUSCLE CELL; ANIMAL; AORTA; AORTIC DISEASES; ATHEROSCLEROSIS; C57BL MOUSE; CELL CULTURE; CORONARY BLOOD VESSEL; DEFICIENCY; ENZYMOLOGY; FEMALE; GENETIC PREDISPOSITION; GENETIC TRANSFECTION; GENETICS; KNOCKOUT MOUSE; MALE; METABOLISM; MORTALITY; PATHOLOGY; PHENOTYPE; PROGNOSIS; SIGNAL TRANSDUCTION; SMOOTH MUSCLE CELL; UPREGULATION; VASCULAR SMOOTH MUSCLE;

ANIMALS; AORTA; AORTIC DISEASES; APOLIPOPROTEINS E; ATHEROSCLEROSIS; CELLS, CULTURED; CORONARY ARTERY DISEASE; CORONARY VESSELS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; INFLAMMATION MEDIATORS; INTERLEUKIN 1 RECEPTOR ANTAGONIST PROTEIN; INTERLEUKIN-1BETA; MACROPHAGES; MALE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUSCLE, SMOOTH, VASCULAR; MYOCYTES, SMOOTH MUSCLE; NEUROPEPTIDES; PHENOTYPE; PLAQUE, ATHEROSCLEROTIC; PROGNOSIS; RAC GTP-BINDING PROTEINS; RAC1 GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; TRANSFECTION; UP-REGULATION; VASCULAR CALCIFICATION;

EID: 84995529456     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.116.308507     Document Type: Article

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