메뉴 건너뛰기




Volumn 173, Issue 23, 2016, Pages 3292-3306

Amino acid transporter SLC6A14 is a novel and effective drug target for pancreatic cancer

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID TRANSPORTER; MESSENGER RNA; N METHYLTRYPTOPHAN; PROTEIN SLC6A14; UNCLASSIFIED DRUG; ALPHA-METHYLTRYPTOPHAN; ANTINEOPLASTIC AGENT; SLC6A14 PROTEIN, HUMAN; TRYPTOPHAN;

EID: 84994218615     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/bph.13616     Document Type: Article
Times cited : (109)

References (48)
  • 1
    • 0042322315 scopus 로고    scopus 로고
    • mTOR as a positive regulator of tumor cell responses to hypoxia
    • Abraham RT (2004). mTOR as a positive regulator of tumor cell responses to hypoxia. Curr Top Microbiol Immunol 279: 299–319.
    • (2004) Curr Top Microbiol Immunol , vol.279 , pp. 299-319
    • Abraham, R.T.1
  • 4
    • 84865210598 scopus 로고    scopus 로고
    • Homeostasis and the importance for a balance between AKT/mTOR activity and intracellular signaling
    • Altomare DA, Khaled AR (2012). Homeostasis and the importance for a balance between AKT/mTOR activity and intracellular signaling. Curr Med Chem 19: 3748–3762.
    • (2012) Curr Med Chem , vol.19 , pp. 3748-3762
    • Altomare, D.A.1    Khaled, A.R.2
  • 6
    • 60849121964 scopus 로고    scopus 로고
    • Combined gene expression analysis of whole-tissue and microdissected pancreatic ductal adenocarcinoma identifies genes specifically overexpressed in tumor epithelia
    • Badea L, Herlea V, Dima SO, Dumitrascu T, Popescu I (2008). Combined gene expression analysis of whole-tissue and microdissected pancreatic ductal adenocarcinoma identifies genes specifically overexpressed in tumor epithelia. Hepatogastroenterology 55: 2016–2027.
    • (2008) Hepatogastroenterology , vol.55 , pp. 2016-2027
    • Badea, L.1    Herlea, V.2    Dima, S.O.3    Dumitrascu, T.4    Popescu, I.5
  • 7
    • 84875776943 scopus 로고    scopus 로고
    • S100P is a metastasis-associated gene that facilitates transendothelial migration of pancreatic cancer cells
    • Barry S, Chelala C, Lines K, Sunamura M, Wang A, Marelli-Berg FM et al. (2013). S100P is a metastasis-associated gene that facilitates transendothelial migration of pancreatic cancer cells. Clin Exp Metastasis 30: 251–264.
    • (2013) Clin Exp Metastasis , vol.30 , pp. 251-264
    • Barry, S.1    Chelala, C.2    Lines, K.3    Sunamura, M.4    Wang, A.5    Marelli-Berg, F.M.6
  • 8
    • 84953298606 scopus 로고    scopus 로고
    • Glutamine transporters in mammalian cells ad their function in physiology and cancer
    • Bhutia YD, Ganapathy V (2015). Glutamine transporters in mammalian cells ad their function in physiology and cancer. Biochim Biophys Acta. doi:10.1016/j.bbamcr.2015.12.017.
    • (2015) Biochim Biophys Acta
    • Bhutia, Y.D.1    Ganapathy, V.2
  • 9
    • 84919644742 scopus 로고    scopus 로고
    • The amino acid transporter SLC6A14 in cancer and its potential use in chemotherapy
    • Bhutia YD, Babu E, Prasad PD, Ganapathy V (2014). The amino acid transporter SLC6A14 in cancer and its potential use in chemotherapy. Asian J Pharm Sci 9: 293–303.
