메뉴 건너뛰기




Volumn 18, Issue 8, 2012, Pages 736-745

Developments in metastatic pancreatic cancer: Is gemcitabine still the standard?

Author keywords

Biomarkers; Chemotherapy; Metastasis; Palliative therapy; Pancreatic neoplasms

Indexed keywords

BEVACIZUMAB; CAPECITABINE; CETUXIMAB; DALOTUZUMAB; DNA TOPOISOMERASE INHIBITOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERLOTINIB; FLUOROURACIL; FOLINIC ACID; GEMCITABINE; GIMERACIL PLUS OTERACIL POTASSIUM PLUS TEGAFUR; IRINOTECAN; OXALIPLATIN; PEMETREXED; PHARMACOLOGICAL BIOMARKER; PLACEBO; PLATINUM DERIVATIVE; SORAFENIB; VELIPARIB;

EID: 84863257020     PISSN: 10079327     EISSN: None     Source Type: Journal    
DOI: 10.3748/wjg.v18.i8.736     Document Type: Article
Times cited : (66)

References (98)
  • 2
    • 84863267012 scopus 로고    scopus 로고
    • Cancer Statistics: 1999-2007
    • Surveillance Epidemiology and End Results. U.S, Report. Available from, Accessed January 31, 2011)
    • Surveillance Epidemiology and End Results. U.S. Cancer Statistics: 1999-2007 Incidence and Mortality Report. Available from:URL: http: //www.seer.cancer.gov/publications/uscs.html (Accessed January 31, 2011)
    • Incidence and Mortality
  • 7
    • 0026101039 scopus 로고
    • Saturation of 2',2'-difluorodeoxycytidine 5'-triphosphate accumulation by mononuclear cells during a phase I trial of gemcitabine
    • Grunewald R, Abbruzzese JL, Tarassoff P, Plunkett W. Saturation of 2',2'-difluorodeoxycytidine 5'-triphosphate accumulation by mononuclear cells during a phase I trial of gemcitabine. Cancer Chemother Pharmacol 1991; 27: 258-262
    • (1991) Cancer Chemother Pharmacol , vol.27 , pp. 258-262
    • Grunewald, R.1    Abbruzzese, J.L.2    Tarassoff, P.3    Plunkett, W.4
  • 9
    • 77649157278 scopus 로고    scopus 로고
    • Fixed-dose-rate gemcitabine: A viable first-line treatment option for advanced pancreatic and biliary tract cancer
    • Milella M, Gelibter AJ, Pino MS, Bossone G, Marolla P, Sperduti I, Cognetti F. Fixed-dose-rate gemcitabine: a viable first-line treatment option for advanced pancreatic and biliary tract cancer. Oncologist 2010; 15: e1-e4
    • (2010) Oncologist , vol.15
    • Milella, M.1    Gelibter, A.J.2    Pino, M.S.3    Bossone, G.4    Marolla, P.5    Sperduti, I.6    Cognetti, F.7
  • 10
    • 0142121290 scopus 로고    scopus 로고
    • Randomized phase II comparison of dose-intense gemcitabine: Thirty-minute infusion and fixed dose rate infusion in patients with pancreatic adenocarcinoma
    • Tempero M, Plunkett W, Ruiz Van Haperen V, Hainsworth J, Hochster H, Lenzi R, Abbruzzese J. Randomized phase II comparison of dose-intense gemcitabine: thirty-minute infusion and fixed dose rate infusion in patients with pancreatic adenocarcinoma. J Clin Oncol 2003; 21: 3402-3408
    • (2003) J Clin Oncol , vol.21 , pp. 3402-3408
    • Tempero, M.1    Plunkett, W.2    Ruiz van Haperen, V.3    Hainsworth, J.4    Hochster, H.5    Lenzi, R.6    Abbruzzese, J.7
  • 11
    • 68949114505 scopus 로고    scopus 로고
    • Phase III, randomized study of gemcitabine and oxaliplatin versus gemcitabine (fixed-dose rate infusion) compared with gemcitabine (30-minute infusion) in patients with pancreatic carcinoma E6201: A trial of the Eastern Cooperative Oncology Group
    • Poplin E, Feng Y, Berlin J, Rothenberg ML, Hochster H, Mitchell E, Alberts S, O'Dwyer P, Haller D, Catalano P, Cella D, Benson AB. Phase III, randomized study of gemcitabine and oxaliplatin versus gemcitabine (fixed-dose rate infusion) compared with gemcitabine (30-minute infusion) in patients with pancreatic carcinoma E6201: a trial of the Eastern Cooperative Oncology Group. J Clin Oncol 2009; 27: 3778-3785
