Dietary rapamycin supplementation reverses age-related vascular dysfunction and oxidative stress, while modulating nutrient-sensing, cell cycle, and senescence pathways

Aging Cell

Volumn 16, Issue 1, 2017, Pages 17-26

  Lesniewski, Lisa A ^a,b,c   Seals, Douglas R ^d   Walker, Ashley E ^a   Henson, Grant D ^c   Blimline, Mark W ^d   Trott, Daniel W ^a   Bosshardt, Gary C ^a   LaRocca, Thomas J ^d   Lawson, Brooke R ^d   Zigler, Melanie C ^d   Donato, Anthony J ^a,b,c,e  

^a Geriatrics Division   (United States)

^b GERIATRIC RESEARCH EDUCATION AND CLINICAL CENTER   (United States)

^c UNIVERSITY OF UTAH   (United States)

^d UNIVERSITY OF COLORADO   (United States)

^e UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

aging; AMPK; arterial stiffness; endothelial function; mTOR; oxidative stress; rapamycin

Indexed keywords

ADVANCED GLYCATION END PRODUCT; CYCLIN DEPENDENT KINASE INHIBITOR 1B; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN P19; RAPAMYCIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; S6 KINASE; SUPEROXIDE; ADENYLATE KINASE; BIOLOGICAL MARKER; CELL CYCLE PROTEIN; GLUCOSE BLOOD LEVEL; INSULIN; TARGET OF RAPAMYCIN KINASE;

AGED; AGING; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; AORTA; ARTERY COMPLIANCE; ARTERY DILATATION; ARTERY ENDOTHELIUM; ARTERY WALL; ARTICLE; B6D2F1 MOUSE; CAROTID ARTERY; CELL CYCLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DRUG EFFECT; DRUG MECHANISM; ENDOTHELIAL DYSFUNCTION; ENZYME ACTIVATION; GLUCOSE TOLERANCE; GROUPS BY AGE; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PULSE WAVE; SENESCENCE; VASCULAR DISEASE; ANIMAL; ARTERIAL STIFFNESS; ARTERY; BLOOD; BODY WEIGHT; C57BL MOUSE; CELL AGING; DIETARY SUPPLEMENT; DRUG EFFECTS; GLUCOSE BLOOD LEVEL; HOMEOSTASIS; INSULIN RESISTANCE; METABOLISM; ORGAN SIZE; PATHOLOGY; PATHOPHYSIOLOGY; VASCULAR ENDOTHELIUM; VASODILATATION;

ADENYLATE KINASE; AGING; ANIMALS; ARTERIES; BIOMARKERS; BLOOD GLUCOSE; BODY WEIGHT; CELL AGING; CELL CYCLE; CELL CYCLE PROTEINS; DIETARY SUPPLEMENTS; ENDOTHELIUM, VASCULAR; HOMEOSTASIS; INSULIN; INSULIN RESISTANCE; MALE; MICE, INBRED C57BL; ORGAN SIZE; OXIDATIVE STRESS; SIROLIMUS; TOR SERINE-THREONINE KINASES; VASCULAR STIFFNESS; VASODILATION;

EID: 84994234466     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/acel.12524     Document Type: Article

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