Interaction of tryptophan derivatives with SLC6A14 (ATB0,+) reveals the potential of the transporter as a drug target for cancer chemotherapy

Biochemical Journal

Volumn 414, Issue 3, 2008, Pages 343-355

  Karunakaran, Senthil ^a   Umapathy, Nagavedi S ^a   Thangaraju, Muthusamy ^a   Hatanaka, Takahiro ^a   Itagaki, Shiro ^a   Munn, David H ^a   Prasad, Puttur D ^a   Ganapathy, Vadivel ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

1 methyltryptophan; Amino acid nutrition; Cancer therapy; Solute carrier family 6 member 14 (SLC6A14); Transport blocker; Tumour cell growth

Indexed keywords

1-METHYLTRYPTOPHAN; AMINO ACID NUTRITION; CANCER THERAPY; SOLUTE CARRIER FAMILY 6 MEMBER 14 (SLC6A14); TRANSPORT BLOCKER; TUMOUR CELL GROWTH;

AMINO ACIDS;

AMINO ACID TRANSPORTER; CARRIER PROTEIN; CHLORIDE ION; GLYCINE TRANSPORTER 1; GLYCINE TRANSPORTER 2; INDOLEAMINE 2,3 DIOXYGENASE; N METHYLTRYPTOPHAN; SODIUM ION; SOLUTE CARRIER FAMILY 6 MEMBER 14; TRYPTOPHAN DERIVATIVE; UNCLASSIFIED DRUG;

AMINO ACID TRANSPORT; ANIMAL CELL; ARTICLE; BREAST CANCER; BREAST EPITHELIUM; CANCER CELL CULTURE; CELL CYCLE ARREST; CELL LINE; CELL STRAIN MCF 7; COLONY FORMATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG TARGETING; ENZYME INHIBITION; EPITHELIUM CELL; FEMALE; HUMAN; HUMAN CELL; IC 50; IMMUNOSURVEILLANCE; INHIBITION KINETICS; MALIGNANT NEOPLASTIC DISEASE; NONHUMAN; OOCYTE; PIGMENT EPITHELIUM; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; STOICHIOMETRY; TUMOR CELL; UPREGULATION; XENOPUS LAEVIS;

AMINO ACID TRANSPORT SYSTEMS; AMINO ACID TRANSPORT SYSTEMS, NEUTRAL; ANIMALS; ANTINEOPLASTIC AGENTS; BIOLOGICAL TRANSPORT, ACTIVE; CELL LINE; CELL LINE, TUMOR; HUMANS; LARGE NEUTRAL AMINO ACID-TRANSPORTER 1; MICE; OOCYTES; PLASMA MEMBRANE NEUROTRANSMITTER TRANSPORT PROTEINS; TRYPTOPHAN; XENOPUS LAEVIS;

EID: 52449118755     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20080622     Document Type: Article

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