-
2
-
-
80052266213
-
The amyloid cascade hypothesis for Alzheimer’s disease: An appraisal for the development of therapeutics
-
Karran E, Mercken M, De Strooper B. The amyloid cascade hypothesis for Alzheimer’s disease: an appraisal for the development of therapeutics. Nat Rev Drug Discov 2011; 10(9): 698-712.
-
(2011)
Nat Rev Drug Discov
, vol.10
, Issue.9
, pp. 698-712
-
-
Karran, E.1
Mercken, M.2
De Strooper, B.3
-
3
-
-
77954977618
-
Neuroinflammation in Alzheimer’s disease: Mechanisms, pathologic consequences and potential for therapeutic manipulation
-
Hensely K. Neuroinflammation in Alzheimer’s disease: mechanisms, pathologic consequences and potential for therapeutic manipulation. J Alzheimer’s Dis 2010; 21(1): 1-14.
-
(2010)
J Alzheimer’s Dis
, vol.21
, Issue.1
, pp. 1-14
-
-
Hensely, K.1
-
5
-
-
80052837439
-
Reactive glia not only associates with plaques but also parallels tangles in Alzheimer’s disease
-
Serrano-Pozo A, Mielke ML, Gomez-Isla T, et al. Reactive glia not only associates with plaques but also parallels tangles in Alzheimer’s disease. Am J Pathology 2011; 179(3): 1373-84.
-
(2011)
Am J Pathology
, vol.179
, Issue.3
, pp. 1373-1384
-
-
Serrano-Pozo, A.1
Mielke, M.L.2
Gomez-Isla, T.3
-
6
-
-
70349570588
-
Systemic infection and disease progression Alzheimer disease
-
Holmes C, Cunningham C, Zotova E, et al. Systemic infection and disease progression Alzheimer disease. Neurology 2009; 73: 768-74.
-
(2009)
Neurology
, vol.73
, pp. 768-774
-
-
Holmes, C.1
Cunningham, C.2
Zotova, E.3
-
7
-
-
79960866529
-
Proinflammatory cytokines, sickness behaviour and Alzheimer disease
-
Holmes C, Cunningham C, Zotova E, et al. Proinflammatory cytokines, sickness behaviour and Alzheimer disease. Neurology 2011; 77: 212-18.
-
(2011)
Neurology
, vol.77
, pp. 212-218
-
-
Holmes, C.1
Cunningham, C.2
Zotova, E.3
-
8
-
-
84874038104
-
Advances in PET imaging of P-glycoprotein function at the blood-brain barrier
-
Syvanen S, Eriksson J. Advances in PET imaging of P-glycoprotein function at the blood-brain barrier. ACS Chemical Neuroscience 2013; 4(2): 225-37.
-
(2013)
ACS Chemical Neuroscience
, vol.4
, Issue.2
, pp. 225-237
-
-
Syvanen, S.1
Eriksson, J.2
-
9
-
-
84923369208
-
Neuroinflammation in Alzheimer’s disease
-
Zhang F, Jiang L. Neuroinflammation in Alzheimer’s disease. Neuropsychiatr Dis Treat 2015; 11: 243-56.
-
(2015)
Neuropsychiatr Dis Treat
, vol.11
, pp. 243-256
-
-
Zhang, F.1
Jiang, L.2
-
11
-
-
24744467358
-
Microglial phagocytosis induced by fibrillary beta-amyloid and IgGs are differentially regulated by proinflammatory cytokines
-
Koenigsknecht-Talboo J, Landreth GE. Microglial phagocytosis induced by fibrillary beta-amyloid and IgGs are differentially regulated by proinflammatory cytokines. J Neurosci 2005; 25: 8240-9.
-
(2005)
J Neurosci
, vol.25
, pp. 8240-8249
-
-
Koenigsknecht-Talboo, J.1
Landreth, G.E.2
-
12
-
-
0036789954
-
Association of factor H of the alternative pathway of complement with agrin and complement receptor 3 in Alzheimer’s disease brain
-
Strohmeyer R, Ramirez M, Cole GJ, et al. Association of factor H of the alternative pathway of complement with agrin and complement receptor 3 in Alzheimer’s disease brain. J Neuroimmunol 2002; 131: 135-46.
