-
1
-
-
0348048874
-
Diabetic retinopathy
-
Frank RN. Diabetic retinopathy. N Engl J Med. 2004;350:48– 58.
-
(2004)
N Engl J Med
, vol.350
-
-
Frank, R.N.1
-
2
-
-
84892422524
-
Diabetic retinopathy and other ocular findings in the diabetes control and complications trial/epidemiology of diabetes interventions and complications study
-
Aiello LP. Diabetic retinopathy and other ocular findings in the diabetes control and complications trial/epidemiology of diabetes interventions and complications study. Diabetes Care. 2014;37:17–23.
-
(2014)
Diabetes Care
, vol.37
, pp. 17-23
-
-
Aiello, L.P.1
-
3
-
-
29144453326
-
Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes
-
Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Study Research Group. Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. N Engl J Med. 2005;353:2643–2653.
-
(2005)
N Engl J Med
, vol.353
, pp. 2643-2653
-
-
-
4
-
-
0023641117
-
Progression of incipient diabetic retinopathy during good glycemic control
-
Engerman RL, Kern TS. Progression of incipient diabetic retinopathy during good glycemic control. Diabetes. 1987;36: 808–812.
-
(1987)
Diabetes
, vol.36
, pp. 808-812
-
-
Engerman, R.L.1
Kern, T.S.2
-
5
-
-
0037342855
-
Effect of reinstitution of good glycemic control on retinal oxidative stress and nitrative stress in diabetic rats
-
Kowluru RA. Effect of reinstitution of good glycemic control on retinal oxidative stress and nitrative stress in diabetic rats. Diabetes. 2003;52:818–823.
-
(2003)
Diabetes
, vol.52
, pp. 818-823
-
-
Kowluru, R.A.1
-
6
-
-
0025067393
-
Overexpression of fibronectin induced by diabetes or high glucose: Phenomenon with a memory
-
Roy S, Sala R, Cagliero E, Lorenzi M. Overexpression of fibronectin induced by diabetes or high glucose: phenomenon with a memory. Proc Natl Acad Sci U S A. 1990;87:404–408.
-
(1990)
Proc Natl Acad Sci U S A
, vol.87
, pp. 404-408
-
-
Roy, S.1
Sala, R.2
Cagliero, E.3
Lorenzi, M.4
-
7
-
-
79953183375
-
Epigenetic changes in mitochondrial superoxide dismutase in the retina and the development of diabetic retinopathy
-
Zhong Q, Kowluru RA. Epigenetic changes in mitochondrial superoxide dismutase in the retina and the development of diabetic retinopathy. Diabetes. 2011;60:1304–1313.
-
(2011)
Diabetes
, vol.60
, pp. 1304-1313
-
-
Zhong, Q.1
Kowluru, R.A.2
-
8
-
-
84886235609
-
AGEs, rather than hyperglycemia are responsible for microvascular complications in diabetes: A “glycoxidation-centric” point of view
-
Chilelli NC, Burlina S, Lapolla A. AGEs, rather than hyperglycemia are responsible for microvascular complications in diabetes: a “glycoxidation-centric” point of view. Nutr Metab Cardiovasc Dis. 2013;23:913–919.
-
(2013)
Nutr Metab Cardiovasc Dis
, vol.23
, pp. 913-919
-
-
Chilelli, N.C.1
Burlina, S.2
Lapolla, A.3
-
9
-
-
77951224619
-
Metabolic memory and diabetic retinopathy: Role of inflammatory mediators in retinal pericytes
-
Kowluru RA, Zhong Q, Kanwar M. Metabolic memory and diabetic retinopathy: role of inflammatory mediators in retinal pericytes. Exp Eye Res. 2010;90:617–623.
-
(2010)
Exp Eye Res
, vol.90
, pp. 617-623
-
-
Kowluru, R.A.1
Zhong, Q.2
Kanwar, M.3
-
10
-
-
77954909054
-
Role of mitochondrial DNA damage in the development of diabetic retinopathy and the metabolic memory phenomenon associated with its progression
-
Madsen-Bouterse SA, Mohammad G, Kanwar M, Kowluru RA. Role of mitochondrial DNA damage in the development of diabetic retinopathy and the metabolic memory phenomenon associated with its progression. Antiox Redox Signal. 2010;13: 797–805.
