Dnmt3a deletion cooperates with the Flt3/ITD mutation to drive leukemogenesis in a murine model

Oncotarget

Volumn 7, Issue 43, 2016, Pages 69124-69135

  Poitras, Jennifer L ^a   Heiser, Diane ^a   Li, Li ^a   Nguyen, Bao ^a   Nagai, Kozo ^a   Duffield, Amy S ^a   Gamper, Christopher ^a   Small, Donald ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Acute myeloid leukemia; DNMT3a; FLT3; Internal tandem duplication; Mouse model

Indexed keywords

CD135 ANTIGEN; DNA METHYLTRANSFERASE 3A; DNA (CYTOSINE 5) METHYLTRANSFERASE; FLT3 PROTEIN, MOUSE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ACUTE MYELOBLASTIC LEUKEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER SURVIVAL; CELL SELF-RENEWAL; CONTROLLED STUDY; DNMT3A GENE; FLT3 GENE; GENE DELETION; GENE DUPLICATION; GENE EXPRESSION; GENE LOSS; GENE MUTATION; HEMATOPOIETIC STEM CELL; HETEROZYGOSITY LOSS; HOMOZYGOSITY; LEUKEMOGENESIS; MOUSE; MUTANT; MYELOID PROGENITOR CELL; MYELOPROLIFERATIVE NEOPLASM; NONHUMAN; STEM CELL EXPANSION; ACUTE DISEASE; ANIMAL; C57BL MOUSE; DISEASE EXACERBATION; DISEASE MODEL; GENETICS; HUMAN; KAPLAN MEIER METHOD; KNOCKOUT MOUSE; MUTATION; MYELOID LEUKEMIA; MYELOPROLIFERATIVE DISORDER; TANDEM REPEAT; TRANSGENIC MOUSE;

ACUTE DISEASE; ANIMALS; DISEASE MODELS, ANIMAL; DISEASE PROGRESSION; DNA (CYTOSINE-5-)-METHYLTRANSFERASES; FMS-LIKE TYROSINE KINASE 3; HUMANS; KAPLAN-MEIER ESTIMATE; LEUKEMIA, MYELOID; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MUTATION; MYELOPROLIFERATIVE DISORDERS; PRECURSOR T-CELL LYMPHOBLASTIC LEUKEMIA-LYMPHOMA; TANDEM REPEAT SEQUENCES;

EID: 84994299034     PISSN: None     EISSN: 19492553     Source Type: Journal    
DOI: 10.18632/oncotarget.11986     Document Type: Article

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