DNA Damage-Induced HSPC Malfunction Depends on ROS Accumulation Downstream of IFN-1 Signaling and Bid Mobilization

Cell Stem Cell

Volumn 19, Issue 6, 2016, Pages 752-767

  Tasdogan, Alpaslan ^a   Kumar, Suresh ^a   Allies, Gabriele ^a   Bausinger, Julia ^a   Beckel, Franziska ^a   Hofemeister, Helmut ^b   Mulaw, Medhanie ^a   Madan, Vikas ^a,c   Scharfetter Kochanek, Karin ^a   Feuring Buske, Michaela ^a   Doehner, Konstanze ^a   Speit, Günter ^a   Stewart, A Francis ^b   Fehling, Hans Joerg ^a  

^a UNIVERSITY HOSPITAL ULM   (Germany)

^b DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^c NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 2A; DNA; INTERFERON; MIXED LINEAGE LEUKEMIA 5 PROTEIN; MIXED LINEAGE LEUKEMIA PROTEIN; PROTEIN BID; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; ACETYLCYSTEINE; HISTONE LYSINE METHYLTRANSFERASE; INTERFERON RECEPTOR; MLL5 PROTEIN, MOUSE; POLYINOSINIC POLYCYTIDYLIC ACID;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL FUNCTION; CONTROLLED STUDY; DNA DAMAGE; FEMALE; GENE INACTIVATION; GENE LOCUS; HEMATOPOIETIC STEM CELL; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEFECT; SIGNAL TRANSDUCTION; ANIMAL; DRUG EFFECTS; HEMATOPOIESIS; INTRACELLULAR SPACE; METABOLISM; NEWBORN; ORAL DRUG ADMINISTRATION; PROTEIN TRANSPORT; SURVIVAL ANALYSIS;

ACETYLCYSTEINE; ADMINISTRATION, ORAL; ANIMALS; ANIMALS, NEWBORN; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DNA DAMAGE; GENETIC LOCI; HEMATOPOIESIS; HEMATOPOIETIC STEM CELLS; HISTONE-LYSINE N-METHYLTRANSFERASE; INTERFERON TYPE I; INTRACELLULAR SPACE; MICE; POLY I-C; PROTEIN TRANSPORT; REACTIVE OXYGEN SPECIES; RECEPTORS, INTERFERON; SIGNAL TRANSDUCTION; SURVIVAL ANALYSIS;

EID: 84994779404     PISSN: 19345909     EISSN: 18759777     Source Type: Journal    
DOI: 10.1016/j.stem.2016.08.007     Document Type: Article

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