-
(2010)
Antiox Redox Signal
, vol.13
, pp. 797-805
-
-
Madsen-Bouterse, S.A.1
Mohammad, G.2
Kanwar, M.3
Kowluru, R.A.4
-
11
-
-
84922330317
-
Retinal mitochondrial DNA mismatch repair in the development of diabetic retinopathy and its continued progression after termination of hyperglycemia
-
Mishra M, Kowluru RA. Retinal mitochondrial DNA mismatch repair in the development of diabetic retinopathy and its continued progression after termination of hyperglycemia. Invest Ophthalmol Vis Sci. 2014;55:6960–6967.
-
(2014)
Invest Ophthalmol Vis Sci
, vol.55
, pp. 6960-6967
-
-
Mishra, M.1
Kowluru, R.A.2
-
12
-
-
84055204963
-
Role of mitochondria biogenesis in the metabolic memory associated with the continued progression of diabetic retinopathy and its regulation by lipoic acid
-
Santos JM, Kowluru RA. Role of mitochondria biogenesis in the metabolic memory associated with the continued progression of diabetic retinopathy and its regulation by lipoic acid. Invest Ophthalmol Vis Sci. 2011;52:8791–8798.
-
(2011)
Invest Ophthalmol Vis Sci
, vol.52
, pp. 8791-8798
-
-
Santos, J.M.1
Kowluru, R.A.2
-
13
-
-
84875037406
-
Impaired transport of mitochondrial transcription factor A (TFAM) and the metabolic memory phenomenon associated with the progression of diabetic retinopathy. Diabetes/Metab
-
Santos JM, Kowluru RA. Impaired transport of mitochondrial transcription factor A (TFAM) and the metabolic memory phenomenon associated with the progression of diabetic retinopathy. Diabetes/Metab Res Rev. 2013;29:204–213.
-
(2013)
Res Rev
, vol.29
, pp. 204-213
-
-
Santos, J.M.1
Kowluru, R.A.2
-
14
-
-
84896304013
-
Posttranslational modification of mitochondrial transcription factor A in impaired mitochondria biogenesis: Implications in diabetic retinopathy and metabolic memory phenomenon
-
Santos JM, Mishra M, Kowluru RA. Posttranslational modification of mitochondrial transcription factor A in impaired mitochondria biogenesis: implications in diabetic retinopathy and metabolic memory phenomenon. Exp Eye Res. 2014;121: 168–177.
-
(2014)
Exp Eye Res
, vol.121
, pp. 168-177
-
-
Santos, J.M.1
Mishra, M.2
Kowluru, R.A.3
-
15
-
-
84878774334
-
Regulation of matrix metalloproteinase-9 by epigenetic modifications and the development of diabetic retinopathy
-
Zhong Q, Kowluru RA. Regulation of matrix metalloproteinase-9 by epigenetic modifications and the development of diabetic retinopathy. Diabetes. 2013;62:2559–2568.
-
(2013)
Diabetes
, vol.62
, pp. 2559-2568
-
-
Zhong, Q.1
Kowluru, R.A.2
-
16
-
-
84867320438
-
Mitochondria DNA replication and DNA methylation in the metabolic memory associated with continued progression of diabetic retinopathy
-
Tewari S, Zhong Q, Santos JM, Kowluru RA. Mitochondria DNA replication and DNA methylation in the metabolic memory associated with continued progression of diabetic retinopathy. Invest Ophthalmol Vis Sci. 2012;53:4881–4888.
-
(2012)
Invest Ophthalmol Vis Sci
, vol.53
, pp. 4881-4888
-
-
Tewari, S.1
Zhong, Q.2
Santos, J.M.3
Kowluru, R.A.4
-
17
-
-
84874534208
-
Epigenetic modification of Sod2 in the development of diabetic retinopathy and in the metabolic memory: Role of histone methylation
-
Zhong Q, Kowluru RA. Epigenetic modification of Sod2 in the development of diabetic retinopathy and in the metabolic memory: role of histone methylation. Invest Ophthalmol Vis Sci. 2013;54:244–250.
-
(2013)
Invest Ophthalmol Vis Sci
, vol.54
, pp. 244-250
-
-
Zhong, Q.1
Kowluru, R.A.2
-
18
-
-
0033753779
-
The DNA methyltransferases of mammals
-
Bestor TH. The DNA methyltransferases of mammals. Hum Mol Genet. 2000;9:2395–2402.
