메뉴 건너뛰기




Volumn 22, Issue 2, 2016, Pages 170-178

Long-term efavirenz use is associated with worse neurocognitive functioning in HIV-infected patients

Author keywords

Efavirenz; Hepatitis C virus coinfection; Long term antiretroviral therapy; Lopinavir ritonavir; Neurocognitive function; Neurotoxicity

Indexed keywords

EFAVIRENZ; LOPINAVIR PLUS RITONAVIR; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; BENZOXAZINE DERIVATIVE; LOPINAVIR; RITONAVIR;

EID: 84960809030     PISSN: 13550284     EISSN: 15382443     Source Type: Journal    
DOI: 10.1007/s13365-015-0382-7     Document Type: Article
Times cited : (112)

References (38)
  • 1
    • 35848953181 scopus 로고    scopus 로고
    • Updated research nosology for HIV-associated neurocognitive disorders
    • COI: 1:STN:280:DC%2BD2snktFyqsQ%3D%3D, PID: 17914061
    • Antinori A, Arendt G, Becker JT et al (2007) Updated research nosology for HIV-associated neurocognitive disorders. Neurology 69(18):1789–1799
    • (2007) Neurology , vol.69 , Issue.18 , pp. 1789-1799
    • Antinori, A.1    Arendt, G.2    Becker, J.T.3
  • 4
    • 78651456899 scopus 로고    scopus 로고
    • Efavirenz concentrations in CSF exceed IC50 for wild-type HIV
    • COI: 1:CAS:528:DC%2BC3MXnsFaisQ%3D%3D, PID: 21098541
    • Best BM, Koopmans PP, Letendre SL et al (2011) Efavirenz concentrations in CSF exceed IC50 for wild-type HIV. J Antimicrob Chemother 66(2):354–357
    • (2011) J Antimicrob Chemother , vol.66 , Issue.2 , pp. 354-357
    • Best, B.M.1    Koopmans, P.P.2    Letendre, S.L.3
  • 5
    • 84890267203 scopus 로고    scopus 로고
    • 8-Hydroxy-efavirenz, the primary metabolite of the antiretroviral drug Efavirenz, stimulates the glycolytic flux in cultured rat astrocytes
    • COI: 1:CAS:528:DC%2BC3sXhsFKjtrvO, PID: 24091996
    • Brandmann M, Nehls U, Dringen R (2013) 8-Hydroxy-efavirenz, the primary metabolite of the antiretroviral drug Efavirenz, stimulates the glycolytic flux in cultured rat astrocytes. Neurochem Res 38(12):2524–2534
    • (2013) Neurochem Res , vol.38 , Issue.12 , pp. 2524-2534
    • Brandmann, M.1    Nehls, U.2    Dringen, R.3
  • 6
    • 84899710769 scopus 로고    scopus 로고
    • Efavirenz promotes beta-secretase expression and increased Abeta1-40,42 via oxidative stress and reduced microglial phagocytosis: implications for HIV associated neurocognitive disorders (HAND)
    • PID: 24759994
    • Brown LA, Jin J, Ferrell D et al (2014) Efavirenz promotes beta-secretase expression and increased Abeta1-40,42 via oxidative stress and reduced microglial phagocytosis: implications for HIV associated neurocognitive disorders (HAND). PLoS One 9(4):e95500
    • (2014) PLoS One , vol.9 , Issue.4 , pp. 95500
    • Brown, L.A.1    Jin, J.2    Ferrell, D.3
  • 7
    • 84875740369 scopus 로고    scopus 로고
    • Neurocognitive impairment in patients randomized to second-line lopinavir/ritonavir-based antiretroviral therapy vs. lopinavir/ritonavir monotherapy
    • COI: 1:CAS:528:DC%2BC38XhslKnsb3N, PID: 22993101
    • Bunupuradah T, Chetchotisakd P, Jirajariyavej S et al (2012) Neurocognitive impairment in patients randomized to second-line lopinavir/ritonavir-based antiretroviral therapy vs. lopinavir/ritonavir monotherapy. J Neurovirol 18(6):479–487
