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Volumn 23, Issue 3, 2006, Pages 359-368

High-risk fludarabine-pretreated B-cell chronic lymphocytic leukemia's high response rate following sequential DHAP and alemtuzumab administration though in absence of molecular remission

Author keywords

Alemtuzumab; CLL; DHAP, autograft; Unmutated IgVH

Indexed keywords

ALEMTUZUMAB; CHLORPHENIRAMINE; CISPLATIN; CYCLOPHOSPHAMIDE; CYTARABINE; DEXAMETHASONE; FLUDARABINE; FOSCARNET SODIUM; GANCICLOVIR; MELPHALAN; MITOXANTRONE;

EID: 33749393174     PISSN: 13570560     EISSN: None     Source Type: Journal    
DOI: 10.1385/MO:23:3:359     Document Type: Article
Times cited : (7)

References (36)
  • 1
    • 0842285686 scopus 로고    scopus 로고
    • Prognosis at diagnosis: Integrating molecular biologic insights into clinical practice for patients with CLL
    • Shanafelt TD, Geyer SM, Kay NE. Prognosis at diagnosis: integrating molecular biologic insights into clinical practice for patients with CLL. Blood 2004; 103: 1202-1210.
    • (2004) Blood , vol.103 , pp. 1202-1210
    • Shanafelt, T.D.1    Geyer, S.M.2    Kay, N.E.3
  • 2
    • 2442554041 scopus 로고    scopus 로고
    • Guidelines on the diagnosis and management of chronic lymphocytic leukemia
    • Guidelines Working Group of the UK CLL Forum. British Committee for Standards in Haematology
    • Oscier D, Fegan C, Hillmen P, et al. Guidelines Working Group of the UK CLL Forum. British Committee for Standards in Haematology. Guidelines on the diagnosis and management of chronic lymphocytic leukemia. Br J Haematol 2004; 125: 294-317.
    • (2004) Br J Haematol , vol.125 , pp. 294-317
    • Oscier, D.1    Fegan, C.2    Hillmen, P.3
  • 3
    • 0027323550 scopus 로고
    • Results of fludarabine and prednisone therapy in 264 patients with chronic lymphocytic leukemia with multivariate analysis-derived prognostic model for response to treatment
    • O'Brien S, Kantarjian H, Beran M, et al. Results of fludarabine and prednisone therapy in 264 patients with chronic lymphocytic leukemia with multivariate analysis-derived prognostic model for response to treatment. Blood 1993; 82: 1695-1700.
    • (1993) Blood , vol.82 , pp. 1695-1700
    • O'Brien, S.1    Kantarjian, H.2    Beran, M.3
  • 4
    • 0027200169 scopus 로고
    • Long-term follow-up of patients with chronic lymphocytic leukemia treated with fludarabine as a single agent
    • Keating MJ, O'Brien S, Kantarjian H, et al. Long-term follow-up of patients with chronic lymphocytic leukemia treated with fludarabine as a single agent. Blood 1993; 81: 2878-2884.
    • (1993) Blood , vol.81 , pp. 2878-2884
    • Keating, M.J.1    O'Brien, S.2    Kantarjian, H.3
  • 5
    • 0029145388 scopus 로고
    • Survival of young patients with chronic lymphocytic leukemia failing fludarabine therapy: A basis for the use of myeloablative regimens
    • Seymour JF, Robertson LE, O'Brien S, Lerner S, Keating MJ. Survival of young patients with chronic lymphocytic leukemia failing fludarabine therapy: a basis for the use of myeloablative regimens. Leuk Lymphoma 1995; 18: 493-496.
    • (1995) Leuk Lymphoma , vol.18 , pp. 493-496
    • Seymour, J.F.1    Robertson, L.E.2    O'Brien, S.3    Lerner, S.4    Keating, M.J.5
  • 6
    • 0036335916 scopus 로고    scopus 로고
    • Results of first salvage therapy for patients refractory to a fludarabine regimen in chronic lymphocytic leukemia
    • Keating MJ, O'Brien S, Kontoyiannis D, et al. Results of first salvage therapy for patients refractory to a fludarabine regimen in chronic lymphocytic leukemia. Leuk Lymphoma 2002; 43: 1755-1762.