-
(2000)
Hum Mol Genet
, vol.9
, pp. 2395-2402
-
-
Bestor, T.H.1
-
19
-
-
84901811688
-
Playing TETris with DNA modifications
-
Delatte B, Deplus R, Fuks F. Playing TETris with DNA modifications. EMBO J. 2014;33:1198–1211.
-
(2014)
EMBO J
, vol.33
, pp. 1198-1211
-
-
Delatte, B.1
Deplus, R.2
Fuks, F.3
-
20
-
-
84862233042
-
Damaged mitochondrial DNA replication system and the development of diabetic retinopathy
-
Tewari S, Santos JM, Kowluru RA. Damaged mitochondrial DNA replication system and the development of diabetic retinopathy. Antiox Redox Signal. 2012;17:492–504.
-
(2012)
Antiox Redox Signal
, vol.17
, pp. 492-504
-
-
Tewari, S.1
Santos, J.M.2
Kowluru, R.A.3
-
21
-
-
84939838944
-
Epigenetic modification of mitochondrial DNA in the development of diabetic retinopathy
-
Mishra M, Kowluru RA. Epigenetic modification of mitochondrial DNA in the development of diabetic retinopathy. Invest Ophthalmol Vis Sci. 2015;56:5133–5142.
-
(2015)
Invest Ophthalmol Vis Sci
, vol.56
, pp. 5133-5142
-
-
Mishra, M.1
Kowluru, R.A.2
-
22
-
-
84988622288
-
Dynamic epigenetic modifications of retinal matrix metalloproteinase-9 in the development of diabetic retinopathy
-
Shan Y, Kowluru R. Dynamic epigenetic modifications of retinal matrix metalloproteinase-9 in the development of diabetic retinopathy. Lab Invest. 2016;96:1040–1049.
-
(2016)
Lab Invest
, vol.96
, pp. 1040-1049
-
-
Shan, Y.1
Kowluru, R.2
-
23
-
-
84893160260
-
Association of promoter methylation statuses of congenital heart defect candidate genes with Tetralogy of Fallot
-
Sheng W, Qian Y, Zhang P, et al. Association of promoter methylation statuses of congenital heart defect candidate genes with Tetralogy of Fallot. J Transl Med. 2014;12:31.
-
(2014)
J Transl Med
, vol.12
, pp. 31
-
-
Sheng, W.1
Qian, Y.2
Zhang, P.3
-
24
-
-
63349085390
-
Epigenetics, oxidative stress, and Alzheimer disease
-
Zawia NH, Lahiri DK, Cardozo-Pelaez F. Epigenetics, oxidative stress, and Alzheimer disease. Free Rad Biol Med. 2009;46: 1241–1249.
-
(2009)
Free Rad Biol Med
, vol.46
, pp. 1241-1249
-
-
Zawia, N.H.1
Lahiri, D.K.2
Cardozo-Pelaez, F.3
-
25
-
-
0142200820
-
Dyslipidemia, but not hyperglycemia induces inflammatory adhesion molecules in human retinal vascular endothelial cells
-
Chen W, Jump DB, Grant MB, Esselman WJ, Busik JV. Dyslipidemia, but not hyperglycemia induces inflammatory adhesion molecules in human retinal vascular endothelial cells. Invest Ophthalmol Vis Sci. 2003;44:5016–5022.
-
(2003)
Invest Ophthalmol Vis Sci
, vol.44
, pp. 5016-5022
-
-
Chen, W.1
Jump, D.B.2
Grant, M.B.3
Esselman, W.J.4
Busik, J.V.5
-
27
-
-
84908101928
-
Sirt1 a negative regulator of matrix metalloproteinase-9 in diabetic retinopathy
-
Kowluru RA, Santos JM, Zhong Q. Sirt1 a negative regulator of matrix metalloproteinase-9 in diabetic retinopathy. Invest Ophthalmol Vis Sci. 2014;55:5653–5660.
-
(2014)
Invest Ophthalmol Vis Sci
, vol.55
, pp. 5653-5660
-
-
Kowluru, R.A.1
Santos, J.M.2
Zhong, Q.3
-
28
-
-
84921917975
-
DCCT/EDIC Research Group. Effect of intensive diabetes therapy on the progression of diabetic retinopathy in patients with type 1 diabetes: 18 years of follow-up in the DCCT/EDIC
-
Lachin JM, White NH, Hainsworth DP, Sun W, Cleary PA, Nathan DM; DCCT/EDIC Research Group. Effect of intensive diabetes therapy on the progression of diabetic retinopathy in patients with type 1 diabetes: 18 years of follow-up in the DCCT/EDIC. Diabetes 2015;64:631–642.