-
(2002)
J Neuroimmunol
, vol.131
, pp. 135-146
-
-
Strohmeyer, R.1
Ramirez, M.2
Cole, G.J.3
-
13
-
-
84861743669
-
Oligomers of beta-amyloid protein (Abeta1-42) induce the activation of cyclooxygenase-2 in astrocytes via an interaction with interleukin-1beta, tumour necrosis factor-alpha, and a nuclear factor kappa-b mechanism in the rat brain
-
Carrero I, Gonzalo MR, Martin B, et al. Oligomers of beta-amyloid protein (Abeta1-42) induce the activation of cyclooxygenase-2 in astrocytes via an interaction with interleukin-1beta, tumour necrosis factor-alpha, and a nuclear factor kappa-b mechanism in the rat brain. Exp Neurol 2012; 236(2): 215-27.
-
(2012)
Exp Neurol
, vol.236
, Issue.2
, pp. 215-227
-
-
Carrero, I.1
Gonzalo, M.R.2
Martin, B.3
-
14
-
-
84943174081
-
Genetics ignite focus on microglial inflammation in Alzheimers’ disease
-
Malik M, Parikh I, Vasquez JB, et al. Genetics ignite focus on microglial inflammation in Alzheimers’ disease. Mol Neurodegener 2015; 10: 52.
-
(2015)
Mol Neurodegener
, vol.10
, pp. 52
-
-
Malik, M.1
Parikh, I.2
Vasquez, J.B.3
-
15
-
-
84903362065
-
Triggering receptor expressed on myeloid cells 2 knockdown exacerbates aging-related neuroinflammation and cognitive deficiency in senescence-accelerated mouse prone 8 mice
-
Jiang T, Yu JT, Zhu XC, et al. Triggering receptor expressed on myeloid cells 2 knockdown exacerbates aging-related neuroinflammation and cognitive deficiency in senescence-accelerated mouse prone 8 mice. Neurobiol Aging 2014; 35(6): 1243-51.
-
(2014)
Neurobiol Aging
, vol.35
, Issue.6
, pp. 1243-1251
-
-
Jiang, T.1
Yu, J.T.2
Zhu, X.C.3
-
16
-
-
84878433339
-
Alzheimer’s disease risk gene CD33 inhibits microglial uptake of amyloid beta
-
Griciuc A, Serrano-Pozzo A, Parrado AR, et al. Alzheimer’s disease risk gene CD33 inhibits microglial uptake of amyloid beta. Neuron 2013; 78: 631-43.
-
(2013)
Neuron
, vol.78
, pp. 631-643
-
-
Griciuc, A.1
Serrano-Pozzo, A.2
Parrado, A.R.3
-
17
-
-
69949118284
-
Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease
-
Streit WJ, Braak H, Xue QS, et al. Dystrophic (senescent) rather than activated microglial cells are associated with tau pathology and likely precede neurodegeneration in Alzheimer’s disease. Acta Neuropathol 2009; 118: 475-85.
-
(2009)
Acta Neuropathol
, vol.118
, pp. 475-485
-
-
Streit, W.J.1
Braak, H.2
Xue, Q.S.3
-
18
-
-
84876006819
-
Functional impairment of microglia coincides with beta-amyloid deposition in mice with Alzheimer-like pathology
-
Krabbe G, Halle A, Matyash V, et al. Functional impairment of microglia coincides with beta-amyloid deposition in mice with Alzheimer-like pathology. PLoS One 2013; 8: e60921.
-
(2013)
PLoS One
, vol.8
, pp. e60921
-
-
Krabbe, G.1
Halle, A.2
Matyash, V.3
-
19
-
-
84858232365
-
Molecular imaging in Alzheimer’s disease
-
Herholz K. Molecular imaging in Alzheimer’s disease. Eur Neurol Rev 2011; 6(1): 16-20.
