메뉴 건너뛰기




Volumn 14, Issue 7, 2010, Pages 570-577

Ornithine alpha-ketoglutarate: Could it be a new therapeutic option for sarcopenia?

Author keywords

ageing; amino acids; ornithine alpha ketoglutarate; Sarcopenia; skeletal muscle

Indexed keywords

MUSCLE PROTEIN; ORNITHINE OXOGLUTARATE; PLACEBO;

EID: 77957963287     PISSN: 12797707     EISSN: 17604788     Source Type: Journal    
DOI: 10.1007/s12603-010-0109-7     Document Type: Review
Times cited : (19)

References (87)
  • 1
    • 33846685534 scopus 로고    scopus 로고
    • The pathology of ageing: Concepts and mechanisms
    • DOI 10.1002/path.2122
    • J. E. Martin M. T. Sheaff 2007 The pathology of ageing: concepts and mechanisms J Pathol 211 111 113 1:STN:280:DC%2BD2s%2FhvFOmtA%3D%3D 10.1002/path.2122 17200949 (Pubitemid 46195509)
    • (2007) Journal of Pathology , vol.211 , Issue.2 , pp. 111-113
    • Martin, J.E.1    Sheaff, M.T.2
  • 2
    • 61549093657 scopus 로고    scopus 로고
    • Nursing home care in the USA
    • 10.1111/j.1447-0594.2008.00513.x 19260973
    • M. Eskildsen T. Price 2009 Nursing home care in the USA Geriatr Gerontol Int 9 1 6 10.1111/j.1447-0594.2008.00513.x 19260973
    • (2009) Geriatr Gerontol Int , vol.9 , pp. 1-6
    • Eskildsen, M.1    Price, T.2
  • 3
    • 13444282118 scopus 로고    scopus 로고
    • Optimizing protein intake in aging
    • DOI 10.1097/00075197-200501000-00014
    • S. Walrand Y. Boirie 2005 Optimizing protein intake in aging Curr Opin Clin Nutr Metab Care 8 89 94 1:CAS:528:DC%2BD2MXhsVyltb0%3D 10.1097/00075197- 200501000-00014 15586006 (Pubitemid 40204451)
    • (2005) Current Opinion in Clinical Nutrition and Metabolic Care , vol.8 , Issue.1 , pp. 89-94
    • Walrand, S.1    Boirie, Y.2
  • 6
    • 20544440861 scopus 로고    scopus 로고
    • Aging muscle
    • 1:CAS:528:DC%2BD2MXktlyltb8%3D 15883415
    • K. S. Nair 2005 Aging muscle Am J Clin Nutr 81 953 963 1:CAS:528:DC%2BD2MXktlyltb8%3D 15883415
    • (2005) Am J Clin Nutr , vol.81 , pp. 953-963
    • Nair, K.S.1
  • 7
    • 0036677193 scopus 로고    scopus 로고
    • Myostatin polymorphisms and age-related sarcopenia in the Italian population
    • 10.1046/j.1532-5415.2002.50376.x 12165013
    • A. M. Corsi L. Ferrucci A. Gozzini A. Tanini M. L. Brandi 2002 Myostatin polymorphisms and age-related sarcopenia in the Italian population J Am Geriatr Soc 50 1463 10.1046/j.1532-5415.2002.50376.x 12165013
    • (2002) J Am Geriatr Soc , vol.50 , pp. 1463
    • Corsi, A.M.1    Ferrucci, L.2    Gozzini, A.3    Tanini, A.4    Brandi, M.L.5
  • 8
    • 0025569356 scopus 로고
    • Action of ornithine alpha-ketoglutarate, ornithine hydrochloride, and calcium alpha-ketoglutarate on plasma amino acid and hormonal patterns in healthy subjects
    • 1:CAS:528:DyaK3cXkslKqtL4%3D 2407764
    • L. Cynober C. Coudray-Lucas J. P. de Bandt J. Guechot C. Aussel M. Salvucci J. Giboudeau 1990 Action of ornithine alpha-ketoglutarate, ornithine hydrochloride, and calcium alpha-ketoglutarate on plasma amino acid and hormonal patterns in healthy subjects J Am Coll Nutr 9 2 12 1:CAS:528:DyaK3cXkslKqtL4%3D 2407764
    • (1990) J Am Coll Nutr , vol.9 , pp. 2-12
    • Cynober, L.1    Coudray-Lucas, C.2    De Bandt, J.P.3    Guechot, J.4    Aussel, C.5    Salvucci, M.6    Giboudeau, J.7
  • 9
    • 4744358642 scopus 로고    scopus 로고
