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Volumn 3, Issue 6, 2012, Pages 375-389

Alemtuzumab use in relapsed and refractory chronic lymphocytic leukemia: A history and discussion of future rational use

Author keywords

agammaglobulinaemia tyrosine kinase; alemtuzumab; B cell; CD52 antigen; chronic; leukemia; lymphocytic; phosphatidylinositol 3 kinase; recurrence

Indexed keywords

ACICLOVIR; ALEMTUZUMAB; CD52 ANTIGEN; COTRIMOXAZOLE; FAMCICLOVIR; FLUDARABINE; PHOSPHATIDYLINOSITOL 3 KINASE; RITUXIMAB; STEROID;

EID: 84993814502     PISSN: 20406207     EISSN: 20406215     Source Type: Journal    
DOI: 10.1177/2040620712458949     Document Type: Review
Times cited : (23)

References (102)
  • 1
    • 84993704493 scopus 로고    scopus 로고
    • Incidence and spectrum of infection in patients treated with alemtuzumab: a multicenter experience, 12th Congress of the European Hematology Association
    • abstract 1036
    • Albo C. Perez-Encinas M. Lavilla E. Dios A. Plaza J. Simiele A. et al. (2007) Incidence and spectrum of infection in patients treated with alemtuzumab: a multicenter experience, 12th Congress of the European Hematology Association. Haematologica 92(Suppl. 1): abstract 1036.
    • (2007) Haematologica , vol.92
    • Albo, C.1    Perez-Encinas, M.2    Lavilla, E.3    Dios, A.4    Plaza, J.5    Simiele, A.6
  • 2
    • 80052188111 scopus 로고    scopus 로고
    • Cyclophosphamide, fludarabine, alemtuzumab, and rituximab as salvage therapy for heavily pretreated patients with chronic lymphocytic leukemia
    • Badoux X. Keating M. Wang X. O'Brien S. Ferrajoli A. Faderl S. et al. (2011) Cyclophosphamide, fludarabine, alemtuzumab, and rituximab as salvage therapy for heavily pretreated patients with chronic lymphocytic leukemia. Blood 118: 2085–2093.
    • (2011) Blood , vol.118 , pp. 2085-2093
    • Badoux, X.1    Keating, M.2    Wang, X.3    O'Brien, S.4    Ferrajoli, A.5    Faderl, S.6
  • 3
    • 80053209157 scopus 로고    scopus 로고
    • Multicenter study of subcutaneous alemtuzumab administered at reduced dose in patients with fludarabine-relapsed/refractory chronic lymphocytic leukemia: final analysis
    • Bezares R. Stemelin G. Diaz A. Argentieri D. Zubiaur E. Garay G. et al. (2011) Multicenter study of subcutaneous alemtuzumab administered at reduced dose in patients with fludarabine-relapsed/refractory chronic lymphocytic leukemia: final analysis. Leukemia Lymphoma 52: 1936–1941.
    • (2011) Leukemia Lymphoma , vol.52 , pp. 1936-1941
    • Bezares, R.1    Stemelin, G.2    Diaz, A.3    Argentieri, D.4    Zubiaur, E.5    Garay, G.6
  • 4
    • 0031027623 scopus 로고    scopus 로고
    • Subcutaneous CAMPATH-1H in fludarabine-resistant/relapsed chronic lymphocytic and b-prolymphocytic leukaemia
    • Bowen A. Zomas A. Emmett E. Matutes E. Dyer M. Catovsky D. (1997) Subcutaneous CAMPATH-1H in fludarabine-resistant/relapsed chronic lymphocytic and b-prolymphocytic leukaemia. British Journal of Haematology 96: 617–619.
    • (1997) British Journal of Haematology , vol.96 , pp. 617-619
    • Bowen, A.1    Zomas, A.2    Emmett, E.3    Matutes, E.4    Dyer, M.5    Catovsky, D.6
  • 5
    • 83255183489 scopus 로고    scopus 로고
    • A phase I study of escalated dose subcutaneous alemtuzumab given weekly with rituximab in relapsed CLL/SLL, ASH Annual Meeting
    • abstract 1381
    • Brown J. Messmer B. Werner L. Mikler E. Fisher D. Lacasce A. et al. (2010) A phase I study of escalated dose subcutaneous alemtuzumab given weekly with rituximab in relapsed CLL/SLL, ASH Annual Meeting. Blood 116: abstract 1381.
    • (2010) Blood , vol.116
    • Brown, J.1    Messmer, B.2    Werner, L.3    Mikler, E.4    Fisher, D.5    Lacasce, A.6
  • 6
    • 0036721489 scopus 로고    scopus 로고
    • Peripheral blood but not tissue dendritic cells express CD52 and are depleted by treatment with alemtuzumab
    • Buggins A. Mufti G. Salisbury J. Codd J. Westwood N. Arno M. et al. (2002) Peripheral blood but not tissue dendritic cells express CD52 and are depleted by treatment with alemtuzumab. Blood 100: 1715–1720.
    • (2002) Blood , vol.100 , pp. 1715-1720
    • Buggins, A.1    Mufti, G.2    Salisbury, J.3    Codd, J.4    Westwood, N.5    Arno, M.6
  • 7
  • 8
    • 0026324276 scopus 로고
    • New modalities of therapy in chronic lymphocytic leukemia
    • Cheson B. (1991) New modalities of therapy in chronic lymphocytic leukemia. Crit Rev Oncol Hematol 11: 167–177.
    • (1991) Crit Rev Oncol Hematol , vol.11 , pp. 167-177
    • Cheson, B.1
  • 9
    • 66349138551 scopus 로고    scopus 로고
    • Etiology and management of tumor lysis syndrome in patients with chronic lymphocytic leukemia
    • Cheson B. (2009) Etiology and management of tumor lysis syndrome in patients with chronic lymphocytic leukemia. Clin Adv Hematol Oncol 7: 263–271.
    • (2009) Clin Adv Hematol Oncol , vol.7 , pp. 263-271
    • Cheson, B.1
  • 10
    • 0029981025 scopus 로고    scopus 로고
    • National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment
    • Cheson B. Bennett J. Grever M. Kay N. Keating M. O'Brien S. et al. (1996) National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment. Blood 87: 4990–4997.
    • (1996) Blood , vol.87 , pp. 4990-4997
    • Cheson, B.1    Bennett, J.2    Grever, M.3    Kay, N.4    Keating, M.5    O'Brien, S.6
  • 11
    • 0023717101 scopus 로고
    • Guidelines for clinical protocols for chronic lymphocytic leukemia: recommendations of the National Cancer Institute-sponsored Working Group
    • Cheson B. Bennett J. Rai K. Grever M. Kay N. Schiffer C. et al. (1988) Guidelines for clinical protocols for chronic lymphocytic leukemia: recommendations of the National Cancer Institute-sponsored Working Group. Am J Hematol 29: 152–163.
    • (1988) Am J Hematol , vol.29 , pp. 152-163
    • Cheson, B.1    Bennett, J.2    Rai, K.3    Grever, M.4    Kay, N.5    Schiffer, C.6
  • 12
    • 84856272135 scopus 로고    scopus 로고
    • An Italian retrospective study on the routine clinical use of low-dose alemtuzumab in relapsed / refractory chronic lymphocytic leukaemia patients
    • Cortelezzi A. Gritti G. Laurenti L. Cuneo A. Ciolli S. Di Renzo N. et al. (2012) An Italian retrospective study on the routine clinical use of low-dose alemtuzumab in relapsed / refractory chronic lymphocytic leukaemia patients. Br J Haematol 156: 481–489.
    • (2012) Br J Haematol , vol.156 , pp. 481-489
    • Cortelezzi, A.1    Gritti, G.2    Laurenti, L.3    Cuneo, A.4    Ciolli, S.5    Di Renzo, N.6
  • 13
    • 70450267533 scopus 로고    scopus 로고
    • Low-dose subcutaneous alemtuzumab in refractory chronic lymphocytic leukaemia (CLL): results of a prospective, single-arm multicentre study
    • Cortelezzi A. Pasquini M. Gardellini A. Gianelli U. Bossi A. Reda G. et al. (2009) Low-dose subcutaneous alemtuzumab in refractory chronic lymphocytic leukaemia (CLL): results of a prospective, single-arm multicentre study. Leukemia 23: 2027–2033.