    • (2002) Leuk Lymphoma , vol.43 , pp. 1755-1762
    • Keating, M.J.1    O'Brien, S.2    Kontoyiannis, D.3
  • 7
    • 0033567907 scopus 로고    scopus 로고
    • Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia
    • Hamblin TJ, Davis Z, Gardiner A, Oscier DG, Stevenson FK. Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia. Blood 1999; 94: 1848-1854.
    • (1999) Blood , vol.94 , pp. 1848-1854
    • Hamblin, T.J.1    Davis, Z.2    Gardiner, A.3    Oscier, D.G.4    Stevenson, F.K.5
  • 8
    • 0036275343 scopus 로고    scopus 로고
    • Genetics of chronic lymphocytic leukemia: Genomic aberrations and V(H) gene mutation status in pathogenesis and clinical course
    • Stilgenbauer S, Bullinger L, Lichter P, Dohner H. Genetics of chronic lymphocytic leukemia: genomic aberrations and V(H) gene mutation status in pathogenesis and clinical course. Leukemia 2002; 16: 993-1007.
    • (2002) Leukemia , vol.16 , pp. 993-1007
    • Stilgenbauer, S.1    Bullinger, L.2    Lichter, P.3    Dohner, H.4
  • 9
    • 0037370910 scopus 로고    scopus 로고
    • Unmutated immunoglobulin variable heavy-chain gene status remains an adverse prognostic factor after autologous stem cell transplantation for chronic lymphocytic leukemia
    • Ritgen M, Lange A, Stilgenbauer S, et al. Unmutated immunoglobulin variable heavy-chain gene status remains an adverse prognostic factor after autologous stem cell transplantation for chronic lymphocytic leukemia. Blood 2003; 101: 2049-2053.
    • (2003) Blood , vol.101 , pp. 2049-2053
    • Ritgen, M.1    Lange, A.2    Stilgenbauer, S.3
  • 10
    • 4344659804 scopus 로고    scopus 로고
    • Role of auto- and allotransplantation in B-cell chronic lymphocytic leukemia
    • Montserrat E. Role of auto- and allotransplantation in B-cell chronic lymphocytic leukemia. Hematol Oncol Clin North Am 2004; 18: 915-926.
    • (2004) Hematol Oncol Clin North Am , vol.18 , pp. 915-926
    • Montserrat, E.1
  • 11
    • 0030897222 scopus 로고    scopus 로고
    • Phase II multicenter study of human CD52 antibody in previously treated chronic lymphocytic leukemia: European study group of Campath-1H treatment in chronic lymphocytic leukemia
    • Osterborg A, Dyer MJ, Bunjes D, et al. Phase II multicenter study of human CD52 antibody in previously treated chronic lymphocytic leukemia: European study group of Campath-1H treatment in chronic lymphocytic leukemia. J Clin Oncol 1997; 15: 1567-1574.
    • (1997) J Clin Oncol , vol.15 , pp. 1567-1574
    • Osterborg, A.1    Dyer, M.J.2    Bunjes, D.3
  • 12
    • 0037106502 scopus 로고    scopus 로고
    • Alemtuzumab in previously treated chronic lymphocytic leukemia patients who also had received fludarabine
    • Rai KR, Freter CE, Mercier RJ, et al. Alemtuzumab in previously treated chronic lymphocytic leukemia patients who also had received fludarabine. J Clin Oncol 2002; 20: 3891-3897.
    • (2002) J Clin Oncol , vol.20 , pp. 3891-3897
    • Rai, K.R.1    Freter, C.E.2    Mercier, R.J.3
  • 13
    • 11144357657 scopus 로고    scopus 로고
    • Alemtuzumab is an effective therapy for chronic lymphocytic leukemia with p53 mutations and deletions
    • Lozanski G, Heerema NA, Flinn IW, et al. Alemtuzumab is an effective therapy for chronic lymphocytic leukemia with p53 mutations and deletions. Blood 2004; 103: 3278-3281.
    • (2004) Blood , vol.103 , pp. 3278-3281
    • Lozanski, G.1    Heerema, N.A.2    Flinn, I.W.3
  • 14
    • 0023818185 scopus 로고
    • Effective salvage therapy for lymphoma with cisplatin in combination with high-dose Ara-C and dexamethasone
    • Velasquez WS, Cabanillas F, Salvador P, et al. Effective salvage therapy for lymphoma with cisplatin in combination with high-dose Ara-C and dexamethasone Blood 1988; 71: 117-122.
