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Volumn 31, Issue 1 SUPPL., 2010, Pages

Considering the case for vitamin B12 fortification of flour

Author keywords

Deficiency; Flour; Fortification; Vitamin B12

Indexed keywords

ABSORPTION; BIOAVAILABILITY; CEREAL; DEVELOPING WORLD; DIGESTION; DISEASE PREVALENCE; FOOD INTAKE; FOOD SUPPLEMENTATION; HEALTH IMPACT; HERBIVORY; IMPLEMENTATION PROCESS; LACTATION; OMNIVORY; PREGNANCY; SERUM; VITAMIN DEFICIENCY;

EID: 77953056988     PISSN: 03795721     EISSN: None     Source Type: Journal    
DOI: 10.1177/15648265100311s104     Document Type: Article
Times cited : (63)

References (69)
  • 1
    • 77953042314 scopus 로고    scopus 로고
    • Institute of Medicine. Dietary Reference Intakes: thiamin, riboflavin, niacin, vitamin 86, folate, vitamin B12, pantothenic acid, biotin, and choline. Washington, DC: National Academies Press
    • Institute of Medicine. Dietary Reference Intakes: thiamin, riboflavin, niacin, vitamin 86, folate, vitamin B12, pantothenic acid, biotin, and choline. Washington, DC: National Academies Press, 2000.
    • (2000)
  • 3
    • 24044507638 scopus 로고    scopus 로고
    • Biochemical indicators of B vitamin status in the US population after folic acid fortification: Results from the national health and nutrition examination survey 1999-2000
    • Pfeiffer CM, Caudill SP, Gunter EW, Osterloh J, Sampson EJ. Biochemical indicators of B vitamin status in the US population after folic acid fortification: results from the National Health and Nutrition Examination Survey 1999-2000. Am J Clin Nutr 2005;82:442-50.
    • (2005) Am. J. Clin. Nutr. , vol.82 , pp. 442-450
    • Pfeiffer, C.M.1    Caudill, S.P.2    Gunter, E.W.3    Osterloh, J.4    Sampson, E.J.5
  • 4
    • 48249084968 scopus 로고    scopus 로고
    • The use of blood concentrations of vitamins and their respective functional indicators to define folate and vitamin B12 status
    • Selhub J, Jacques PF, Dallal G, Choumenkovitch S, Rogers G. The use of blood concentrations of vitamins and their respective functional indicators to define folate and vitamin B12 status. Food Nutr Bull 2008;29:S67-73.
    • (2008) Food Nutr. Bull. , vol.29
    • Selhub, J.1    Jacques, P.F.2    Dallal, G.3    Choumenkovitch, S.4    Rogers, G.5
  • 5
    • 33846102164 scopus 로고    scopus 로고
    • Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification
    • Morris MS, Jacques PF, Rosenberg IH, Selhub J. Folate and vitamin B-12 status in relation to anemia, macrocytosis, and cognitive impairment in older Americans in the age of folic acid fortification. Am J Clin Nutr 2007;85:193-200.
    • (2007) Am. J. Clin. Nutr. , vol.85 , pp. 193-200
    • Morris, M.S.1    Jacques, P.F.2    Rosenberg, I.H.3    Selhub, J.4
  • 6
    • 0025335524 scopus 로고
    • Diagnosis of cobalamin deficiency: II. Relative sensitivities of serum cobalamin, methylmalonic acid, and total homocysteine concentrations
    • DOI 10.1002/ajh.2830340205
    • Lindenbaum J, Savage DG, Stabler SP, Allen RH. Diagnosis of cobalamin deficiency: II. Relative sensitivities of serum cobalamin, methylmalonic acid, and total homocysteine concentrations. Am J Hematol 1990;34:99-107. (Pubitemid 20180101)
    • (1990) American Journal of Hematology , vol.34 , Issue.2 , pp. 99-107
    • Lindenbaum, J.1    Savage, D.G.2    Stabler, S.P.3    Allen, R.H.4
  • 8
    • 14844317329 scopus 로고    scopus 로고
    • Holotranscobalamin-a first choice assay for diagnosing early vitamin B deficiency?
    • Hvas AM, Nexo E. Holotranscobalamin-a first choice assay for diagnosing early vitamin B deficiency? J Intern Med 2005;257:289-98.