    • (2012) J Neurovirol , vol.18 , Issue.6 , pp. 479-487
    • Bunupuradah, T.1    Chetchotisakd, P.2    Jirajariyavej, S.3
  • 8
    • 20644464770 scopus 로고    scopus 로고
    • Lopinavir concentrations in cerebrospinal fluid exceed the 50% inhibitory concentration for HIV
    • COI: 1:CAS:528:DC%2BD2MXktlKlurs%3D, PID: 15905676
    • Capparelli EV, Holland D, Okamoto C et al (2005) Lopinavir concentrations in cerebrospinal fluid exceed the 50% inhibitory concentration for HIV. AIDS 19(9):949–952
    • (2005) AIDS , vol.19 , Issue.9 , pp. 949-952
    • Capparelli, E.V.1    Holland, D.2    Okamoto, C.3
  • 9
    • 4644336047 scopus 로고    scopus 로고
    • Predictive validity of global deficit scores in detecting neuropsychological impairment in HIV infection
    • PID: 15512922
    • Carey CL, Woods SP, Gonzalez R et al (2004) Predictive validity of global deficit scores in detecting neuropsychological impairment in HIV infection. J Clin Exp Neuropsychol 26(3):307–319
    • (2004) J Clin Exp Neuropsychol , vol.26 , Issue.3 , pp. 307-319
    • Carey, C.L.1    Woods, S.P.2    Gonzalez, R.3
  • 10
    • 17644381960 scopus 로고    scopus 로고
    • Hepatitis C augments cognitive deficits associated with HIV infection and methamphetamine
    • COI: 1:STN:280:DC%2BD2M3hslersg%3D%3D, PID: 15851720
    • Cherner M, Letendre S, Heaton RK et al (2005) Hepatitis C augments cognitive deficits associated with HIV infection and methamphetamine. Neurology 64(8):1343–1347
    • (2005) Neurology , vol.64 , Issue.8 , pp. 1343-1347
    • Cherner, M.1    Letendre, S.2    Heaton, R.K.3
  • 11
    • 79955458684 scopus 로고    scopus 로고
    • Efavirenz associated with cognitive disorders in otherwise asymptomatic HIV-infected patients
    • COI: 1:CAS:528:DC%2BC3MXkvValtb0%3D, PID: 21502598
    • Ciccarelli N, Fabbiani M, Di Giambenedetto S et al (2011) Efavirenz associated with cognitive disorders in otherwise asymptomatic HIV-infected patients. Neurology 76(16):1403–1409
    • (2011) Neurology , vol.76 , Issue.16 , pp. 1403-1409
    • Ciccarelli, N.1    Fabbiani, M.2    Di Giambenedetto, S.3
  • 12
    • 28144452516 scopus 로고    scopus 로고
    • Impact of efavirenz on neuropsychological performance and symptoms in HIV-infected individuals
    • COI: 1:CAS:528:DC%2BD2MXht1yntLrM, PID: 16287792
    • Clifford DB, Evans S, Yang Y et al (2005) Impact of efavirenz on neuropsychological performance and symptoms in HIV-infected individuals. Ann Intern Med 143(10):714–721
    • (2005) Ann Intern Med , vol.143 , Issue.10 , pp. 714-721
    • Clifford, D.B.1    Evans, S.2    Yang, Y.3
  • 13
    • 76749119501 scopus 로고    scopus 로고
    • Long-term impact of efavirenz on neuropsychological performance and symptoms in HIV-infected individuals (ACTG 5097s)
    • PID: 20133265
    • Clifford DB, Evans S, Yang Y, Acosta EP, Ribaudo H, Gulick RM (2009) Long-term impact of efavirenz on neuropsychological performance and symptoms in HIV-infected individuals (ACTG 5097s). HIV Clin Trials 10(6):343–355
    • (2009) HIV Clin Trials , vol.10 , Issue.6 , pp. 343-355
    • Clifford, D.B.1    Evans, S.2    Yang, Y.3    Acosta, E.P.4    Ribaudo, H.5    Gulick, R.M.6
  • 14