    • (2009) Leukemia , vol.23 , pp. 2027-2033
    • Cortelezzi, A.1    Pasquini, M.2    Gardellini, A.3    Gianelli, U.4    Bossi, A.5    Reda, G.6
  • 14
    • 15244362778 scopus 로고    scopus 로고
    • A pilot study of low-dose subcutaneous alemtuzumab therapy for patients with chemotherapy-refractory chronic lymphocytic leukemia
    • Cortelezzi A. Pasquini M. Sarina B. Bertani G. Grifoni F. Colombi M. et al. (2005) A pilot study of low-dose subcutaneous alemtuzumab therapy for patients with chemotherapy-refractory chronic lymphocytic leukemia. Haematologica 90: 410–412.
    • (2005) Haematologica , vol.90 , pp. 410-412
    • Cortelezzi, A.1    Pasquini, M.2    Sarina, B.3    Bertani, G.4    Grifoni, F.5    Colombi, M.6
  • 15
    • 84858636448 scopus 로고    scopus 로고
    • The clinically active BTK inhibitor PCI-32765 targets B-cell receptor- and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia
    • de Rooij M. Kuil A. Geest C. Eldering E. Chang B. Buggy J. et al. (2012) The clinically active BTK inhibitor PCI-32765 targets B-cell receptor- and chemokine-controlled adhesion and migration in chronic lymphocytic leukemia. Blood 119: 2590–2594.
    • (2012) Blood , vol.119 , pp. 2590-2594
    • de Rooij, M.1    Kuil, A.2    Geest, C.3    Eldering, E.4    Chang, B.5    Buggy, J.6
  • 17
    • 0025652892 scopus 로고
    • Remission induction in patients with lymphoid malignancies using unconjugated CAMPATH-1 monoclonal antibodies
    • Dyer M. Hale G. Marcus R. Waldmann H. (1990) Remission induction in patients with lymphoid malignancies using unconjugated CAMPATH-1 monoclonal antibodies. Leukemia Lymphoma 2: 179–193.
    • (1990) Leukemia Lymphoma , vol.2 , pp. 179-193
    • Dyer, M.1    Hale, G.2    Marcus, R.3    Waldmann, H.4
  • 18
    • 84993682076 scopus 로고    scopus 로고
    • Final results of oral fludarabine with concomitant subcutaneous alemtuzumab in relapse / refractory b-chronic lymphocytic leukaemia (B-CLL): the FLUSALEM study, 14th Congress of the European Hematology Association
    • abstract 0353
    • Egle A. Melchardt T. Pleyer L. Tinhofer I. Lang A. Keil F. et al. (2009) Final results of oral fludarabine with concomitant subcutaneous alemtuzumab in relapse / refractory b-chronic lymphocytic leukaemia (B-CLL): the FLUSALEM study, 14th Congress of the European Hematology Association, Haematologica 94(Suppl. 2): abstract 0353.
    • (2009) Haematologica , vol.94
    • Egle, A.1    Melchardt, T.2    Pleyer, L.3    Tinhofer, I.4    Lang, A.5    Keil, F.6
  • 19
    • 84993708895 scopus 로고    scopus 로고
    • The BENDALEM CLL 6 AGMT study - bendamustine combined with alemtuzumab in relapsed / refractory chronic lymphocytic leukemia (CLL): results of a planned interim analysis, ASH Annual Meeting
    • abstract 4633
    • Egle A. Melchardt T. Weiss L. Steurer M. Greil R. (2010) The BENDALEM CLL 6 AGMT study - bendamustine combined with alemtuzumab in relapsed / refractory chronic lymphocytic leukemia (CLL): results of a planned interim analysis, ASH Annual Meeting, Blood 116: abstract 4633.
    • (2010) Blood , vol.116
    • Egle, A.1    Melchardt, T.2    Weiss, L.3    Steurer, M.4    Greil, R.5
  • 20
    • 27244451794 scopus 로고    scopus 로고
    • Fludarabine in combination with alemtuzumab is effective and feasible in patients with relapsed or refractory B-cell chronic lymphocytic leukemia: results of a phase II trial
    • Elter T. Borchmann P. Schulz H. Reiser M. Trelle S. Schnell R. et al. (2005) Fludarabine in combination with alemtuzumab is effective and feasible in patients with relapsed or refractory B-cell chronic lymphocytic leukemia: results of a phase II trial. J Clin Oncol 23: 7024–7031.
    • (2005) J Clin Oncol , vol.23 , pp. 7024-7031
    • Elter, T.1    Borchmann, P.2    Schulz, H.3    Reiser, M.4    Trelle, S.5    Schnell, R.6
  • 21
    • 82555169679 scopus 로고    scopus 로고
    • Fludarabine plus alemtuzumab versus fludarabine alone in patients with previously treated chronic lymphocytic leukaemia: a randomised phase 3 trial
    • Elter T. Gercheva-Kyuchukova L. Pylylpenko H. Robak T. Jaksic B. Rekhtman G. et al. (2011) Fludarabine plus alemtuzumab versus fludarabine alone in patients with previously treated chronic lymphocytic leukaemia: a randomised phase 3 trial. Lancet Oncol 12: 1204–1213.
    • (2011) Lancet Oncol , vol.12 , pp. 1204-1213
    • Elter, T.1    Gercheva-Kyuchukova, L.2    Pylylpenko, H.3    Robak, T.4    Jaksic, B.5    Rekhtman, G.6
  • 22
    • 84871249105 scopus 로고    scopus 로고
    • Fludarabine and cyclophosphamide in combination with alemtuzumab (FCCam) in patients with primary high-risk, relapsed or refractory chronic lymphocytic leukemia
    • May epub ahead of print
    • Elter T. James R. Busch R. Winkler D. Ritgen M. Bottcher S. et al. (2012) Fludarabine and cyclophosphamide in combination with alemtuzumab (FCCam) in patients with primary high-risk, relapsed or refractory chronic lymphocytic leukemia. Leukemia 15 May (epub ahead of print).
    • (2012) Leukemia
    • Elter, T.1    James, R.2    Busch, R.3    Winkler, D.4    Ritgen, M.5    Bottcher, S.6
  • 23
    • 77952573871 scopus 로고    scopus 로고
    • Alemtuzumab by continuous intravenous infusion followed by subcutaneous injection plus rituximab in the treatment of patients with chronic lymphocytic leukemia recurrence
    • Faderl S. Ferrajoli A. Wierda W. O'Brien S. Lerner S. Keating M. (2010) Alemtuzumab by continuous intravenous infusion followed by subcutaneous injection plus rituximab in the treatment of patients with chronic lymphocytic leukemia recurrence. Cancer 116: 2360–2365.
    • (2010) Cancer , vol.116 , pp. 2360-2365
    • Faderl, S.1    Ferrajoli, A.2    Wierda, W.3    O'Brien, S.4    Lerner, S.5    Keating, M.6
  • 24
    • 0038724252 scopus 로고    scopus 로고
    • Experience with alemtuzumab plus rituximab in patients with relapsed and refractory lymphoid malignancies
    • Faderl S. Thomas D. O'Brien S. Garcia-Manero G. Kantarjian H. Giles F. et al. (2003) Experience with alemtuzumab plus rituximab in patients with relapsed and refractory lymphoid malignancies. Blood 101: 3413–3415.
    • (2003) Blood , vol.101 , pp. 3413-3415
    • Faderl, S.1    Thomas, D.2    O'Brien, S.3    Garcia-Manero, G.4    Kantarjian, H.5    Giles, F.6
  • 25
    • 0042071567 scopus 로고    scopus 로고
    • Phase II study of alemtuzumab in chronic lymphoproliferative disorders
    • Ferrajoli A. O'Brien S. Cortes J. Giles F. Thomas D. Faderl S. et al. (2003) Phase II study of alemtuzumab in chronic lymphoproliferative disorders. Cancer 98: 773–778.
    • (2003) Cancer , vol.98 , pp. 773-778
    • Ferrajoli, A.1    O'Brien, S.2    Cortes, J.3    Giles, F.4    Thomas, D.5    Faderl, S.6
  • 26
    • 40449085707 scopus 로고    scopus 로고
    • Pilot experience with continuous infusion alemtuzumab in patients with fludarabine-refractory chronic lymphocytic leukemia
    • Ferrajoli A. Wierda W. Lapushin R. O'Brien S. Faderl S. Browning M. et al. (2008) Pilot experience with continuous infusion alemtuzumab in patients with fludarabine-refractory chronic lymphocytic leukemia. Eur J Haematol 80: 296–298.
