Suppression of retinol-binding protein 4 with RNA oligonucleotide prevents high-fat diet-induced metabolic syndrome and non-alcoholic fatty liver disease in mice

Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids

Volumn 1811, Issue 12, 2011, Pages 1045-1053

  Tan, Yi ^a   Sun, Lun Quan ^b   Kamal, Mohammad A ^a   Wang, Xiaoyang ^a   Seale, J Paul ^c   Qu, Xianqin ^a  

^a UNIVERSITY OF TECHNOLOGY SYDNEY   (Australia)

^b Oligos Etc Inc   (United States)

^c University of Sydney   (Australia)

Author keywords

Anti RBP4 RNA oligonucleotide; High fat diet fed mice; Metabolic syndrome; Non alcoholic fatty liver disease; RBP4 inhibition; Retinol binding protein 4

Indexed keywords

ADIPOCYTOKINE; ANTI RETINOL BINDING PROTEIN 4 RNA OLIGONUCLEOTIDE; ENZYME INHIBITOR; FAT DROPLET; GLUCOSE TRANSPORTER 4; LIVER ENZYME; MESSENGER RNA; RETINOL BINDING PROTEIN 4; ROSIGLITAZONE; UNCLASSIFIED DRUG;

ADIPOCYTE; ADIPOSE TISSUE; ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD CHEMISTRY; BLOOD LEVEL; CONTROLLED STUDY; ENZYME INHIBITION; GENE EXPRESSION; GENETIC TRANSFECTION; GLUCOSE TOLERANCE TEST; HISTOLOGY; HYPERGLYCEMIA; HYPERINSULINEMIA; IMPAIRED GLUCOSE TOLERANCE; IN VIVO STUDY; LIPID DIET; MALE; METABOLIC DISORDER; MOUSE; NONALCOHOLIC FATTY LIVER; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

3T3-L1 CELLS; ADIPOCYTES; ADIPOSE TISSUE; ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; DIET, HIGH-FAT; FATTY LIVER; GLUCOSE TRANSPORTER TYPE 4; INSULIN; INSULIN RESISTANCE; LIVER; MALE; METABOLIC SYNDROME X; MICE; MICE, INBRED C57BL; OLIGONUCLEOTIDES, ANTISENSE; RETINOL-BINDING PROTEINS, PLASMA; THIAZOLIDINEDIONES; TRANSFECTION;

MUS;

EID: 80155189466     PISSN: 13881981     EISSN: 18792618     Source Type: Journal    
DOI: 10.1016/j.bbalip.2011.09.011     Document Type: Article

References (36)