    • (1988) Blood , vol.71 , pp. 117-122
    • Velasquez, W.S.1    Cabanillas, F.2    Salvador, P.3
  • 15
    • 0030886589 scopus 로고    scopus 로고
    • Long-term follow-up of platinum-based lymphoma salvage regimens. The MD Anderson Cancer Center experience
    • Rodriguez-Monge EJ, Cabanillas F. Long-term follow-up of platinum-based lymphoma salvage regimens. The MD Anderson Cancer Center experience. Hematol Oncol Clin North Am 1997; 11: 937-947.
    • (1997) Hematol Oncol Clin North Am , vol.11 , pp. 937-947
    • Rodriguez-Monge, E.J.1    Cabanillas, F.2
  • 16
    • 0029981025 scopus 로고    scopus 로고
    • National Cancer Institute - Sponsored Working Group guidelines for chronic lymphocytic leukemia: Revised guidelines for diagnosis and treatment
    • Cheson BD, Bennett JM, Grever M, et al. National Cancer Institute - sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment. Blood 1996; 87: 4990-4997.
    • (1996) Blood , vol.87 , pp. 4990-4997
    • Cheson, B.D.1    Bennett, J.M.2    Grever, M.3
  • 17
    • 0036076178 scopus 로고    scopus 로고
    • Safety and efficacy of subcutaneous Campath-1H for treating residual disease in patients with chronic lymphocytic leukemia responding to fludarabine
    • Montillo M, Cafro AM, Tedeschi A, et al. Safety and efficacy of subcutaneous Campath-1H for treating residual disease in patients with chronic lymphocytic leukemia responding to fludarabine. Haematologica 2002; 87: 695-700.
    • (2002) Haematologica , vol.87 , pp. 695-700
    • Montillo, M.1    Cafro, A.M.2    Tedeschi, A.3
  • 18
    • 17744381950 scopus 로고    scopus 로고
    • High-dose mitoxantrone + melphalan (MITO/L-PAM) as conditioning regimen supported by peripheral blood progenitor cell (PBPC) autograft in 113 lymphoma patients: High tolerability with reversible cardiotoxicity
    • Tarella C, Zallio F, Caracciolo D, et al. High-dose mitoxantrone + melphalan (MITO/L-PAM) as conditioning regimen supported by peripheral blood progenitor cell (PBPC) autograft in 113 lymphoma patients: high tolerability with reversible cardiotoxicity. Leukemia 2001; 15: 256-263.
    • (2001) Leukemia , vol.15 , pp. 256-263
    • Tarella, C.1    Zallio, F.2    Caracciolo, D.3
  • 19
    • 0028858311 scopus 로고
    • Both early and committed progenitors are more frequent in peripheral blood than in bone marrow during mobilization induced by high-dose chemotherapy + G-CSF
    • Tarella C, Benedetti G, Caracciolo D, et al. Both early and committed progenitors are more frequent in peripheral blood than in bone marrow during mobilization induced by high-dose chemotherapy + G-CSF. Br J Haemat 1995; 91: 535-543.
    • (1995) Br J Haemat , vol.91 , pp. 535-543
    • Tarella, C.1    Benedetti, G.2    Caracciolo, D.3
  • 20
    • 0033642606 scopus 로고    scopus 로고
    • Real-time polymerase chain reaction of immunoglobulin rearrangements for quantitative evaluation of minimal residual disease in multiple myeloma
    • Ladetto M, Donovan JW, Harig S, et al. Real-time polymerase chain reaction of immunoglobulin rearrangements for quantitative evaluation of minimal residual disease in multiple myeloma. Biol Blood Marrow Transplant 2000; 6: 241-253.
    • (2000) Biol Blood Marrow Transplant , vol.6 , pp. 241-253
    • Ladetto, M.1    Donovan, J.W.2    Harig, S.3
  • 21
    • 0034655973 scopus 로고    scopus 로고
    • Immunoglobulin heavy-chain consensus probes for real-time PCR quantification of residual disease in acute lymphoblastic leukemia
    • Donovan JW, Ladetto M, Zou G, et al. Immunoglobulin heavy-chain consensus probes for real-time PCR quantification of residual disease in acute lymphoblastic leukemia. Blood 2000; 95: 2651-2658.