    • Ornithine alpha-ketoglutarate as a potent precursor of arginine and nitric oxide: A new job for an old friend
    • 1:CAS:528:DC%2BD2cXosVOjsLs%3D 15465801
    • L. Cynober 2004 Ornithine alpha-ketoglutarate as a potent precursor of arginine and nitric oxide: a new job for an old friend J Nutr 134 2858S 2862S 1:CAS:528:DC%2BD2cXosVOjsLs%3D 15465801
    • (2004) J Nutr , vol.134
    • Cynober, L.1
  • 10
    • 0032701014 scopus 로고    scopus 로고
    • Nutritional and clinical efficacy of ornithine alpha-ketoglutarate in severe burn patients
    • DOI 10.1016/S0261-5614(98)80029-0
    • L. Donati F. Ziegler G. Pongelli M. S. Signorini 1999 Nutritional and clinical efficacy of ornithine alpha-ketoglutarate in severe burn patients Clin Nutr 18 307 311 1:CAS:528:DyaK1MXnvFagtbY%3D 10.1016/S0261-5614(98)80029-0 10601539 (Pubitemid 29527741)
    • (1999) Clinical Nutrition , vol.18 , Issue.5 , pp. 307-311
    • Donati, L.1    Ziegler, F.2    Pongelli, G.3    Signorini, M.S.4
  • 11
    • 0025095157 scopus 로고
    • Effects of an amino acid solution enriched with either branched chain amino acids or ornithine-alpha-ketoglutarate on the postoperative intracellular amino acid concentration of skeletal muscle
    • 1:STN:280:DyaK3c7pvFCrsA%3D%3D 10.1002/bjs.1800770227 2107958
    • F. Hammarqvist J. Wernerman R. Ali E. Vinnars 1990 Effects of an amino acid solution enriched with either branched chain amino acids or ornithine-alpha-ketoglutarate on the postoperative intracellular amino acid concentration of skeletal muscle Br J Surg 77 214 218 1:STN:280: DyaK3c7pvFCrsA%3D%3D 10.1002/bjs.1800770227 2107958
    • (1990) Br J Surg , vol.77 , pp. 214-218
    • Hammarqvist, F.1    Wernerman, J.2    Ali, R.3    Vinnars, E.4
  • 12
    • 0029787554 scopus 로고    scopus 로고
    • Ornithine-alpha-ketoglutarate (OKG) supplementation is more effective than its component salts in traumatized rats
    • 1:CAS:528:DyaK28XlsF2ltbw%3D 8814202
    • M. Jeevanandam N. J. Holaday S. R. Petersen 1996 Ornithine-alpha- ketoglutarate (OKG) supplementation is more effective than its component salts in traumatized rats J Nutr 126 2141 2150 1:CAS:528:DyaK28XlsF2ltbw%3D 8814202
    • (1996) J Nutr , vol.126 , pp. 2141-2150
    • Jeevanandam, M.1    Holaday, N.J.2    Petersen, S.R.3
  • 13
    • 0028180152 scopus 로고
    • Ornithine alpha-ketoglutarate limits muscle protein breakdown without stimulating tumor growth in rats bearing Yoshida ascites hepatoma
    • 10.1016/0026-0495(94)90274-7 8028516
    • T. Le Bricon L. Cynober V. E. Baracos 1994 Ornithine alpha-ketoglutarate limits muscle protein breakdown without stimulating tumor growth in rats bearing Yoshida ascites hepatoma Metabolism 43 899 905 10.1016/0026-0495(94)90274-7 8028516
    • (1994) Metabolism , vol.43 , pp. 899-905
    • Le Bricon, T.1    Cynober, L.2    Baracos, V.E.3
  • 14
    • 0036962492 scopus 로고    scopus 로고
    • Muscle changes in aging
    • 1:CAS:528:DC%2BD3sXkslGhur4%3D 12474025
    • R. Basu A. Basu K. S. Nair 2002 Muscle changes in aging J Nutr Health Aging 6 336 341 1:CAS:528:DC%2BD3sXkslGhur4%3D 12474025
    • (2002) J Nutr Health Aging , vol.6 , pp. 336-341
    • Basu, R.1    Basu, A.2    Nair, K.S.3
  • 15
    • 0028950365 scopus 로고
