Inhibiting TLR2 activation attenuates amyloid accumulation and glial activation in a mouse model of Alzheimer's disease

Brain, Behavior, and Immunity

Volumn 58, Issue , 2016, Pages 191-200

  McDonald, Claire L ^a   Hennessy, Edel ^c   Rubio Araiz, Ana ^a   Keogh, Brian ^b   McCormack, William ^a   McGuirk, Peter ^b   Reilly, Mary ^b   Lynch, Marina A ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b Opsona Therapeutics Ltd   (Ireland)

^c SAN FRANCISCO GENERAL HOSPITAL   (United States)

Author keywords

Alzheimer's disease; Amyloid (A ); APP PS1 mice; Astrocytic activation; Cognitive function; Microglial activation; Neuroinflammation; Toll like receptor 2 (TLR2)

Indexed keywords

ADVANCED GLYCATION END PRODUCT; AMYLOID A PROTEIN; AMYLOID PRECURSOR PROTEIN; HIGH MOBILITY GROUP B1 PROTEIN; IMMUNOGLOBULIN G; PRESENILIN 1; TOLL LIKE RECEPTOR 2; ANTIBODY; PRESENILIN 1, MOUSE; TLR2 PROTEIN, MOUSE;

ALZHEIMER DISEASE; AMYLOID PLAQUE; ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEGENERATIVE DISEASE; DISEASE COURSE; FEMALE; IMMUNOREACTIVITY; INFLAMMATION; MACROGLIA; MALE; MOUSE; NERVOUS SYSTEM INFLAMMATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR BINDING; SPATIAL LEARNING; TRANSGENIC MOUSE; WILD TYPE; ANIMAL; ANTAGONISTS AND INHIBITORS; ASTROCYTE; DISEASE MODEL; ENCEPHALITIS; GENETICS; HIPPOCAMPUS; IMMUNOLOGY; MAZE TEST; METABOLISM; MICROGLIA;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; ANTIBODIES; ASTROCYTES; DISEASE MODELS, ANIMAL; ENCEPHALITIS; FEMALE; HIPPOCAMPUS; MALE; MAZE LEARNING; MICE; MICE, TRANSGENIC; MICROGLIA; PLAQUE, AMYLOID; PRESENILIN-1; TOLL-LIKE RECEPTOR 2;

EID: 84995475623     PISSN: 08891591     EISSN: 10902139     Source Type: Journal    
DOI: 10.1016/j.bbi.2016.07.143     Document Type: Article

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