Isosteric replacements of the carboxylic acid of drug candidate VX-787: Effect of charge on antiviral potency and kinase activity of azaindole-based influenza PB2 inhibitors

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 9, 2015, Pages 1990-1994

  Boyd, Michael J ^a   Bandarage, Upul K ^a   Bennett, Hamilton ^a   Byrn, Randal R ^a   Davies, Ioana ^a   Gu, Wenxin ^a   Jacobs, Marc ^a   Ledeboer, Mark W ^a   Ledford, Brian ^a   Leeman, Joshua R ^a   Perola, Emanuele ^a   Wang, Tiansheng ^a   Bennani, Youssef ^a   Clark, Michael P ^a   Charifson, Paul S ^a  

^a VERTEX PHARMACEUTICALS   (United States)

Author keywords

Influenza; Isostere; VX 787

Indexed keywords

ANTIVIRUS AGENT; CARBOXYLIC ACID; HETEROCYCLIC COMPOUND; INDOLE DERIVATIVE; PB2 PROTEIN, INFLUENZA VIRUS; PROTEIN KINASE INHIBITOR; VIRAL PROTEIN; VX-787;

ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; ENZYMOLOGY; INFLUENZA A VIRUS; METABOLISM; MICROBIAL SENSITIVITY TEST; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTIVIRAL AGENTS; AZA COMPOUNDS; CARBOXYLIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; INDOLES; INFLUENZA A VIRUS; MICROBIAL SENSITIVITY TESTS; MOLECULAR STRUCTURE; PROTEIN KINASE INHIBITORS; STRUCTURE-ACTIVITY RELATIONSHIP; VIRAL PROTEINS;

EID: 84937759587     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2015.03.013     Document Type: Article

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