    • (2008) Eur J Haematol , vol.80 , pp. 296-298
    • Ferrajoli, A.1    Wierda, W.2    Lapushin, R.3    O'Brien, S.4    Faderl, S.5    Browning, M.6
  • 27
    • 78649471912 scopus 로고    scopus 로고
    • Clinical outcome of pretreated B-cell chronic lymphocytic leukemia following alemtuzumab therapy: a retrospective study on various cytogenetic risk categories
    • Fiegl M. Erdel M. Tinhofer I. Brychtova Y. Panovska A. Doubek M. et al. (2010) Clinical outcome of pretreated B-cell chronic lymphocytic leukemia following alemtuzumab therapy: a retrospective study on various cytogenetic risk categories. Annals of Oncology 21: 2410–2419.
    • (2010) Annals of Oncology , vol.21 , pp. 2410-2419
    • Fiegl, M.1    Erdel, M.2    Tinhofer, I.3    Brychtova, Y.4    Panovska, A.5    Doubek, M.6
  • 28
    • 33751009390 scopus 로고    scopus 로고
    • Routine clinical use of alemtuzumab in patients with heavily pretreated B-cell chronic lymphocytic leukemia: a nation-wide retrospective study in Austria
    • Fiegl M. Falkner A. Hopfinger G. Brugger S. Zabernigg A. Bauer F. et al. (2006) Routine clinical use of alemtuzumab in patients with heavily pretreated B-cell chronic lymphocytic leukemia: a nation-wide retrospective study in Austria. Cancer 107: 2408–2416.
    • (2006) Cancer , vol.107 , pp. 2408-2416
    • Fiegl, M.1    Falkner, A.2    Hopfinger, G.3    Brugger, S.4    Zabernigg, A.5    Bauer, F.6
  • 29
    • 80052359492 scopus 로고    scopus 로고
    • Successful alemtuzumab retreatment in progressive B-cell chronic lymphocytic leukemia: a multicenter survey in 30 patients
    • Fiegl M. Falkner F. Steurer M. Zojer N. Hopfinger G. Haslbauer F. et al. (2011) Successful alemtuzumab retreatment in progressive B-cell chronic lymphocytic leukemia: a multicenter survey in 30 patients. Ann Hematol 90: 1083–1091.
    • (2011) Ann Hematol , vol.90 , pp. 1083-1091
    • Fiegl, M.1    Falkner, F.2    Steurer, M.3    Zojer, N.4    Hopfinger, G.5    Haslbauer, F.6
  • 30
    • 76649142414 scopus 로고    scopus 로고
    • Analysis of minimal residual disease (MRD) from the phase 2 multicenter study of subcutaneous (SC) alemtuzumab combined with fludarabine for treatment of relapsed / refractory B-cell chronic lymphocytic leukemia (CLL), ASH Annual Meeting
    • abstract 3111
    • Flowers C. Rosenthal H. Brown J. Stock W. Katzen H. Lakhanpal S. et al. (2007) Analysis of minimal residual disease (MRD) from the phase 2 multicenter study of subcutaneous (SC) alemtuzumab combined with fludarabine for treatment of relapsed / refractory B-cell chronic lymphocytic leukemia (CLL), ASH Annual Meeting. Blood 110: abstract 3111.
    • (2007) Blood , vol.110
    • Flowers, C.1    Rosenthal, H.2    Brown, J.3    Stock, W.4    Katzen, H.5    Lakhanpal, S.6
  • 31
    • 84857844598 scopus 로고    scopus 로고
    • PI3Kδ inhibitors in cancer: rationale and serendipity merge in the clinic
    • Fruman D. Rommel C. (2011) PI3Kδ inhibitors in cancer: rationale and serendipity merge in the clinic. Cancer Discov 1: 562–572.
    • (2011) Cancer Discov , vol.1 , pp. 562-572
    • Fruman, D.1    Rommel, C.2
  • 33
    • 33750025381 scopus 로고    scopus 로고
    • Fludarabine and alemtuzumab versus fludarabine and rituximab in the treatment of relapsed B-cell chronic lymphocytic leukemia: results from a phase II study. ASH Annual Meeting
    • abstract 5046
    • Gribben J. Stephans K. Marshal B. (2005) Fludarabine and alemtuzumab versus fludarabine and rituximab in the treatment of relapsed B-cell chronic lymphocytic leukemia: results from a phase II study. ASH Annual Meeting. Blood 106: abstract 5046.
    • (2005) Blood , vol.106
    • Gribben, J.1    Stephans, K.2    Marshal, B.3
  • 34
    • 84857527105 scopus 로고    scopus 로고
    • Low dose alemtuzumab in patients with fludarabine-refractory chronic lymphocytic leukemia
    • Gritti G. Reda G. Maura F. Piciocchi A. Baldini L. Molica S. et al. (2012) Low dose alemtuzumab in patients with fludarabine-refractory chronic lymphocytic leukemia. Leukemia Lymphoma 53: 424–429.
    • (2012) Leukemia Lymphoma , vol.53 , pp. 424-429
    • Gritti, G.1    Reda, G.2    Maura, F.3    Piciocchi, A.4    Baldini, L.5    Molica, S.6
  • 35
    • 41149101075 scopus 로고    scopus 로고
    • Combination therapy with fludarabine and rituximab followed by alemtuzumab in the first-line treatment of patients with chronic lymphocytic leukemia or small lymphocytic lymphoma: a phase 2 trial of the Minnie Pearl Cancer Research Network
    • Hainsworth J. Vazquez E. Spigel D. Raefsky E. Bearden J. Saez R. et al. (2008) Combination therapy with fludarabine and rituximab followed by alemtuzumab in the first-line treatment of patients with chronic lymphocytic leukemia or small lymphocytic lymphoma: a phase 2 trial of the Minnie Pearl Cancer Research Network. Cancer 112: 1288–1295.
    • (2008) Cancer , vol.112 , pp. 1288-1295
    • Hainsworth, J.1    Vazquez, E.2    Spigel, D.3    Raefsky, E.4    Bearden, J.5    Saez, R.6
  • 36
    • 0020591822 scopus 로고
    • Removal of T cells from bone marrow for transplantation: a monoclonal antilymphocyte antibody that fixes human complement
    • Hale G. Bright S. Chumbley G. Hoang T. Metcalf D. Munro A. et al. (1983 a) Removal of T cells from bone marrow for transplantation: a monoclonal antilymphocyte antibody that fixes human complement. Blood 62: 873–882.
    • (1983) Blood , vol.62 , pp. 873-882
    • Hale, G.1    Bright, S.2    Chumbley, G.3    Hoang, T.4    Metcalf, D.5    Munro, A.6
  • 37
    • 0024204319 scopus 로고
    • Remission induction in non-Hodgkin lymphoma with reshaped human monoclonal antibody CAMPATH-1H
    • Hale G. Dyer M. Clark M. Phillips J. Marcus R. Riechmann L. et al. (1988) Remission induction in non-Hodgkin lymphoma with reshaped human monoclonal antibody CAMPATH-1H. Lancet 2: 1394–1399.
    • (1988) Lancet , vol.2 , pp. 1394-1399
    • Hale, G.1    Dyer, M.2    Clark, M.3    Phillips, J.4    Marcus, R.5    Riechmann, L.6
  • 38
    • 3843129540 scopus 로고    scopus 로고
    • Blood concentrations of alemtuzumab and antiglobulin responses in patients with chronic lymphocytic leukemia following intravenous or subcutaneous routes of administration
    • Hale G. Rebello P. Brettman L. Fegan C. Kennedy B. Kimby E. et al. (2004) Blood concentrations of alemtuzumab and antiglobulin responses in patients with chronic lymphocytic leukemia following intravenous or subcutaneous routes of administration. Blood 104: 948–955.
    • (2004) Blood , vol.104 , pp. 948-955
    • Hale, G.1    Rebello, P.2    Brettman, L.3    Fegan, C.4    Kennedy, B.5    Kimby, E.6
  • 39
    • 0020835433 scopus 로고
    • Effects of monoclonal anti-lymphocyte antibodies in vivo in monkeys and humans
    • Hale G. Swirsky D. Hayhoe F. Waldmann H. (1983 b) Effects of monoclonal anti-lymphocyte antibodies in vivo in monkeys and humans. Mol Biol Med 1: 321–334.
