Male subfertility induced by heterozygous expression of catalytically inactive glutathione peroxidase 4 is rescued in vivo by systemic inactivation of the Alox15 gene

Journal of Biological Chemistry

Volumn 291, Issue 45, 2016, Pages 23578-23588

  Brütsch, Simone Hanna ^a   Rademacher, Marlena ^a   Roth, Sophia Regina ^a   Müller, Karin ^b   Eder, Susanne ^b   Viertel, Dagmar ^b   Franz, Christiane ^b   Kuhn, Hartmut ^a   Borchert, Astrid ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b LEIBNIZ INSTITUTE FOR ZOO AND WILDLIFE RESEARCH   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; ANIMALS; BIOLOGICAL ORGANS; ENZYMES; GENES; MAMMALS; MITOCHONDRIA; PEPTIDES; PLANTS (BOTANY);

ANTI-OXIDATIVE ENZYMES; ARACHIDONIC ACIDS; GLUTATHIONE PEROXIDASE; MALE INFERTILITY; REPRODUCTIVE SYSTEMS; STRUCTURAL ALTERATIONS; STRUCTURAL PROTEINS; WILD-TYPE LEVELS;

GENE EXPRESSION;

ALANINE; ARACHIDONATE 15 LIPOXYGENASE; PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE; SELENOCYSTEINE; ALOX15 PROTEIN, MOUSE; ARACHIDONATE 12 LIPOXYGENASE; GLUTATHIONE PEROXIDASE; GLUTATHIONE PEROXIDASE 4, MOUSE; OXYGEN;

ALOX15 GENE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL VACUOLE; CONTROLLED STUDY; EMBRYO; EPIDIDYMIS; FEMALE; GENE INACTIVATION; HETEROZYGOUS EXPRESSION; IN VIVO STUDY; MALE; MALE FERTILITY; MALE INFERTILITY; MALE SUBFERTILITY; MITOCHONDRION; MOUSE; NEWBORN; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPERM; SPERMATOZOON MOTILITY; SUBFERTILITY; ANIMAL; CYTOLOGY; DOWN REGULATION; GENE TARGETING; GENETICS; KNOCKOUT MOUSE; METABOLISM; MUTATION; OXIDATIVE STRESS; PATHOLOGY; SPERMATOZOON;

ANIMALS; ARACHIDONATE 12-LIPOXYGENASE; ARACHIDONATE 15-LIPOXYGENASE; DOWN-REGULATION; FEMALE; GENE KNOCK-IN TECHNIQUES; GLUTATHIONE PEROXIDASE; INFERTILITY, MALE; MALE; MICE; MICE, KNOCKOUT; MITOCHONDRIA; MUTATION; OXIDATIVE STRESS; OXYGEN; SPERM MOTILITY; SPERMATOZOA;

EID: 84994212708     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.738930     Document Type: Article

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