HIV non-nucleoside reverse transcriptase inhibitor efavirenz reduces neural stem cell proliferation in vitro and in vivo

Cell Transplantation

Volumn 25, Issue 11, 2016, Pages 1967-1977

  Jin, Jingji ^a   Grimmig, Bethany ^a   Izzo, James ^a   Brown, Lecia A M ^a   Hudson, Charles ^b   Smith, Adam J ^a   Tan, Jun ^a,b   Bickford, Paula C ^a,b   Giunta, Brian ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Efavirenz (EFV); Neural stem cells (NSCs); Oxidative stress

Indexed keywords

ADENOSINE TRIPHOSPHATE; CASPASE 3; EFAVIRENZ; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NESTIN; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; PROTEIN BAX; BENZOXAZINE DERIVATIVE; RNA DIRECTED DNA POLYMERASE INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BRDU ASSAY; C57BL 6 MOUSE; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; ENZYME RELEASE; IMMUNOCYTOCHEMISTRY; IN VITRO STUDY; IN VIVO STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; MTT ASSAY; NERVE CELL NECROSIS; NEURAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SUBVENTRICULAR ZONE; ANIMAL; C57BL MOUSE; CELL CULTURE; CYTOLOGY; DRUG EFFECTS; FEMALE; IMMUNOHISTOCHEMISTRY; INTRAPERITONEAL DRUG ADMINISTRATION; LATERAL BRAIN VENTRICLE; METABOLISM; PHOSPHORYLATION;

ADENOSINE TRIPHOSPHATE; ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BENZOXAZINES; CASPASE 3; CELL PROLIFERATION; CELLS, CULTURED; FEMALE; IMMUNOHISTOCHEMISTRY; INJECTIONS, INTRAPERITONEAL; LATERAL VENTRICLES; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, INBRED C57BL; NEURAL STEM CELLS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PHOSPHORYLATION; RATS; REVERSE TRANSCRIPTASE INHIBITORS;

EID: 84994745828     PISSN: 09636897     EISSN: 15553892     Source Type: Journal    
DOI: 10.3727/096368916X691457     Document Type: Article

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