The neuroprotection of Sinomenine against ischemic stroke in mice by suppressing NLRP3 inflammasome via AMPK signaling

International Immunopharmacology

Volumn 40, Issue , 2016, Pages 492-500

  Qiu, Jing ^a   Wang, Min ^c   Zhang, Jun ^b,d   Cai, Qing ^b   Lu, Dan ^b   Li, Yansong ^c   Dong, Yushu ^a   Zhao, Tianzhi ^b   Chen, Huisheng ^a  

^a GENERAL HOSPITAL OF NORTHERN THEATER COMMAND   (China)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

^c The 463 Hospital of Chinese PLA   (China)

^d Dalang Hospital   (China)

Author keywords

AMPK; Glia; Ischemic stroke; NLRP3 inflammasome; Secondary brain injury; Sinomenine

Indexed keywords

CRYOPYRIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 6; SINOMENINE; TUMOR NECROSIS FACTOR; ANTIINFLAMMATORY AGENT; GLUCOSE; MORPHINAN DERIVATIVE; NLRP3 PROTEIN, MOUSE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; ASTROCYTE; BRAIN EDEMA; BRAIN HISTOLOGY; BRAIN INFARCTION; BRAIN ISCHEMIA; BRAIN WATER; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; GLIAL CELL CULTURE; IN VITRO STUDY; IN VIVO STUDY; MALE; MICROGLIA; MIDDLE CEREBRAL ARTERY OCCLUSION; MOUSE; NERVE CELL NECROSIS; NEUROLOGIC DISEASE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANIMAL; C57BL MOUSE; CELL CULTURE; DRUG EFFECTS; HUMAN; METABOLISM; PHYSIOLOGY; STROKE;

AMP-ACTIVATED PROTEIN KINASES; ANIMALS; ANTI-INFLAMMATORY AGENTS; ASTROCYTES; BRAIN ISCHEMIA; CELLS, CULTURED; GLUCOSE; HUMANS; INFLAMMASOMES; MALE; MICE; MICE, INBRED C57BL; MORPHINANS; NEUROPROTECTION; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; SIGNAL TRANSDUCTION; STROKE;

EID: 84994361364     PISSN: 15675769     EISSN: 18781705     Source Type: Journal    
DOI: 10.1016/j.intimp.2016.09.024     Document Type: Article

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