-
(2011)
Eur Neurol Rev
, vol.6
, Issue.1
, pp. 16-20
-
-
Herholz, K.1
-
20
-
-
0035845283
-
In-vivo measurement of activated microglia in dementia
-
Cagnin A, Brooks DJ, Kennedy AM, et al. In-vivo measurement of activated microglia in dementia. Lancet 2001; 358: 461-7.
-
(2001)
Lancet
, vol.358
, pp. 461-467
-
-
Cagnin, A.1
Brooks, D.J.2
Kennedy, A.M.3
-
21
-
-
56349144614
-
Microglia, amyloid and cognition in Alzheimer’s disease: An 11CRPk11195-PET and 11CPIB-PET study
-
Edison P, Archer HA, Gerhard A, et al. Microglia, amyloid and cognition in Alzheimer’s disease: an 11CRPk11195-PET and 11CPIB-PET study. Neurobiol Dis 2008; 32: 412-19.
-
(2008)
Neurobiol Dis
, vol.32
, pp. 412-419
-
-
Edison, P.1
Archer, H.A.2
Gerhard, A.3
-
23
-
-
0025332027
-
Anti-inflammatory drugs and Alzheimer’s disease
-
McGeer PL, McGeer E, Rogers J, et al. Anti-inflammatory drugs and Alzheimer’s disease. Lancet 1990; 335: 1037.
-
(1990)
Lancet
, vol.335
, pp. 1037
-
-
McGeer, P.L.1
McGeer, E.2
Rogers, J.3
-
24
-
-
33847339301
-
NSAIDs and Alzheimer disease: Epidemiological, animal model and clinical studies
-
McGeer PL, McGeer EG. NSAIDs and Alzheimer disease: Epidemiological, animal model and clinical studies. Neurobiol Aging 2007; 88: 639-47.
-
(2007)
Neurobiol Aging
, vol.88
, pp. 639-647
-
-
McGeer, P.L.1
McGeer, E.G.2
-
25
-
-
84948712806
-
Involvement of inflammation in Alzheimers’ disease pathogenesis and therapeutic potential of antiinflammatory agents
-
Shadfar S, Hwang CJ, Lim MS, et al. Involvement of inflammation in Alzheimers’ disease pathogenesis and therapeutic potential of antiinflammatory agents. Arch Pharm Res 2015; 38: 2106-19.
-
(2015)
Arch Pharm Res
, vol.38
, pp. 2106-2119
-
-
Shadfar, S.1
Hwang, C.J.2
Lim, M.S.3
-
26
-
-
84891715379
-
Rheumatoid arthritis and Alzheimer’s disease: Genetic and epigenetic links in inflammatory regulation
-
Ferraccioli G, Carbonella A, Gremese E, et al. Rheumatoid arthritis and Alzheimer’s disease: genetic and epigenetic links in inflammatory regulation. Discov Med 2012; 14(79): 379-88.
-
(2012)
Discov Med
, vol.14
, Issue.79
, pp. 379-388
-
-
Ferraccioli, G.1
Carbonella, A.2
Gremese, E.3
-
27
-
-
0027268393
-
Clinical trial of indomethacin in Alzheimers’ disease
-
Rogers J, Kirby LC, Hempelman SR, et al. Clinical trial of indomethacin in Alzheimers’ disease. Neurology 1993; 43: 1609-11.
-
(1993)
Neurology
, vol.43
, pp. 1609-1611
-
-
Rogers, J.1
Kirby, L.C.2
Hempelman, S.R.3
-
28
-
-
44849140748
-
No effect of one-year treatment with indomethacin on Alzheimer’s disease progression: A randomised controlled trial
-
De Jong D, Jansen R, Hoefnagels W, et al. No effect of one-year treatment with indomethacin on Alzheimer’s disease progression: a randomised controlled trial. PloS One 2008; 3: e147.