    • (2009) J Clin Oncol , vol.27 , pp. 3778-3785
    • Poplin, E.1    Feng, Y.2    Berlin, J.3    Rothenberg, M.L.4    Hochster, H.5    Mitchell, E.6    Alberts, S.7    O'Dwyer, P.8    Haller, D.9    Catalano, P.10    Cella, D.11    Benson, A.B.12
  • 16
    • 65349163336 scopus 로고    scopus 로고
    • Human equilibrative nucleoside transporter 1 and human concentrative nucleoside transporter 3 predict survival after adjuvant gemcitabine therapy in resected pancreatic adenocarcinoma
    • Maréchal R, Mackey JR, Lai R, Demetter P, Peeters M, Polus M, Cass CE, Young J, Salmon I, Devière J, Van Laethem JL. Human equilibrative nucleoside transporter 1 and human concentrative nucleoside transporter 3 predict survival after adjuvant gemcitabine therapy in resected pancreatic adenocarcinoma. Clin Cancer Res 2009; 15: 2913-2919
    • (2009) Clin Cancer Res , vol.15 , pp. 2913-2919
    • Maréchal, R.1    Mackey, J.R.2    Lai, R.3    Demetter, P.4    Peeters, M.5    Polus, M.6    Cass, C.E.7    Young, J.8    Salmon, I.9    Devière, J.10    van Laethem, J.L.11
  • 18
    • 79959548041 scopus 로고    scopus 로고
    • The ribonucleotide reductase large subunit (RRM1) as a predictive factor in patients with cancer
    • Jordheim LP, Sève P, Trédan O, Dumontet C. The ribonucleotide reductase large subunit (RRM1) as a predictive factor in patients with cancer. Lancet Oncol 2011; 12: 693-702
    • (2011) Lancet Oncol , vol.12 , pp. 693-702
    • Jordheim, L.P.1    Sève, P.2    Trédan, O.3    Dumontet, C.4
  • 20
    • 33745712217 scopus 로고    scopus 로고
    • Gemcitabine resistance due to deoxycytidine kinase deficiency can be reverted by fruitfly deoxynucleoside kinase, DmdNK, in human uterine sarcoma cells
    • Jordheim LP, Galmarini CM, Dumontet C. Gemcitabine resistance due to deoxycytidine kinase deficiency can be reverted by fruitfly deoxynucleoside kinase, DmdNK, in human uterine sarcoma cells. Cancer Chemother Pharmacol 2006; 58: 547-554
    • (2006) Cancer Chemother Pharmacol , vol.58 , pp. 547-554
    • Jordheim, L.P.1    Galmarini, C.M.2    Dumontet, C.3
  • 24
    • 75449107159 scopus 로고    scopus 로고
    • Tranilast strongly sensitizes pancreatic cancer cells to gemcitabine via decreasing protein expression of ribonucleotide reductase 1
    • Mitsuno M, Kitajima Y, Ohtaka K, Kai K, Hashiguchi K, Nakamura J, Hiraki M, Noshiro H, Miyazaki K. Tranilast strongly sensitizes pancreatic cancer cells to gemcitabine via decreasing protein expression of ribonucleotide reductase 1. Int J Oncol 2010; 36: 341-349
    • (2010) Int J Oncol , vol.36 , pp. 341-349
    • Mitsuno, M.1    Kitajima, Y.2    Ohtaka, K.3    Kai, K.4    Hashiguchi, K.5    Nakamura, J.6    Hiraki, M.7    Noshiro, H.8    Miyazaki, K.9
  • 30
    • 78449305536 scopus 로고    scopus 로고
    • Gemcitabine metabolic and transporter gene polymorphisms are associated with drug toxicity and efficacy in patients with locally advanced pancreatic cancer
    • Tanaka M, Javle M, Dong X, Eng C, Abbruzzese JL, Li D. Gemcitabine metabolic and transporter gene polymorphisms are associated with drug toxicity and efficacy in patients with locally advanced pancreatic cancer. Cancer 2010; 116: 5325-5335
    • (2010) Cancer , vol.116 , pp. 5325-5335