    • (1983) Mol Biol Med , vol.1 , pp. 321-334
    • Hale, G.1    Swirsky, D.2    Hayhoe, F.3    Waldmann, H.4
  • 40
    • 84861808494 scopus 로고    scopus 로고
    • FCA: forget chemoimmunotherapy with alemtuzumab?
    • Hallek M. (2012) FCA: forget chemoimmunotherapy with alemtuzumab? Blood 119: 5059–5060.
    • (2012) Blood , vol.119 , pp. 5059-5060
    • Hallek, M.1
  • 41
    • 45149100665 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines
    • Hallek M. Cheson B. Catovsky D. Caligaris-Cappio F. Dighiero G. Dohner H. et al. (2008) Guidelines for the diagnosis and treatment of chronic lymphocytic leukemia: a report from the International Workshop on Chronic Lymphocytic Leukemia updating the National Cancer Institute-Working Group 1996 guidelines. Blood 111: 5446–5456.
    • (2008) Blood , vol.111 , pp. 5446-5456
    • Hallek, M.1    Cheson, B.2    Catovsky, D.3    Caligaris-Cappio, F.4    Dighiero, G.5    Dohner, H.6
  • 42
    • 79959404661 scopus 로고    scopus 로고
    • Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765
    • Herman S. Gordon A. Hertlein E. Ramanunni A. Zhang X. Jaglowski S. et al. (2011) Bruton tyrosine kinase represents a promising therapeutic target for treatment of chronic lymphocytic leukemia and is effectively targeted by PCI-32765. Blood 117: 6287–6296.
    • (2011) Blood , vol.117 , pp. 6287-6296
    • Herman, S.1    Gordon, A.2    Hertlein, E.3    Ramanunni, A.4    Zhang, X.5    Jaglowski, S.6
  • 43
    • 37649004407 scopus 로고    scopus 로고
    • Alemtuzumab compared with chlorambucil as first-line therapy for chronic lymphocytic leukemia
    • Hillmen P. Skotnicki A. Robak T. Jaksic B. Dmoszynska A. Wu J. et al. (2007) Alemtuzumab compared with chlorambucil as first-line therapy for chronic lymphocytic leukemia. J Clin Oncol 25: 5616–5623.
    • (2007) J Clin Oncol , vol.25 , pp. 5616-5623
    • Hillmen, P.1    Skotnicki, A.2    Robak, T.3    Jaksic, B.4    Dmoszynska, A.5    Wu, J.6
  • 44
    • 80053345977 scopus 로고    scopus 로고
    • The phosphoinositide 3’-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia
    • Hoellenriegel J. Meadows S. Sivina M. Wierda W. Kantarjian H. Keating M. et al. (2011) The phosphoinositide 3’-kinase delta inhibitor, CAL-101, inhibits B-cell receptor signaling and chemokine networks in chronic lymphocytic leukemia. Blood 118: 3603–3612.
    • (2011) Blood , vol.118 , pp. 3603-3612
    • Hoellenriegel, J.1    Meadows, S.2    Sivina, M.3    Wierda, W.4    Kantarjian, H.5    Keating, M.6
  • 45
    • 38849131246 scopus 로고    scopus 로고
    • Alemtuzumab in clinical practice: a British Columbia experience
    • Hui D. Lam W. Toze C. Delorme M. Noble M. Klimo P. et al. (2008) Alemtuzumab in clinical practice: a British Columbia experience. Leukemia Lymphoma 49: 218–226.
    • (2008) Leukemia Lymphoma , vol.49 , pp. 218-226
    • Hui, D.1    Lam, W.2    Toze, C.3    Delorme, M.4    Noble, M.5    Klimo, P.6
  • 46
    • 84993711277 scopus 로고    scopus 로고
    • Alemtuzumab in fludarabine-refractory CLL, 14th Congress of the European Hematology Association
    • abstract 1559
    • Ionita H. Cheveresan L. Inonita I. Cheveresan M. (2009) Alemtuzumab in fludarabine-refractory CLL, 14th Congress of the European Hematology Association. Haematologica 94(Suppl. 2): abstract 1559.
    • (2009) Haematologica , vol.94
    • Ionita, H.1    Cheveresan, L.2    Inonita, I.3    Cheveresan, M.4
  • 47
    • 57449111685 scopus 로고    scopus 로고
    • Phase II study of subcutaneous alemtuzumab without dose escalation in patients with advanced-stage, relapsed chronic lymphocytic leukaemia
    • Karlsson C. Lundin J. Kimby E. Kennedy B. Moreton P. Hillmen P. et al. (2009) Phase II study of subcutaneous alemtuzumab without dose escalation in patients with advanced-stage, relapsed chronic lymphocytic leukaemia. Br J Haematol 144: 78–85.
    • (2009) Br J Haematol , vol.144 , pp. 78-85
    • Karlsson, C.1    Lundin, J.2    Kimby, E.3    Kennedy, B.4    Moreton, P.5    Hillmen, P.6
  • 48
    • 84993692525 scopus 로고    scopus 로고
    • The alemtuzumab treatment of refractory to fludarabine chronic lymphocytic leukemia patients. ASH Annual Meeting
    • abstract 4415
    • Kataeva E. Golenkov A. Triphonova E. Buravtsova I. (2009) The alemtuzumab treatment of refractory to fludarabine chronic lymphocytic leukemia patients. ASH Annual Meeting. Blood 114: abstract 4415.
    • (2009) Blood , vol.114
    • Kataeva, E.1    Golenkov, A.2    Triphonova, E.3    Buravtsova, I.4
  • 49
    • 85027943274 scopus 로고    scopus 로고
    • Alemtuzumab maintenance may safely prolong chemotherapy-free intervals in chronic lymphocytic leukemia
    • Kaufman M. Caramanica A. Janson D. Driscoll N. Johnson C. Kohn N. et al. (2011) Alemtuzumab maintenance may safely prolong chemotherapy-free intervals in chronic lymphocytic leukemia. Med Oncol 28: 532–538.
    • (2011) Med Oncol , vol.28 , pp. 532-538
    • Kaufman, M.1    Caramanica, A.2    Janson, D.3    Driscoll, N.4    Johnson, C.5    Kohn, N.6
  • 50
    • 0037092951 scopus 로고    scopus 로고
    • Therapeutic role of alemtuzumab (CAMPATH-1H) in patients who have failed fludarabine: results of a large international study
    • Keating M. (2002) Therapeutic role of alemtuzumab (CAMPATH-1H) in patients who have failed fludarabine: results of a large international study. Blood 99: 3554–3561.
    • (2002) Blood , vol.99 , pp. 3554-3561
    • Keating, M.1
  • 51
    • 0037085770 scopus 로고    scopus 로고
    • CAMPATH-1H and fludarabine in combination are highly active in refractory chronic lymphocytic leukemia
    • Kennedy B. (2002) CAMPATH-1H and fludarabine in combination are highly active in refractory chronic lymphocytic leukemia. Blood 99: 2245–2247.
    • (2002) Blood , vol.99 , pp. 2245-2247
    • Kennedy, B.1
  • 52
    • 78751553221 scopus 로고    scopus 로고
    • CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability
    • Lannutti B. Meadows S. Herman S. Kashishian A. Steiner B. Johnson A. et al. (2011) CAL-101, a p110delta selective phosphatidylinositol-3-kinase inhibitor for the treatment of B-cell malignancies, inhibits PI3K signaling and cellular viability. Blood 117: 591–594.
    • (2011) Blood , vol.117 , pp. 591-594
    • Lannutti, B.1    Meadows, S.2    Herman, S.3    Kashishian, A.4    Steiner, B.5    Johnson, A.6
  • 53
    • 35549000261 scopus 로고    scopus 로고
    • Experience with alemtuzumab in treatment of chronic lymphocytic leukaemia in the Netherlands
    • Laros-Van Gorkom B. Huisman C. Wijermans P. Schipperus M. (2007) Experience with alemtuzumab in treatment of chronic lymphocytic leukaemia in the Netherlands. Neth J Med 65: 333–338.
