Vitamin B12 deficiency in the brain leads to DNA hypomethylation in the TCblR/CD320 knockout mouse

Nutrition and Metabolism

Volumn 9, Issue , 2012, Pages

  Fernàndez Roig, Sílvia ^a,b   Lai, Shao Chiang ^c   Murphy, Michelle M ^a,b   Fernandez Ballart, Joan ^a,b   Quadros, Edward V ^c,d  

^a UNIVERSITAT ROVIRA I VIRGILI   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c SUNY DOWNSTATE MEDICAL CENTER   (United States)

^d SUNY Downstate Medical Center   (United States)

Author keywords

Brain; Global DNA methylation; Transcobalamin receptor knock out mice; Vitamin B12 deficiency

Indexed keywords

CYANOCOBALAMIN; GENOMIC DNA; TRANSCOBALAMIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CYANOCOBALAMIN DEFICIENCY; DNA METHYLATION; MOUSE; NONHUMAN;

MUS;

EID: 84865796799     PISSN: None     EISSN: 17437075     Source Type: Journal    
DOI: 10.1186/1743-7075-9-41     Document Type: Article

References (18)

1. Folate, vitamin B12 and vitamin B6 and one carbon metabolism. Selhub J, J Nutr Health Aging 2002 6 39 42 11813080 (Pubitemid 35364170)
2. Two major forms of DNA (cytosine-5) methyltransferase in human somatic tissues. Hsu DW, Lin MJ, Lee TL, Wen SC, Chen X, Shen CK, Proc Natl Acad Sci U S A 1999 96 9751 9756 10.1073/pnas.96.17.9751 10449766 (Pubitemid 29398804)
3. Epigenetics: regulation through repression. Wolffe AP, Matzke MA, Science 1999 286 481 486 10.1126/science.286.5439.481 10521337
4. Methylated DNA and MeCP2 recruit histone deacetylase to repress transcription. Jones PL, Veenstra GJ, Wade PA, Vermaak D, Kass SU, Landsberger N, Strouboulis J, Wolffe AP, Nat Genet 1998 19 187 191 10.1038/561 9620779 (Pubitemid 28248804)
5. Chromosomal instability and tumors promoted by DNA hypomethylation. Eden A, Gaudet F, Waghmare A, Jaenisch R, Science 2003 300 455 10.1126/science. 1083557 12702868 (Pubitemid 36444319)
6. The role of DNA methylation in cancer genetic and epigenetics. Laird PW, Jaenisch R, Annu Rev Genet 1996 30 441 464 10.1146/annurev.genet.30.1.441 8982461 (Pubitemid 27015267)
7. Increase in plasma homocysteine associated with parallel increases in plasma S-adenosylhomocysteine and lymphocyte DNA hypomethylation. Yi P, Melnyk S, Pogribna M, Pogribny IP, Hine RJ, James SJ, J Biol Chem 2000 275 29318 29323 10.1074/jbc.M002725200 10884384 (Pubitemid 32043802)
8. Vitamin B12, folic acid, and the nervous system. Reynolds E, Lancet Neurol 2006 5 949 960 10.1016/S1474-4422(06)70598-1 17052662 (Pubitemid 44556551)
9. Vitamin B12, demyelination, remyelination and repair in multiple sclerosis. Miller A, Korem M, Almog R, Galboiz Y, J Neurol Sci 2005 233 93 97 10.1016/j.jns.2005.03.009 15896807 (Pubitemid 40804822)
10. Localized folate and vitamin B-12 deficiency in squamous cell lung cancer is associated with global DNA hypomethylation. Piyathilake CJ, Johanning GL, Macaluso M, Whiteside M, Oelschlager DK, Heimburger DC, Grizzle WE, Nutr Cancer 2000 37 99 107 10.1207/S15327914NC3701-13 10965526 (Pubitemid 30650673)
11. Vitamin B-12 deficiency induces anomalies of base substitution and methylation in the DNA of rat colonic epithelium. Choi SW, Friso S, Ghandour H, Bagley PJ, Selhub J, Mason JB, J Nutr 2004 134 750 755 15051821 (Pubitemid 38456239)
12. Global DNA hypomethylation is associated with NTD-affected pregnancy: A case-control study. Chen X, Guo J, Lei Y, Zou J, Lu X, Bao Y, Wu L, Wu J, Zheng X, Shen Y, Wu BL, Zhang T, Birth Defects Res A Clin Mol Teratol 2010 88 575 581 10.1002/bdra.20670 20641100
13. Vitamin B12. Quadros EV, Modern Analytical Methodologies in Fat- and Water-Soluble Vitamins John Wiley & Sons, Inc, New York, Song WO, Beecher R, Eitenmiller RR, 2000 313 328
14. User Guide, MethylFlash Methylated DNA Quantification Kit (Colorimetric) [ http://www.epigentek.com/catalog/methylflash-methylated-dna-quantification- kit-colorimetric-p-2094.html ]
15. Protein mediated vitamin uptake, Adsorptive endocytosis of the transcobalamin II-cobalamin complex by cultured human fibroblasts. Youngdahl-Turner P, Mellman IS, Allen RH, Rosenberg LE, Exp Cell Res 1979 118 127 134 10.1016/0014-4827(79)90590-1 759210 (Pubitemid 9081555)
16. Cobalamin. Markle HV, Crit Rev Clin Lab Sci 1996 33 247 356 10.3109/10408369609081009 8875026 (Pubitemid 26318871)
17. Proceedings of the Trans-HHS Workshop: diet, DNA methylation processes and health. Ross SA, Poirier L, J Nutr 2002 132 2329S 2332S 12163686 (Pubitemid 34848101)
18. Histone modifications affect timing of oligodendrocyte progenitor differentiation in the developing rat brain. Shen S, Li J, Casaccia-Bonnefil P, J Cell Biol 2005 169 577 589 10.1083/jcb.200412101 15897262 (Pubitemid 41002851)