    • (2005) J. Intern. Med. , vol.257 , pp. 289-298
    • Hvas, A.M.1    Nexo, E.2
  • 10
    • 47649133075 scopus 로고    scopus 로고
    • Fraction of total plasma vitamin B12 bound to transcobalamin correlates with cognitive function in elderly Latinos with depressive symptoms
    • Garrod MG, Green R, Allen LH, Mungas DM, Jagust WJ, Haan MN, Miller JW. Fraction of total plasma vitamin B12 bound to transcobalamin correlates with cognitive function in elderly Latinos with depressive symptoms. Clin Chem 2008;54:1210-7.
    • (2008) Clin. Chem. , vol.54 , pp. 1210-1217
    • Garrod, M.G.1    Green, R.2    Allen, L.H.3    Mungas, D.M.4    Jagust, W.J.5    Haan, M.N.6    Miller, J.W.7
  • 12
    • 0013893404 scopus 로고
    • Vitamin B12 turnover in man. The assimilation of vitamin B12 from natural foodstuff by man and estimates of minimal dietary requirements
    • Heyssel R, Bozian R, Darby W, Bell M. Vitamin B12 turnover in man. The assimilation of vitamin B12 from natural foodstuff by man and estimates of minimal dietary requirements. Am J Clin Nutr 1966;18:176-84.
    • (1966) Am. J. Clin. Nutr. , vol.18 , pp. 176-184
    • Heyssel, R.1    Bozian, R.2    Darby, W.3    Bell, M.4
  • 14
    • 0004189360 scopus 로고
    • 2nd ed. Oxford, UK: Blackwell Scientific Publications
    • Chanarin I. The megaloblastic anaemias, 2nd ed. Oxford, UK: Blackwell Scientific Publications, 1979.
    • (1979) The Megaloblastic Anaemias
    • Chanarin, I.1
  • 16
    • 48249083808 scopus 로고    scopus 로고
    • Review of the magnitude of folate and vitamin B12 deficiencies worldwide
    • McLean E, de Benoist B, Allen LH. Review of the magnitude of folate and vitamin B12 deficiencies worldwide. Food Nutr Bull 2008;29:S38-51.
    • (2008) Food Nutr. Bull. , vol.29
    • McLean, E.1    De Benoist, B.2    Allen, L.H.3
  • 17
    • 4043106965 scopus 로고    scopus 로고
    • Folate and vitamin B12 status in the Americas
    • discussion S34
    • Allen LH. Folate and vitamin B12 status in the Americas. Nutr Rev 2004;62:S29-33; discussion S34.
    • (2004) Nutr. Rev. , vol.62
    • Allen, L.H.1
  • 18
    • 0029891583 scopus 로고    scopus 로고
    • Prevalence of undiagnosed pernicious anemia in the elderly
    • Carmel R. Prevalence of undiagnosed pernicious anemia in the elderly. Arch Intern Med 1996;156:1097-100.
    • (1996) Arch. Intern. Med. , vol.156 , pp. 1097-1100
    • Carmel, R.1
  • 19
  • 20
    • 0038507376 scopus 로고    scopus 로고
    • Vitamin B-12 status, particularly holotranscobalamin II and methylmalonic acid concentrations, and hyperhomocysteinemia in vegetarians
    • Herrmann W, Schorr H, Obeid R, Geisel J. Vitamin B-12 status, particularly holotranscobalamin II and methylmalonic acid concentrations, and hyperhomocysteinemia in vegetarians. Am J Clin Nutr 2003;78:131-6.
    • (2003) Am. J. Clin. Nutr. , vol.78 , pp. 131-136
    • Herrmann, W.1    Schorr, H.2    Obeid, R.3    Geisel, J.4
  • 23
    • 0038348195 scopus 로고    scopus 로고
    • Nutrition and health-potential health benefits and risks of vegetarianism and limited consumption of meat in The Netherlands
    • Dagnelie PC. [Nutrition and health-potential health benefits and risks of vegetarianism and limited consumption of meat in The Netherlands]. Ned Tijdschr Geneeskd 2003;147:1308-13.