    • (2007) Neth J Med , vol.65 , pp. 333-338
    • Laros-Van Gorkom, B.1    Huisman, C.2    Wijermans, P.3    Schipperus, M.4
  • 54
    • 24944566741 scopus 로고    scopus 로고
    • Low-dose intravenous alemtuzumab therapy in pretreated patients affected by chronic lymphocytic leukemia. A single center experience
    • Laurenti L. Piccioni P. Tarnani M. Efremov D. Fiorini A. Garzia M. et al. (2005) Low-dose intravenous alemtuzumab therapy in pretreated patients affected by chronic lymphocytic leukemia. A single center experience. Haematologica 90: 1143–1145.
    • (2005) Haematologica , vol.90 , pp. 1143-1145
    • Laurenti, L.1    Piccioni, P.2    Tarnani, M.3    Efremov, D.4    Fiorini, A.5    Garzia, M.6
  • 55
    • 84861795688 scopus 로고    scopus 로고
    • Excess mortality after treatment with fludarabine and cyclophosphamide in combination with alemtuzumab in previously untreated patients with chronic lymphocytic leukemia in a randomized phase 3 trial
    • Lepretre S. Aurran T. Mahe B. Cazin B. Tournilhac O. Maisonneuve H. et al. (2012) Excess mortality after treatment with fludarabine and cyclophosphamide in combination with alemtuzumab in previously untreated patients with chronic lymphocytic leukemia in a randomized phase 3 trial. Blood 119: 5104–5110.
    • (2012) Blood , vol.119 , pp. 5104-5110
    • Lepretre, S.1    Aurran, T.2    Mahe, B.3    Cazin, B.4    Tournilhac, O.5    Maisonneuve, H.6
  • 56
    • 0027537357 scopus 로고
    • Differential response in a patient treated with Campath-1H monoclonal antibody for refractory non-Hodgkin lymphoma
    • Lim S. Davey G. Marcus R. (1993) Differential response in a patient treated with Campath-1H monoclonal antibody for refractory non-Hodgkin lymphoma. Lancet 341: 432–433.
    • (1993) Lancet , vol.341 , pp. 432-433
    • Lim, S.1    Davey, G.2    Marcus, R.3
  • 57
    • 21744442455 scopus 로고    scopus 로고
    • Filgrastim and alemtuzumab (Campath-1H) for refractory chronic lymphocytic leukemia
    • Lin T. Flinn I. Lucas M. Porcu P. Sickler J. Moran M. et al. (2005) Filgrastim and alemtuzumab (Campath-1H) for refractory chronic lymphocytic leukemia. Leukemia 19: 1207–1210.
    • (2005) Leukemia , vol.19 , pp. 1207-1210
    • Lin, T.1    Flinn, I.2    Lucas, M.3    Porcu, P.4    Sickler, J.5    Moran, M.6
  • 58
    • 11144357657 scopus 로고    scopus 로고
    • Alemtuzumab is an effective therapy for chronic lymphocytic leukemia with p 53 mutations and deletions
    • Lozanski G. Heerema N. Flinn I. Smith L. Harbison J. Webb J. et al. (2004) Alemtuzumab is an effective therapy for chronic lymphocytic leukemia with p 53 mutations and deletions. Blood 103: 3278–3281.
    • (2004) Blood , vol.103 , pp. 3278-3281
    • Lozanski, G.1    Heerema, N.2    Flinn, I.3    Smith, L.4    Harbison, J.5    Webb, J.6
  • 59
    • 0036683449 scopus 로고    scopus 로고
    • Phase II trial of subcutaneous anti-CD52 monoclonal antibody alemtuzumab (Campath-1H) as first-line treatment for patients with B-cell chronic lymphocytic leukemia (B-CLL)
    • Lundin J. Kimby E. Bjorkholm M. Broliden P. Celsing F. Hjalmar V. et al. (2002) Phase II trial of subcutaneous anti-CD52 monoclonal antibody alemtuzumab (Campath-1H) as first-line treatment for patients with B-cell chronic lymphocytic leukemia (B-CLL). Blood 100: 768–773.
    • (2002) Blood , vol.100 , pp. 768-773
    • Lundin, J.1    Kimby, E.2    Bjorkholm, M.3    Broliden, P.4    Celsing, F.5    Hjalmar, V.6
  • 60
    • 0031757274 scopus 로고    scopus 로고
    • CAMPATH-1H monoclonal antibody in therapy for previously treated low-grade non-Hodgkin's lymphomas: a phase II multicenter study. European Study Group of CAMPATH-1H Treatment in Low-Grade Non-Hodgkin's Lymphoma
    • Lundin J. Osterborg A. Brittinger G. Crowther D. Dombret H. Engert A. et al. (1998) CAMPATH-1H monoclonal antibody in therapy for previously treated low-grade non-Hodgkin's lymphomas: a phase II multicenter study. European Study Group of CAMPATH-1H Treatment in Low-Grade Non-Hodgkin's Lymphoma. J Clin Oncol 16: 3257–3263.
    • (1998) J Clin Oncol , vol.16 , pp. 3257-3263
    • Lundin, J.1    Osterborg, A.2    Brittinger, G.3    Crowther, D.4    Dombret, H.5    Engert, A.6
  • 61
    • 1542503801 scopus 로고    scopus 로고
    • Cellular immune reconstitution after subcutaneous alemtuzumab (anti-CD52 monoclonal antibody, CAMPATH-1H) treatment as first-line therapy for B-cell chronic lymphocytic leukaemia
    • Lundin J. Porwit-Macdonald A. Rossmann E. Karlsson C. Edman P. Rezvany M. et al. (2004) Cellular immune reconstitution after subcutaneous alemtuzumab (anti-CD52 monoclonal antibody, CAMPATH-1H) treatment as first-line therapy for B-cell chronic lymphocytic leukaemia. Leukemia 18: 484–490.
    • (2004) Leukemia , vol.18 , pp. 484-490
    • Lundin, J.1    Porwit-Macdonald, A.2    Rossmann, E.3    Karlsson, C.4    Edman, P.5    Rezvany, M.6
  • 62
    • 33749393174 scopus 로고    scopus 로고
    • High-risk fludarabine-pretreated B-cell chronic lymphocytic leukemia's high response rate following sequential DHAP and alemtuzumab administration though in absence of molecular remission
    • Majolino I. Ladetto M. Locasciulli A. Drandi D. Benedetti F. Gallamini A. et al. (2006) High-risk fludarabine-pretreated B-cell chronic lymphocytic leukemia's high response rate following sequential DHAP and alemtuzumab administration though in absence of molecular remission. Med Oncol 23: 359–368.
    • (2006) Med Oncol , vol.23 , pp. 359-368
    • Majolino, I.1    Ladetto, M.2    Locasciulli, A.3    Drandi, D.4    Benedetti, F.5    Gallamini, A.6
  • 63
    • 33745299246 scopus 로고    scopus 로고
    • Infectious complications associated with alemtuzumab use for lymphoproliferative disorders
    • Martin S. Marty F. Fiumara K. Treon S. Gribben J. Baden L. (2006) Infectious complications associated with alemtuzumab use for lymphoproliferative disorders. Clin Infect Dis 43: 16–24.
    • (2006) Clin Infect Dis , vol.43 , pp. 16-24
    • Martin, S.1    Marty, F.2    Fiumara, K.3    Treon, S.4    Gribben, J.5    Baden, L.6
  • 64
    • 31444453579 scopus 로고    scopus 로고
    • Alemtuzumab induces caspase-independent cell death in human chronic lymphocytic leukemia cells through a lipid raft-dependent mechanism
    • Mone A. Cheney C. Banks A. Tridandapani S. Mehter N. Guster S. et al. (2006) Alemtuzumab induces caspase-independent cell death in human chronic lymphocytic leukemia cells through a lipid raft-dependent mechanism. Leukemia 20: 272–279.
    • (2006) Leukemia , vol.20 , pp. 272-279
    • Mone, A.1    Cheney, C.2    Banks, A.3    Tridandapani, S.4    Mehter, N.5    Guster, S.6
  • 65
    • 80054107144 scopus 로고    scopus 로고
    • An open-label, pilot study of fludarabine, cyclophosphamide, and alemtuzumab in relapsed / refractory patients with B-cell chronic lymphocytic leukemia
    • Montillo M. Tedeschi A. Petrizzi V. Ricci F. Crugnola M. Spriano M. et al. (2011) An open-label, pilot study of fludarabine, cyclophosphamide, and alemtuzumab in relapsed / refractory patients with B-cell chronic lymphocytic leukemia. Blood 118: 4079–4085.