    • (2014) Asian J Pharm Sci , vol.9 , pp. 293-303
    • Bhutia, Y.D.1    Babu, E.2    Prasad, P.D.3    Ganapathy, V.4
  • 10
    • 84935519595 scopus 로고    scopus 로고
    • Amino acid transporters in cancer and their relevance to “glutamine addiction”: novel targets for the design of a new class of anticancer drugs
    • Bhutia YD, Babu E, Ramachandran S, Ganapathy V (2015). Amino acid transporters in cancer and their relevance to “glutamine addiction”: novel targets for the design of a new class of anticancer drugs. Cancer Res 75: 1782–1788.
    • (2015) Cancer Res , vol.75 , pp. 1782-1788
    • Bhutia, Y.D.1    Babu, E.2    Ramachandran, S.3    Ganapathy, V.4
  • 11
    • 84863269083 scopus 로고    scopus 로고
    • Differential expression of metabolic genes in tumor and stromal components of primary and metastatic loci in pancreatic adenocarcinoma
    • Chaika NV, Yu F, Purohit V, Mehla K, Lazenby AJ, DiMaio D et al. (2012). Differential expression of metabolic genes in tumor and stromal components of primary and metastatic loci in pancreatic adenocarcinoma. PLoS One 7: e32996.
    • (2012) PLoS One , vol.7
    • Chaika, N.V.1    Yu, F.2    Purohit, V.3    Mehla, K.4    Lazenby, A.J.5    DiMaio, D.6
  • 12
    • 80054800227 scopus 로고    scopus 로고
    • Alpha-methyl-L-tryptophan: mechanisms for tracer localization of epileptogenic brain regions
    • Chugani DC (2011). Alpha-methyl-L-tryptophan: mechanisms for tracer localization of epileptogenic brain regions. Biomark Med 5: 567–575.
    • (2011) Biomark Med , vol.5 , pp. 567-575
    • Chugani, D.C.1
  • 13
    • 79959191028 scopus 로고    scopus 로고
    • mTOR signaling in protein homeostasis: less is more?
    • Conn CS, Qian SB (2011). mTOR signaling in protein homeostasis: less is more? Cell Cycle 10: 1940–1947.
    • (2011) Cell Cycle , vol.10 , pp. 1940-1947
    • Conn, C.S.1    Qian, S.B.2
  • 14
    • 84873048782 scopus 로고    scopus 로고
    • The plasma membrane transporter SLC5A8 suppresses tumour progression through depletion of survivin without involving its transport function
    • Coothankandaswamy V, Elangovan S, Singh N, Prasad PD, Thangaraju M, Ganapathy V (2013). The plasma membrane transporter SLC5A8 suppresses tumour progression through depletion of survivin without involving its transport function. Biochem J 450: 169–178.
    • (2013) Biochem J , vol.450 , pp. 169-178
    • Coothankandaswamy, V.1    Elangovan, S.2    Singh, N.3    Prasad, P.D.4    Thangaraju, M.5    Ganapathy, V.6
  • 16
  • 18
    • 84882469223 scopus 로고    scopus 로고
    • Protein digestion and absorption
    • In, Johnson LR, Ghishan FK, Kunitz JD, (eds)., Academic Press, London
    • Ganapathy V (2012). Protein digestion and absorption. In: Johnson LR, Ghishan FK, Kunitz JD et al. (eds). Physiology of the Gastrointestinal Tract. Academic Press: London, pp. 1595–1623.
    • (2012) Physiology of the Gastrointestinal Tract , pp. 1595-1623
    • Ganapathy, V.1
  • 21
    • 57749111596 scopus 로고    scopus 로고
    • Nutrient transporters in cancer: relevance to Warburg hypothesis and beyond
    • Ganapathy V, Thangaraju M, Prasad PD (2009). Nutrient transporters in cancer: relevance to Warburg hypothesis and beyond. Pharmacol Ther 121: 29–40.
    • (2009) Pharmacol Ther , vol.121 , pp. 29-40
    • Ganapathy, V.1    Thangaraju, M.2    Prasad, P.D.3
  • 24
    • 0032486268 scopus 로고    scopus 로고
    • Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism
    • Hara K, Yonezawa K, Weng QP, Kozlowski MT, Belham C, Avruch J (1998). Amino acid sufficiency and mTOR regulate p70 S6 kinase and eIF-4E BP1 through a common effector mechanism. J Biol Chem 273: 14484–14494.