    • (2000) Blood , vol.95 , pp. 2651-2658
    • Donovan, J.W.1    Ladetto, M.2    Zou, G.3
  • 22
    • 2942586613 scopus 로고    scopus 로고
    • Telomere length correlates with histopathogenesis according to the germinal center in mature B-cell lymphoproliferative disorders
    • Ladetto M, Compagno M, Ricca I, et al. Telomere length correlates with histopathogenesis according to the germinal center in mature B-cell lymphoproliferative disorders. Blood 2004; 103: 4644-4650.
    • (2004) Blood , vol.103 , pp. 4644-4650
    • Ladetto, M.1    Compagno, M.2    Ricca, I.3
  • 23
    • 0030698409 scopus 로고    scopus 로고
    • A novel nested- PCR strategy for the detection of rearranged immunoglobulin heavy-chain genes in B cell tumors
    • Voena C, Ladetto M, Astolfi M, et al. A novel nested- PCR strategy for the detection of rearranged immunoglobulin heavy-chain genes in B cell tumors. Leukemia 1997; 11: 1793-1798.
    • (1997) Leukemia , vol.11 , pp. 1793-1798
    • Voena, C.1    Ladetto, M.2    Astolfi, M.3
  • 25
    • 0037092951 scopus 로고    scopus 로고
    • Therapeutic role of alemtuzumab (Campath-1H) in patients who have failed fludarabine: Results of a large international study
    • Keating MJ, Flinn I, Jain V, et al. Therapeutic role of alemtuzumab (Campath-1H) in patients who have failed fludarabine: results of a large international study. Blood 2002; 99: 3554-3561.
    • (2002) Blood , vol.99 , pp. 3554-3561
    • Keating, M.J.1    Flinn, I.2    Jain, V.3
  • 26
    • 0036683449 scopus 로고    scopus 로고
    • Phase II trial of subcutaneous anti-CD52 monoclonal antibody alemtuzumab (Campath-1H) as first line treatment for patients with B-cell chronic lymphocytic leukemia (B-CLL)
    • Lundin J, Kimby E, Bjorkholm M, et al. Phase II trial of subcutaneous anti-CD52 monoclonal antibody alemtuzumab (Campath-1H) as first line treatment for patients with B-cell chronic lymphocytic leukemia (B-CLL). Blood 2002; 100: 768-773.
    • (2002) Blood , vol.100 , pp. 768-773
    • Lundin, J.1    Kimby, E.2    Bjorkholm, M.3
  • 27
    • 0036534380 scopus 로고    scopus 로고
    • Frequency and type of serious infections in fludarabine-refractory B-cell chronic lymphocytic leukemia and small lymphocytic lymphoma: Implications for clinical trials in this patient population
    • Perkins JG, Flynn JM, Howard RS, Byrd JC. Frequency and type of serious infections in fludarabine-refractory B-cell chronic lymphocytic leukemia and small lymphocytic lymphoma: implications for clinical trials in this patient population. Cancer 2002; 94: 2033-2039.
    • (2002) Cancer , vol.94 , pp. 2033-2039
    • Perkins, J.G.1    Flynn, J.M.2    Howard, R.S.3    Byrd, J.C.4
  • 28
    • 0034254354 scopus 로고    scopus 로고
    • Successful in vivo purging of CD34-containing peripheral blood harvests in mantle cell and indolent lymphoma: Evidence for a role of both chemotherapy and rituximab infusion
    • Magni M, Di Nicola M, Devizzi L, et al. Successful in vivo purging of CD34-containing peripheral blood harvests in mantle cell and indolent lymphoma: evidence for a role of both chemotherapy and rituximab infusion. Blood 2000; 96: 864-869.
    • (2000) Blood , vol.96 , pp. 864-869
    • Magni, M.1    Di Nicola, M.2    Devizzi, L.3
  • 29
    • 0032437075 scopus 로고    scopus 로고
    • PBSC mobilization, collection and positive selection in patients with chronic lymphocytic leukemia
    • Scimè R, Indovina A, Santoro A, et al. PBSC mobilization, collection and positive selection in patients with chronic lymphocytic leukemia. Bone Marrow Transplant 1998; 22: 1159-1165.