    • (2011) Blood , vol.118 , pp. 4079-4085
    • Montillo, M.1    Tedeschi, A.2    Petrizzi, V.3    Ricci, F.4    Crugnola, M.5    Spriano, M.6
  • 67
    • 79955461011 scopus 로고    scopus 로고
    • Subcutaneous versus intravenous administration of bortezomib in patients with relapsed multiple myeloma: a randomised, phase 3, non-inferiority study
    • Moreau P. Pylypenko H. Grosicki S. Karamanesht I. Leleu X. Grishunina M. et al. (2011) Subcutaneous versus intravenous administration of bortezomib in patients with relapsed multiple myeloma: a randomised, phase 3, non-inferiority study. Lancet Oncol 12: 431–440.
    • (2011) Lancet Oncol , vol.12 , pp. 431-440
    • Moreau, P.1    Pylypenko, H.2    Grosicki, S.3    Karamanesht, I.4    Leleu, X.5    Grishunina, M.6
  • 68
    • 21144456107 scopus 로고    scopus 로고
    • Eradication of minimal residual disease in B-cell chronic lymphocytic leukemia after alemtuzumab therapy is associated with prolonged survival
    • Moreton P. Kennedy B. Lucas G. Leach M. Rassam S. Haynes A. et al. (2005) Eradication of minimal residual disease in B-cell chronic lymphocytic leukemia after alemtuzumab therapy is associated with prolonged survival. J Clin Oncol 23: 2971–2979.
    • (2005) J Clin Oncol , vol.23 , pp. 2971-2979
    • Moreton, P.1    Kennedy, B.2    Lucas, G.3    Leach, M.4    Rassam, S.5    Haynes, A.6
  • 69
    • 8644274039 scopus 로고    scopus 로고
    • A pilot trial of rituximab and alemtuzumab combination therapy in patients with relapsed and / or refractory chronic lymphocytic leukemia (CLL)
    • Nabhan C. Patton D. Gordon L. Riley M. Kuzel T. Tallman M. et al. (2004) A pilot trial of rituximab and alemtuzumab combination therapy in patients with relapsed and / or refractory chronic lymphocytic leukemia (CLL). Leukemia Lymphoma 45: 2269–2273.
    • (2004) Leukemia Lymphoma , vol.45 , pp. 2269-2273
    • Nabhan, C.1    Patton, D.2    Gordon, L.3    Riley, M.4    Kuzel, T.5    Tallman, M.6
  • 70
    • 19444377855 scopus 로고    scopus 로고
    • Alemtuzumab induces enhanced apoptosis in vitro in B-cells from patients with chronic lymphocytic leukemia by antibody-dependent cellular cytotoxicity
    • Nuckel H. Frey U. Roth A. Duhrsen U. Siffert W. (2005) Alemtuzumab induces enhanced apoptosis in vitro in B-cells from patients with chronic lymphocytic leukemia by antibody-dependent cellular cytotoxicity. Eur J Pharmacol 514: 217–224.
    • (2005) Eur J Pharmacol , vol.514 , pp. 217-224
    • Nuckel, H.1    Frey, U.2    Roth, A.3    Duhrsen, U.4    Siffert, W.5
  • 71
    • 84867843137 scopus 로고    scopus 로고
    • Combination of the Bruton's tyrosine kinase (BTK) inhibitor PCI-32765 with bendamustine (B)/rituximab (R) (BR) in patients (pts) with relapsed / refractory (r/r) chronic lymphocytic leukemia (CLL): interim results of a phase Ib / II study, ASCO Annual Meeting
    • abstract 6515
    • O'Brien S. Barrientos J. Flinn I. Barr P. Burger J. Navarro T. et al. (2012) Combination of the Bruton's tyrosine kinase (BTK) inhibitor PCI-32765 with bendamustine (B)/rituximab (R) (BR) in patients (pts) with relapsed / refractory (r/r) chronic lymphocytic leukemia (CLL): interim results of a phase Ib / II study, ASCO Annual Meeting. J Clin Oncol 30(Suppl.): abstract 6515.
    • (2012) J Clin Oncol , vol.30
    • O'Brien, S.1    Barrientos, J.2    Flinn, I.3    Barr, P.4    Burger, J.5    Navarro, T.6
  • 72
    • 84861345119 scopus 로고    scopus 로고
    • The Bruton's tyrosine kinase (BTK) inhibitor PCI-32765 induces durable responses in relapsed or refractory (r/r) chronic lymphocytic leukemia / small lymphocytic lymphoma (CLL/SLL): follow-up of a phase Ib / II study, ASH Annual Meeting
    • abstract 983
    • O'Brien S. Burger J. Blum K. Furman R. Coutre S. Sharman J. et al. (2011) The Bruton's tyrosine kinase (BTK) inhibitor PCI-32765 induces durable responses in relapsed or refractory (r/r) chronic lymphocytic leukemia / small lymphocytic lymphoma (CLL/SLL): follow-up of a phase Ib / II study, ASH Annual Meeting. Blood 118: abstract 983.
    • (2011) Blood , vol.118
    • O'Brien, S.1    Burger, J.2    Blum, K.3    Furman, R.4    Coutre, S.5    Sharman, J.6
  • 73
    • 33750199616 scopus 로고    scopus 로고
    • Updated guidelines on the management of cytomegalovirus reactivation in patients with chronic lymphocytic leukemia treated with alemtuzumab
    • O'Brien S. Keating M. Mocarski E. (2006) Updated guidelines on the management of cytomegalovirus reactivation in patients with chronic lymphocytic leukemia treated with alemtuzumab. Clin Lymphoma Myeloma 7: 125–130.
    • (2006) Clin Lymphoma Myeloma , vol.7 , pp. 125-130
    • O'Brien, S.1    Keating, M.2    Mocarski, E.3
  • 74
    • 41349087090 scopus 로고    scopus 로고
    • Valganciclovir prevents cytomegalovirus reactivation in patients receiving alemtuzumab-based therapy
    • O'Brien S. Ravandi F. Riehl T. Wierda W. Huang X. Tarrand J. et al. (2008) Valganciclovir prevents cytomegalovirus reactivation in patients receiving alemtuzumab-based therapy. Blood 111: 1816–1819.
    • (2008) Blood , vol.111 , pp. 1816-1819
    • O'Brien, S.1    Ravandi, F.2    Riehl, T.3    Wierda, W.4    Huang, X.5    Tarrand, J.6
  • 75
    • 0030897222 scopus 로고    scopus 로고
    • Phase II multicenter study of human CD52 antibody in previously treated chronic lymphocytic leukemia. European Study Group of CAMPATH-1H Treatment in Chronic Lymphocytic Leukemia
    • Osterborg A. Dyer M. Bunjes D. Pangalis G. Bastion Y. Catovsky D. et al. (1997) Phase II multicenter study of human CD52 antibody in previously treated chronic lymphocytic leukemia. European Study Group of CAMPATH-1H Treatment in Chronic Lymphocytic Leukemia. J Clin Oncol 15: 1567–1574.
    • (1997) J Clin Oncol , vol.15 , pp. 1567-1574
    • Osterborg, A.1    Dyer, M.2    Bunjes, D.3    Pangalis, G.4    Bastion, Y.5    Catovsky, D.6
  • 76
    • 0029937765 scopus 로고    scopus 로고
    • Humanized CD52 monoclonal antibody Campath-1H as first-line treatment in chronic lymphocytic leukaemia
    • Osterborg A. Fassas A. Anagnostopoulos A. Dyer M. Catovsky D. Mellstedt H. (1996) Humanized CD52 monoclonal antibody Campath-1H as first-line treatment in chronic lymphocytic leukaemia. Br J Haematol 93: 151–153.
    • (1996) Br J Haematol , vol.93 , pp. 151-153
    • Osterborg, A.1    Fassas, A.2    Anagnostopoulos, A.3    Dyer, M.4    Catovsky, D.5    Mellstedt, H.6
  • 77
    • 70450265546 scopus 로고    scopus 로고
    • Management guidelines for the use of alemtuzumab in chronic lymphocytic leukemia
    • Osterborg A. Foa R. Bezares R. Dearden C. Dyer M. Geisler C. et al. (2009) Management guidelines for the use of alemtuzumab in chronic lymphocytic leukemia. Leukemia 23: 1980–1988.