    • Tanaka, M.1    Javle, M.2    Dong, X.3    Eng, C.4    Abbruzzese, J.L.5    Li, D.6
  • 31
    • 0029835349 scopus 로고    scopus 로고
    • Development of a novel form of an oral 5-fluorouracil derivative (S-1) directed to the potentiation of the tumor selective cytotoxicity of 5-fluorouracil by two biochemical modulators
    • Shirasaka T, Shimamato Y, Ohshimo H, Yamaguchi M, Kato T, Yonekura K, Fukushima M. Development of a novel form of an oral 5-fluorouracil derivative (S-1) directed to the potentiation of the tumor selective cytotoxicity of 5-fluorouracil by two biochemical modulators. Anticancer Drugs 1996; 7: 548-557
    • (1996) Anticancer Drugs , vol.7 , pp. 548-557
    • Shirasaka, T.1    Shimamato, Y.2    Ohshimo, H.3    Yamaguchi, M.4    Kato, T.5    Yonekura, K.6    Fukushima, M.7
  • 32
    • 0032819756 scopus 로고    scopus 로고
    • An early phase II study of oral S-1, a newly developed 5-fluorouracil derivative for advanced and recurrent gastrointestinal cancers. The S-1 Gastrointestinal Cancer Study Group
    • Sugimachi K, Maehara Y, Horikoshi N, Shimada Y, Sakata Y, Mitachi Y, Taguchi T. An early phase II study of oral S-1, a newly developed 5-fluorouracil derivative for advanced and recurrent gastrointestinal cancers. The S-1 Gastrointestinal Cancer Study Group. Oncology 1999; 57: 202-210
    • (1999) Oncology , vol.57 , pp. 202-210
    • Sugimachi, K.1    Maehara, Y.2    Horikoshi, N.3    Shimada, Y.4    Sakata, Y.5    Mitachi, Y.6    Taguchi, T.7
  • 36
    • 0036682041 scopus 로고    scopus 로고
    • Phase III Study of gemcitabine in combination with fluorouracil versus gemcitabine alone in patients with advanced pancreatic carcinoma: Eastern Cooperative Oncology Group Trial E2297
    • Berlin JD, Catalano P, Thomas JP, Kugler JW, Haller DG, Benson AB. Phase III study of gemcitabine in combination with fluorouracil versus gemcitabine alone in patients with advanced pancreatic carcinoma: Eastern Cooperative Oncology Group Trial E2297. J Clin Oncol 2002; 20: 3270-3275
    • (2002) J Clin Oncol , vol.20 , pp. 3270-3275
    • Berlin, J.D.1    Catalano, P.2    Thomas, J.P.3    Kugler, J.W.4    Haller, D.G.5    Benson, A.B.6
  • 37
    • 28344452125 scopus 로고    scopus 로고
    • A randomized, prospective, multicenter, phase III trial of gemcitabine, 5-fluorouracil (5-FU), folinic acid vs gemcitabine alone in patients with advanced pancreatic cancer
    • abstract LBA 4009
    • Riess H, Helm A, Niedergethmann M, Schmidt-Wolf I, Moik M, Hammer C, Zippel K, Weigang-Köhler K, Stauch M, Oettle H. A randomized, prospective, multicenter, phase III trial of gemcitabine, 5-fluorouracil (5-FU), folinic acid vs gemcitabine alone in patients with advanced pancreatic cancer. J Clin Oncol 2005; 23: abstract LBA 4009
    • (2005) J Clin Oncol , vol.23
    • Riess, H.1    Helm, A.2    Niedergethmann, M.3    Schmidt-Wolf, I.4    Moik, M.5    Hammer, C.6    Zippel, K.7    Weigang-Köhler, K.8    Stauch, M.9    Oettle, H.10
  • 38
    • 0032127244 scopus 로고    scopus 로고
    • Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue
    • Miwa M, Ura M, Nishida M, Sawada N, Ishikawa T, Mori K, Shimma N, Umeda I, Ishitsuka H. Design of a novel oral fluoropyrimidine carbamate, capecitabine, which generates 5-fluorouracil selectively in tumours by enzymes concentrated in human liver and cancer tissue. Eur J Cancer 1998; 34: 1274-1281
    • (1998) Eur J Cancer , vol.34 , pp. 1274-1281
    • Miwa, M.1    Ura, M.2    Nishida, M.3    Sawada, N.4    Ishikawa, T.5    Mori, K.6    Shimma, N.7    Umeda, I.8    Ishitsuka, H.9