-
(2015)
Diabetes
, vol.64
, pp. 631-642
-
-
Lachin, J.M.1
White, N.H.2
Hainsworth, D.P.3
Sun, W.4
Cleary, P.A.5
Nathan, D.M.6
-
29
-
-
84906331499
-
Epigenetic modifications of Nrf2-mediated glutamate-cysteine ligase: Implications for the development of diabetic retinopathy and the metabolic memory phenomenon associated with its continued progression
-
Mishra M, Zhong Q, Kowluru RA. Epigenetic modifications of Nrf2-mediated glutamate-cysteine ligase: implications for the development of diabetic retinopathy and the metabolic memory phenomenon associated with its continued progression. Free Rad Biol Med. 2014;75C:129–139.
-
(2014)
Free Rad Biol Med
, vol.75C
, pp. 129-139
-
-
Mishra, M.1
Zhong, Q.2
Kowluru, R.A.3
-
30
-
-
84925519612
-
Epigenetic mechanisms in diabetic complications and metabolic memory
-
Reddy MA, Zhang E, Natarajan R. Epigenetic mechanisms in diabetic complications and metabolic memory. Diabetologia. 2015;58:443–455.
-
(2015)
Diabetologia
, vol.58
, pp. 443-455
-
-
Reddy, M.A.1
Zhang, E.2
Natarajan, R.3
-
31
-
-
77951843664
-
Effect of prior intensive therapy in type 1 diabetes on 10-year progression of retinopathy in the DCCT/EDIC: Comparison of adults and adolescents
-
White NH, Sun W, Cleary PA, et al. Effect of prior intensive therapy in type 1 diabetes on 10-year progression of retinopathy in the DCCT/EDIC: comparison of adults and adolescents. Diabetes. 2010;59:1244–1253.
-
(2010)
Diabetes
, vol.59
, pp. 1244-1253
-
-
White, N.H.1
Sun, W.2
Cleary, P.A.3
-
33
-
-
34548138278
-
Epigenetics: A historical overview
-
Holliday R. Epigenetics: a historical overview. Epigenetics 2006;1:76–80.
-
(2006)
Epigenetics
, vol.1
, pp. 76-80
-
-
Holliday, R.1
-
34
-
-
84872196941
-
Reduced RAN expression and disrupted transport between cytoplasm and nucleus; a key event in Alzheimer’s disease pathophysiology
-
Mastroeni D, Chouliaras L, Grover A, et al. Reduced RAN expression and disrupted transport between cytoplasm and nucleus; a key event in Alzheimer’s disease pathophysiology. PLoS One. 2013;8:e53349.
-
(2013)
Plos One
, vol.8
-
-
Mastroeni, D.1
Chouliaras, L.2
Grover, A.3
-
35
-
-
73549111178
-
Dynamic regulation of DNA methylation during mammalian development
-
Guibert S, Forne T, Weber M. Dynamic regulation of DNA methylation during mammalian development. Epigenomics. 2009;1:81–98.
-
(2009)
Epigenomics
, vol.1
, pp. 81-98
-
-
Guibert, S.1
Forne, T.2
Weber, M.3
-
37
-
-
84938566124
-
Genome-wide analysis of DNA methylation in subjects with type 1 diabetes identifies epigenetic modifications associated with proliferative diabetic retinopathy
-
Agardh E, Lundstig A, Perfilyev A, et al. Genome-wide analysis of DNA methylation in subjects with type 1 diabetes identifies epigenetic modifications associated with proliferative diabetic retinopathy. BMC Med. 2015;13:182.
-
(2015)
BMC Med
, vol.13
, pp. 182
-
-
Agardh, E.1
Lundstig, A.2
Perfilyev, A.3
-
38
-
-
84897489404
-
Evaluating the role of epigenetic histone modifications in the metabolic memory of type 1 diabetes
-
Miao F, Chen Z, Genuth S, et al. Evaluating the role of epigenetic histone modifications in the metabolic memory of type 1 diabetes. Diabetes. 2014;63:1748–1762.