    • Altered response of protein synthesis to nutritional state and endurance training in old rats
    • 1:CAS:528:DyaK2MXktFGntrw%3D 7864110
    • L. Mosoni M. C. Valluy B. Serrurier J. Prugnaud C. Obled C. Y. Guezennec P. P. Mirand 1995 Altered response of protein synthesis to nutritional state and endurance training in old rats Am J Physiol 268 E328 335 1:CAS:528: DyaK2MXktFGntrw%3D 7864110
    • (1995) Am J Physiol , vol.268 , pp. 328-335
    • Mosoni, L.1    Valluy, M.C.2    Serrurier, B.3    Prugnaud, J.4    Obled, C.5    Guezennec, C.Y.6    Mirand, P.P.7
  • 16
    • 0034485454 scopus 로고    scopus 로고
    • The response of muscle protein anabolism to combined hyperaminoacidemia and glucose-induced hyperinsulinemia is impaired in the elderly
    • DOI 10.1210/jc.85.12.4481
    • E. Volpi B. Mittendorfer B. B. Rasmussen R. R. Wolfe 2000 The response of muscle protein anabolism to combined hyperaminoacidemia and glucose-induced hyperinsulinemia is impaired in the elderly J Clin Endocrinol Metab 85 4481 4490 1:CAS:528:DC%2BD3MXis1Cnug%3D%3D 10.1210/jc.85.12.4481 11134097 (Pubitemid 32157622)
    • (2000) Journal of Clinical Endocrinology and Metabolism , vol.85 , Issue.12 , pp. 4481-4490
    • Volpi, E.1    Mittendorfer, B.2    Rasmussen, B.B.3    Wolfe, R.R.4
  • 17
    • 0033929799 scopus 로고    scopus 로고
    • The effect of age on protein metabolism
    • DOI 10.1097/00075197-200001000-00007
    • K. R. Short K. S. Nair 2000 The effect of age on protein metabolism Curr Opin Clin Nutr Metab Care 3 39 44 1:CAS:528:DC%2BD3cXos1Ojsw%3D%3D 10.1097/00075197-200001000-00007 10642082 (Pubitemid 30469103)
    • (2000) Current Opinion in Clinical Nutrition and Metabolic Care , vol.3 , Issue.1 , pp. 39-44
    • Short, K.R.1    Nair, K.S.2
  • 18
    • 0031979765 scopus 로고    scopus 로고
    • High-protein meals do not enhance myofibrillar synthesis after resistance exercise in 62- to 75-yr-old men and women
    • 1:CAS:528:DyaK1cXislyhu70%3D 9575829
    • S. Welle C. A. Thornton 1998 High-protein meals do not enhance myofibrillar synthesis after resistance exercise in 62- to 75-yr-old men and women Am J Physiol 274 E677 683 1:CAS:528:DyaK1cXislyhu70%3D 9575829
    • (1998) Am J Physiol , vol.274 , pp. 677-683
    • Welle, S.1    Thornton, C.A.2
  • 20
    • 0032921840 scopus 로고    scopus 로고
    • Postexercise net protein synthesis in human muscle from orally administered amino acids
    • 1:CAS:528:DyaK1MXislClt74%3D 10198297
    • K. D. Tipton A. A. Ferrando S. M. Phillips D. Doyle Jr. R. R. Wolfe 1999 Postexercise net protein synthesis in human muscle from orally administered amino acids Am J Physiol 276 E628 634 1:CAS:528:DyaK1MXislClt74%3D 10198297
    • (1999) Am J Physiol , vol.276 , pp. 628-634
    • Tipton, K.D.1    Ferrando, A.A.2    Phillips, S.M.3    Doyle, Jr.D.4    Wolfe, R.R.5
  • 22
    • 0036790054 scopus 로고    scopus 로고
    • Regulation of muscle protein by amino acids
    • 1:CAS:528:DC%2BD38Xnsl2ktLo%3D 12368421
    • R. R. Wolfe 2002 Regulation of muscle protein by amino acids J Nutr 132 3219S 3224S 1:CAS:528:DC%2BD38Xnsl2ktLo%3D 12368421
    • (2002) J Nutr , vol.132
    • Wolfe, R.R.1
  • 23
    • 38949086515 scopus 로고    scopus 로고
    • Co-ingestion of leucine with protein does not further augment post-exercise muscle protein synthesis rates in elderly men
