Vitamin B-12 and cognition in children

Advances in Nutrition

Volumn 7, Issue 5, 2016, Pages 879-888

  Venkatramanan, Sudha ^a   Armata, Ilianna E ^a   Strupp, Barbara J ^a   Finkelstein, Julia L ^a,b  

^a Cornell University ^*  (United States)

^b ST JOHN'S NATIONAL ACADEMY OF HEALTH SCIENCES   (India)

Author keywords

Brain; Child; Cobalamin; Cognition; Vitamin B 12

Indexed keywords

CYANOCOBALAMIN;

ATTENTION; BLOOD; CHILD; CHILD DEVELOPMENT; CHILD NUTRITION; COGNITION; COGNITION DISORDERS; COMPLICATION; CYANOCOBALAMIN DEFICIENCY; DIETARY SUPPLEMENT; DRUG EFFECTS; HUMAN; MEMORY; NUTRITIONAL STATUS;

ATTENTION; CHILD; CHILD DEVELOPMENT; CHILD NUTRITIONAL PHYSIOLOGICAL PHENOMENA; COGNITION; COGNITION DISORDERS; DIETARY SUPPLEMENTS; HUMANS; MEMORY; NUTRITIONAL STATUS; VITAMIN B 12; VITAMIN B 12 DEFICIENCY;

EID: 84992744194     PISSN: 21618313     EISSN: 21565376     Source Type: Journal    
DOI: 10.3945/an.115.012021     Document Type: Review

References (67)

