Calcium Homeostasis Disruption - A Bridge Connecting Cadmium-Induced Apoptosis, Autophagy and Tumorigenesis

Oncology Research and Treatment

Volumn 38, Issue 6, 2015, Pages 311-315

  Zhou, Xuehai ^a   Hao, Weiming ^a   Shi, Haifeng ^a   Hou, Yongzhong ^a   Xu, Qinggang ^a  

^a JIANGSU UNIVERSITY   (China)

Author keywords

Apoptosis; Autophagy; Cadmium; Calcium homeostasis; Tumorigenesis

Indexed keywords

CADMIUM; CALCIUM; CALCIUM CHANNEL L TYPE; CALCIUM CHANNEL N TYPE; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; MEGALIN; MEMBRANE PHOSPHOLIPID; METALLOTHIONEIN; MULTIDRUG RESISTANCE PROTEIN 1; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; PHOSPHATIDYLCHOLINE; PHOSPHATIDYLINOSITOL; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; ZINC TRANSPORTER; ZINC TRANSPORTER 1; ZINC TRANSPORTER 14; ZINC TRANSPORTER 2; ZINC TRANSPORTER 8;

APOPTOSIS; AUTOPHAGY (CELLULAR); CALCIUM HOMEOSTASIS; CALCIUM SIGNALING; CANCER RISK; CARCINOGENESIS; CELL DIFFERENTIATION; CELL DIVISION; CELL GROWTH; CELL MEMBRANE; CELL TRANSFORMATION; CELL TRANSPORT; COMPLEX FORMATION; ENDOCYTOSIS; GENE OVEREXPRESSION; HUMAN; INTESTINE EPITHELIUM CELL; METASTASIS; MOLECULAR PATHOLOGY; NONHUMAN; ONCOGENE; PROTEIN PROTEIN INTERACTION; REVIEW; AUTOPHAGY; CHEMICALLY INDUCED; DRUG EFFECTS; HOMEOSTASIS; METABOLISM;

APOPTOSIS; AUTOPHAGY; CADMIUM; CALCIUM; CARCINOGENESIS; HOMEOSTASIS; HUMANS;

EID: 84994120951     PISSN: 22965270     EISSN: 22965262     Source Type: Journal    
DOI: 10.1159/000431032     Document Type: Review

References (59)