    • (2003) Ned Tijdschr Geneeskd , vol.147 , pp. 1308-1313
    • Dagnelie, P.C.1
  • 25
    • 0030866169 scopus 로고    scopus 로고
    • Vitamin B-12 deficiency is very prevalent in lactating Guatemalan women and their infants at three months postpartum
    • Casterline JE, Allen LH, Ruel MT. Vitamin B-12 deficiency is very prevalent in lactating Guatemalan women and their infants at three months postpartum. J Nutr 1997;127:1966-72.
    • (1997) J. Nutr. , vol.127 , pp. 1966-1972
    • Casterline, J.E.1    Allen, L.H.2    Ruel, M.T.3
  • 26
    • 34247880201 scopus 로고    scopus 로고
    • Prevalent vitamin B-12 deficiency in twelve-month-old Guatemalan infants is predicted by maternal B-12 deficiency and infant diet
    • Jones KM, Ramirez-Zea M, Zuleta C, Allen LH. Prevalent vitamin B-12 deficiency in twelve-month-old Guatemalan infants is predicted by maternal B-12 deficiency and infant diet. J Nutr 2007;137:1307-13.
    • (2007) J. Nutr. , vol.137 , pp. 1307-1313
    • Jones, K.M.1    Ramirez-Zea, M.2    Zuleta, C.3    Allen, L.H.4
  • 27
    • 0242659349 scopus 로고    scopus 로고
    • Kenyan school children have multiple micronutrient deficiencies, but increased plasma vitamin B-12 is the only detectable micronutrient response to meat or milk supplementation
    • Siekmann JH, Allen LH, Bwibo NO, Demment MW, Murphy SP, Neumann CG. Kenyan school children have multiple micronutrient deficiencies, but increased plasma vitamin B-12 is the only detectable micronutrient response to meat or milk supplementation. J Nutr 2003;133:3972S-80S.
    • (2003) J. Nutr. , vol.133
    • Siekmann, J.H.1    Allen, L.H.2    Bwibo, N.O.3    Demment, M.W.4    Murphy, S.P.5    Neumann, C.G.6
  • 29
    • 0035991852 scopus 로고    scopus 로고
    • Impact of vitamin B-12 deficiency during lactation on maternal and infant health
    • Allen LH. Impact of vitamin B-12 deficiency during lactation on maternal and infant health. Adv Exp Med Biol 2002;503:57-67.
    • (2002) Adv. Exp. Med. Biol. , vol.503 , pp. 57-67
    • Allen, L.H.1
  • 33
    • 0035136347 scopus 로고    scopus 로고
    • Associations of foodcobalamin malabsorption with ethnic origin, age, Helicobacter pylori infection, and serum markers of gastritis
    • Carmel R, Aurangzeb I, Qian D. Associations of foodcobalamin malabsorption with ethnic origin, age, Helicobacter pylori infection, and serum markers of gastritis. Am J Gastroenterol 2001;96:63-70.
    • (2001) Am. J. Gastroenterol. , vol.96 , pp. 63-70
    • Carmel, R.1    Aurangzeb, I.2    Qian, D.3
  • 34
    • 0041417599 scopus 로고    scopus 로고
    • Plasma vitamin B-12 concentrations in an elderly Latino population are predicted by serum gastrin concentrations and crystalline vitamin B-12 intake
    • Campbell AK, Miller JW, Green R, Haan MN, Allen LH. Plasma vitamin B-12 concentrations in an elderly Latino population are predicted by serum gastrin concentrations and crystalline vitamin B-12 intake. J Nutr 2003;133:2770-6.
    • (2003) J. Nutr. , vol.133 , pp. 2770-2776
    • Campbell, A.K.1    Miller, J.W.2    Green, R.3    Haan, M.N.4    Allen, L.H.5
  • 35
    • 0030771355 scopus 로고    scopus 로고
    • Cobalamin, the stomach, and aging
    • Carmel R. Cobalamin, the stomach, and aging. Am J Clin Nutr 1997;66:750-9.
    • (1997) Am. J. Clin. Nutr. , vol.66 , pp. 750-759
    • Carmel, R.1
  • 37
    • 0036170011 scopus 로고    scopus 로고
    • The Chilean flour folic acid fortification program reduces serum homocysteine levels and masks vitamin B-12 deficiency in elderly people
    • Hirsch S, de la Maza P, Barrera G, Gattas V, Petermann M, Bunout D. The Chilean flour folic acid fortification program reduces serum homocysteine levels and masks vitamin B-12 deficiency in elderly people. J Nutr 2002;132:289-91.