    • (1998) Bone Marrow Transplant , vol.22 , pp. 1159-1165
    • Scimè, R.1    Indovina, A.2    Santoro, A.3
  • 30
    • 9144222685 scopus 로고    scopus 로고
    • Impact of frontline fludarabine and cyclophosphamide combined treatment on peripheral blood stem cell mobilization in B-cell chronic lymphocytic leukemia
    • Tournilhac O, Cazin B, Lepretre S, et al. Impact of frontline fludarabine and cyclophosphamide combined treatment on peripheral blood stem cell mobilization in B-cell chronic lymphocytic leukemia. Blood 2004; 103: 363-365.
    • (2004) Blood , vol.103 , pp. 363-365
    • Tournilhac, O.1    Cazin, B.2    Lepretre, S.3
  • 31
    • 1642292996 scopus 로고    scopus 로고
    • The prognostic impact of autologous stem cell transplantation in patients with chronic lymphocytic leukemia: A riskmatched analysis based on the VH gene mutational status
    • Dreger P, Stilgenbauer S, Benner A, et al. The prognostic impact of autologous stem cell transplantation in patients with chronic lymphocytic leukemia: a riskmatched analysis based on the VH gene mutational status. Blood 2004; 103: 2850-2858.
    • (2004) Blood , vol.103 , pp. 2850-2858
    • Dreger, P.1    Stilgenbauer, S.2    Benner, A.3
  • 32
    • 0038528397 scopus 로고    scopus 로고
    • Treatment-related mortality and graft-versus-leukemia activity after allogeneic stem cell transplantation for chronic lymphocytic leukemia using intensity-reduced conditioning
    • Dreger P, Brand R, Hansz J, et al. Treatment-related mortality and graft-versus-leukemia activity after allogeneic stem cell transplantation for chronic lymphocytic leukemia using intensity-reduced conditioning. Leukemia 2003; 17: 841-848.
    • (2003) Leukemia , vol.17 , pp. 841-848
    • Dreger, P.1    Brand, R.2    Hansz, J.3
  • 33
    • 2642551675 scopus 로고    scopus 로고
    • Graft-versus-leukemia activity may overcome therapeutic resistance of chronic lymphocytic leukemia with unmutated immunoglobulin variable heavy-chain gene status: Implications of minimal residual disease measurement with quantitative PCR
    • Ritgen M, Stilgenbauer S, von Neuhoff N, et al. Graft-versus-leukemia activity may overcome therapeutic resistance of chronic lymphocytic leukemia with unmutated immunoglobulin variable heavy-chain gene status: implications of minimal residual disease measurement with quantitative PCR. Blood 2004; 104: 2600-2602.
    • (2004) Blood , vol.104 , pp. 2600-2602
    • Ritgen, M.1    Stilgenbauer, S.2    Von Neuhoff, N.3
  • 34
    • 3242668097 scopus 로고    scopus 로고
    • The role of stem cell transplantation in chronic lymphocytic leukemia
    • Rizouli V, Gribben Jg J. The role of stem cell transplantation in chronic lymphocytic leukemia. Semin Hematol 2004; 41: 246-253.
    • (2004) Semin Hematol , vol.41 , pp. 246-253
    • Rizouli, V.1    Gribben, Jg.J.2
  • 35
    • 0035871445 scopus 로고    scopus 로고
    • Rituximab using a thrice weekly dosing schedule in B-cell chronic lymphocytic leukemia and small lymphocytic lymphoma demonstrates clinical activity and acceptable toxicity
    • Byrd JC, Murphy T, Howard RS, et al. Rituximab using a thrice weekly dosing schedule in B-cell chronic lymphocytic leukemia and small lymphocytic lymphoma demonstrates clinical activity and acceptable toxicity. J Clin Oncol 2001; 19: 2153-2164.
    • (2001) J Clin Oncol , vol.19 , pp. 2153-2164
    • Byrd, J.C.1    Murphy, T.2    Howard, R.S.3
  • 36
    • 0038724252 scopus 로고    scopus 로고
    • Experience with alemtuzumab plus rituximab in patients with relapsed and refractory lymphoid malignancies
    • Faderl S, Thomas DA, O'Brien S, et al. Experience with alemtuzumab plus rituximab in patients with relapsed and refractory lymphoid malignancies. Blood 2003; 101: 3413-3415.
    • (2003) Blood , vol.101 , pp. 3413-3415
    • Faderl, S.1    Thomas, D.A.2    O'Brien, S.3


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