1. Satarug S, Moore MR: Emerging roles of cadmium and heme oxygenase in type-2 diabetes and cancer susceptibility. Tohoku J Exp Med 2012;228:267-288.
2. Satarug S, Garrett SH, Sens MA, Sens DA: Cadmium, environmental exposure, and health outcomes. Cien Saude Colet 2011;16:2587-2602.
3. Hartwig A: Cadmium and cancer. Met Ions Life Sci 2013;11:491-507.
4. Thevenod F, Lee WK: Toxicology of cadmium and its damage to mammalian organs. Met Ions Life Sci 2013;11:415-490.
5. Nair AR, Degheselle O, Smeets K, et al.: Cadmium-induced pathologies: Where is the oxidative balance lost (or not)? Int J Mol Sci 2013;14:6116-6143.
6. Fujishiro H, Yano Y, Takada Y, et al.: Roles of ZIP8, ZIP14, and DMT1 in transport of cadmium and manganese in mouse kidney proximal tubule cells. Metallomics 2012;4:700-708.
7. Takahashi S, Yamamoto C, Kaji T: Expression of ZIP8 in vascular endothelial cells after exposure to cadmium. Yakugaku Zasshi 2014;134:805-807.
8. Leslie EM, Liu J, Klaassen CD, Waalkes MP: Acquired cadmium resistance in metallothionein-I/II(-/-) knockout cells: Role of the T-type calcium channel Cacnalpha1G in cadmium uptake. Mol Pharmacol 2006;69:629-639.
9. Olivi L, Bressler J: Maitotoxin stimulates Cd influx in Madin-Darby kidney cells by activating Ca-permeable cation channels. Cell Calcium 2000;27:187-193.
10. Kovacs G, Danko T, Bergeron MJ, et al.: Heavy metal cations permeate the TRPV6 epithelial cation channel. Cell Calcium 2011;49:43-55.
11. Miura S, Takahashi K, Imagawa T, et al.: Involvement of TRPA1 activation in acute pain induced by cadmium in mice. Mol Pain 2013;9:7.
12. 2+)-ATPase activity of human erythrocyte ghosts. Biochim Biophys Acta 1985;845:48-53.
13. Biagioli M, Pifferi S, Ragghianti M, et al.: Endoplasmic reticulum stress and alteration in calcium homeostasis are involved in cadmium-induced apoptosis. Cell Calcium 2008;43:184-195.
14. Ohrvik H, Ulleras E, Oskarsson A, Tallkvist J: Effects of cadmium on calcium transporter SPCA, calcium homeostasis and beta-casein expression in the murine mammary epithelium. Toxicol Lett 2011;201:80-85.
15. 2+from intracellular Ca storage. Toxicol Lett 2010;192:115-118.
16. Xu B, Chen S, Luo Y, et al.: Calcium signaling is involved in cadmium-induced neuronal apoptosis via induction of reactive oxygen species and activation of MAPK/mTOR network. PLoS One 2011;6:e19052.
17. Lawal AO, Ellis EM: Phospholipase C mediates cadmium-dependent apoptosis in HEK 293 cells. Basic Clin Pharmacol Toxicol 2012;110:510-517.
18. Fokina NN, Ruokolainen TR, Nemova NN, Bakhmet IN: Changes of blue mussels Mytilus edulis L. lipid composition under cadmium and copper toxic effect. Biol Trace Elem Res 2013;154:217-225.
19. Modi HR, Katyare SS: Cadmium exposure-induced alterations in the lipid/phospholipids composition of rat brain microsomes and mitochondria. Neurosci Lett 2009;464:108-112.
20. Greineisen WE, Speck M, Shimoda LM, et al.: Lipid body accumulation alters calcium signaling dynamics in immune cells. Cell Calcium 2014;56:169-180.
21. Chen L, Liu L, Luo Y, Huang S: MAPK and mTOR pathways are involved in cadmium-induced neuronal apoptosis. J Neurochem 2008;105:251-261.
22. Jiang C, Yuan Y, Hu F, et al.: Cadmium induces PC12 cells apoptosis via an extracellular signal-regulated kinase and c-jun N-terminal kinase-mediated mitochondrial apoptotic pathway. Biol Trace Elem Res 2014;158:249-258.
23. Chen S, Xu Y, Xu B, et al.: CaMKII is involved in cadmium activation of MAPK and mTOR pathways leading to neuronal cell death. J Neurochem 2011;119:1108-1118.
24. 2-dependent apoptosis through JNK-and p53-mediated pathways in skin epidermal cell line. Toxicol Sci 2010;113:127-137.
25. Lewis A, Hayashi T, Su TP, Betenbaugh MJ: Bcl-2 family in inter-organelle modulation of calcium signaling; Roles in bioenergetics and cell survival. J Bioenerg Biomembr 2014;46:1-15.
26. Yuan Y, Jiang C, Hu F, et al.: The role of mitogen-activated protein kinase in cadmium-induced primary rat cerebral cortical neurons apoptosis via a mitochondrial apoptotic pathway. J Trace Elem Med Biol 2015;29:275-283.
27. Wang SH, Shih YL, Ko WC, et al.: Cadmium-induced autophagy and apoptosis are mediated by a calcium signaling pathway. Cell Mol Life Sci 2008;65:3640-3652.
28. Lemarie A, Lagadic-Gossmann D, Morzadec C, et al.: Cadmium induces caspase-independent apoptosis in liver Hep3B cells: Role for calcium in signaling oxidative stress-related impairment of mitochondria and relocation of endonuclease G and apoptosis-inducing factor. Free Radic Biol Med 2004;36:1517-1531.
29. Shih CM, Wu JS, Ko WC, et al.: Mitochondria-mediated caspase-independent apoptosis induced by cadmium in normal human lung cells. J Cell Biochem 2003;89:335-347.
30. Cande C, Cohen I, Daugas E, et al.: Apoptosis-inducing factor (AIF): A novel caspase-independent death effector released from mitochondria. Biochimie 2002;84:215-222.
