Different modes of endothelial-smooth muscle cell interaction elicit differential β-catenin phosphorylations and endothelial functions

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 5, 2014, Pages 1855-1860

  Chang, Shun Fu ^a   Chen, Li Jing ^b   Lee, Pei Ling ^b   Lee, Ding Yu ^b   Chien, Shu ^c   Chiu, Jeng Jiann ^b  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

^c UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Endothelial permeability; Inflammation

Indexed keywords

BETA CATENIN; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN RECEPTOR; CONNEXIN 43; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; INTERCELLULAR ADHESION MOLECULE 1; MUTANT PROTEIN; SERINE; SMAD1 PROTEIN; SMAD5 PROTEIN; SMALL INTERFERING RNA; THREONINE; TYROSINE; VASCULAR CELL ADHESION MOLECULE 1; VASCULAR ENDOTHELIAL CADHERIN;

ARTICLE; CELL ADHESION; CELL INTERACTION; CELL NUCLEUS; COCULTURE; CONTROLLED STUDY; CYTOPLASM; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; MONOCYTE; PARACRINE SIGNALING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SMOOTH MUSCLE FIBER;

ENDOTHELIAL PERMEABILITY; INFLAMMATION;

ANIMALS; ANTIGENS, CD; BETA CATENIN; BONE MORPHOGENETIC PROTEIN RECEPTORS, TYPE II; BONE MORPHOGENETIC PROTEINS; CADHERINS; CATTLE; CELL ADHESION; CELL COMMUNICATION; CELL COMPARTMENTATION; CELL MEMBRANE PERMEABILITY; CONNEXIN 43; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; MODELS, BIOLOGICAL; MONOCYTES; MYOCYTES, SMOOTH MUSCLE; PARACRINE COMMUNICATION; PHOSPHORYLATION; PHOSPHOTHREONINE; PHOSPHOTYROSINE; PROTEIN BINDING; PROTEIN-TYROSINE KINASES; PROTEOLYSIS; SMAD5 PROTEIN; UBIQUITIN; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84893491386     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1323761111     Document Type: Article

References (18)

1. Daugherty RL, Gottardi CJ (2007) Phospho-regulation of β-catenin adhesion and signaling functions. Physiology (Bethesda) 22:303-309.
2. Faux MC, Coates JL, Kershaw NJ, Layton MJ, Burgess AW (2010) Independent interactions of phosphorylated β-catenin with E-cadherin at cell-cell contacts and APC at cell protrusions. PLoS ONE 5(11):e14127.
3. Piedra J, et al. (2003) p120 Catenin-associated Fer and Fyn tyrosine kinases regulate β-catenin Tyr-142 phosphorylation and β-catenin- α-catenin Interaction. Mol Cell Biol 23(7):2287-2297.
4. de Jesus Perez VA, et al. (2009) Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt-beta-catenin and Wnt-RhoA-Rac1 pathways. J Cell Biol 184(1):83-99.
5. Segal SS, Duling BR (1989) Conduction of vasomotor responses in arterioles: A role for cell-to-cell coupling? Am J Physiol 256(3 Pt 2):H838-H845.
6. Chiu JJ, Chien S (2011) Effects of disturbed flow on vascular endothelium: Pathophysiological basis and clinical perspectives. Physiol Rev 91(1):327-387.
7. Heberlein KR, Straub AC, Isakson BE (2009) The myoendothelial junction: Breaking through the matrix? Microcirculation 16(4):307-322.
8. Navarro P, Ruco L, Dejana E (1998) Differential localization of VE-and N-cadherins in human endothelial cells: VE-cadherin competes with N-cadherin for junctional localization. J Cell Biol 140(6):1475-1484.
9. Ale-Agha N, et al. (2009) HuR regulates gap junctional intercellular communication by controlling beta-catenin levels and adherens junction integrity. Hepatology 50(5):1567-1576.
10. Vinken M, et al. (2011) Connexins: Sensors and regulators of cell cycling. Biochim Biophys Acta 1815(1):13-25.
11. Liu Z, et al. (2010) Mechanical tugging force regulates the size of cell-cell junctions. Proc Natl Acad Sci USA 107(22):9944-9949.
12. Gottardi CJ, Gumbiner BM (2004) Distinct molecular forms of β-catenin are targeted to adhesive or transcriptional complexes. J Cell Biol 167(2):339-349.
13. Cho HH, Joo HJ, Song JS, Bae YC, Jung JS (2008) Crossregulation of β-catenin/Tcf pathway by NF-kappaB is mediated by lzts2 in human adipose tissue-derived mesenchymal stem cells. Biochim Biophys Acta 1783(3):419-428.
14. Chang SF, et al. (2008) Tumor cell cycle arrest induced by shear stress: Roles of integrins and Smad. Proc Natl Acad Sci USA 105(10):3927-3932.
15. Yao Y, et al. (2010) Inhibition of bone morphogenetic proteins protects against atherosclerosis and vascular calcification. Circ Res 107(4):485-494.
16. Derwall M, et al. (2012) Inhibition of bone morphogenetic protein signaling reduces vascular calcification and atherosclerosis. Arterioscler Thromb Vasc Biol 32(3):613-622.
17. Kim CW, et al. (2013) Anti-inflammatory and antiatherogenic role of BMP receptor II in endothelial cells. Arterioscler Thromb Vasc Biol 33(6):1350-1359.
18. Straub AC, et al. (2012) Endothelial cell expression of haemoglobin α regulates nitric oxide signalling. Nature 491(7424):473-477.