    • 33845775666 scopus 로고    scopus 로고
    • HIV and antiretroviral therapy in the brain: neuronal injury and repair
    • COI: 1:CAS:528:DC%2BD28XhtlemtL7O, PID: 17180161
    • Ellis R, Langford D, Masliah E (2007) HIV and antiretroviral therapy in the brain: neuronal injury and repair. Nat Rev Neurosci 8(1):33–44
    • (2007) Nat Rev Neurosci , vol.8 , Issue.1 , pp. 33-44
    • Ellis, R.1    Langford, D.2    Masliah, E.3
  • 15
    • 84863115545 scopus 로고    scopus 로고
    • Hepatitis C virus infects the endothelial cells of the blood–brain barrier
    • COI: 1:CAS:528:DC%2BC38XivFyjt7s%3D, PID: 22138189, e6
    • Fletcher NF, Wilson GK, Murray J et al (2012) Hepatitis C virus infects the endothelial cells of the blood–brain barrier. Gastroenterology 142(3):634–643, e6
    • (2012) Gastroenterology , vol.142 , Issue.3 , pp. 634-643
    • Fletcher, N.F.1    Wilson, G.K.2    Murray, J.3
  • 16
    • 84863743741 scopus 로고    scopus 로고
    • Acute HCV/HIV coinfection is associated with cognitive dysfunction and cerebral metabolite disturbance, but not increased microglial cell activation
    • COI: 1:CAS:528:DC%2BC38XhtVOnsb%2FP, PID: 22808022
    • Garvey LJ, Pavese N, Ramlackhansingh A et al (2012) Acute HCV/HIV coinfection is associated with cognitive dysfunction and cerebral metabolite disturbance, but not increased microglial cell activation. PLoS One 7(7):e38980
    • (2012) PLoS One , vol.7 , Issue.7 , pp. 38980
    • Garvey, L.J.1    Pavese, N.2    Ramlackhansingh, A.3
  • 17
    • 28044459173 scopus 로고    scopus 로고
    • Prediction of neuropsychiatric adverse events associated with long-term efavirenz therapy, using plasma drug level monitoring
    • COI: 1:CAS:528:DC%2BD2MXhtlaht7rI, PID: 16267739
    • Gutierrez F, Navarro A, Padilla S et al (2005) Prediction of neuropsychiatric adverse events associated with long-term efavirenz therapy, using plasma drug level monitoring. Clin Infect Dis 41(11):1648–1653
    • (2005) Clin Infect Dis , vol.41 , Issue.11 , pp. 1648-1653
    • Gutierrez, F.1    Navarro, A.2    Padilla, S.3
  • 18
    • 78650834306 scopus 로고    scopus 로고
    • HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER study
    • COI: 1:STN:280:DC%2BC3M%2FlsFyqtA%3D%3D, PID: 21135382
    • Heaton RK, Clifford DB, Franklin DR Jr et al (2010) HIV-associated neurocognitive disorders persist in the era of potent antiretroviral therapy: CHARTER study. Neurology 75(23):2087–2096
    • (2010) Neurology , vol.75 , Issue.23 , pp. 2087-2096
    • Heaton, R.K.1    Clifford, D.B.2    Franklin, D.R.3
  • 19
    • 67649088051 scopus 로고    scopus 로고
    • The aging of human-immunodeficiency-virus-associated neurocognitive disorders
    • Ikezu T (2009) The aging of human-immunodeficiency-virus-associated neurocognitive disorders. J NeuroImmune Pharm 4(2):161–162
    • (2009) J NeuroImmune Pharm , vol.4 , Issue.2 , pp. 161-162
    • Ikezu, T.1
  • 20
    • 12144286811 scopus 로고    scopus 로고
    • Psychiatric and neurocognitive disorders among HIV-positive and negative veterans in care: veterans aging cohort five-site study
    • PID: 15075498
    • Justice AC, McGinnis KA, Atkinson JH et al (2004) Psychiatric and neurocognitive disorders among HIV-positive and negative veterans in care: veterans aging cohort five-site study. AIDS 18(Suppl 1):S49–S59
