Interleukin-2 alters distribution of CD144 (VE-cadherin) in endothelial cells

Journal of Translational Medicine

Volumn 12, Issue 1, 2014, Pages

  Kim, Dae W ^a   Zloza, Andrew ^a   Broucek, Joseph ^a   Schenkel, Jason M ^b   Ruby, Carl ^a   Samaha, Georges ^a   Kaufman, Howard L ^c  

^a RUSH UNIVERSITY MEDICAL CENTER   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^c RUTGERS CANCER INSTITUTE OF NEW JERSEY   (United States)

Author keywords

CD144; Interleukin 2; Vascular leak syndrome; VE cadherin

Indexed keywords

INTERLEUKIN 2; VASCULAR ENDOTHELIAL CADHERIN; CD146 ANTIGEN; MCAM PROTEIN, HUMAN; PRIMER DNA;

ADULT; AGED; ARTICLE; CELL MEMBRANE PERMEABILITY; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE RESPONSE; DRUG MEGADOSE; ENDOTHELIUM CELL; EX VIVO STUDY; FEMALE; HUMAN; HUMAN CELL; IN VITRO STUDY; KIDNEY CARCINOMA; LUNG ENDOTHELIUM; MALE; METASTATIC MELANOMA; PATHOPHYSIOLOGY; PROTEIN LOCALIZATION; PROTEIN TARGETING; VASCULAR DISEASE; VASCULAR LEAK SYNDROME; CELL CULTURE; CYTOLOGY; IMMUNOLOGY; METABOLISM; MIDDLE AGED; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; POLYMERASE CHAIN REACTION;

ADULT; AGED; ANTIGENS, CD146; BASE SEQUENCE; CELLS, CULTURED; DNA PRIMERS; ENDOTHELIAL CELLS; FEMALE; HUMANS; INTERLEUKIN-2; MALE; MIDDLE AGED; POLYMERASE CHAIN REACTION;

EID: 84902662286     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-12-113     Document Type: Article

References (12)

1. Rosenberg SA, Yang JC, Topalian SL, Schwartzentruber DJ, Weber JS, Parkinson DR, Seipp CA, Einhorn JH, White DE. Treatment of 283 consecutive patients with metastatic melanoma or renal cell cancer using high-dose bolus interleukin 2. JAMA 1994, 271:907-913. 10.1001/jama.1994.03510360033032, 8120958.
2. Atkins MB. Cytokine-based therapy and biochemotherapy for advanced melanoma. Clin Cancer Res 2006, 12:2353s-2358s. 10.1158/1078-0432.CCR-05-2503, 16609058.
3. Rosenberg SA, Lotze MT, Muul LM, Chang AE, Avis FP, Leitman S, Linehan WM, Robertson CN, Lee RE, Rubin JT, Seipp CA, Simpson CG, White DE. A progress report on the treatment of 157 patients with advanced cancer using lymphokine-activated killer cells and interleukin-2 or high-dose interleukin-2 alone. N Engl J Med 1987, 316:889-897. 10.1056/NEJM198704093161501, 3493432.
4. West WH, Tauer KW, Yannelli JR, Marshall GD, Orr DW, Thurman GB, Oldham RK. Constant-infusion recombinant interleukin-2 in adoptive immunotherapy of advanced cancer. N Engl J Med 1987, 316:898-905. 10.1056/NEJM198704093161502, 3493433.
5. Alileche A. Interleukin-2 and cancer: critical analysis of results, problems and expectations. Med Hypotheses 2003, 60:202-208. 10.1016/S0306-9877(02)00359-6, 12606236.
6. Cotran RS, Pober JS, Gimbrone MA, Springer TA, Wiebke EA, Gaspari AA, Rosenberg SA, Lotze MT. Endothelial activation during interleukin 2 immunotherapy. A possible mechanism for the vascular leak syndrome. J Immunol 1988, 140:1883-1888.
7. Baluna R, Rizo J, Gordon BE, Ghetie V, Vitetta ES. Evidence for a structural motif in toxins and interleukin-2 that may be responsible for binding to endothelial cells and initiating vascular leak syndrome. Proc Natl Acad Sci USA 1999, 96:3957-3962. 10.1073/pnas.96.7.3957, 22402, 10097145.
8. Guan H, Singh NP, Singh UP, Nagarkatti PS, Nagarkatti M. Resveratrol prevents endothelial cells injury in high-dose interleukin-2 therapy against melanoma. PLoS One 2012, 7:e35650. 10.1371/journal.pone.0035650, 3331985, 22532866.
9. Schenkel JM, Fraser KA, Vezys V, Masopust D. Sensing and alarm function of resident memory CD8(+) T cells. Nat Immunol 2013, 14:509-513. 10.1038/ni.2568, 3631432, 23542740.
10. Krieg C, Letourneau S, Pantaleo G, Boyman O. Improved IL-2 immunotherapy by selective stimulation of IL-2 receptors on lymphocytes and endothelial cells. Proc Natl Acad Sci USA 2010, 107:11906-11911. 10.1073/pnas.1002569107, 2900642, 20547866.
11. Vestweber D, Broermann A, Schulte D. Control of endothelial barrier function by regulating vascular endothelial-cadherin. Curr Opin Hematol 2010, 17:230-236. 10.1097/MOH.0b013e328338664b, 20393283.
12. Fainaru O, Adini I, Benny O, Bazinet L, Pravda E, D'amato R, Folkman J. Doxycycline induces membrane expression of VE-cadherin on endothelial cells and prevents vascular hyperpermeability. FASEB J 2008, 22:3728-3735. 10.1096/fj.08-110494, 18606869.