Humanized CD52 monoclonal antibody Campath-1H as first-line treatment in chronic lymphocytic leukaemia

British Journal of Haematology

Volumn 93, Issue 1, 1996, Pages 151-153

  Österborg, Anders ^a   Fassas, Athanasios S ^b   Anagnostopoulos, Achilles ^b   Dyer, Martin J S ^c   Catovsky, Daniel ^c   Mellstedt, Håkan ^a  

^a KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^b Papanicolaou General Hospital   (Greece)

^c INSTITUTE OF CANCER RESEARCH   (United Kingdom)

Author keywords

Campath 1H; chronic lymphocytic leukaemia; monoclonal antibody; therapy

Indexed keywords

ALEMTUZUMAB; MONOCLONAL ANTIBODY; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER IMMUNOTHERAPY; CHRONIC LYMPHATIC LEUKEMIA; CLINICAL ARTICLE; CLINICAL TRIAL; FEMALE; HUMAN; INTRAVENOUS DRUG ADMINISTRATION; LYMPHOCYTOPENIA; MALE; PRIORITY JOURNAL; SUBCUTANEOUS DRUG ADMINISTRATION; VIRUS INFECTION;

ADULT; AGED; ANTIGENS, CD; ANTIGENS, NEOPLASM; DRUG ADMINISTRATION SCHEDULE; FEMALE; GLYCOPROTEINS; HUMANS; INJECTIONS, INTRAVENOUS; INJECTIONS, SUBCUTANEOUS; LEUKEMIA, LYMPHOCYTIC, CHRONIC; MALE; MIDDLE AGED;

EID: 0029937765     PISSN: 00071048     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2141.1996.450989.x     Document Type: Article

References (12)

1. Cheson, B.D., Bennet, J.M., Rai, K.R., Grever, M.R., Kay, N.E., Schiffer, C.A., Oken, M.M., Keating, M.J., Boldt, D.H., Kempin, S.J. & Foon, K.A. (1988) Guidelines for clinical protocols for chronic lymphocytic leukemia: recommendations of the National Cancer Institute-sponsored Working Group. American Journal of Hematology, 29, 152-163.
2. Dyer, M.J.S., Barge, R., Matutes, E., de Schouwer, P.J.J.C., Yuille, M.A.R., Emmet, E., Kluin-Nelemans, H.C., Fibbe, W.E., Fussel, J., Nethersell, A.B.W., Willemze, R. & Catovsky, D. (1995) Successful treatment of T-cell prolymphocytic leukaemia (T-PLL) with human CD52 antibody, Campath-1H. Abstract, Annual Meeting of the British Society of Haematology.
3. Dyer, M.J.S., Hale, G., Marcus, R. & Waldman, R. (1990) Remission induction in patients with lymphoid malignancies using unconjugated Campath-1 monoclonal antibodies. Leukemia and Lymphoma, 2, 179-193.
4. Gilleece, M.H. & Dexter, T.M. (1993) Effect of Campath-1H antibody on human hematopoietic progenitors in vitro. Blood, 82, 807-812.
5. Hale, G., Clark, M. & Waldmann, H. (1985) Therapeutic potential of rat monoclonal antibodies: isotype specificity of antibody-dependent cell-mediated cytotoxicity with human lymphocytes. Journal of Immunology, 134, 3056-3061.
6. Hale, G., Dyer, M.J.S., Clark, M.R., Phillips, J.M., Marcus, R., Riechmann, L., Winter, G. & Waldmann, H. (1988) Remission induction in non-Hodgkin lymphoma with reshaped human monoclonal antibody Campath-1H. Lancet, i, 1394-1399.
7. Juliusson, G. & Liliemark, J. (1993) High complete remission rate from 2-chloro-2́-deoxyadenosine in previously treated patients with B-cell chronic lymphocytic leukemia: response predicted by rapid decrease of blood lymphocyte count. Journal of Clinical Oncology, 11, 679-689.
8. Keating, M.J., O'Brien, S., Kantarjian, H., Plunkett, W., Estey, E., Koller, C., Beran, M. & Freireich, E.J. (1993) Long-term follow-up of patients with chronic lymphocytic leukemia treated with fludarabine as a single agent. Blood, 81, 2878-2884.
9. Lim, S.H., Davey, G. & Marcus, R. (1993) Differential response in a patient treated with Campath-1H monoclonal antibody for refractory non-Hodgkin lymphoma. Lancet, 341, 432-433.
10. Rai, K.R., Sawitsky, A., Cronkite, E.P., Chanana, A.D., Levy, R.N. & Pasternack, B.S. (1975) Clinical staging of chronic lymphocytic leukemia. Blood, 46, 219-234.
11. Riechmann, L., Clark, M., Waldmann, H. & Winter, G. (1988) Reshaping human antibodies for therapy. Nature, 332, 323-327.
12. Saven, A., Lemon, R.H., Kosty, M., Beutler, E. & Piro, L.D. (1995) 2-Chlorodeoxy-adenosine activity in patients with untreated chronic lymphocytic leukemia. Journal of Clinical Oncology, 13, 570-574.