    • (2004) AIDS , vol.18 , pp. S49-S59
    • Justice, A.C.1    McGinnis, K.A.2    Atkinson, J.H.3
  • 21
    • 77954412968 scopus 로고    scopus 로고
    • HIV-associated neurocognitive disorders in sub-Saharan Africa: a pilot study in Cameroon
    • PID: 20626870
    • Kanmogne GD, Kuate CT, Cysique LA et al (2010) HIV-associated neurocognitive disorders in sub-Saharan Africa: a pilot study in Cameroon. BMC Neurol 10:60
    • (2010) BMC Neurol , vol.10 , pp. 60
    • Kanmogne, G.D.1    Kuate, C.T.2    Cysique, L.A.3
  • 22
    • 0035912198 scopus 로고    scopus 로고
    • Pathways to neuronal injury and apoptosis in HIV-associated dementia
    • COI: 1:CAS:528:DC%2BD3MXjt1Kqs7g%3D, PID: 11309629
    • Kaul M, Garden GA, Lipton SA (2001) Pathways to neuronal injury and apoptosis in HIV-associated dementia. Nature 410(6831):988–994
    • (2001) Nature , vol.410 , Issue.6831 , pp. 988-994
    • Kaul, M.1    Garden, G.A.2    Lipton, S.A.3
  • 23
    • 84859230231 scopus 로고    scopus 로고
    • Central nervous system complications in HIV disease: HIV-associated neurocognitive disorder
    • PID: 22156215
    • Letendre S (2011) Central nervous system complications in HIV disease: HIV-associated neurocognitive disorder. Top Antivir Med 19(4):137–142
    • (2011) Top Antivir Med , vol.19 , Issue.4 , pp. 137-142
    • Letendre, S.1
  • 24
    • 27944472632 scopus 로고    scopus 로고
    • The effects of hepatitis C, HIV, and methamphetamine dependence on neuropsychological performance: biological correlates of disease
    • COI: 1:CAS:528:DC%2BD2MXhtFCqsrvI, PID: 16251831
    • Letendre SL, Cherner M, Ellis RJ et al (2005) The effects of hepatitis C, HIV, and methamphetamine dependence on neuropsychological performance: biological correlates of disease. AIDS 19(Suppl 3):S72–S78
    • (2005) AIDS , vol.19 , pp. S72-S78
    • Letendre, S.L.1    Cherner, M.2    Ellis, R.J.3
  • 25
    • 84960832010 scopus 로고    scopus 로고
    • Letendre S, Croteau D, Ellis Ret al. Lower CSAR are associated with global neurocognitive impairment in antiretroviral-treated people with HIV. In: 18th Conference on Retroviruses and Opportunistic Infections. Boston, MA, 2011: Abstract 408
    • Letendre S, Croteau D, Ellis Ret al. Lower CSAR are associated with global neurocognitive impairment in antiretroviral-treated people with HIV. In: 18th Conference on Retroviruses and Opportunistic Infections. Boston, MA, 2011: Abstract 408
  • 26
    • 84893774157 scopus 로고    scopus 로고
    • The veterans aging cohort study index is associated with concurrent risk for neurocognitive impairment
    • PID: 24442225
    • Marquine MJ, Umlauf A, Rooney AS et al (2014) The veterans aging cohort study index is associated with concurrent risk for neurocognitive impairment. J Acquir Immune Defic Syndr 65(2):190–197
    • (2014) J Acquir Immune Defic Syndr , vol.65 , Issue.2 , pp. 190-197
    • Marquine, M.J.1    Umlauf, A.2    Rooney, A.S.3
  • 27
    • 84861523793 scopus 로고    scopus 로고
    • Intra-individual variability across neurocognitive domains in chronic hepatitis C infection: elevated dispersion is associated with serostatus and unemployment risk