  • 39
    • 0037208590 scopus 로고    scopus 로고
    • Combining capecitabine and gemcitabine in patients with advanced pancreatic carcinoma: A phase I/II trial
    • Hess V, Salzberg M, Borner M, Morant R, Roth AD, Ludwig C, Herrmann R. Combining capecitabine and gemcitabine in patients with advanced pancreatic carcinoma: a phase I/II trial. J Clin Oncol 2003; 21: 66-68
    • (2003) J Clin Oncol , vol.21 , pp. 66-68
    • Hess, V.1    Salzberg, M.2    Borner, M.3    Morant, R.4    Roth, A.D.5    Ludwig, C.6    Herrmann, R.7
  • 46
    • 34548351767 scopus 로고    scopus 로고
    • Phase II study of combination chemotherapy with gemcitabine and cisplatin for patients with metastatic pancreatic cancer
    • Ueno H, Okusaka T, Ikeda M, Morizane C, Ogura T, Hagihara A, Tanaka T. Phase II study of combination chemotherapy with gemcitabine and cisplatin for patients with metastatic pancreatic cancer. Jpn J Clin Oncol 2007; 37: 515-520
    • (2007) Jpn J Clin Oncol , vol.37 , pp. 515-520
    • Ueno, H.1    Okusaka, T.2    Ikeda, M.3    Morizane, C.4    Ogura, T.5    Hagihara, A.6    Tanaka, T.7
  • 47
    • 0032990022 scopus 로고    scopus 로고
    • Supraadditive effect of 2',2'-difluorodeoxycytidine (gemcitabine) in combination with oxaliplatin in human cancer cell lines
    • Faivre S, Raymond E, Woynarowski JM, Cvitkovic E. Supraadditive effect of 2',2'-difluorodeoxycytidine (gemcitabine) in combination with oxaliplatin in human cancer cell lines. Cancer Chemother Pharmacol 1999; 44: 117-123
    • (1999) Cancer Chemother Pharmacol , vol.44 , pp. 117-123
    • Faivre, S.1    Raymond, E.2    Woynarowski, J.M.3    Cvitkovic, E.4
  • 48
    • 0037083621 scopus 로고    scopus 로고
    • Gemcitabine alone or with cisplatin for the treatment of patients with locally advanced and/or metastatic pancreatic carcinoma: A prospective, randomized phase III study of the Gruppo Oncologia dell'Italia Meridionale
    • Colucci G, Giuliani F, Gebbia V, Biglietto M, Rabitti P, Uomo G, Cigolari S, Testa A, Maiello E, Lopez M. Gemcitabine alone or with cisplatin for the treatment of patients with locally advanced and/or metastatic pancreatic carcinoma: a prospective, randomized phase III study of the Gruppo Oncologia dell'Italia Meridionale. Cancer 2002; 94: 902-910
    • (2002) Cancer , vol.94 , pp. 902-910
    • Colucci, G.1    Giuliani, F.2    Gebbia, V.3    Biglietto, M.4    Rabitti, P.5    Uomo, G.6    Cigolari, S.7    Testa, A.8    Maiello, E.9    Lopez, M.10
  • 54
    • 0033981350 scopus 로고    scopus 로고
    • Phase II Study of the multitargeted antifolate LY231514 (ALIMTA, MTA, pemetrexed disodium) in patients with advanced pancreatic cancer
    • Miller KD, Picus J, Blanke C, John W, Clark J, Shulman LN, Thornton D, Rowinsky E, Loehrer PJ. Phase II study of the multitargeted antifolate LY231514 (ALIMTA, MTA, pemetrexed disodium) in patients with advanced pancreatic cancer. Ann Oncol 2000; 11: 101-103
    • (2000) Ann Oncol , vol.11 , pp. 101-103
    • Miller, K.D.1    Picus, J.2    Blanke, C.3    John, W.4    Clark, J.5    Shulman, L.N.6    Thornton, D.7    Rowinsky, E.8    Loehrer, P.J.9
  • 57
    • 0037224197 scopus 로고    scopus 로고
    • Efficacy of camptothecin analog DX-8951f (Exatecan Mesylate) on human pancreatic cancer in an orthotopic metastatic model
    • Sun FX, Tohgo A, Bouvet M, Yagi S, Nassirpour R, Moossa AR, Hoffman RM. Efficacy of camptothecin analog DX-8951f (Exatecan Mesylate) on human pancreatic cancer in an orthotopic metastatic model. Cancer Res 2003; 63: 80-85
