Notch1 mutation leads to valvular calcification through enhanced myofibroblast mechanotransduction

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 35, Issue 7, 2015, Pages 1597-1605

  Chen, Joseph ^a   Ryzhova, Larisa M ^a   Sewell Loftin, M K ^a   Brown, Christopher B ^b   Huppert, Stacey S ^b   Baldwin, H Scott ^c   David Merryman, W ^a  

^a VANDERBILT UNIVERSITY   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^c CINCINNATI CHILDREN'S HOSPITAL MEDICAL CENTER   (United States)

Author keywords

aortic valve; cadherin 11; calcification; Notch1

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BONE MORPHOGENETIC PROTEIN; CADHERIN; CADHERIN 11; MITOGEN ACTIVATED PROTEIN KINASE; NOTCH1 RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TRANSCRIPTION FACTOR RUNX2; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; MITOGEN ACTIVATED PROTEIN KINASE KINASE 2; OSTEOBLAST CADHERIN; RUNX2 PROTEIN, MOUSE;

ANIMAL CELL; AORTA VALVE; AORTA VALVE DISEASE; ARTICLE; CALCIFIC AORTIC VALVE DISEASE; CALCINOSIS; CELL ACTIVATION; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENE MUTATION; IN VITRO STUDY; MECHANOTRANSDUCTION; MOUSE; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; UPREGULATION; ANIMAL; AORTA VALVE STENOSIS; GENETICS; HUMAN; METABOLISM; MUTATION; PATHOLOGY;

ANIMALS; AORTIC VALVE; AORTIC VALVE STENOSIS; CADHERINS; CALCINOSIS; CORE BINDING FACTOR ALPHA 1 SUBUNIT; HUMANS; MAP KINASE KINASE 2; MECHANOTRANSDUCTION, CELLULAR; MICE; MUTATION; MYOFIBROBLASTS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, NOTCH1;

EID: 84933048926     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.114.305095     Document Type: Article

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