    • (1998) J Biol Chem , vol.273 , pp. 14484-14494
    • Hara, K.1    Yonezawa, K.2    Weng, Q.P.3    Kozlowski, M.T.4    Belham, C.5    Avruch, J.6
  • 25
    • 78650508742 scopus 로고    scopus 로고
    • CXCL17 and ICAM2 are associated with a potential anti-tumor immune response in early intraepithelial stages of human pancreatic carcinogenesis
    • Hiraoka N, Yamazaki-Itoh R, Ino Y, Mizuguchi Y, Yamada T, Hirohashi S et al. (2011). CXCL17 and ICAM2 are associated with a potential anti-tumor immune response in early intraepithelial stages of human pancreatic carcinogenesis. Gastroenterology 140: 310–321.
    • (2011) Gastroenterology , vol.140 , pp. 310-321
    • Hiraoka, N.1    Yamazaki-Itoh, R.2    Ino, Y.3    Mizuguchi, Y.4    Yamada, T.5    Hirohashi, S.6
  • 26
    • 0030455754 scopus 로고    scopus 로고
    • An example of nutrient control of gene expression: amino acid-dependent regulation of asparagine synthetase
    • Hutson RG, Warskulat U, Haussinger D, Kilberg MS (1996). An example of nutrient control of gene expression: amino acid-dependent regulation of asparagine synthetase. Clin Nutr 15: 327–331.
    • (1996) Clin Nutr , vol.15 , pp. 327-331
    • Hutson, R.G.1    Warskulat, U.2    Haussinger, D.3    Kilberg, M.S.4
  • 27
    • 79952528125 scopus 로고    scopus 로고
    • c and thereby promotes tumor growth
    • Ishimoto T, Nagano O, Yae T, Tamada M, Motohara T, Oshima H et al. (2011). CD44 variant regulates redox status in cancer cells by stabilizing the xCT subunit of system x−cand thereby promotes tumor growth. Cancer Cell 19: 387–400.
    • (2011) Cancer Cell , vol.19 , pp. 387-400
    • Ishimoto, T.1    Nagano, O.2    Yae, T.3    Tamada, M.4    Motohara, T.5    Oshima, H.6
  • 28
    • 84884676252 scopus 로고    scopus 로고
    • Nutrient signaling to mTOR and cell growth
    • Jewell JL, Guan KL (2013). Nutrient signaling to mTOR and cell growth. Trends Biochem Sci 38: 233–242.
    • (2013) Trends Biochem Sci , vol.38 , pp. 233-242
    • Jewell, J.L.1    Guan, K.L.2
  • 31
    • 52449118755 scopus 로고    scopus 로고
    • ,+) reveals the potential of the transporter as a drug target for cancer chemotherapy
    • Karunakaran S, Umapathy NS, Thangaraju M, Hatanaka T, Itagaki S, Munn DH et al. (2008). Interaction of tryptophan derivatives with SLC6A14 (ATB0,+) reveals the potential of the transporter as a drug target for cancer chemotherapy. Biochem J 414: 343–355.
    • (2008) Biochem J , vol.414 , pp. 343-355
    • Karunakaran, S.1    Umapathy, N.S.2    Thangaraju, M.3    Hatanaka, T.4    Itagaki, S.5    Munn, D.H.6
  • 32
    • 80052404126 scopus 로고    scopus 로고
    • ,+) protein, a highly concentrative and broad specific amino acid transporter, is a novel and effective drug target for treatment of estrogen receptor-positive breast cancer
    • Karunakaran S, Ramachandran S, Coothankandaswamy V, Elangovan S, Babu E, Periyasamy-Thandavan S et al. (2011). SLC6A14 (ATB0,+) protein, a highly concentrative and broad specific amino acid transporter, is a novel and effective drug target for treatment of estrogen receptor-positive breast cancer. J Biol Chem 286: 31830–31838.