    • PID: 22533778
    • Morgan EE, Woods SP, Rooney A, Perry W, Grant I, Letendre SL (2012) Intra-individual variability across neurocognitive domains in chronic hepatitis C infection: elevated dispersion is associated with serostatus and unemployment risk. Clin Neuropsychol 26(4):654–674
    • (2012) Clin Neuropsychol , vol.26 , Issue.4 , pp. 654-674
    • Morgan, E.E.1    Woods, S.P.2    Rooney, A.3    Perry, W.4    Grant, I.5    Letendre, S.L.6
  • 28
    • 84867288689 scopus 로고    scopus 로고
    • Antiretroviral neurotoxicity
    • COI: 1:CAS:528:DC%2BC38XhsVyiu7fM, PID: 22811264
    • Robertson K, Liner J, Meeker RB (2012a) Antiretroviral neurotoxicity. J Neurovirol 18(5):388–399
    • (2012) J Neurovirol , vol.18 , Issue.5 , pp. 388-399
    • Robertson, K.1    Liner, J.2    Meeker, R.B.3
  • 29
    • 84865482221 scopus 로고    scopus 로고
    • Improved neuropsychological and neurological functioning across three antiretroviral regimens in diverse resource-limited settings: AIDS Clinical Trials Group study a5199, the International Neurological Study
    • COI: 1:CAS:528:DC%2BC38Xht1ynsbfF, PID: 22661489
    • Robertson K, Jiang H, Kumwenda J et al (2012b) Improved neuropsychological and neurological functioning across three antiretroviral regimens in diverse resource-limited settings: AIDS Clinical Trials Group study a5199, the International Neurological Study. Clin Infect Dis 55(6):868–876
    • (2012) Clin Infect Dis , vol.55 , Issue.6 , pp. 868-876
    • Robertson, K.1    Jiang, H.2    Kumwenda, J.3
  • 30
    • 33747059622 scopus 로고    scopus 로고
    • Antiretroviral therapy improves cognitive impairment in HIV+ individuals in sub-Saharan Africa
    • COI: 1:STN:280:DC%2BD28vktFOjtw%3D%3D, PID: 16864825
    • Sacktor N, Nakasujja N, Skolasky R et al (2006) Antiretroviral therapy improves cognitive impairment in HIV+ individuals in sub-Saharan Africa. Neurology 67(2):311–314
    • (2006) Neurology , vol.67 , Issue.2 , pp. 311-314
    • Sacktor, N.1    Nakasujja, N.2    Skolasky, R.3
  • 31
    • 84880800135 scopus 로고    scopus 로고
    • Virological efficacy in cerebrospinal fluid and neurocognitive status in patients with long-term monotherapy based on lopinavir/ritonavir: an exploratory study
    • COI: 1:CAS:528:DC%2BC3sXht1Gitr7E, PID: 23922957
    • Santos JR, Munoz-Moreno JA, Molto J et al (2013) Virological efficacy in cerebrospinal fluid and neurocognitive status in patients with long-term monotherapy based on lopinavir/ritonavir: an exploratory study. PLoS One 8(7):e70201
    • (2013) PLoS One , vol.8 , Issue.7 , pp. 70201
    • Santos, J.R.1    Munoz-Moreno, J.A.2    Molto, J.3
  • 32
    • 77957031964 scopus 로고    scopus 로고
    • Cerebral function tests reveal differences in HIV-infected subjects with and without chronic HCV co-infection
    • COI: 1:STN:280:DC%2BC3cfmtlagtw%3D%3D, PID: 20132257
    • Thiyagarajan A, Garvey LJ, Pflugrad H et al (2010) Cerebral function tests reveal differences in HIV-infected subjects with and without chronic HCV co-infection. Clin Microbiol Infect 16(10):1579–1584
    • (2010) Clin Microbiol Infect , vol.16 , Issue.10 , pp. 1579-1584
    • Thiyagarajan, A.1    Garvey, L.J.2    Pflugrad, H.3