    • (2009) Leukemia , vol.23 , pp. 1980-1988
    • Osterborg, A.1    Foa, R.2    Bezares, R.3    Dearden, C.4    Dyer, M.5    Geisler, C.6
  • 78
    • 27144437196 scopus 로고    scopus 로고
    • The efficacy of alemtuzumab for refractory chronic lymphocytic leukemia in relation to cytogenetic abnormalities of p53
    • Osuji N. Del Giudice I. Matutes E. Wotherspoon A. Dearden C. Catovsky D. (2005) The efficacy of alemtuzumab for refractory chronic lymphocytic leukemia in relation to cytogenetic abnormalities of p53. Haematologica 90: 1435–1436.
    • (2005) Haematologica , vol.90 , pp. 1435-1436
    • Osuji, N.1    Del Giudice, I.2    Matutes, E.3    Wotherspoon, A.4    Dearden, C.5    Catovsky, D.6
  • 79
    • 84863769805 scopus 로고    scopus 로고
    • Alemtuzumab in combination with methylprednisolone is a highly effective induction regimen for patients with chronic lymphocytic leukemia and deletion of TP53: final results of the National Cancer Research Institute CLL 206 trial
    • Pettitt A. Jackson R. Carruthers S. Dodd J. Dodd S. Oates M. et al. (2012) Alemtuzumab in combination with methylprednisolone is a highly effective induction regimen for patients with chronic lymphocytic leukemia and deletion of TP53: final results of the National Cancer Research Institute CLL 206 trial. J Clin Oncol 30: 1647–1655.
    • (2012) J Clin Oncol , vol.30 , pp. 1647-1655
    • Pettitt, A.1    Jackson, R.2    Carruthers, S.3    Dodd, J.4    Dodd, S.5    Oates, M.6
  • 80
    • 33746137366 scopus 로고    scopus 로고
    • Alemtuzumab in combination with high-dose methylprednisolone is a logical, feasible and highly active therapeutic regimen in chronic lymphocytic leukaemia patients with p 53 defects
    • Pettitt A. Matutes E. Oscier D. (2006) Alemtuzumab in combination with high-dose methylprednisolone is a logical, feasible and highly active therapeutic regimen in chronic lymphocytic leukaemia patients with p 53 defects. Leukemia 20: 1441–1445.
    • (2006) Leukemia , vol.20 , pp. 1441-1445
    • Pettitt, A.1    Matutes, E.2    Oscier, D.3
  • 81
    • 84863011553 scopus 로고    scopus 로고
    • The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo
    • Ponader S. Chen S. Buggy J. Balakrishnan K. Gandhi V. Wierda W. et al. (2012) The Bruton tyrosine kinase inhibitor PCI-32765 thwarts chronic lymphocytic leukemia cell survival and tissue homing in vitro and in vivo. Blood 119: 1182–1189.
    • (2012) Blood , vol.119 , pp. 1182-1189
    • Ponader, S.1    Chen, S.2    Buggy, J.3    Balakrishnan, K.4    Gandhi, V.5    Wierda, W.6
  • 82
    • 84863778287 scopus 로고    scopus 로고
    • ERIC recommendations on TP 53 mutation analysis in chronic lymphocytic leukemia
    • Pospisilova S. Gonzalez D. Malcikova J. Trbusek M. Rossi D. Kater A. et al. (2012) ERIC recommendations on TP 53 mutation analysis in chronic lymphocytic leukemia. Leukemia 26: 1458-1461.
    • (2012) Leukemia , vol.26 , pp. 1458-1461
    • Pospisilova, S.1    Gonzalez, D.2    Malcikova, J.3    Trbusek, M.4    Rossi, D.5    Kater, A.6
  • 83
    • 0037106502 scopus 로고    scopus 로고
    • Alemtuzumab in previously treated chronic lymphocytic leukemia patients who also had received fludarabine
    • Rai K. Freter C. Mercier R. Cooper M. Mitchell B. Stadtmauer E. et al. (2002) Alemtuzumab in previously treated chronic lymphocytic leukemia patients who also had received fludarabine. J Clin Oncol 20: 3891–3897.
    • (2002) J Clin Oncol , vol.20 , pp. 3891-3897
    • Rai, K.1    Freter, C.2    Mercier, R.3    Cooper, M.4    Mitchell, B.5    Stadtmauer, E.6
  • 84
    • 1542343949 scopus 로고    scopus 로고
    • Early prediction of outcome and response to alemtuzumab therapy in chronic lymphocytic leukemia
    • Rawstron A. Kennedy B. Moreton P. Dickinson A. Cullen M. Richards S. et al. (2004) Early prediction of outcome and response to alemtuzumab therapy in chronic lymphocytic leukemia. Blood 103: 2027–2031.
    • (2004) Blood , vol.103 , pp. 2027-2031
    • Rawstron, A.1    Kennedy, B.2    Moreton, P.3    Dickinson, A.4    Cullen, M.5    Richards, S.6
  • 85
    • 33750091306 scopus 로고    scopus 로고
    • Reconstitution of the T-cell repertoire following treatment with alemtuzumab (anti-CD52 monoclonal antibody) in patients with B-cell chronic lymphocytic leukaemia
    • Rezvany M. Tehrani M. Karlsson C. Lundin J. Rabbani H. Osterborg A. et al. (2006) Reconstitution of the T-cell repertoire following treatment with alemtuzumab (anti-CD52 monoclonal antibody) in patients with B-cell chronic lymphocytic leukaemia. Br J Haematol 135: 475–485.
    • (2006) Br J Haematol , vol.135 , pp. 475-485
    • Rezvany, M.1    Tehrani, M.2    Karlsson, C.3    Lundin, J.4    Rabbani, H.5    Osterborg, A.6
  • 87
    • 0842322860 scopus 로고    scopus 로고
    • Efficacy and tolerability of alemtuzumab (CAMPATH-1H) in the salvage treatment of B-cell chronic lymphocytic leukemia–change of regimen needed?
    • Rieger K. von Grunhagen U. Fietz T. Thiel E. Knauf W. (2004) Efficacy and tolerability of alemtuzumab (CAMPATH-1H) in the salvage treatment of B-cell chronic lymphocytic leukemia–change of regimen needed? Leukemia Lymphoma 45: 345–349.
    • (2004) Leukemia Lymphoma , vol.45 , pp. 345-349
    • Rieger, K.1    von Grunhagen, U.2    Fietz, T.3    Thiel, E.4    Knauf, W.5
  • 88
    • 80051580618 scopus 로고    scopus 로고
    • Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths
    • Siegel R. Ward E. Brawley O. Jemal A. (2011) Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin 61: 212–236.
    • (2011) CA Cancer J Clin , vol.61 , pp. 212-236
    • Siegel, R.1    Ward, E.2    Brawley, O.3    Jemal, A.4
  • 90
    • 79551472206 scopus 로고    scopus 로고
    • Subcutaneous alemtuzumab combined with oral dexamethasone, followed by alemtuzumab maintenance or allo-sct in CLL with 17p- or refractory to fludarabine - interim analysis of the CLL2O trial of the GCLLSG and GCGCLL/MW, ASH Annual Meeting
    • abstract 920
    • Stilgenbauer S. Cymbalista F. Leblond V. Delmer A. Zenz T. Winkler D. et al. (2010) Subcutaneous alemtuzumab combined with oral dexamethasone, followed by alemtuzumab maintenance or allo-sct in CLL with 17p- or refractory to fludarabine - interim analysis of the CLL2O trial of the GCLLSG and GCGCLL/MW, ASH Annual Meeting. Blood 116: abstract 920.
    • (2010) Blood , vol.116
    • Stilgenbauer, S.1    Cymbalista, F.2    Leblond, V.3    Delmer, A.4    Zenz, T.5    Winkler, D.6
  • 91
    • 0037043653 scopus 로고    scopus 로고
    • Campath-1H-induced complete remission of chronic lymphocytic leukemia despite p 53 gene mutation and resistance to chemotherapy
    • Stilgenbauer S. Dohner H. (2002) Campath-1H-induced complete remission of chronic lymphocytic leukemia despite p 53 gene mutation and resistance to chemotherapy. New Eng J Med 347: 452–453.