1. P. Trayhurn, and I.S. Wood Adipokines: inflammation and the pleiotropic role of white adipose tissue Br. J. Nutr. 92 2004 347 355 (Pubitemid 40277057)
2. R.S. Ahima, and S.Y. Osei Adipokines in obesity Front. Horm. Res. 36 2008 182 197
3. N. Takashima, H. Tomoike, and N. Iwai Retinol-binding protein 4 and insulin resistance N. Engl. J. Med. 355 2006 1392 1395
4. M.V. Eynatten, and P.M. Humpert Retinol-binding protein-4 in experimental and clinical metabolic disease Expert Rev. Mol. Diagn. 8 2008 289 299 (Pubitemid 351724708)
5. Q. Yang, T.E. Graham, N. Mody, F. Preitner, O.D. Peroni, J.M. Zabolotny, L. Quadro, and B.B. Kahn Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes Nature 436 2005 357 362
6. T.E. Graham, Q. Yang, M. Blüher, A. Hammarstedt, T.P. Ciaraldi, R.R. Henry, C.J. Wason, A. Oberbach, P. Jansson, U. Smith, and B.B. Kahn Retinol-binding protein 4 and insulin resistance in lean, obese and diabetic subjects N. Engl. J. Med. 354 2006 2552 2563 (Pubitemid 43882351)
7. Y.M. Cho, B.S. Youn, H. Lee, N. Lee, S.S. Min, S.H. Kwak, H.K. Lee, and K.S. Park Plasma retinol-binding protein-4 concentrations are elevated in human subjects with impaired glucose tolerance and type 2 diabetes Diabetes Care 29 2006 2457 2461 (Pubitemid 44912252)
8. M. Broch, J. Vendrell, W. Ricart, C. Richart, and J.M. Fernández-Real Circulating retinol-binding protein-4, insulin sensitivity, insulin secretion, and insulin disposition index in obese and nonobese subjects Diabetes Care 30 2007 1802 1806 (Pubitemid 47036355)
9. S.H. Choi, S.H. Kwak, B.S. Youn, S. Lim, Y.J. Park, H. Lee, Y.M. Cho, Y.B. Kim, K.S. Park, and H.C. Jang High plasma retinol binding protein-4 and low plasma adiponectin concentrations are associated with severity of glucose intolerance in women with previous gestational diabetes mellitus J. Clin. Endocrinol. Metab. 93 2008 3142 3148
10. V. Nobili, N. Alkhouri, A. Alibi, S. Ottino, R. Lopez, M. Manco, and A.E. Feldstein Retinol-binding protein 4: a promising circulating marker of liver damage in pediatric nonalcoholic fatty liver disease Clin. Gastroenterol. Hepatol. 7 2009 575 579
11. N. Stefan, A.M. Hennige, H. Staiger, J. Machann, F. Schick, E. Schleicher, A. Fritsche, and H.U. Häring High circulating retinol-binding protein 4 is associated with elevated liver fat but not with total, subcutaneous, visceral, or intramyocellular fat in humans Diabetes Care 30 2007 1173 1178 (Pubitemid 46684644)
12. H. Wu, W. Jia, Y. Bao, J. Lu, J. Zhu, R. Wang, Y. Chen, and K. Xiang Serum retinol binding protein 4 and nonalcoholic fatty liver disease in patients with type 2 diabetes mellitus Diabetes Res. Clin. Pract. 79 2008 185 190
13. A. Tönjes, M. Blüher, and M. Stumvoll Retinol-binding protein 4 and new adipocytokines in nonalcoholic fatty liver disease Curr. Pharm. Des. 16 2010 1921 1928
14. M. Promintzer, M. Krebs, J. Todoric, A. Luger, M.G. Bischof, P. Nowotny, O. Wagner, H. Esterbauer, and C. Anderwald Insulin resistance is unrelated to circulating retinol binding protein and protein C inhibitor J. Clin. Endocrinol. Metab. 92 2007 4306 4312 (Pubitemid 350074749)
15. A. Yao-Borengasser, V. Varma, A.M. Bodles, N. Rasouli, B. Phanavanh, M.J. Lee, T. Starks, L.M. Kern, H.J. Spencer, A.A. Rashidi, R.E. McGehee, S.K. Fried, and P.A. Kern Retinol binding protein 4 expression in humans: relationship to insulin resistance, inflammation, and response to pioglitazone J. Clin. Endocrinol. Metab. 92 2007 2590 2597 (Pubitemid 47037362)
16. J. Gómez-Ambrosi, A. Rodríguez, V. Catalán, B. Ramírez, C. Silva, F. Rotellar, M.J. Gil, J. Salvador, and G. Frühbeck Serum retinol-binding protein 4 is not increased in obesity or obesity-associated type 2 diabetes mellitus, but is reduced after relevant reductions in body fat following gastric bypass Clin. Endocrinol. (Oxf) 69 2008 208 215 (Pubitemid 352009009)
17. J. Janke, S. Engeli, M. Boschmann, F. Adams, J. Bohnke, F.C. Luft, A.M. Sharma, and J. Jordan Retinol-binding protein 4 in human obesity Diabetes 55 2006 2805 2810 (Pubitemid 44923680)