-
(2008)
PloS One
, vol.3
, pp. e147
-
-
De Jong, D.1
Jansen, R.2
Hoefnagels, W.3
-
29
-
-
47549107705
-
Cognitive function over time in the Alzheimer’s disease anti-inflammatory prevention trial (ADAPT): Results of a randomised, controlled trial of naproxen and celecoxib
-
ADAPT Research Group, Martin BK, Szekely C, et al. Cognitive function over time in the Alzheimer’s disease anti-inflammatory prevention trial (ADAPT): results of a randomised, controlled trial of naproxen and celecoxib. Arch Neurol 2008; 65: 896-905.
-
(2008)
Arch Neurol
, vol.65
, pp. 896-905
-
-
Martin, B.K.1
Szekely, C.2
-
30
-
-
79960769591
-
Extended results of the Alzheimer’s disease anti-inflammatory prevention trial
-
Breitner JC, Baker LD, Montine TJ, et al. Extended results of the Alzheimer’s disease anti-inflammatory prevention trial. Alzheimer’s Dement 2011; 7: 402-11.
-
(2011)
Alzheimer’s Dement
, vol.7
, pp. 402-411
-
-
Breitner, J.C.1
Baker, L.D.2
Montine, T.J.3
-
31
-
-
84861314593
-
Aspirin, steroidal and non-steroidal anti-inflammatory drugs for the treatment of Alzheimer’s disease
-
Feb 15
-
Jaturapatpom D, Isaac MG, McCleery J, et al. Aspirin, steroidal and non-steroidal anti-inflammatory drugs for the treatment of Alzheimer’s disease. Cochrane Database Syst Rev 2012 Feb 15;(2): CD006378.
-
(2012)
Cochrane Database Syst Rev
, Issue.2
, pp. CD006378
-
-
Jaturapatpom, D.1
Isaac, M.G.2
McCleery, J.3
-
32
-
-
84948823160
-
Alzheimer’s Disease: Exploring the role of inflammation and implications for treatment
-
McCaulley ME, Grush KA. Alzheimer’s Disease: Exploring the role of inflammation and implications for treatment. Int J Alzheimers Dis 2015; 2015: 515248.
-
(2015)
Int J Alzheimers Dis
, vol.2015
, pp. 515248
-
-
McCaulley, M.E.1
Grush, K.A.2
-
33
-
-
0025807206
-
Elevated circulating tumour necrosis factor levels in Alzheimer’s disease
-
Fillit H, Ding WH, Buee L, et al. Elevated circulating tumour necrosis factor levels in Alzheimer’s disease. Neurosci Lett 1991; 129(2): 318-20.
-
(1991)
Neurosci Lett
, vol.129
, Issue.2
, pp. 318-320
-
-
Fillit, H.1
Ding, W.H.2
Buee, L.3
-
34
-
-
37049002092
-
Perispinal etanercept for treatment of Alzheimers’ disease
-
Tobinick E. Perispinal etanercept for treatment of Alzheimers’ disease. Curr Alzheimer Res 2007; 4(5): 550-52.
-
(2007)
Curr Alzheimer Res
, vol.4
, Issue.5
, pp. 550-552
-
-
Tobinick, E.1
-
35
-
-
84992454719
-
The Safety and Tolerability of Etanercept in Alzheimer’s Disease (STEADI-09): A Phase II double blind randomised placebo controlled trial
-
Supp
-
Holmes C, et al. The Safety and Tolerability of Etanercept in Alzheimer’s Disease (STEADI-09): A Phase II double blind randomised placebo controlled trial. Alzheimer’s and Dementia: Journal of the Alzheimer’s Association. Supp. 2014; 10(4): 273
-
(2014)
Alzheimer’s and Dementia: Journal of the Alzheimer’s Association.
, vol.10
, Issue.4
, pp. 273
-
-
Holmes, C.1
-
36
-
-
78651066204
-
Anti-TNF-α reduces amyloid plaques and tau phosphorylation and induces CD11c-positive dendritic-like cell in the APP/PS1 transgenic mouse brains
-
Shi JQ, Shen W, Chen J, et al. Anti-TNF-α reduces amyloid plaques and tau phosphorylation and induces CD11c-positive dendritic-like cell in the APP/PS1 transgenic mouse brains. Brain Res 2011; 1368: 239-47.