    • (2003) Cancer Res , vol.63 , pp. 80-85
    • Sun, F.X.1    Tohgo, A.2    Bouvet, M.3    Yagi, S.4    Nassirpour, R.5    Moossa, A.R.6    Hoffman, R.M.7
  • 60
    • 18744367197 scopus 로고    scopus 로고
    • Phase III results of exatecan (DX-8951f) versus gemcitabine (Gem) in chemotherapy-naive patients with advanced pancreatic cancer (APC)
    • abstract LBA 4005
    • Cheverton P, Friess H, Andras C, T. Salek, C. Geddes, G. Bodoky, J. Valle, Y. Humblet. Phase III results of exatecan (DX-8951f) versus gemcitabine (Gem) in chemotherapy-naive patients with advanced pancreatic cancer (APC). J Clin Oncol 2004; 22: abstract LBA 4005
    • (2004) J Clin Oncol , vol.22
    • Cheverton, P.1    Friess, H.2    Andras, C.3    Salek, T.4    Geddes, C.5    Bodoky, G.6    Valle, J.7    Humblet, Y.8
  • 63
    • 35048857384 scopus 로고    scopus 로고
    • Meta-analysis of randomised trials comparing gemcitabine-based doublets versus gemcitabine alone in patients with advanced and metastatic pancreatic cancer
    • Banu E, Banu A, Fodor A, Landi B, Rougier P, Chatellier G, Andrieu JM, Oudard S. Meta-analysis of randomised trials comparing gemcitabine-based doublets versus gemcitabine alone in patients with advanced and metastatic pancreatic cancer. Drugs Aging 2007; 24: 865-879
    • (2007) Drugs Aging , vol.24 , pp. 865-879
    • Banu, E.1    Banu, A.2    Fodor, A.3    Landi, B.4    Rougier, P.5    Chatellier, G.6    Andrieu, J.M.7    Oudard, S.8
  • 64
    • 42349093032 scopus 로고    scopus 로고
    • Meta-analysis of randomized trials: Evaluation of benefit from gemcitabine-based combination chemotherapy applied in advanced pancreatic cancer
    • Heinemann V, Boeck S, Hinke A, Labianca R, Louvet C. Meta-analysis of randomized trials: evaluation of benefit from gemcitabine-based combination chemotherapy applied in advanced pancreatic cancer. BMC Cancer 2008; 8: 82
    • (2008) BMC Cancer , vol.8 , pp. 82
    • Heinemann, V.1    Boeck, S.2    Hinke, A.3    Labianca, R.4    Louvet, C.5
  • 66
    • 43549094700 scopus 로고    scopus 로고
    • New therapeutic directions for advanced pancreatic cancer: Targeting the epidermal growth factor and vascular endothelial growth factor pathways
    • Burris H, Rocha-Lima C. New therapeutic directions for advanced pancreatic cancer: targeting the epidermal growth factor and vascular endothelial growth factor pathways. Oncologist 2008; 13: 289-298
    • (2008) Oncologist , vol.13 , pp. 289-298
    • Burris, H.1    Rocha-Lima, C.2
  • 67
    • 51749121596 scopus 로고    scopus 로고
    • Targeted therapies for pancreatic cancer
    • Danovi SA, Wong HH, Lemoine NR. Targeted therapies for pancreatic cancer. Br Med Bull 2008; 87: 97-130
    • (2008) Br Med Bull , vol.87 , pp. 97-130
    • Danovi, S.A.1    Wong, H.H.2    Lemoine, N.R.3
  • 68
  • 69
    • 56249104160 scopus 로고    scopus 로고
    • Challenges in developing targeted therapy for pancreatic adenocarcinoma
    • Mahalingam D, Giles F. Challenges in developing targeted therapy for pancreatic adenocarcinoma. Expert Opin Ther Targets 2008; 12: 1389-1401
    • (2008) Expert Opin Ther Targets , vol.12 , pp. 1389-1401
    • Mahalingam, D.1    Giles, F.2
  • 70
    • 0027293748 scopus 로고
    • Coexpression of epidermal growth factor receptor and ligands in human pancreatic cancer is associated with enhanced tumor aggressiveness