    • (2002) J. Nutr. , vol.132 , pp. 289-291
    • Hirsch, S.1    De La Maza, P.2    Barrera, G.3    Gattas, V.4    Petermann, M.5    Bunout, D.6
  • 38
    • 0030772749 scopus 로고    scopus 로고
    • Nutritional status indicators and their interactions in rural Guatemalan elderly: A study in San Pedro Ayampuc
    • King JE, Mazariegos M, Valdez C, Castaneda C, Solomons NW. Nutritional status indicators and their interactions in rural Guatemalan elderly: a study in San Pedro Ayampuc. Am J Clin Nutr 1997;66:795-802.
    • (1997) Am. J. Clin. Nutr. , vol.66 , pp. 795-802
    • King, J.E.1    Mazariegos, M.2    Valdez, C.3    Castaneda, C.4    Solomons, N.W.5
  • 39
    • 48249129119 scopus 로고    scopus 로고
    • Conclusions of a WHO technical consultation on folate and vitamin B12 deficiencies
    • de Benoist B. Conclusions of a WHO Technical Consultation on folate and vitamin B12 deficiencies. Food Nutr Bull 2008;29:S238-44.
    • (2008) Food Nutr. Bull. , vol.29
    • De Benoist, B.1
  • 40
    • 48249154610 scopus 로고    scopus 로고
    • A high prevalence of biochemical evidence of vitamin B12 or folate deficiency does not translate into a comparable prevalence of anemia
    • Metz J. A high prevalence of biochemical evidence of vitamin B12 or folate deficiency does not translate into a comparable prevalence of anemia. Food Nutr Bull 2008;29:S74-85.
    • (2008) Food Nutr. Bull. , vol.29
    • Metz, J.1
  • 41
    • 4244153977 scopus 로고    scopus 로고
    • Hematological and biochemical responses of rural Mexican preschoolers to iron alone or iron plus micronutrients
    • Reid ED, Lopez P, Galaviz IA, Isoard F, Rosado JL, Allen L. Hematological and biochemical responses of rural Mexican preschoolers to iron alone or iron plus micronutrients. FASEB J 2001;15:A731.
    • (2001) FASEB J. , vol.15
    • Reid, E.D.1    Lopez, P.2    Galaviz, I.A.3    Isoard, F.4    Rosado, J.L.5    Allen, L.6
  • 42
    • 43049115794 scopus 로고    scopus 로고
    • Effect of vitamin B12 deficiency on neurodevelopment in infants: Current knowledge and possible mechanisms
    • Dror DK, Allen LH. Effect of vitamin B12 deficiency on neurodevelopment in infants: current knowledge and possible mechanisms. Nutr Rev 2008;66:250-5.
    • (2008) Nutr. Rev. , vol.66 , pp. 250-255
    • Dror, D.K.1    Allen, L.H.2
  • 43
    • 36248955119 scopus 로고    scopus 로고
    • Homocysteine, vitamins, and vascular disease prevention
    • McCully KS. Homocysteine, vitamins, and vascular disease prevention. Am J Clin Nutr 2007;86:1563S-8S.
    • (2007) Am. J. Clin. Nutr. , vol.86
    • McCully, K.S.1
  • 44
    • 48249139847 scopus 로고    scopus 로고
    • Effects of folate and vitamin B12 on cognitive function in adults and the elderly
    • Rosenberg IH. Effects of folate and vitamin B12 on cognitive function in adults and the elderly. Food Nutr Bull 2008;29:S132-42.
    • (2008) Food Nutr. Bull. , vol.29
    • Rosenberg, I.H.1
  • 47
    • 48249134365 scopus 로고    scopus 로고
    • Effects of folate and vitamin B12 deficiencies during pregnancy on fetal, infant, and child development
    • Molloy AM, Kirke PN, Brody LC, Scott JM, Mills JL. Effects of folate and vitamin B12 deficiencies during pregnancy on fetal, infant, and child development. Food Nutr Bull 2008;29:S101-11.
