Interleukin 2 activates brain microvascular endothelial cells resulting in destabilization of adherens junctions

Journal of Biological Chemistry

Volumn 291, Issue 44, 2016, Pages 22913-22923

  Wylezinski, Lukasz S ^a   Hawiger, Jacek ^a,b,c  

^a Departments of Biomedical Engineering and Molecular Physiology and Biophysics   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c DEPARTMENT OF VETERANS AFFAIRS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; BLOOD VESSELS; CELLS; CYTOLOGY; DISEASES; GLYCOPROTEINS; MICROCIRCULATION; NEUROLOGY; PHOSPHORYLATION; PROTEINS;

BLOOD-BRAIN BARRIER; BRAIN MICROVASCULAR ENDOTHELIAL CELLS; CANCER IMMUNOTHERAPY; CENTRAL NERVOUS SYSTEMS; DELETERIOUS EFFECTS; NEUROLOGICAL DISORDERS; NUCLEAR FACTOR KAPPAB; SRC HOMOLOGY 2 DOMAINS;

ENDOTHELIAL CELLS;

ADAPTOR PROTEIN; BETA CATENIN; CD31 ANTIGEN; F ACTIN; HYBRID PROTEIN; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; PROTEIN P120; PROTEIN P120 CATENIN COMPLEX; PROTEIN TYROSINE PHOSPHATASE SHP; SRC HOMOLOGY 2 DOMAIN CONTAINING PROTEIN TYROSINE PHOSPHATASE 2; TRANSCRIPTION FACTOR RELA; TUMOR NECROSIS FACTOR; UNCLASSIFIED DRUG; VASCULAR ENDOTHELIAL CADHERIN; VASCULAR ENDOTHELIAL CADHERIN BETA CATENIN COMPLEX; VASCULAR ENDOTHELIAL CADHERIN PROTEIN P120 COMPLEX; VON WILLEBRAND FACTOR;

ADHERENS JUNCTION; ANIMAL CELL; ARTICLE; BRAIN CAPILLARY ENDOTHELIAL CELL; CELL ACTIVATION; CELL DISRUPTION; CELL INTERACTION; CELL MEMBRANE PERMEABILITY; CELL TRANSPORT; CONTROLLED STUDY; CYTOSKELETON; HUMAN; HUMAN CELL; HUMAN VERSUS ANIMAL COMPARISON; NONHUMAN; PERMEABILITY BARRIER; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN TRANSPORT; RAT; SIGNAL TRANSDUCTION; ANIMAL; BLOOD BRAIN BARRIER; BRAIN; CAPILLARY PERMEABILITY; CELL CULTURE; ENDOTHELIUM CELL; GENETICS; METABOLISM; MICROVASCULATURE; MOUSE; VASCULARIZATION;

ADHERENS JUNCTIONS; ANIMALS; BETA CATENIN; BLOOD-BRAIN BARRIER; BRAIN; CAPILLARY PERMEABILITY; CELLS, CULTURED; CHEMOKINE CCL2; ENDOTHELIAL CELLS; HUMANS; INTERLEUKIN-2; MICE; MICROVESSELS; NF-KAPPA B; SIGNAL TRANSDUCTION;

EID: 84993115840     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M116.729038     Document Type: Article

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