  • 33
    • 84869223148 scopus 로고    scopus 로고
    • Dendritic spine injury induced by the 8-hydroxy metabolite of efavirenz
    • COI: 1:CAS:528:DC%2BC38Xhslyjs7zP, PID: 22984227
    • Tovar-y-Romo LB, Bumpus NN, Pomerantz D et al (2012) Dendritic spine injury induced by the 8-hydroxy metabolite of efavirenz. J Pharmacol Exp Ther 343(3):696–703
    • (2012) J Pharmacol Exp Ther , vol.343 , Issue.3 , pp. 696-703
    • Tovar-y-Romo, L.B.1    Bumpus, N.N.2    Pomerantz, D.3
  • 34
    • 80052891622 scopus 로고    scopus 로고
    • Screening for cognitive impairment in human immunodeficiency virus
    • PID: 21921226
    • Valcour V, Paul R, Chiao S, Wendelken LA, Miller B (2011) Screening for cognitive impairment in human immunodeficiency virus. Clin Infect Dis 53(8):836–842
    • (2011) Clin Infect Dis , vol.53 , Issue.8 , pp. 836-842
    • Valcour, V.1    Paul, R.2    Chiao, S.3    Wendelken, L.A.4    Miller, B.5
  • 35
    • 84155163271 scopus 로고    scopus 로고
    • Hepatitis C virus co-infection increases neurocognitive impairment severity and risk of death in treated HIV/AIDS
    • PID: 21925684
    • Vivithanaporn P, Nelles K, DeBlock L, Newman SC, Gill MJ, Power C (2012) Hepatitis C virus co-infection increases neurocognitive impairment severity and risk of death in treated HIV/AIDS. J Neurol Sci 312(1–2):45–51
    • (2012) J Neurol Sci , vol.312 , Issue.1-2 , pp. 45-51
    • Vivithanaporn, P.1    Nelles, K.2    DeBlock, L.3    Newman, S.C.4    Gill, M.J.5    Power, C.6
  • 36
    • 77952247818 scopus 로고    scopus 로고
    • Does acute hepatitis C infection affect the central nervous system in HIV-1 infected individuals?
    • COI: 1:STN:280:DC%2BC3crksV2rtw%3D%3D, PID: 19780944
    • Winston A, Garvey L, Scotney E et al (2010) Does acute hepatitis C infection affect the central nervous system in HIV-1 infected individuals? J Viral Hepat 17(6):419–426
    • (2010) J Viral Hepat , vol.17 , Issue.6 , pp. 419-426
    • Winston, A.1    Garvey, L.2    Scotney, E.3
  • 37
    • 79954585502 scopus 로고    scopus 로고
    • Superior neurocognitive function is associated with central nervous system antiretroviral drug penetration only in regimens containing more than three antiretroviral agents
    • PID: 21487256
    • Winston A, Garvey L, Sabin CA (2011) Superior neurocognitive function is associated with central nervous system antiretroviral drug penetration only in regimens containing more than three antiretroviral agents. AIDS 25(7):1014–1015
    • (2011) AIDS , vol.25 , Issue.7 , pp. 1014-1015
    • Winston, A.1    Garvey, L.2    Sabin, C.A.3
  • 38
    • 84857999639 scopus 로고    scopus 로고
    • Dynamics of cognitive change in HIV-infected individuals commencing three different initial antiretroviral regimens: a randomized, controlled study
    • COI: 1:CAS:528:DC%2BC38XmtFWmtbk%3D, PID: 22151608
    • Winston A, Puls R, Kerr SJ et al (2012) Dynamics of cognitive change in HIV-infected individuals commencing three different initial antiretroviral regimens: a randomized, controlled study. HIV Med 13(4):245–251
    • (2012) HIV Med , vol.13 , Issue.4 , pp. 245-251
    • Winston, A.1    Puls, R.2    Kerr, S.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.