Cadmium induces PC12 cells apoptosis via an extracellular signal-regulated kinase and c-Jun N-terminal kinase-mediated mitochondrial apoptotic pathway

Biological Trace Element Research

Volumn 158, Issue 2, 2014, Pages 249-258

  Jiang, Chenyang ^a   Yuan, Yan ^a   Hu, Feifei ^a   Wang, Qiwen ^a,b   Zhang, Kangbao ^a   Wang, Yi ^a   Gu, Jianhong ^a   Liu, Xuezhong ^a   Bian, Jianchun ^a   Liu, Zongping ^a  

^a YANGZHOU UNIVERSITY   (China)

^b GUIZHOU UNIVERSITY OF ENGINEERING SCIENCE   (China)

Author keywords

Apoptosis; Cadmium; Mitochondrial pathway; Mitogen activated protein kinase; PC12 cells

Indexed keywords

APOPTOSIS INDUCING FACTOR; CADMIUM; CASPASE 3; CYTOCHROME C; ENDONUCLEASE G; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; ARTICLE; BRAIN ATROPHY; BRAIN CELL; CELL NUCLEUS; CELL VIABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REGULATION; ENZYME RELEASE; INTRACELLULAR SIGNALING; MITOCHONDRION; NERVE CELL NECROSIS; NEUROTOXICITY; NONHUMAN; PC12 CELL LINE; PROTEIN CLEAVAGE; PROTEIN LOCALIZATION; RAT; ANIMAL; APOPTOSIS; CELL SURVIVAL; DOSE RESPONSE; DRUG EFFECTS; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

ANIMALS; APOPTOSIS; CADMIUM; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, DRUG; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MAP KINASE SIGNALING SYSTEM; MITOCHONDRIA; PC12 CELLS; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84899639654     PISSN: 01634984     EISSN: 15590720     Source Type: Journal    
DOI: 10.1007/s12011-014-9918-6     Document Type: Article

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