    • Yamanaka Y, Friess H, Kobrin MS, Buchler M, Beger HG, Korc M. Coexpression of epidermal growth factor receptor and ligands in human pancreatic cancer is associated with enhanced tumor aggressiveness. Anticancer Res 1993; 13: 565-569
    • (1993) Anticancer Res , vol.13 , pp. 565-569
    • Yamanaka, Y.1    Friess, H.2    Kobrin, M.S.3    Buchler, M.4    Beger, H.G.5    Korc, M.6
  • 71
    • 0037010091 scopus 로고    scopus 로고
    • Epidermal growth factor receptor-targeted therapy for pancreatic cancer
    • Xiong HQ, Abbruzzese JL. Epidermal growth factor receptor-targeted therapy for pancreatic cancer. Semin Oncol 2002; 29: 31-37
    • (2002) Semin Oncol , vol.29 , pp. 31-37
    • Xiong, H.Q.1    Abbruzzese, J.L.2
  • 73
    • 0036690404 scopus 로고    scopus 로고
    • Effects of the epidermal growth factor receptor inhibitor OSI-774, Tarceva, on downstream signaling pathways and apoptosis in human pancreatic adenocarcinoma
    • Ng SS, Tsao MS, Nicklee T, Hedley DW. Effects of the epidermal growth factor receptor inhibitor OSI-774, Tarceva, on downstream signaling pathways and apoptosis in human pancreatic adenocarcinoma. Mol Cancer Ther 2002; 1: 777-783
    • (2002) Mol Cancer Ther , vol.1 , pp. 777-783
    • Ng, S.S.1    Tsao, M.S.2    Nicklee, T.3    Hedley, D.W.4
  • 75
    • 0034235955 scopus 로고    scopus 로고
    • Epidermal growth factor receptor blockade by antibody IMC-C225 inhibits growth of a human pancreatic carcinoma xenograft in nude mice
    • Overholser JP, Prewett MC, Hooper AT, Waksal HW, Hicklin DJ. Epidermal growth factor receptor blockade by antibody IMC-C225 inhibits growth of a human pancreatic carcinoma xenograft in nude mice. Cancer 2000; 89: 74-82
    • (2000) Cancer , vol.89 , pp. 74-82
    • Overholser, J.P.1    Prewett, M.C.2    Hooper, A.T.3    Waksal, H.W.4    Hicklin, D.J.5
  • 77
    • 38049041406 scopus 로고    scopus 로고
    • Erlotinib/gemcitabine for first-line treatment of locally advanced or metastatic adenocarcinoma of the pancreas
    • discussion 1706-1709, 1712, 1715
    • Senderowicz AM, Johnson JR, Sridhara R, Zimmerman P, Justice R, Pazdur R. Erlotinib/gemcitabine for first-line treatment of locally advanced or metastatic adenocarcinoma of the pancreas. Oncology (Williston Park) 2007; 21: 1696-1706; discussion 1706-1709, 1712, 1715
    • (2007) Oncology (Williston Park) , vol.21 , pp. 1696-1706
    • Senderowicz, A.M.1    Johnson, J.R.2    Sridhara, R.3    Zimmerman, P.4    Justice, R.5    Pazdur, R.6
  • 78
    • 4344590997 scopus 로고    scopus 로고
    • Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: A multicenter phase II Trial
    • Xiong HQ, Rosenberg A, LoBuglio A, Schmidt W, Wolff RA, Deutsch J, Needle M, Abbruzzese JL. Cetuximab, a monoclonal antibody targeting the epidermal growth factor receptor, in combination with gemcitabine for advanced pancreatic cancer: a multicenter phase II Trial. J Clin Oncol 2004; 22: 2610-2616
    • (2004) J Clin Oncol , vol.22 , pp. 2610-2616
    • Xiong, H.Q.1    Rosenberg, A.2    Lobuglio, A.3    Schmidt, W.4    Wolff, R.A.5    Deutsch, J.6    Needle, M.7    Abbruzzese, J.L.8
  • 80
    • 45449087897 scopus 로고    scopus 로고
    • Targeting angiogenesis in pancreatic cancer
    • Philip PA. Targeting angiogenesis in pancreatic cancer. Lancet 2008; 371: 2062-2064
    • (2008) Lancet , vol.371 , pp. 2062-2064
    • Philip, P.A.1
  • 81
    • 0034769734 scopus 로고    scopus 로고
    • Pancreas microenvironment promotes VEGF expression and tumor growth: Novel window models for pancreatic tumor angiogenesis and microcirculation