    • (2008) Food Nutr. Bull. , vol.29
    • Molloy, A.M.1    Kirke, P.N.2    Brody, L.C.3    Scott, J.M.4    Mills, J.L.5
  • 48
    • 49349096698 scopus 로고    scopus 로고
    • Maternal nutrition, intrauterine programming and consequential risks in the offspring
    • Yajnik CS, Deshmukh US. Maternal nutrition, intrauterine programming and consequential risks in the offspring. Rev Endocr Metab Disord 2008;9:203-11.
    • (2008) Rev. Endocr. Metab. Disord. , vol.9 , pp. 203-211
    • Yajnik, C.S.1    Deshmukh, U.S.2
  • 49
    • 19044364357 scopus 로고    scopus 로고
    • Homocysteine and vitamin B12 status relate to bone turnover markers, broadband ultrasound attenuation, and fractures in healthy elderly people
    • Dhonukshe-Rutten RA, Pluijm SM, de Groot LC, Lips P, Smit JH, van Staveren WA. Homocysteine and vitamin B12 status relate to bone turnover markers, broadband ultrasound attenuation, and fractures in healthy elderly people. J Bone Miner Res 2005;20:921-9.
    • (2005) J. Bone Miner. Res. , vol.20 , pp. 921-929
    • Dhonukshe-Rutten, R.A.1    Pluijm, S.M.2    De Groot, L.C.3    Lips, P.4    Smit, J.H.5    Van Staveren, W.A.6
  • 51
    • 21844454981 scopus 로고    scopus 로고
    • Relation between homocysteine and B-vitamin status indicators and bone mineral density in older Americans
    • Morris MS, Jacques PF, Selhub J. Relation between homocysteine and B-vitamin status indicators and bone mineral density in older Americans. Bone 2005;37:234-42.
    • (2005) Bone , vol.37 , pp. 234-242
    • Morris, M.S.1    Jacques, P.F.2    Selhub, J.3
  • 52
    • 1642399817 scopus 로고    scopus 로고
    • Low serum vitamin B-12 levels are associated with increased hip bone loss in older women: A prospective study
    • Stone KL, Bauer DC, Sellmeyer D, Cummings SR. Low serum vitamin B-12 levels are associated with increased hip bone loss in older women: a prospective study. J Clin Endocrinol Metab 2004;89:1217-21.
    • (2004) J. Clin. Endocrinol. Metab. , vol.89 , pp. 1217-1221
    • Stone, K.L.1    Bauer, D.C.2    Sellmeyer, D.3    Cummings, S.R.4
  • 54
    • 0030330498 scopus 로고    scopus 로고
    • Effects of vitamin B12 on cell proliferation and cellular alkaline phosphatase activity in human bone marrow stromal osteoprogenitor cells and UMR106 osteoblastic cells
    • Kim GS, Kim CH, Park JY, Lee KU, Park CS. Effects of vitamin B12 on cell proliferation and cellular alkaline phosphatase activity in human bone marrow stromal osteoprogenitor cells and UMR106 osteoblastic cells. Metabolism 1996;45:1443-6.
    • (1996) Metabolism , vol.45 , pp. 1443-1446
    • Kim, G.S.1    Kim, C.H.2    Park, J.Y.3    Lee, K.U.4    Park, C.S.5
  • 57
    • 59649115415 scopus 로고    scopus 로고
    • Is it time for vitamin B-12 fortification? What are the questions?
    • Green R. Is it time for vitamin B-12 fortification? What are the questions? Am J Clin Nutr 2009: 89: 712S-6S.
    • (2009) Am. J. Clin. Nutr. , vol.89
    • Green, R.1
  • 58
    • 27744463119 scopus 로고    scopus 로고
    • Vitamin B12 deficiency is the dominant nutritional cause of hyperhomocysteinemia in a folic acid-fortified population
    • Green R, Miller JW. Vitamin B12 deficiency is the dominant nutritional cause of hyperhomocysteinemia in a folic acid-fortified population. Clin Chem Lab Med 2005;43:1048-51.
    • (2005) Clin. Chem. Lab. Med. , vol.43 , pp. 1048-1051
    • Green, R.1    Miller, J.W.2
  • 59
    • 0029067620 scopus 로고
    • Does folic acid harm people with vitamin B12 deficiency?
