Heparan sulfate binding promotes accumulation of intravitreally delivered adeno-associated viral vectors at the retina for enhanced transduction but weakly influences tropism

Journal of Virology

Volumn 90, Issue 21, 2016, Pages 9878-9888

  Woodard, Kenton T ^a,b   Liang, Katharine J ^a,b   Bennett, William C ^b   Samulski, R Jude ^b  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEPARAN SULFATE; PARVOVIRUS VECTOR;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; CORRELATION ANALYSIS; EX VIVO STUDY; FLUORESCENCE IN SITU HYBRIDIZATION; GENE EXPRESSION; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; RETINAL OUTER NUCLEAR LAYER; RETINAL PIGMENT EPITHELIUM; SEROTYPE; TRANSGENE; VIRAL TROPISM; VIRUS ATTACHMENT; VIRUS CAPSID; VIRUS MUTANT; VIRUS MUTATION; ANIMAL; DEPENDOPARVOVIRUS; GENE THERAPY; GENE TRANSFER; GENE VECTOR; GENETICS; METABOLISM; PHYSIOLOGY; PROCEDURES; RETINA; TROPISM; VIROLOGY;

ANIMALS; CAPSID; DEPENDOVIRUS; GENE TRANSFER TECHNIQUES; GENETIC THERAPY; GENETIC VECTORS; HEPARITIN SULFATE; HUMANS; MICE; RETINA; TRANSDUCTION, GENETIC; TRANSGENES; TROPISM;

EID: 84994036993     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.01568-16     Document Type: Article

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