-
(2014)
Diabetes
, vol.63
, pp. 1748-1762
-
-
Miao, F.1
Chen, Z.2
Genuth, S.3
-
39
-
-
84969776770
-
Epigenomic profiling reveals an association between persistence of DNA methylation and metabolic memory in the DCCT/EDIC type 1 diabetes cohort
-
Chen Z, Miao F, Paterson AD, et al. Epigenomic profiling reveals an association between persistence of DNA methylation and metabolic memory in the DCCT/EDIC type 1 diabetes cohort. Proc Natl Acad Sci U S A. 2016;113:E3002–E3011.
-
(2016)
Proc Natl Acad Sci U S A
, vol.113
, pp. E3002-E3011
-
-
Chen, Z.1
Miao, F.2
Paterson, A.D.3
-
40
-
-
79952749156
-
DNA methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria
-
Shock LS, Thakkar PV, Peterson EJ, Moran RG, Taylor SM. DNA methyltransferase 1, cytosine methylation, and cytosine hydroxymethylation in mammalian mitochondria. Proc Natl Acad Sci U S A. 2011;108:3630–3635.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 3630-3635
-
-
Shock, L.S.1
Thakkar, P.V.2
Peterson, E.J.3
Moran, R.G.4
Taylor, S.M.5
-
41
-
-
84863986133
-
Functions of DNA methylation: Islands, start sites gene bodies and beyond
-
Jones PA. Functions of DNA methylation: islands, start sites gene bodies and beyond. Nat Rev Genet. 2012;13:484–492.
-
(2012)
Nat Rev Genet
, vol.13
, pp. 484-492
-
-
Jones, P.A.1
-
43
-
-
0034305821
-
DNA methylation in health and disease
-
Robertson KD, Wolffe AP. DNA methylation in health and disease. Nat Rev Genet. 2000;1:11–19.
-
(2000)
Nat Rev Genet
, vol.1
, pp. 11-19
-
-
Robertson, K.D.1
Wolffe, A.P.2
-
44
-
-
58149252632
-
Prolonged effect of intensive therapy on the risk of retinopathy complications in patients with type 1 diabetes mellitus: 10 years after the Diabetes Control and Complications Trial
-
White NH, Sun W, Cleary PA, et al. Prolonged effect of intensive therapy on the risk of retinopathy complications in patients with type 1 diabetes mellitus: 10 years after the Diabetes Control and Complications Trial. Arch Ophthalmol. 2008;126:1707–1715.
-
(2008)
Arch Ophthalmol
, vol.126
, pp. 1707-1715
-
-
White, N.H.1
Sun, W.2
Cleary, P.A.3
-
45
-
-
34547858127
-
Metabolic memory phenomenon and accumulation of peroxynitrite in retinal capillaries
-
Kowluru RA, Kanwar M, Kennedy A. Metabolic memory phenomenon and accumulation of peroxynitrite in retinal capillaries. Exp Diabetes Res. 2007;2007:2196.
-
(2007)
Exp Diabetes Res
, vol.2007
-
-
Kowluru, R.A.1
Kanwar, M.2
Kennedy, A.3
-
46
-
-
84885357617
-
Photoreceptor cells are major contributors to diabetes-induced oxidative stress and local inflammation in the retina
-
Du Y, Veenstra A, Palczewski K, Kern TS. Photoreceptor cells are major contributors to diabetes-induced oxidative stress and local inflammation in the retina. Proc Natl Acad Sci U S A. 2013;110:16586–16591.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 16586-16591
-
-
Du, Y.1
Veenstra, A.2
Palczewski, K.3
Kern, T.S.4
-
47
-
-
84966359120
-
Retinal neurodegeneration may precede microvascular changes characteristic of diabetic retinopathy in diabetes mellitus
-
Sohn EH, van Dijk HW, Jiao C, et al. Retinal neurodegeneration may precede microvascular changes characteristic of diabetic retinopathy in diabetes mellitus. Proc Natl Acad Sci U S A. 2016;113:E2655–E2664.
-
(2016)
Proc Natl Acad Sci U S A
, vol.113
, pp. E2655-E2664
-
-
Sohn, E.H.1
Van Dijk, H.W.2
Jiao, C.3
-
48
-
-
84861118721
-
Early neurodegeneration in the retina of type 2 diabetic patients
-
van Dijk HW, Verbraak FD, Kok PH, et al. Early neurodegeneration in the retina of type 2 diabetic patients. Invest Ophthalmol Vis Sci. 2012;53:2715–2719.
-
(2012)
Invest Ophthalmol Vis Sci
, vol.53
, pp. 2715-2719
-
-
Van Dijk, H.W.1
Verbraak, F.D.2
Kok, P.H.3
|