An example of nutrient control of gene expression: Amino acid-dependent regulation of asparagine synthetase

Clinical Nutrition

Volumn 15, Issue 6, 1996, Pages 327-331

  Hutson, R G ^a   Warskulat, U ^a   Haussinger D ^a   Kilberg, M S ^a  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; ASPARTATE AMMONIA LIGASE; CYCLOHEXIMIDE; DACTINOMYCIN; GLUTAMINE; HISTIDINOL; MESSENGER RNA;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CLONE; CONTROL SYSTEM; CULTURE MEDIUM; DNA LIBRARY; GENE EXPRESSION; HEPATOMA CELL; NONHUMAN; RAT; RECEPTOR UPREGULATION;

EID: 0030455754     PISSN: 02615614     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0261-5614(96)80009-4     Document Type: Article

References (37)

1. Clarke S D, Abraham S. Gene expression: nutrient control of pre-and post-transcriptional events. FASEB J 1992; 6: 3146-3152
2. Clarke S D, Jump D B. In: Berdanier C D, Hargrove J L, eds. CRC Press Reviews. Boca Raton: CRC Press 1992: 227-246
3. Dawson P A, Metherall J E, Ridgway N D, Brown M S, Goldstein J L. Genetic distinction between sterol-mediated transcriptional and posttranscriptional control of 3-Hydroxy-3-Methylglutaryl-Coenzyme A reductase. J Biol Chem 1991; 266: 9128-9134
4. Klausner R D, Roulaut T A, Harford J B. Regulating the fate of mRNA: the control of cellular iron metabolism. Cell 1993; 72: 19-28
5. Bremner I, Beattie J H. Metallothionein and the trace minerals. Annu Rev Nutr 1990; 10: 63-83
6. Goldstein J L, Brown M S. Regulation of the mevalonate pathway. Nature 1990; 343: 425-430
7. Lee A S. Coordinated regulation of a set of genes by glucose and calcium ionophores in mammalian cells. Trends Biochem Sci 1987; 12: 20-23
8. Hinnebusch A G. Translational control of GCN4: an in vivo barometer of initiation-factor activity. Trends Biochem Sei 1994; 19: 409-414
9. Hope I A, Struhl K. GCN4 protein, synthesized in vitro, binds HIS3 regulatory sequences: implications for general control of amino acid biosynthetic genes in yeast. Cell 1985; 43: 177-188
10. Abastado J P, Miller P F, Jackson B M, Hinnebusch A G. Suppression of ribosomal reinitiation at upstream open reading frames in amino acid-starved cells forms the basis for GCN4 translational control. Mol Cell Biol 1991; 11: 486-496
11. Ogawa H, Fujioka M, Su Y, Kanamoto R, Pilot H C. Nutritional regulation and tissue-specific expression of the serine dehydratase gene in rat. J Biol Chem 1991; 266: 20412-20417
12. Gong S S, Basilico C. A mammalian temperature-sensitive mutation affecting G1 progression results from a single amino acid substitution in asparagine synthetase. Nucleic Acids Res 1990; 18: 3509-3513
13. Bracy D S, Handlogten M E, Barber E F, Han H P, Kilberg M S. Cis-inhibition, trans-inhibition, and repression of hepatic amino acid transport mediated by System A. J Biol Chem 1986; 261: 1514-1520
14. Shotwell M A, Mattes P M, Jayme D W, Oxender D L. Regulation of amino acid transport System L in Chinese hamster ovary cells. J Biol Chem 1982; 257: 2974-2980
15. Shay N F, Nick H S, Kilberg M S. Molecular cloning of an amino acid-regulated mRNA (amino acid starvation-induced) in rat hepatoma cells. J Biol Chem 1990; 265: 17844-17848
16. Lainet R O, Laipis P J, Shay N F, Kilberg M S. Identification of an amino acid-regulated mRNA from rat liver as the mammalian equivalent of bacterial ribosomal protein L22. J Biol Chem 1991; 266: 16969-16972
17. Laine R O, Shay N F, Kilberg M S. Nuclear retention of the induced mRNA following amino acid-dependent transcriptional regulation of mammalian ribosomal proteins L17 and S25. J Biol Chem 1994; 269: 9693-9697