    • (2011) J Biol Chem , vol.286 , pp. 31830-31838
    • Karunakaran, S.1    Ramachandran, S.2    Coothankandaswamy, V.3    Elangovan, S.4    Babu, E.5    Periyasamy-Thandavan, S.6
  • 33
  • 34
    • 1842583789 scopus 로고    scopus 로고
    • Development by self-digestion: molecular mechanisms and biological functions of autophagy
    • Levine B, Klionsky DJ (2004). Development by self-digestion: molecular mechanisms and biological functions of autophagy. Dev Cell 6: 463–477.
    • (2004) Dev Cell , vol.6 , pp. 463-477
    • Levine, B.1    Klionsky, D.J.2
  • 35
    • 83455177213 scopus 로고    scopus 로고
    • Target of rapamycin (TOR) in nutrient signaling and growth control
    • Loewith R, Hall MN (2011). Target of rapamycin (TOR) in nutrient signaling and growth control. Genetics 189: 1177–1201.
    • (2011) Genetics , vol.189 , pp. 1177-1201
    • Loewith, R.1    Hall, M.N.2
  • 36
    • 84928346634 scopus 로고    scopus 로고
    • Implementing guidelines on reporting research using animals (ARRIVE etc.): new requirements for publication in BJP
    • McGrath JC, Lilley E (2015). Implementing guidelines on reporting research using animals (ARRIVE etc.): new requirements for publication in BJP. Br J Pharmacol 172: 3189–3193.
    • (2015) Br J Pharmacol , vol.172 , pp. 3189-3193
    • McGrath, J.C.1    Lilley, E.2
  • 37
    • 57649231823 scopus 로고    scopus 로고
    • Therapeutic strategy targeting the mTOR-HIF-1alpha-VEGF pathway in ovarian clear cell adenocarcinoma
    • Miyazawa M, Yasuda M, Fujita M, Kajiwara H, Hirabayashi K, Takekoshi S et al. (2009). Therapeutic strategy targeting the mTOR-HIF-1alpha-VEGF pathway in ovarian clear cell adenocarcinoma. Pathol Int 59: 19–27.
    • (2009) Pathol Int , vol.59 , pp. 19-27
    • Miyazawa, M.1    Yasuda, M.2    Fujita, M.3    Kajiwara, H.4    Hirabayashi, K.5    Takekoshi, S.6
  • 38
    • 84902554019 scopus 로고    scopus 로고
    • ,+ transport activity by PET with the cationic amino acid O-2((2-[(18)F]fluoroethyl)methyl-amino)ethyltyrosine
    • Muller A, Chiotellis A, Keller C, Ametamey SM, Schibli R, Mu L et al. (2014). Imaging tumour ATB0,+transport activity by PET with the cationic amino acid O-2((2-[(18)F]fluoroethyl)methyl-amino)ethyltyrosine. Mol Imaging Biol 16: 412–420.
    • (2014) Mol Imaging Biol , vol.16 , pp. 412-420
    • Muller, A.1    Chiotellis, A.2    Keller, C.3    Ametamey, S.M.4    Schibli, R.5    Mu, L.6
  • 39
    • 59049087460 scopus 로고    scopus 로고
    • Bidirectional transport of amino acids regulates mTOR and autophagy
    • Nicklin P, Bergman P, Zhang B, Triantafellow E, Wang H, Nyfeler B et al. (2009). Bidirectional transport of amino acids regulates mTOR and autophagy. Cell 136: 521–534.
    • (2009) Cell , vol.136 , pp. 521-534
    • Nicklin, P.1    Bergman, P.2    Zhang, B.3    Triantafellow, E.4    Wang, H.5    Nyfeler, B.6
  • 40
    • 69249228672 scopus 로고    scopus 로고
    • FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt
    • Pei H, Li L, Fridley BL, Jenkins GD, Kalari KR, Lingle W et al. (2009). FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt. Cancer Cell 16: 259–266.