1. Scott JM, Molloy AM. The discovery of vitamin B(12). Ann Nutr Metab 2012;61:239-45.
2. Rush EC, Katre P, Yajnik CS. Vitamin B12: one carbon metabolism, fetal growth and programming for chronic disease. Eur J Clin Nutr 2014; 68:2-7.
3. Morris MS. The role of B vitamins in preventing and treating cognitive impairment and decline. Adv Nutr 2012;3:801-12.
4. Briani C, Dalla Torre C, Citton V, Manara R, Pompanin S, Binotto G, Adami F. Cobalamin deficiency: clinical picture and radiological findings. Nutrients 2013;5:4521-39.
5. Pawlak R, Lester SE, Babatunde T. The prevalence of cobalamin deficiency among vegetarians assessed by serum vitamin B12: a review of literature. Eur J Clin Nutr 2014;68:541-8.
6. Finkelstein JL, Layden AJ, Stover PJ. Vitamin B-12 and perinatal health. Adv Nutr 2015;6:552-63.
7. Swaminathan S, Thomas T, Kurpad AV. B-vitamin interventions for women and children in low-income populations. Curr Opin Clin Nutr Metab Care 2015;18:295-306.
8. Stabler SP, Allen RH. Vitamin B12 deficiency as a worldwide problem. Annu Rev Nutr 2004;24:299-326.
9. Dror DK, Allen LH. Interventions with vitamins B6, B12 and C in pregnancy. Paediatr Perinat Epidemiol 2012;26 Suppl 1:55-74.
10. Carmel R. Efficacy and safety of fortification and supplementation with vitamin B12: biochemical and physiological effects. Food Nutr Bull 2008; 29(2, Suppl)S177-87.
11. Allen LH, Rosenberg IH, Oakley GP, Omenn GS. Considering the case for vitamin B12 fortification of flour. Food Nutr Bull 2010; 31(1, Suppl)S36-46.
12. Kumar N. Neurologic aspects of cobalamin (B12) deficiency. Handb Clin Neurol 2014;120:915-26.
13. Alpers DH, Russell-Jones G. Gastric intrinsic factor: the gastric and small intestinal stages of cobalamin absorption. a personal journey. Biochimie 2013;95:989-94.
14. Molloy AM, Kirke PN, Brody LC, Scott JM, Mills JL. Effects of folate and vitamin B12 deficiencies during pregnancy on fetal, infant, and child development. Food Nutr Bull 2008;29(2 Suppl):S101-11; discussion S12-5.
15. Lloyd-Wright Z, Hvas AM, Moller J, Sanders TA, Nexo E. Holotranscobalamin as an indicator of dietary vitamin B12 deficiency. Clin Chem 2003;49:2076-8.
16. Carmel R. Biomarkers of cobalamin (vitamin B-12) status in the epidemiologic setting: a critical overview of context, applications, and performance characteristics of cobalamin, methylmalonic acid, and holotranscobalamin II. Am J Clin Nutr 2011;94:348S-58S.
17. Yetley EA, Pfeiffer CM, Phinney KW, Bailey RL, Blackmore S, Bock JL, Brody LC, Carmel R, Curtin LR, Durazo-Arvizu RA, et al. Biomarkers of vitamin B-12 status in NHANES: a roundtable summary. Am J Clin Nutr 2011;94:313S-21S.
18. Yetley EA, Coates PM, Johnson CL. Overview of a roundtable on NHANES monitoring of biomarkers of folate and vitamin B-12 status: measurement procedure issues. Am J Clin Nutr 2011;94:297S-302S.
19. Yetley EA, Johnson CL. Folate and vitamin B-12 biomarkers in NHANES: history of their measurement and use. Am J Clin Nutr 2011;94:322S-31S.
20. Georgieff MK. Nutrition and the developing brain: nutrient priorities and measurement. Am J Clin Nutr 2007;85:614S-20S.
21. Kretchmer N, Beard JL, Carlson S. The role of nutrition in the development of normal cognition. Am J Clin Nutr 1996;63:997S-1001S.
22. Thompson RA, Nelson CA. Developmental science and the media. Early brain development. Am Psychol 2001;56:5-15.
23. Ramakrishna T. Vitamins and brain development. Physiol Res 1999;48: 175-87.
24. Black MM. Effects of vitamin B12 and folate deficiency on brain development in children. Food Nutr Bull 2008; 29(2, Suppl)S126-31.
25. Reynolds E. Vitamin B12, folic acid, and the nervous system. Lancet Neurol 2006;5:949-60.
26. Lövblad K, Ramelli G, Remonda L, Nirkko AC, Ozdoba C, Schroth G. Retardation of myelination due to dietary vitamin B12 deficiency: cranial MRI findings. Pediatr Radiol 1997;27:155-8.
27. Dror DK, Allen LH. Effect of vitamin B12 deficiency on neurodevelopment in infants: current knowledge and possible mechanisms. Nutr Rev 2008;66:250-5.