-
(2011)
Brain Res
, vol.1368
, pp. 239-247
-
-
Shi, J.Q.1
Shen, W.2
Chen, J.3
-
37
-
-
84873531039
-
Long-term treatment of thalidomide ameliorates amyloid-like pathology through inhibition of β-secretase in a mouse model of Alzheimer’s disease
-
He P, Cheng X, Staufenbiel M, et al Long-term treatment of thalidomide ameliorates amyloid-like pathology through inhibition of β-secretase in a mouse model of Alzheimer’s disease. PLoS One 2013; 8(2): e55091.
-
(2013)
PLoS One
, vol.8
, Issue.2
, pp. e55091
-
-
He, P.1
Cheng, X.2
Staufenbiel, M.3
-
38
-
-
0034651101
-
Inflammatory mechanisms in Alzheimer’s disease: Inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARγ agonists
-
Combs CK, Johnson DE, Karlo JC, et al. Inflammatory mechanisms in Alzheimer’s disease: Inhibition of beta-amyloid-stimulated proinflammatory responses and neurotoxicity by PPARγ agonists. J Neurosci 2000; 20: 558-67.
-
(2000)
J Neurosci
, vol.20
, pp. 558-567
-
-
Combs, C.K.1
Johnson, D.E.2
Karlo, J.C.3
-
39
-
-
77956090575
-
Rosiglitazone monotherapy in mild to moderate Alzheimer’s disease: Results from a randomised, double blind, placebo-controlled phase III study
-
Gold M, Alderton C, Zvartau-Hind M, et al. Rosiglitazone monotherapy in mild to moderate Alzheimer’s disease: Results from a randomised, double blind, placebo-controlled phase III study. Dement Geriatr Cogn Disord 2010; 30: 131-46.
-
(2010)
Dement Geriatr Cogn Disord
, vol.30
, pp. 131-146
-
-
Gold, M.1
Alderton, C.2
Zvartau-Hind, M.3
-
40
-
-
63049105150
-
Emerging role of the cannabinoid receptor CB2 in immune regulation: Therapeutic prospects for neuroinflammation
-
Cabral GA, Griffin-Thomas L. Emerging role of the cannabinoid receptor CB2 in immune regulation: Therapeutic prospects for neuroinflammation. Expert Rev Mol Med 2009; 11: e3.
-
(2009)
Expert Rev Mol Med
, vol.11
, pp. e3
-
-
Cabral, G.A.1
Griffin-Thomas, L.2
-
41
-
-
79952390569
-
Randomised, controlled crossover trial of dronabinol, 2.5mg, for agitation in 2 patients with dementia
-
Walther S, Schupbach B, Seifritz E, et al. Randomised, controlled crossover trial of dronabinol, 2.5mg, for agitation in 2 patients with dementia. J Clin Psychopharmacol 2011; 31: 256-8.
-
(2011)
J Clin Psychopharmacol
, vol.31
, pp. 256-258
-
-
Walther, S.1
Schupbach, B.2
Seifritz, E.3
-
42
-
-
77957357526
-
Reductions in amyloid-beta-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation
-
Parachikova A, Vasilevko V, Cribbs DH, et al. Reductions in amyloid-beta-derived neuroinflammation, with minocycline, restore cognition but do not significantly affect tau hyperphosphorylation. J Alzheimers Dis 2010; 21(2): 527-42.
-
(2010)
J Alzheimers Dis
, vol.21
, Issue.2
, pp. 527-542
-
-
Parachikova, A.1
Vasilevko, V.2
Cribbs, D.H.3
-
43
-
-
84964632197
-
Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer’s like pathology
-
Olmos-Alonso A, Schetters ST, Sri S, et al. Pharmacological targeting of CSF1R inhibits microglial proliferation and prevents the progression of Alzheimer’s like pathology. Brain 2016; 139(Pt3): 891-907.
-
(2016)
Brain
, vol.139
, pp. 891-907
-
-
Olmos-Alonso, A.1
Schetters, S.T.2
Sri, S.3
|