Retinol-binding protein 4 induces hepatic mitochondrial dysfunction and promotes hepatic steatosis

Journal of Clinical Endocrinology and Metabolism

Volumn 101, Issue 11, 2016, Pages 4338-4348

  Liu, Yan ^a   Mu, Di ^a   Chen, Hongen ^a   Li, Di ^a   Song, Jiayi ^a   Zhong, Yuan ^a   Xia, Min ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

FATTY ACID; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; LONG CHAIN ACYL COENZYME A DEHYDROGENASE; MESSENGER RNA; RETINOL BINDING PROTEIN 4; SIRTUIN 3; TRIACYLGLYCEROL; PLASMA RETINOL BINDING PROTEIN; RBP4 PROTEIN, HUMAN;

ACETYLATION; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL SIZE; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE MODEL; DISORDERS OF MITOCHONDRIAL FUNCTIONS; FATTY ACID OXIDATION; FATTY LIVER; FEMALE; FOOD INTAKE; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; LIPID DIET; LIPID LIVER LEVEL; LIPID METABOLISM; MALE; MIDDLE AGED; NONALCOHOLIC FATTY LIVER; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN BINDING; WILD TYPE; ANIMAL; C57BL MOUSE; LIVER DISEASE; METABOLISM; MOUSE; TRANSGENIC MOUSE;

ANIMALS; DISEASE MODELS, ANIMAL; HUMANS; LIVER DISEASES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MITOCHONDRIAL DISEASES; NON-ALCOHOLIC FATTY LIVER DISEASE; RETINOL-BINDING PROTEINS, PLASMA;

EID: 84994854364     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2016-1320     Document Type: Article

References (39)

