Glutathione peroxidase 4 prevents necroptosis in mouse erythroid precursors

Blood

Volumn 127, Issue 1, 2016, Pages 139-148

  Canli, Özge ^a   Alankus, Yasemin B ^b   Grootjans, Sasker ^c   Vegi, Naidu ^d   Hültner, Lothar ^e   Hoppe, Philipp S ^f   Schroeder, Timm ^f   Vandenabeele, Peter ^c   Bornkamm, Georg W ^e   Greten, Florian R ^a  

^a INSTITUTE FOR TUMOR BIOLOGY AND EXPERIMENTAL THERAPY   (Germany)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^c GHENT UNIVERSITY   (Belgium)

^d UNIVERSITY HOSPITAL ULM   (Germany)

^e INSTITUTE OF EPIDEMIOLOGY   (Germany)

^f ETH ZURICH   (Switzerland)

Author keywords

Gpx4 is essential for preventing anemia in mice via inhibiting RIP3 dependent necroptosis in erythroid precursor cells; Ros accumulation and lipid peroxidation in erythroid precursor cells trigger receptor independent activation of necroptosis

Indexed keywords

ALCOHOL; ALPHA TOCOPHEROL; CASPASE 8; CD71 ANTIGEN; DOUBLE STRANDED DNA ANTIBODY; ERYTHROPOIETIN; FAS ANTIGEN; HEMOGLOBIN; INTERLEUKIN 6; LIPID HYDROPEROXIDE; PHOSPHOLIPID HYDROPEROXIDE GLUTATHIONE PEROXIDASE; POLY(ADENOSINE DIPHOSPHATE RIBOSE); PROTEIN; REACTIVE OXYGEN METABOLITE; RECEPTOR INTERACTING PROTEIN 3; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; GLUTATHIONE PEROXIDASE; PHOSPHOLIPID-HYDROPEROXIDE GLUTATHIONE PEROXIDASE; RECEPTOR INTERACTING PROTEIN SERINE THREONINE KINASE; RIPK3 PROTEIN, MOUSE;

ADOPTIVE TRANSFER; ALPHA TOCOPHEROL DEFICIENCY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY BLOOD LEVEL; ARTICLE; BONE MARROW CELL; CELL COUNT; CELL DEATH; CELL DIFFERENTIATION; CELL MATURATION; CELL PROLIFERATION; CELL SURVIVAL; COLONY FORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; ERYTHROBLAST; ERYTHROCYTE COUNT; ERYTHROID PRECURSOR CELL; EXPERIMENTAL ANEMIA; EXTRAMEDULLARY HEMATOPOIESIS; GENE DELETION; HALF LIFE TIME; HEMATOCRIT; HEMOGLOBIN BLOOD LEVEL; HORMONE BLOOD LEVEL; IN VITRO STUDY; IN VIVO STUDY; LIPID PEROXIDATION; MOUSE; NECROPTOSIS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DEPLETION; PROTEIN PHOSPHORYLATION; RETICULOCYTE; RETICULOCYTE COUNT; SIGNAL TRANSDUCTION; SPLEEN SIZE; ANIMAL; APOPTOSIS; CELL CULTURE; ENZYME IMMUNOASSAY; ERYTHROID CELL; FLOW CYTOMETRY; HUMAN; KNOCKOUT MOUSE; METABOLISM; NECROSIS; PATHOLOGY; PHYSIOLOGY; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CELL DIFFERENTIATION; CELL PROLIFERATION; CELLS, CULTURED; ERYTHROID CELLS; FLOW CYTOMETRY; GLUTATHIONE PEROXIDASE; HUMANS; IMMUNOENZYME TECHNIQUES; MICE; MICE, KNOCKOUT; NECROSIS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; RECEPTOR-INTERACTING PROTEIN SERINE-THREONINE KINASES;

EID: 84955476379     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2015-06-654194     Document Type: Article

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