28. Fernàndez-Roig S, Lai SC, Murphy MM, Fernandez-Ballart J, Quadros EV. Vitamin B12 deficiency in the brain leads to DNA hypomethylation in the TCblR/CD320 knockout mouse. Nutr Metab (Lond) 2012;9:41.
29. Pepper MR, Black MM. B12 in fetal development. Semin Cell Dev Biol 2011;22:619-23.
30. Lozoff B, Georgieff MK. Iron deficiency and brain development. Semin Pediatr Neurol 2006;13:158-65.
31. Bertolo RF, McBreairty LE. The nutritional burden of methylation reactions. Curr Opin Clin Nutr Metab Care 2013;16:102-8.
32. Selhub J, Bagley LC, Miller J, Rosenberg IH. B vitamins, homocysteine, and neurocognitive function in the elderly. Am J Clin Nutr 2000;71: 614S-20S.
33. Selhub J. Folate, vitamin B12 and vitamin B6 and one carbon metabolism. J Nutr Health Aging 2002;6:39-42.
34. Strain JJ, Dowey L, Ward M, Pentieva K, McNulty H. B-vitamins, homocysteine metabolism and CVD. Proc Nutr Soc 2004;63:597-603.
35. Obeid R. The metabolic burden of methyl donor deficiency with focus on the betaine homocysteine methyltransferase pathway. Nutrients 2013;5:3481-95.
36. Hollenbeck CB. An introduction to the nutrition and metabolism of choline. Cent Nerv Syst Agents Med Chem 2012;12:100-13.
37. Schmidt RJ, Hansen RL, Hartiala J, Allayee H, Schmidt LC, Tancredi DJ, Tassone F, Hertz-Picciotto I. Prenatal vitamins, one-carbon metabolism gene variants, and risk for autism. Epidemiology 2011;22:476-85.
38. Ssonko M, Ddungu H, Musisi S. Low serum vitamin B12 levels among psychiatric patients admitted in Butabika mental hospital in Uganda. BMC Res Notes 2014;7:90.
39. Al-Farsi YM, Waly MI, Deth RC, Al-Sharbati MM, Al-Shafaee M, Al-Farsi O, Al-Khaduri MM, Gupta I, Ali A, Al-Khalili M, et al. Low folate and vitamin B12 nourishment is common in Omani children with newly diagnosed autism. Nutrition 2013;29:537-41.
40. Hintikka J, Tolmunen T, Tanskanen A, Viinamaki H. High vitamin B12 level and good treatment outcome may be associated in major depressive disorder. BMC Psychiatry 2003;3:17.
41. Tiemeier H, van Tuijl HR, Hofman A, Meijer J, Kiliaan AJ, Breteler MM. Vitamin B12, folate, and homocysteine in depression: the Rotterdam Study. Am J Psychiatry 2002;159:2099-101.
42. Di Rosa G, Lenzo P, Parisi E, Neri M, Guerrera S, Nicotera A, Alibrandi A, Germano E, Caccamo D, Spano M, et al. Role of plasma homocysteine levels and MTHFR polymorphisms on IQ scores in children and young adults with epilepsy treated with antiepileptic drugs. Epilepsy Behav 2013;29:548-51.
43. Bhate V, Deshpande S, Bhat D, Joshi N, Ladkat R, Watve S, Fall C, de Jager CA, Refsum H, Yajnik C. Vitamin B12 status of pregnant Indian women and cognitive function in their 9-year-old children. Food Nutr Bull 2008;29:249-54.
44. Veena SR, Krishnaveni GV, Srinivasan K, Wills AK, Muthayya S, Kurpad AV, Yajnik CS, Fall CH. Higher maternal plasma folate but not vitamin B-12 concentrations during pregnancy are associated with better cognitive function scores in 9-to 10-year-old children in South India. J Nutr 2010;140:1014-22.
45. Bhate VK, Joshi SM, Ladkat RS, Deshmukh US, Lubree HG, Katre PA, Bhat DS, Rush EC, Yajnik CS. Vitamin B12 and folate during pregnancy and offspring motor, mental and social development at 2 years of age. J Dev Orig Health Dis 2012;3:123-30.
46. Wu BT, Dyer RA, King DJ, Richardson KJ, Innis SM. Early second trimester maternal plasma choline and betaine are related to measures of early cognitive development in term infants. PLoS One 2012;7: e43448.
47. Bonilla C, Lawlor DA, Taylor AE, Gunnell DJ, Ben-Shlomo Y, Ness AR, Timpson NJ, St Pourcain B, Ring SM, Emmett PM, et al. Vitamin B-12 status during pregnancy and child's IQ at age 8: a Mendelian randomization study in the Avon longitudinal study of parents and children. PLoS One 2012;7:e51084.
48. Villamor E, Rifas-Shiman SL, Gillman MW, Oken E. Maternal intake of methyl-donor nutrients and child cognition at 3 years of age. Paediatr Perinat Epidemiol 2012;26:328-35.