    • (2002) New Eng J Med , vol.347 , pp. 452-453
    • Stilgenbauer, S.1    Dohner, H.2
  • 92
    • 69849107362 scopus 로고    scopus 로고
    • Subcutaneous alemtuzumab in fludarabine-refractory chronic lymphocytic leukemia: clinical results and prognostic marker analyses from the CLL2H study of the German Chronic Lymphocytic Leukemia Study Group
    • Stilgenbauer S. Zenz T. Winkler D. Buhler A. Schlenk R. Groner S. et al. (2009) Subcutaneous alemtuzumab in fludarabine-refractory chronic lymphocytic leukemia: clinical results and prognostic marker analyses from the CLL2H study of the German Chronic Lymphocytic Leukemia Study Group. J Clin Oncol 27: 3994–4001.
    • (2009) J Clin Oncol , vol.27 , pp. 3994-4001
    • Stilgenbauer, S.1    Zenz, T.2    Winkler, D.3    Buhler, A.4    Schlenk, R.5    Groner, S.6
  • 93
    • 84993790415 scopus 로고    scopus 로고
    • Bendamustine and alemtuzumab (Ben Cam) combination in relapsed and refractory chronic lymphocytic leukaemia (CLL): interim report of the Italian trial, 16th Congress of the European Hematology Association
    • abstract 0099
    • Tedeschi A. Coscia M. Rossi D. Ricci F. D'Arena G. Orlandi E. et al. (2011) Bendamustine and alemtuzumab (Ben Cam) combination in relapsed and refractory chronic lymphocytic leukaemia (CLL): interim report of the Italian trial, 16th Congress of the European Hematology Association. Haematologica 96(Suppl. 2): abstract 0099.
    • (2011) Haematologica , vol.96
    • Tedeschi, A.1    Coscia, M.2    Rossi, D.3    Ricci, F.4    D'Arena, G.5    Orlandi, E.6
  • 94
    • 10744231366 scopus 로고    scopus 로고
    • Maintenance therapy with a monthly injection of alemtuzumab prolongs response duration in patients with refractory B-cell chronic lymphocytic leukemia / small lymphocytic lymphoma (B-CLL/SLL)
    • Thieblemont C. Bouafia F. Hornez E. Dumontet C. Tartas S. Antal D. et al. (2004) Maintenance therapy with a monthly injection of alemtuzumab prolongs response duration in patients with refractory B-cell chronic lymphocytic leukemia / small lymphocytic lymphoma (B-CLL/SLL). Leukemia Lymphoma 45: 711–714.
    • (2004) Leukemia Lymphoma , vol.45 , pp. 711-714
    • Thieblemont, C.1    Bouafia, F.2    Hornez, E.3    Dumontet, C.4    Tartas, S.5    Antal, D.6
  • 95
    • 84993734647 scopus 로고    scopus 로고
    • Treatment of B-CLL and T cell non-Hodgkin lymphomas patients with alemtuzumab; the experience of a single Romanian center, 16th Congress of the European Hematology Association
    • abstract 1189
    • Ursuleac I. Georgescu O. Vasilica M. Niculescu-Mizil E. Stoia R. Badelita S. et al. (2011) Treatment of B-CLL and T cell non-Hodgkin lymphomas patients with alemtuzumab; the experience of a single Romanian center, 16th Congress of the European Hematology Association. Haematologica 96(Suppl. 2): abstract 1189.
    • (2011) Haematologica , vol.96
    • Ursuleac, I.1    Georgescu, O.2    Vasilica, M.3    Niculescu-Mizil, E.4    Stoia, R.5    Badelita, S.6
  • 96
    • 79951786213 scopus 로고    scopus 로고
    • Incidence of cytomegalovirus infection and disease in patients with lymphoproliferative disorders treated with alemtuzumab
    • Vallejo C. Rios E. de La Serna J. Jarque I. Ferra C. Sanchez-Godoy P. et al. (2011) Incidence of cytomegalovirus infection and disease in patients with lymphoproliferative disorders treated with alemtuzumab. Exp Rev Hematol 4: 9–16.
    • (2011) Exp Rev Hematol , vol.4 , pp. 9-16
    • Vallejo, C.1    Rios, E.2    de La Serna, J.3    Jarque, I.4    Ferra, C.5    Sanchez-Godoy, P.6
  • 97
    • 79955817714 scopus 로고    scopus 로고
    • Long term survival report of the UKCLL 02 trial: a phase II study of subcutaneous alemtuzumab in patients with fludarabine refractory CLL (on behalf of the NCRI CLL trials sub-group), ASH Annual Meeting
    • abstract 922
    • Varghese A. Sayala H. Moreton P. Jones R. Rawstron A. Sheila J. et al. (2010) Long term survival report of the UKCLL 02 trial: a phase II study of subcutaneous alemtuzumab in patients with fludarabine refractory CLL (on behalf of the NCRI CLL trials sub-group), ASH Annual Meeting. Blood 116: abstract 922.
    • (2010) Blood , vol.116
    • Varghese, A.1    Sayala, H.2    Moreton, P.3    Jones, R.4    Rawstron, A.5    Sheila, J.6
  • 98
    • 0027194472 scopus 로고
    • Structure of the CAMPATH-1 antigen, a glycosylphosphatidylinositol-anchored glycoprotein which is an exceptionally good target for complement lysis
    • Xia M. Hale G. Lifely M. Ferguson M. Campbell D. Packman L. et al. (1993) Structure of the CAMPATH-1 antigen, a glycosylphosphatidylinositol-anchored glycoprotein which is an exceptionally good target for complement lysis. Biochem J 293: 633–640.
    • (1993) Biochem J , vol.293 , pp. 633-640
    • Xia, M.1    Hale, G.2    Lifely, M.3    Ferguson, M.4    Campbell, D.5    Packman, L.6
  • 99
    • 0027283918 scopus 로고
    • Efficient complement-mediated lysis of cells containing the CAMPATH-1 (CDw52) antigen
    • Xia M. Hale G. Waldmann H. (1993) Efficient complement-mediated lysis of cells containing the CAMPATH-1 (CDw52) antigen. Mol Immunol 30: 1089–1096.
    • (1993) Mol Immunol , vol.30 , pp. 1089-1096
    • Xia, M.1    Hale, G.2    Waldmann, H.3
  • 100
    • 0025878925 scopus 로고
    • Characterization of the CAMPATH-1 (CDw52) antigen: Biochemical analysis and cDNA cloning reveal an unusually small peptide backbone
    • Xia M. Tone M. Packman L. Hale G. Waldmann H. (1991) Characterization of the CAMPATH-1 (CDw52) antigen: Biochemical analysis and cDNA cloning reveal an unusually small peptide backbone. Eur J Immunol 21: 1677–1684.
    • (1991) Eur J Immunol , vol.21 , pp. 1677-1684
    • Xia, M.1    Tone, M.2    Packman, L.3    Hale, G.4    Waldmann, H.5
  • 101
    • 84993734667 scopus 로고    scopus 로고
    • Monoclonal anti-CD52 antibody treatment in chronic lymphocytic leukemia patients that are refractory to fludarabine-containing chemotherapy regimens, 16th Congress of the European Hematology Association
    • abstract 1186
    • Zagoskina P. Zotina E. Grishina I. Demyanova V. (2011) Monoclonal anti-CD52 antibody treatment in chronic lymphocytic leukemia patients that are refractory to fludarabine-containing chemotherapy regimens, 16th Congress of the European Hematology Association. Haematologica 96(Suppl. 2): abstract 1186.
    • (2011) Haematologica , vol.96
    • Zagoskina, P.1    Zotina, E.2    Grishina, I.3    Demyanova, V.4
  • 102
    • 84993692691 scopus 로고    scopus 로고
    • Pentostatin, alemtuzumab, and low dose rituximab is effective therapy for relapsed / refractory chronic lymphocytic leukemia / small lymphocytic lymphoma (CLL), ASH Annual Meeting
    • abstract 1790
    • Zent C. Laplant B. Link B. Call T. Shanafelt T. Bowen D. et al. (2011) Pentostatin, alemtuzumab, and low dose rituximab is effective therapy for relapsed / refractory chronic lymphocytic leukemia / small lymphocytic lymphoma (CLL), ASH Annual Meeting. Blood 118: abstract 1790.
    • (2011) Blood , vol.118
    • Zent, C.1    Laplant, B.2    Link, B.3    Call, T.4    Shanafelt, T.5    Bowen, D.6


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