31. Liu W, Zhao H, Wang Y, et al.: Calcium-calmodulin signaling elicits mitochondrial dysfunction and the release of cytochrome c during cadmium-induced apoptosis in primary osteoblasts. Toxicol Lett 2014;224:1-6.
32. Xu S, Pi H, Chen Y, et al.: Cadmium induced DRP1-dependent mitochondrial fragmentation by disturbing calcium homeostasis in its hepatotoxicity. Cell Death Dis 2013;4:e540.
33. Peng L, Men X, Zhang W, et al.: Dynamin-related protein 1 is implicated in endoplasmic reticulum stress-induced pancreatic beta-cell apoptosis. Int J Mol Med 2011;28:161-169.
34. Wang Q, Zhu J, Zhang K, et al.: Induction of cytoprotective autophagy in PC-12 cells by cadmium. Biochem Biophys Res Commun 2013;438:186-192.
35. Dong Z, Wang L, Xu J, et al.: Promotion of autophagy and inhibition of apoptosis by low concentrations of cadmium in vascular endothelial cells. Toxicol In Vitro 2009;23:105-110.
36. Son YO, Wang X, Hitron JA, et al.: Cadmium induces autophagy through ROS-dependent activation of the LKB1-AMPK signaling in skin epidermal cells. Toxicol Appl Pharmacol 2011;255:287-296.
37. Wang SH, Shih YL, Kuo TC, et al.: Cadmium toxicity toward autophagy through ROS-activated GSK-3beta in mesangial cells. Toxicol Sci 2009;108:124-131.
38. Il'yasova D, Schwartz GG: Cadmium and renal cancer. Toxicol Appl Pharmacol 2005;207:179-186.
39. Goyer RA, Liu J, Waalkes MP: Cadmium and cancer of prostate and testis. Biometals 2004;17:555-558.
40. Vinceti M, Venturelli M, Sighinolfi C, et al.: Case-control study of toenail cadmium and prostate cancer risk in Italy. Sci Total Environ 2007;373:77-81.
41. Adams SV, Quraishi SM, Shafer MM, et al.: Dietary cadmium exposure and risk of breast, endometrial, and ovarian cancer in the Women's Health Initiative. Environ Health Perspect 2014;122:594-600.
42. Nagata C, Nagao Y, Nakamura K, et al.: Cadmium exposure and the risk of breast cancer in Japanese women. Breast Cancer Res Treat 2013;138:235-239.
43. Strumylaite L, Bogusevicius A, Abdrachmanovas O, et al.: Cadmium concentration in biological media of breast cancer patients. Breast Cancer Res Treat 2011;125:511-517.
44. Strumylaite L, Bogusevicius A, Ryselis S, et al.: [Association between cadmium and breast cancer]. Medicina 2008;44:415-420.
45. Feki-Tounsi M, Hamza-Chaffai A: Cadmium as a possible cause of bladder cancer: A review of accumulated evidence. Environ Sci Pollut Res Int 2014;21:10561-10573.
46. Mohajer R, Salehi MH, Mohammadi J, et al.: The status of lead and cadmium in soils of high prevalenct gastrointestinal cancer region of Isfahan. J Res Med Sci 2013;18:210-214.
47. Beveridge R, Pintos J, Parent ME, et al.: Lung cancer risk associated with occupational exposure to nickel, chromium VI, and cadmium in two population-based case-control studies in Montreal. Am J Ind Med 2010;53:476-485.
48. Demir N, Turksoy VA, Kayaalti Z, et al.: The evaluation of arsenic and cadmium levels in biological samples of cases with lung cancer. Tuberk Toraks 2014;62:191-198.
49. Stayner L, Smith R, Thun M, et al.: A dose-response analysis and quantitative assessment of lung cancer risk and occupational cadmium exposure. Ann Epidemiol 1992;2:177-194.
50. Hechtenberg S, Schafer T, Benters J, Beyersmann D: Effects of cadmium on cellular calcium and proto-oncogene expression. Ann Clin Lab Sci 1996;26:512-521.
51. Joseph P, Muchnok TK, Klishis ML, et al.: Cadmium-induced cell transformation and tumorigenesis are associated with transcriptional activation of c-fos, c-jun, and c-myc proto-oncogenes: Role of cellular calcium and reactive oxygen species. Toxicol Sci 2001;61:295-303.
52. Hou Y, Moreau F, Chadee K: PPARgamma is an E3 ligase that induces the degradation of NFkappaB/p65. Nat Commun 2012;3:1300.
53. Hou Y, Zhang Z, Xu Q, et al.: Inhibitor of growth 4 induces NFkappaB/p65 ubiquitin-dependent degradation. Oncogene 2014;33:1997-2003.
54. Hou Y, Gao J, Xu H, et al.: PPARgamma E3 ubiquitin ligase regulates MUC1-C oncoprotein stability. Oncogene 2014;33:5619-5625.
55. Dang CV: MYC on the path to cancer. Cell 2012;149:22-35.
56. Morton JP, Sansom OJ: MYC-y mice: From tumour initiation to therapeutic targeting of endogenous MYC. Mol Oncol 2013;7:248-258.
57. Zhang Z, Xu Y, Xu Q, Hou Y: PPARgamma against tumors by different signaling pathways. Onkologie 2013;36:598-601.
58. Misra UK, Gawdi G, Akabani G, Pizzo SV: Cadmium-induced DNA synthesis and cell proliferation in macrophages: The role of intracellular calcium and signal transduction mechanisms. Cell Signal 2002;14:327-340.
59. Liu Z, Han G, Cao Y, et al.: Calcium/calmodulin-dependent protein kinase II enhances metastasis of human gastric cancer by upregulating nuclear factorkappaB and AKT-mediated matrix metalloproteinase9 production. Mol Med Rep 2014;10:2459-2464.