Activities of JNJ63623872 and oseltamivir against influenza A H1N1pdm and H3N2 virus infections in mice

Antiviral Research

Volumn 136, Issue , 2016, Pages 45-50

  Smee, Donald F ^a   Barnard, Dale L ^a   Jones, Steven M ^b,c  

^a UTAH STATE UNIVERSITY   (United States)

^b VERTEX PHARMACEUTICALS   (United States)

^c Revolution Medicines Inc   (United States)

Author keywords

Antiviral; Influenza; JNJ63623872; Mice; Oseltamivir; PB2 inhibitor

Indexed keywords

4 ACETAMIDO 5 AMINO 3 (1 ETHYLPROPOXY) 1 CYCLOHEXENE 1 CARBOXYLIC ACID; ANTIVIRUS AGENT; JNJ 63623872; PLACEBO; UNCLASSIFIED DRUG; INDOLE DERIVATIVE; OSELTAMIVIR; VX-787;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ARTICLE; BODY WEIGHT; COMPARATIVE ANATOMY; DISEASE SEVERITY; DRUG SYNTHESIS; FEMALE; IN VIVO STUDY; INFLUENZA A (H1N1); INFLUENZA A (H3N2); LUNG HEMORRHAGE SCORE; LUNG WEIGHT; MORTALITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; RESPIRATORY TRACT PARAMETERS; WEIGHT REDUCTION; ANIMAL; COMBINATION DRUG THERAPY; COMPARATIVE STUDY; DRUG DEVELOPMENT; DRUG EFFECTS; INFLUENZA A VIRUS (H1N1); INFLUENZA A VIRUS (H3N2); LUNG; ORTHOMYXOVIRUS INFECTION; VIROLOGY; VIRUS LOAD; VIRUS REPLICATION;

ANIMALS; ANTIVIRAL AGENTS; DRUG DISCOVERY; DRUG THERAPY, COMBINATION; INDOLES; INFLUENZA A VIRUS, H1N1 SUBTYPE; INFLUENZA A VIRUS, H3N2 SUBTYPE; LUNG; MICE; ORTHOMYXOVIRIDAE INFECTIONS; OSELTAMIVIR; VIRAL LOAD; VIRUS REPLICATION;

EID: 84994160267     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2016.10.009     Document Type: Article

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