    • Dickinson CJ. Does folic acid harm people with vitamin B12 deficiency? QJM 1995;88:357-64.
    • (1995) QJM , vol.88 , pp. 357-364
    • Dickinson, C.J.1
  • 61
    • 38049152741 scopus 로고    scopus 로고
    • In vitamin B12 deficiency, higher serum folate is associated with increased total homocysteine and methylmalonic acid concentrations
    • Selhub J, Morris MS, Jacques PF. In vitamin B12 deficiency, higher serum folate is associated with increased total homocysteine and methylmalonic acid concentrations. Proc Natl Acad Sci U S A 2007;104:19995-20000.
    • (2007) Proc. Natl. Acad. Sci. U S A , vol.104 , pp. 19995-20000
    • Selhub, J.1    Morris, M.S.2    Jacques, P.F.3
  • 62
    • 34447289625 scopus 로고    scopus 로고
    • Cognitive impairment in older Americans in the age of folic acid fortification
    • Berry RJ, Carter HK, Yang Q. Cognitive impairment in older Americans in the age of folic acid fortification. Am J Clin Nutr 2007;86:265-7;
    • (2007) Am. J. Clin. Nutr. , vol.86 , pp. 265-267
    • Berry, R.J.1    Carter, H.K.2    Yang, Q.3
  • 63
    • 77953060346 scopus 로고    scopus 로고
    • author reply
    • author reply 67-9.
  • 65
    • 49449095497 scopus 로고    scopus 로고
    • Bread cofortified with folic acid and vitamin B-12 improves the folate and vitamin B-12 status of healthy older people: A randomized controlled trial
    • Winkels RM, Brouwer IA, Clarke R, Katan MB, Verhoef P. Bread cofortified with folic acid and vitamin B-12 improves the folate and vitamin B-12 status of healthy older people: a randomized controlled trial. Am J Clin Nutr 2008;88:348-55.
    • (2008) Am. J. Clin. Nutr. , vol.88 , pp. 348-355
    • Winkels, R.M.1    Brouwer, I.A.2    Clarke, R.3    Katan, M.B.4    Verhoef, P.5
  • 66
    • 2442543248 scopus 로고    scopus 로고
    • Breakfast cereal fortified with folic acid, vitamin B-6, and vitamin B-12 increases vitamin concentrations and reduces homocysteine concentrations: A randomized trial
    • Tucker KL, Olson B, Bakun P, Dallal GE, Selhub J, Rosenberg IH. Breakfast cereal fortified with folic acid, vitamin B-6, and vitamin B-12 increases vitamin concentrations and reduces homocysteine concentrations: a randomized trial. Am J Clin Nutr 2004;79:805-11.
    • (2004) Am. J. Clin. Nutr. , vol.79 , pp. 805-811
    • Tucker, K.L.1    Olson, B.2    Bakun, P.3    Dallal, G.E.4    Selhub, J.5    Rosenberg, I.H.6
  • 67
    • 48249135749 scopus 로고    scopus 로고
    • Establishing safe and potentially efficacious fortification contents for folic acid and vitamin B12
    • Dary O. Establishing safe and potentially efficacious fortification contents for folic acid and vitamin B12. Food Nutr Bull 2008;29:S214-24.
    • (2008) Food Nutr. Bull. , vol.29
    • Dary, O.1
  • 68
    • 77953049977 scopus 로고    scopus 로고
    • Fortifying with vitamin B12 does not affect dough handling or bread color
    • Available at:, Accessed 20 November
    • Strouts BL. Fortifying with vitamin B12 does not affect dough handling or bread color. Flour Fortification Initiative, 1998. Available at: http://www.sph.emory.edu/wheatflour/inpractice.php Accessed 20 November 2009.
    • (1998) Flour Fortification Initiative
    • Strouts, B.L.1
  • 69
    • 49449094148 scopus 로고    scopus 로고
    • Are we ready for mandatory fortification with vitamin B-12?
    • Refsum H, Smith AD. Are we ready for mandatory fortification with vitamin B-12? Am J Clin Nutr 2008;88:253-4.
    • (2008) Am. J. Clin. Nutr. , vol.88 , pp. 253-254
    • Refsum, H.1    Smith, A.D.2


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