    • DOI 10.1017/S0007114507812013, PII S0007114507812013
    • R. Koopman L. B. Verdijk M. Beelen M. Gorselink A. N. Kruseman A. J. Wagenmakers H. Kuipers L. J. van Loon 2008 Co-ingestion of leucine with protein does not further augment post-exercise muscle protein synthesis rates in elderly men Br J Nutr 99 571 580 1:CAS:528:DC%2BD1cXivFekur8%3D 10.1017/ S0007114507812013 17697406 (Pubitemid 351223425)
    • (2008) British Journal of Nutrition , vol.99 , Issue.3 , pp. 571-580
    • Koopman, R.1    Verdijk, L.B.2    Beelen, M.3    Gorselink, M.4    Kruseman, A.N.5    Wagenmakers, A.J.M.6    Kuipers, H.7    Van Loon, L.J.C.8
  • 24
    • 0032080924 scopus 로고    scopus 로고
    • Exogenous amino acids stimulate net muscle protein synthesis in the elderly
    • 1:CAS:528:DyaK1cXjt1Srt7k%3D 10.1172/JCI939 9576765
    • E. Volpi A. A. Ferrando C. W. Yeckel K. D. Tipton R. R. Wolfe 1998 Exogenous amino acids stimulate net muscle protein synthesis in the elderly J Clin Invest 101 2000 2007 1:CAS:528:DyaK1cXjt1Srt7k%3D 10.1172/JCI939 9576765
    • (1998) J Clin Invest , vol.101 , pp. 2000-2007
    • Volpi, E.1    Ferrando, A.A.2    Yeckel, C.W.3    Tipton, K.D.4    Wolfe, R.R.5
  • 25
    • 0032835655 scopus 로고    scopus 로고
    • Oral amino acids stimulate muscle protein anabolism in the elderly despite higher first-pass splanchnic extraction
    • 1:CAS:528:DyaK1MXmt1alsLo%3D 10484364
    • E. Volpi B. Mittendorfer S. E. Wolf R. R. Wolfe 1999 Oral amino acids stimulate muscle protein anabolism in the elderly despite higher first-pass splanchnic extraction Am J Physiol 277 E513 520 1:CAS:528:DyaK1MXmt1alsLo%3D 10484364
    • (1999) Am J Physiol , vol.277 , pp. 513-520
    • Volpi, E.1    Mittendorfer, B.2    Wolf, S.E.3    Wolfe, R.R.4
  • 26
    • 0030897107 scopus 로고    scopus 로고
    • Splanchnic and whole-body leucine kinetics in young and elderly men
    • 1:CAS:528:DyaK2sXpvVWnsw%3D%3D 9022534
    • Y. Boirie P. Gachon B. Beaufrere 1997 Splanchnic and whole-body leucine kinetics in young and elderly men Am J Clin Nutr 65 489 495 1:CAS:528: DyaK2sXpvVWnsw%3D%3D 9022534
    • (1997) Am J Clin Nutr , vol.65 , pp. 489-495
    • Boirie, Y.1    Gachon, P.2    Beaufrere, B.3
  • 27
    • 0042068305 scopus 로고    scopus 로고
    • Essential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adults
    • 1:CAS:528:DC%2BD3sXlvF2is70%3D 12885705
    • E. Volpi H. Kobayashi M. Sheffield-Moore B. Mittendorfer R. R. Wolfe 2003 Essential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adults Am J Clin Nutr 78 250 258 1:CAS:528:DC%2BD3sXlvF2is70%3D 12885705
    • (2003) Am J Clin Nutr , vol.78 , pp. 250-258
    • Volpi, E.1    Kobayashi, H.2    Sheffield-Moore, M.3    Mittendorfer, B.4    Wolfe, R.R.5
  • 28
    • 0036792227 scopus 로고    scopus 로고
    • Influence of the protein digestion rate on protein turnover in young and elderly subjects
    • 1:CAS:528:DC%2BD38Xnsl2ktLg%3D 12368423
    • M. Dangin Y. Boirie C. Guillet B. Beaufrere 2002 Influence of the protein digestion rate on protein turnover in young and elderly subjects J Nutr 132 3228S 3233S 1:CAS:528:DC%2BD38Xnsl2ktLg%3D 12368423
    • (2002) J Nutr , vol.132
    • Dangin, M.1    Boirie, Y.2    Guillet, C.3    Beaufrere, B.4
  • 29
    • 0036138646 scopus 로고    scopus 로고