49. Boeke CE, Gillman MW, Hughes MD, Rifas-Shiman SL, Villamor E, Oken E. Choline intake during pregnancy and child cognition at age 7 years. Am J Epidemiol 2013;177:1338-47.
50. del Río Garcia C, Torres-Sanchez L, Chen J, Schnaas L, Hernandez C, Osorio E, Portillo MG, Lopez-Carrillo L. Maternal MTHFR 677C>T genotype and dietary intake of folate and vitamin B(12): their impact on child neurodevelopment. Nutr Neurosci 2009;12:13-20.
51. Eilander A, Muthayya S, van der Knaap H, Srinivasan K, Thomas T, Kok FJ, Kurpad AV, Osendarp SJ. Undernutrition, fatty acid and micronutrient status in relation to cognitive performance in Indian school children: a cross-sectional study. Br J Nutr 2010;103:1056-64.
52. Louwman MW, van Dusseldorp M, van de Vijver FJ, Thomas CM, Schneede J, Ueland PM, Refsum H, van Staveren WA. Signs of impaired cognitive function in adolescents with marginal cobalamin status. Am J Clin Nutr 2000;72:762-9.
53. Nguyen CT, Gracely EJ, Lee BK. Serum folate but not vitamin B-12 concentrations are positively associated with cognitive test scores in children aged 6-16 years. J Nutr 2013;143:500-4.
54. Strand TA, Taneja S, Ueland PM, Refsum H, Bahl R, Schneede J, Sommerfelt H, Bhandari N. Cobalamin and folate status predicts mental development scores in North Indian children 12-18 mo of age. Am J Clin Nutr 2013;97:310-7.
55. Kvestad I, Taneja S, Kumar T, Hysing M, Refsum H, Yajnik CS, Bhandari N, Strand TA. Folate, vitamin BSG. Vitamin B12 and folic acid improve gross motor and problem-solving skills in young North Indian children: a randomized placebo-controlled trial. PLoS One 2015;10:e0129915.
56. Masalha R, Afawi Z, Mahajnah M, Mashal A, Hallak M, Ibrahim A, Bolotin A, Ifergane G, Wirguin I. The impact of nutritional vitamin B12, folate and hemoglobin deficiency on school performance of elementary school children. J Pediatr Neurol 2008;6:6.
57. Duong MC, Mora-Plazas M, Marin C, Villamor E. Vitamin B-12 deficiency in children is associated with grade repetition and school absenteeism, independent of folate, iron, zinc, or vitamin a status biomarkers. J Nutr 2015;145:1541-8.
58. Gewa CA, Weiss RE, Bwibo NO, Whaley S, Sigman M, Murphy SP, Harrison G, Neumann CG. Dietary micronutrients are associated with higher cognitive function gains among primary school children in rural Kenya. Br J Nutr 2009;101:1378-87.
59. Ahmadi A, Sohrabi Z, Eftekhari MH. Evaluating the relationship between breakfast pattern and short-term memory in junior high school girls. Pak J Biol Sci 2009;12:742-5.
60. Rosenberg IH, Miller JW. Nutritional factors in physical and cognitive functions of elderly people. Am J Clin Nutr 1992; 55(6, Suppl)1237S-43S.
61. Pasricha SR, Shet AS, Black JF, Sudarshan H, Prashanth NS, Biggs BA. Vitamin B-12, folate, iron, and vitamin A concentrations in rural Indian children are associated with continued breastfeeding, complementary diet, and maternal nutrition. Am J Clin Nutr 2011;94:1358-70.
62. de Jager CA, Dye L, de Bruin EA, Butler L, Fletcher J, Lamport DJ, Latulippe ME, Spencer JP, Wesnes K. Criteria for validation and selection of cognitive tests for investigating the effects of foods and nutrients. Nutr Rev 2014;72:162-79.
63. Isaacs E, Oates J, ILSI Europe a.i.s.b.l. Nutrition and cognition: assessing cognitive abilities in children and young people. Eur J Nutr 2008;47 Suppl 3:4-24.
64. Strupp BJ, Diamond A. Assessing cognitive function in animal models of mental retardation. Ment Retard Dev Disabil Res Rev 1996;2:216-26.
65. Strupp BJ, Levitsky DA. Enduring cognitive effects of early malnutrition: a theoretical reappraisal. J Nutr 1995; 125(8, Suppl)2221S-32S.
66. Wainwright PE, Colombo J. Nutrition and the development of cognitive functions: interpretation of behavioral studies in animals and human infants. Am J Clin Nutr 2006;84:961-70.
67. Patel SA, Murray-Kolb LE, LeClerq SC, Khatry SK, Tielsch JM, Katz J, Christian P. Household wealth and neurocognitive development disparities among school-aged children in Nepal. Paediatr Perinat Epidemiol 2013;27:575-86.