1. Angulo P. Nonalcoholic fatty liver disease. N Engl J Med. 2002; 346:1221-1231.
2. Loomba R, Sanyal AJ. The global NAFLD epidemic. Nat Rev Gastroenterol Hepatol. 2013;10(11):686-690.
3. Min HK, Kapoor A, Fuchs M, et al. Increased hepatic synthesis and dysfunction of cholesterol metabolism is associated with the severity of nonalcoholic fatty liver disease. Cell Metab. 2012;15(5):665-674.
4. Yang L, Li P, Fu S, et al. Defective hepatic autophagy in obesity promotes ER stress and causes insulin resistance. Cell Metab. 2010; 11(6):467-478.
5. Ozcan U, Cao Q, Yilmaz E, et al. Endoplasmic reticulum stress links obesity, insulin action, and type 2 diabetes. Science. 2004; 306(5695):457-461.
6. Gaens KH, Niessen PM, Rensen SS, et al. Endogenous formation of Nϵ-(carboxymethyl)lysine is increased in fatty livers and induces inflammatory markers in an in vitro model of hepatic steatosis. J Hepatol. 2012;56(3):647-655.
7. Farese RV Jr, Zechner R, Newgard CB, et al. The problem of establishing relationships between hepatic steatosis and hepatic insulin resistance. Cell Metab. 2012;15(5):570-573.
8. Sun Z, Lazar MA. Dissociating fatty liver and diabetes. Trends Endocrinol Metab. 2013;24(1):4-12.
9. Fabbrini E, Sullivan S, Klein S. Obesity and nonalcoholic fatty liver disease: biochemical, metabolic, and clinical implications. Hepatology. 2010;51(2):679-689.
10. Begriche K, Massart J, Robin MA, et al. Mitochondrial adaptations and dysfunctions in nonalcoholic fatty liver disease. Hepatology. 2013;58(4):1497-1507.
11. Pessayre D, Fromenty B. NASH: a mitochondrial disease. J Hepatol. 2005;42:928-940.
12. Kotnik P, Fischer-Posovszky P, Wabitsch M. RBP4: a controversial adipokine. Eur J Endocrinol. 2011;165:703-711.
13. Yang Q, Graham TE, Mody N, et al. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature. 2005;436:356-362.
14. Graham TE, Yang Q, Blüher M, et al. Retinol-binding protein 4 and insulin resistance in lean, obese, and diabetic subjects.NEngl JMed. 2006;354(24):2552-2563.
15. van Hoek M, Dehghan A, Zillikens MC, et al. An RBP4 promoter polymorphism increases risk of type 2 diabetes. Diabetologia. 2008; 51(8):1423-1428.
16. Meisinger C, Rückert IM, Rathmann W, et al. Retinol-binding protein 4 is associated with prediabetes in adults from the general population: the Cooperative Health Research in the Region of Augsburg (KORA) F4 Study. Diabetes Care. 2011;34(7):1648-1650.
17. Faghihi T, Radfar M, Abdoli E, et al. Association of serum retinolbinding protein 4 with insulin resistance and metabolic parameters during olanzapine therapy. Clin Endocrinol (Oxf). 2012;76(2): 207-211.
18. Sun Q, Kiernan UA, Shi L, et al. Plasma retinol-binding protein 4 (RBP4) levels and risk of coronary heart disease: a prospective analysis among women in the nurses' health study. Circulation. 2013; 127(19):1938-1947.
19. Seo JA, Kim NH, Park SY, et al. Serum retinol-binding protein 4 levels are elevated in non-alcoholic fatty liver disease. Clin Endocrinol ( Oxf). 2008;68(4):555-560.
20. Alkhouri N, Lopez R, Berk M, et al. Serum retinol-binding protein 4 levels in patients with nonalcoholic fatty liver disease. J Clin Gastroenterol. 2009;43(10):985-989.
21. Nobili V, Alkhouri N, Alisi A, et al. Retinol-binding protein 4: a promising circulating marker of liver damage in pediatric nonalcoholicfatty liver disease. Clin Gastroenterol Hepatol. 2009;7(5):575-579.
22. XiaM,Liu Y,GuoH,et al. Retinol binding protein4stimulates hepatic sterol regulatory element-binding protein 1 and increases lipogenesis through the peroxisome proliferator-activated receptor-γ coactivator 1β-dependent pathway. Hepatology. 2013;58:564-575.
23. Tan Y, Sun LQ, Kamal MA, et al. Suppression of retinol-binding protein 4 with RNA oligonucleotide prevents high-fat diet-induced metabolic syndrome and non-alcoholic fatty liver disease in mice. Biochim Biophys Acta. 2011;1811(12):1045-1053.
24. Quadro L, Blaner WS, Hamberger L, et al. Muscle expression of human retinol-binding protein (RBP). Suppression of the visual defect of RBP knockout mice. J Biol Chem. 2002;277:30191-30197.
25. Tous M, Ferre N, Camps J, et al. Feeding apolipoprotein E-knockout mice with cholesterol and fat enriched diets may be a model of non-alcoholic steatohepatitis. Mol Cell Biochem. 2005;268:53e8.
26. Moraes-Vieira PM, Yore MM, Dwyer PM, et al. RBP4 activates antigen-presenting cells, leading to adipose tissue inflammation and systemic insulin resistance. Cell Metab. 2014;19(3):512-526.
27. Moraes-Vieira PM, Castoldi A, Aryal P, et al. Antigen presentation and T-cell activation are critical for RBP4-induced insulin resistance. Diabetes. 2016;65(5):1317-1327.
28. García-Ruiz C, Baulies A, Mari M, García-Rovés PM, Fernandez-Checa JC. Mitochondrial dysfunction in non-alcoholic fatty liver disease and insulin resistance: cause or consequence? Free Radic Res. 2013;47:854-868.
29. Hirschey MD, Shimazu T, Goetzman E, et al. SIRT3 regulates mitochondrial fatty-acid oxidation by reversible enzyme deacetylation. Nature. 2010;464:121-125.
30. Tacke F, Weiskirchen R, Trautwein C. Liver function critically determines serum retinol-binding protein 4 (RBP4) levels in patients with chronic liver disease and cirrhosis. Hepatology. 2008;48(5): 1724-1725; author reply 1725-1726.
31. Sivitz WI, Yorek MA. Mitochondrial dysfunction in diabetes: from molecular mechanisms to functional significance and therapeutic opportunities. Antioxid Redox Signal. 2010;12:537-577.
32. Postic C, Girard J. Contribution of de novo fatty acid synthesis to hepatic steatosis and insulin resistance: lessons from genetically engineered mice. J Clin Invest. 2008;118:829-838.
33. Calvo SE, Mootha VK. The mitochondrial proteome and human disease. Annu Rev Genomics Hum Genet. 2010;11:25-44.
34. Hirschey MD, Shimazu T, Jing E, et al. SIRT3 deficiency and mitochondrial protein hyperacetylation accelerate the development of the metabolic syndrome. Mol Cell. 2011;44:177-190.
35. Kim SC, Sprung R, Chen Y, et al. Substrate and functional diversity of lysine acetylation revealed by a proteomics survey. Mol Cell. 2006;23:607-618.
36. Pérez-Carreras M, Del Hoyo P, Martín MA, et al. Defective hepatic mitochondrial respiratory chain in patients with nonalcoholic steatohepatitis. Hepatology. 2003;38:999-1007.
37. Begriche K, Igoudjil A, Pessayre D, et al. Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it. Mitochondrion. 2006;6:1-28.
38. Farjo KM, Farjo RA, Halsey S, et al. Retinol-binding protein 4 induces inflammation in human endothelial cells by an NADPH oxidase-and nuclear factor κ B-dependent and retinol-independent mechanism. Mol Cell Biol. 2012;32(24):5103-5115.
39. Norseen J, Hosooka T, Hammarstedt A, et al. Retinol-binding protein 4 inhibits insulin signaling in adipocytes by inducing proinflammatory cytokines in macrophages through a c-Jun N-terminal kinase-and toll-like receptor 4-dependent and retinol-independent mechanism. Mol Cell Biol. 2012;32(10):2010-2019.