18. Laine R O, Hutson R H, Kilberg M S. Eukaryotic gene expression: metabolite control by amino acids. In: Cohn W, Moldave K, eds. Progress in Nucleic Acid Research and Molecular Biology. San Diego: Academic Press, 1996.
19. Pohjanpelto P, Hölttä E. Deprivation of a single amino acid induces protein synthesis-dependent increases in c-jun, c-myc, and ornithine decarboxylase mRNAs in Chinese hamster ovary cells. Mol Cell Biol 1990; 10: 5814-5821
20. Hutson R H, Kilberg M S. Cloning of rat asparagine synthetase and specificity of the amino acid-dependent control of its mRNA content. Biochem J 1994; 304: 745-750
21. Marten N W, Burke E J, Hayden J M, Straus D S. Effect of amino acid limitation on the expression of 19 genes in rat hepatoma cells. FASEB J 1994; 8: 538-544
22. Straus D S, Burke E J, Marten N W. Induction of insulin-like growth factor binding Protein-1 gene expression in liver of protein-restricted rats and in rat hepatoma cells limited for a single amino acid. Endocrinology 1993; 132: 1090-1100
23. Chen Z P, Chen K Y. Mechanism of regulation of ornithine decarboxylase gene expression by asparagine in a variant mouse neuroblastoma cell line. J Biol Chem 1992; 267: 6946-6951
24. Everson W V, Flaim K E, Susco D M, Kimball S R, Jefferson L S. Effect of amino acid deprivation on initiation of protein synthesis in rat hepatocytes. Am J Physiol 1989; 256: C18-C25
25. Gong S S, Guerrini L, Basilico C. Regulation of asparagine synthetase gene expression by amino acid starvation. Mol Cell Biol 1991; 11: 6059-6066
26. Arfin S A, Simpson D R, Chiang C S, Andrulis I L, Wesley G. A role for asparaginyl-tRNA in the regulation of asparagine synthetase in a mammalian cell line. Proc Natl Acad Sci USA
27. Andrulis I L, Hatfield G W, Arfin S M. Asparaginyl-tRNA aminoacylation levels and asparagine synthetase expression in cultured Chinese hamster ovary cells. J Biol Chem 1979; 254: 10629-10633
28. Greco A, Gong S S, Ittman M, Basilico C. Organization and expression of the cell cycle gene, ts11, that encodes asparagine synthetase. Mol Cell Biol 1989; 9: 2350-2359
29. Guerrini L, Gong S S, Mangasarian K, Basilico C. Cis- and Transacting elements involved in amino acid regulation of asparagine synthetase gene expression. Mol Cell Biol 1993; 13: 3202-3212
30. Haussinger D. Hepatocyte heterogeneity in glutamine and ammonia metabolism and the role of an intercellular glutamine cycle during ureogenesis in perfused rat liver. Eur J Biochem 1983; 133: 269-274
31. Hansen B S, Vaughan M H, Wang L. Reversible inhibition by histidinol of protein synthesis in human cells at the activation of histidine. J Biol Chem 1972; 247: 3854-3857
32. Cassio D, Lemoine F, Waller J, Sandrin E, Boissonnas R A. Selective inhibition of aminoacyl ribonucleic acid synthetases by aminoalkyl adenylates. Biochemistry 1967; 6: 827-835
33. White M F, Gazzola G C, Christensen H N. Cationic amino acid transport into cultured animal cells I. influx into cultured human fibroblasts. J Biol Chem 1982; 257: 4443-4449
34. White M F, Christensen H N. Cationic amino acid transport into cultured animal cells II. transport system barely perceptible in ordinary hepatocytes, but active in hepatoma cell lines. J Biol Chem 1982; 257: 4450-4457
35. White M F, Christensen H N. Simultaneous regulation of amino acid influx and efflux by system A in the hepatoma cell HTC. J Biol Chem 1983; 258: 8028-8038
36. Jagus R, Anderson W F, Safer B. The regulation of initiation of mammalian protein synthesis. Prog Nucleic Acids Res Mol Biol 1981; 25: 127-183
37. Ledford B E, Jacobs D F. Translation kinetics in cultured mouse hepatoma cells, regulation of albumin synthesis by amino acids. Eur J Biochem 1985; 152: 611-618