    • Tsuzuki Y, Mouta Carreira C, Bockhorn M, Xu L, Jain RK, Fukumura D. Pancreas microenvironment promotes VEGF expression and tumor growth: novel window models for pancreatic tumor angiogenesis and microcirculation. Lab Invest 2001; 81: 1439-1451
    • (2001) Lab Invest , vol.81 , pp. 1439-1451
    • Tsuzuki, Y.1    Mouta Carreira, C.2    Bockhorn, M.3    Xu, L.4    Jain, R.K.5    Fukumura, D.6
  • 85
    • 33846212284 scopus 로고    scopus 로고
    • Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinomamodel PLC/PRF/5
    • Liu L, Cao Y, Chen C, Zhang X, McNabola A, Wilkie D, Wilhelm S, Lynch M, Carter C. Sorafenib blocks the RAF/MEK/ERK pathway, inhibits tumor angiogenesis, and induces tumor cell apoptosis in hepatocellular carcinomamodel PLC/PRF/5. Cancer Res 2006; 66: 11851-11858
    • (2006) Cancer Res , vol.66 , pp. 11851-11858
    • Liu, L.1    Cao, Y.2    Chen, C.3    Zhang, X.4    McNabola, A.5    Wilkie, D.6    Wilhelm, S.7    Lynch, M.8    Carter, C.9
  • 93
    • 79960202283 scopus 로고    scopus 로고
    • The safety of IPI-926, a novel hedgehog pathway inhibitor, in combination with gemcitabine in patients (pts) with metastatic pancreatic cancer
    • abstr 4114
    • Stephenson J, Richards DA, Wolpin BM.The safety of IPI-926, a novel hedgehog pathway inhibitor, in combination with gemcitabine in patients (pts) with metastatic pancreatic cancer. J Clin Oncol 2011; 29: abstr 4114
    • (2011) J Clin Oncol , vol.29
    • Stephenson, J.1    Richards, D.A.2    Wolpin, B.M.3
  • 94
    • 20044374358 scopus 로고    scopus 로고
    • Irinotecan plus oxaliplatin and leucovorin-modulated fluorouracil in advanced pancreatic cancer--a Groupe Tumeurs Digestives of the Federation Nationale des Centres de Lutte Contre le Cancer study
    • Conroy T, Paillot B, François E, Bugat R, Jacob JH, Stein U, Nasca S, Metges JP, Rixe O, Michel P, Magherini E, Hua A, Deplanque G. Irinotecan plus oxaliplatin and leucovorin-modulated fluorouracil in advanced pancreatic cancer--a Groupe Tumeurs Digestives of the Federation Nationale des Centres de Lutte Contre le Cancer study. J Clin Oncol 2005; 23: 1228-1236
    • (2005) J Clin Oncol , vol.23 , pp. 1228-1236
    • Conroy, T.1    Paillot, B.2    François, E.3    Bugat, R.4    Jacob, J.H.5    Stein, U.6    Nasca, S.7    Metges, J.P.8    Rixe, O.9    Michel, P.10    Magherini, E.11    Hua, A.12    Deplanque, G.13
  • 96
    • 79958776238 scopus 로고    scopus 로고
    • Metastatic pancreatic cancer: Old drugs, new paradigms
    • Conroy T, Gavoille C, Adenis A. Metastatic pancreatic cancer: old drugs, new paradigms. Curr Opin Oncol 2011; 23: 390-395
    • (2011) Curr Opin Oncol , vol.23 , pp. 390-395
    • Conroy, T.1    Gavoille, C.2    Adenis, A.3
  • 97
    • 79961024581 scopus 로고    scopus 로고
    • Metastatic pancreatic cancer--is FOLFIRINOX the new standard?
    • Saif MW, Chabot J. Chemotherapy: Metastatic pancreatic cancer--is FOLFIRINOX the new standard? Nat Rev Clin Oncol 2011; 8: 452-453
    • (2011) Nat Rev Clin Oncol , vol.8 , pp. 452-453
    • Saif, M.W.1    Chemotherapy Chabot, J.2
  • 98
    • 78650684875 scopus 로고    scopus 로고
    • FOLFIRINOX: A new standard treatment for advanced pancreatic cancer?
    • Kim R. FOLFIRINOX: a new standard treatment for advanced pancreatic cancer? Lancet Oncol 2011; 12: 8-9
    • (2011) Lancet Oncol , vol.12 , pp. 8-9
    • Kim, R.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.