18. A.O. Chavez, D.K. Coletta, S. Kamath, D.T. Cromack, A. Monroy, F. Folli, R.A. DeFronzo, and D. Tripathy Retinol-binding protein 4 is associated with impaired glucose tolerance but not with whole body or hepatic insulin resistance in Mexican Americans Am. J. Physiol. Endocrinol. Metab. 296 2009 E758 E764
19. C. Cengiz, Y. Ardicoglu, S. Bulut, and S. Boyacioglu Serum retinol-binding protein 4 in patients with nonalcoholic fatty liver disease: does it have a significant impact on pathogenesis? Eur. J. Gastroenterol. Hepatol. 22 2010 813 819
20. J.B. Kim, and B.M. Spiegelman Promotes adipocyte differentiation and gene expression linked to fatty acid metabolism Genes Dev. 10 1996 1096 1107 (Pubitemid 26152851)
21. J. Mercader, N. Granados, M.L. Bonet, and A. Palou All-trans retinoic acid decreases murine adipose retinol binding protein 4 production Cell. Physiol. Biochem. 22 2008 363 372
22. Y. Wu, G. Zhang, Y. Li, Y. Jin, R. Dale, L.Q. Sun, and M. Wang Inhibition of highly pathogenic avian H5N1 influenza virus replication by Anti-RBP4nucleotides targeting NS1 gene Biochem. Biophys. Res. Commun. 365 2008 369 374 (Pubitemid 350137299)
23. J.M. Ye, M.A. Iglesias, D.G. Watson, B. Ellis, L. Wood, P.B. Jensen, R.V. Sørensen, P.J. Larsen, G.J. Cooney, K. Wassermann, and E.W. Kraegen PPARalpha/gamma ragaglitazar eliminates fatty liver and enhances insulin action in fat-fed rats in the absence of hepatomegaly Am. J. Physiol. Endocrinol. Metab. 284 2003 E531 E540
24. S. Guo, K.D. Copps, X. Dong, S. Park, Z. Cheng, A. Pocai, L. Rossetti, M. Sajan, R.V. Farese, and M.F. White The Irs1 branch of the insulin signaling cascade plays a dominant role in hepatic nutrient homeostasis Mol. Cell. Biol. 29 2009 5070 5083
25. F. Hong, S. Radaeva, H.N. Pan, Z. Tian, R. Veech, and B. Gao Interleukin 6 alleviates hepatic steatosis and ischemia/reperfusion injury in mice with fatty liver disease Hepatology 40 2004 933 941 (Pubitemid 39288127)
26. L. Quadro, L. Hamberger, V. Colantuoni, M. Gottesman, and W.S. Blane Understanding the physiological role of retinolbinding protein in vitamin A metabolism using transgenic and knockout mouse models Mol. Aspects Med. 24 2003 421 430 (Pubitemid 37324654)
27. R. Blomhoff, and H.K. Blomhoff Overview of retinoid metabolism and function J. Neurobiol. 66 2006 606 630 (Pubitemid 43941649)
28. E. Esteve, W. Ricart, and J.M. Fernandez-Real Adipocytokines and insulin resistance the possible role of lipocalin-2, retinol binding protein-4, and adiponectin Diabetes Care 32 2009 S362 S367
29. V. Samuel, Z.X. Lui, X. Qu, C.L. Yu, Y. Chen, H. Zong, and G.I. Shulman Mechanism of insulin resistance in non-alcoholic fatty liver disease J. Biol. Chem. 279 2004 32345 33253
30. A. Motani, Z. Wang, M. Conn, K. Siegler, Y. Zhang, Q. Liu, S. Johnstone, H. Xu, S. Thibault, Y. Wang, P. Fan, R. Connors, H. Le, G. Xu, N. Walker, B. Shan, and P. Coward Identification and characterization of a non-retinoid ligand for retinol-binding protein 4 which lowers serum retinol-binding protein 4 levels in vivo J. Biol. Chem. 284 2009 7673 7680
31. R.K. Schindhelm, M. Diamant, J.M. Dekker, M.E. Tushuizen, T. Teerlink, and R.J. Heine Alanine aminotransferase as a marker of non-alcoholic fatty liver disease in relation to type 2 Diabetes mellitus and cardiovascular disease Diabetes Metab. Res. Rev. 22 2006 437 443 (Pubitemid 44774047)
32. K. Houseknecht, and B. Kahn Molecular mechanisms for insulin-stimulated glucose transport: regulation of Glut4 translocation J. Anim. Sci. 75 1997 32 45
33. P.R. Shepherd, L. Gnudi, E. Tozzo, H. Yang, F. Leach, and B.B. Kahn Adipose cell hyperplasia and enhanced glucose disposal in transgenic mice overexpressing GLUT4 selectively in adipose tissue J. Biol. Chem. 268 1993 22243 22246 (Pubitemid 23318260)
34. J.L. Evans, J.J. Lin, and I.D. Goldfine Novel approach to treat insulin resistance, type 2 diabetes, and the metabolic syndrome: simultaneous activation of PPARalpha, PPARgamma, and PPARdelta Curr. Diabetes Rev. 1 2005 299 307
35. S. Song The role of increased liver triglyceride content: a culprit of diabetic hyperglycaemia? Diabetes Metab. Res. Rev. 18 2002 5 12 (Pubitemid 34257361)
36. A. Vidal-Puig, and S. O'Rahilly Metabolism: controlling the glucose factory Nature 413 2001 125 126