    • (2009) Cancer Cell , vol.16 , pp. 259-266
    • Pei, H.1    Li, L.2    Fridley, B.L.3    Jenkins, G.D.4    Kalari, K.R.5    Lingle, W.6
  • 42
    • 84976865494 scopus 로고    scopus 로고
    • The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands
    • Southan C, Sharman JL, Benson HE, Faccenda E, Pawson AJ, Alexander SP et al. (2016). The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. Nucl Acids Res 44: D1054–D1068.
    • (2016) Nucl Acids Res , vol.44 , pp. D1054-D1068
    • Southan, C.1    Sharman, J.L.2    Benson, H.E.3    Faccenda, E.4    Pawson, A.J.5    Alexander, S.P.6
  • 43
    • 84892566999 scopus 로고    scopus 로고
    • Physical biology in cancer. 4. Physical cues guide tumor cell adhesion and migration
    • Stroka KM, Konstantopoulos K (2014). Physical biology in cancer. 4. Physical cues guide tumor cell adhesion and migration. Am J Physiol Cell Physiol 306: C98–C109.
    • (2014) Am J Physiol Cell Physiol , vol.306 , pp. C98-C109
    • Stroka, K.M.1    Konstantopoulos, K.2
  • 44
    • 84885378901 scopus 로고    scopus 로고
    • Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target
    • Timmerman LA, Holton T, Yuneva M, Louie RJ, Padro M, Daemen A et al. (2013). Glutamine sensitivity analysis identifies the xCT antiporter as a common triple-negative breast tumor therapeutic target. Cancer Cell 24: 450–465.
    • (2013) Cancer Cell , vol.24 , pp. 450-465
    • Timmerman, L.A.1    Holton, T.2    Yuneva, M.3    Louie, R.J.4    Padro, M.5    Daemen, A.6
  • 45
    • 84858604270 scopus 로고    scopus 로고
    • Metabolic reprogramming: a cancer hallmark even Warburg did not anticipate
    • Ward PS, Thompson CB (2012). Metabolic reprogramming: a cancer hallmark even Warburg did not anticipate. Cancer Cell 21: 297–308.
    • (2012) Cancer Cell , vol.21 , pp. 297-308
    • Ward, P.S.1    Thompson, C.B.2
  • 46
    • 84863257020 scopus 로고    scopus 로고
    • Developments in metastatic pancreatic cancer: is gemcitabine still the standard?
    • Ying JE, Zhu LM, Liu BX (2012). Developments in metastatic pancreatic cancer: is gemcitabine still the standard? World J Gastroenterol 18: 736–745.
    • (2012) World J Gastroenterol , vol.18 , pp. 736-745
    • Ying, J.E.1    Zhu, L.M.2    Liu, B.X.3
  • 47
    • 84884570719 scopus 로고    scopus 로고
    • Integration of metabolomics and transcriptomics revealed a fatty acid network exerting growth inhibitory effects in human pancreatic cancer
    • Zhang G, He P, Tan H, Budhu A, Gaedcke J, Ghadimi BM et al. (2013). Integration of metabolomics and transcriptomics revealed a fatty acid network exerting growth inhibitory effects in human pancreatic cancer. Clin Cancer Res 19: 4983–4993.
    • (2013) Clin Cancer Res , vol.19 , pp. 4983-4993
    • Zhang, G.1    He, P.2    Tan, H.3    Budhu, A.4    Gaedcke, J.5    Ghadimi, B.M.6
  • 48
    • 78650510609 scopus 로고    scopus 로고
    • mTOR: from growth signal integration to cancer, diabetes and ageing
    • Zoncu R, Efeyan A, Sabatini DM (2011). mTOR: from growth signal integration to cancer, diabetes and ageing. Nat Rev Mol Cell Biol 12: 21–35.
    • (2011) Nat Rev Mol Cell Biol , vol.12 , pp. 21-35
    • Zoncu, R.1    Efeyan, A.2    Sabatini, D.M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.