    • Postprandial stimulation of muscle protein synthesis in old rats can be restored by a leucine-supplemented meal
    • D. Dardevet C. Sornet G. Bayle J. Prugnaud C. Pouyet J. Grizard 2002 Postprandial stimulation of muscle protein synthesis in old rats can be restored by a leucine-supplemented meal J Nutr 132 95 100 1:CAS:528: DC%2BD38Xjt1emsA%3D%3D 11773514 (Pubitemid 34042461)
    • (2002) Journal of Nutrition , vol.132 , Issue.1 , pp. 95-100
    • Dardevet, D.1    Sornet, C.2    Bayle, G.3    Prugnaud, J.4    Pouyet, C.5    Grizard, J.6
  • 30
    • 0033735644 scopus 로고    scopus 로고
    • Stimulation of in vitro rat muscle protein synthesis by leucine decreases with age
    • 1:CAS:528:DC%2BD3cXnvVOlsbs%3D 11053498
    • D. Dardevet C. Sornet M. Balage J. Grizard 2000 Stimulation of in vitro rat muscle protein synthesis by leucine decreases with age J Nutr 130 2630 2635 1:CAS:528:DC%2BD3cXnvVOlsbs%3D 11053498
    • (2000) J Nutr , vol.130 , pp. 2630-2635
    • Dardevet, D.1    Sornet, C.2    Balage, M.3    Grizard, J.4
  • 31
    • 33746876019 scopus 로고    scopus 로고
    • Leucine supplementation improves muscle protein synthesis in elderly men independently of hyperaminoacidaemia
    • DOI 10.1113/jphysiol.2006.110742
    • I. Rieu M. Balage C. Sornet C. Giraudet E. Pujos J. Grizard L. Mosoni D. Dardevet 2006 Leucine supplementation improves muscle protein synthesis in elderly men independently of hyperaminoacidaemia J Physiol 575 305 315 1:CAS:528:DC%2BD28Xpslaitbc%3D 10.1113/jphysiol.2006.110742 16777941 (Pubitemid 44182713)
    • (2006) Journal of Physiology , vol.575 , Issue.1 , pp. 305-315
    • Rieu, I.1    Balage, M.2    Sornet, C.3    Giraudet, C.4    Pujos, E.5    Grizard, J.6    Mosoni, L.7    Dardevet, D.8
  • 32
    • 65549171522 scopus 로고    scopus 로고
    • Long-term leucine supplementation does not increase muscle mass or strength in healthy elderly men
    • 1:CAS:528:DC%2BD1MXlt1Ort7c%3D 10.3945/ajcn.2008.26668 19321567
    • S. Verhoeven K. Vanschoonbeek L. B. Verdijk R. Koopman W. K. Wodzig P. Dendale L. J. van Loon 2009 Long-term leucine supplementation does not increase muscle mass or strength in healthy elderly men Am J Clin Nutr 89 1468 1475 1:CAS:528:DC%2BD1MXlt1Ort7c%3D 10.3945/ajcn.2008.26668 19321567
    • (2009) Am J Clin Nutr , vol.89 , pp. 1468-1475
    • Verhoeven, S.1    Vanschoonbeek, K.2    Verdijk, L.B.3    Koopman, R.4    Wodzig, W.K.5    Dendale, P.6    Van Loon, L.J.7
  • 34
    • 0036246852 scopus 로고    scopus 로고
    • Pulse protein feeding pattern restores stimulation of muscle protein synthesis during the feeding period in old rats
    • M. A. Arnal L. Mosoni D. Dardevet M. C. Ribeyre G. Bayle J. Prugnaud P. Patureau Mirand 2002 Pulse protein feeding pattern restores stimulation of muscle protein synthesis during the feeding period in old rats J Nutr 132 1002 1008 1:CAS:528:DC%2BD38XjvFSnsbo%3D 11983828 (Pubitemid 34493565)
    • (2002) Journal of Nutrition , vol.132 , Issue.5 , pp. 1002-1008
    • Arnal, M.-A.1    Mosoni, L.2    Dardevet, D.3    Ribeyre, M.-C.4    Bayle, G.5    Prugnaud, J.6    Patureau Mirand, P.7
  • 37
    • 56049122435 scopus 로고    scopus 로고
    • Functional impact of high protein intake on healthy elderly people
    • 1:CAS:528:DC%2BD1cXht1ymtbzK 10.1152/ajpendo.90536.2008 18697911
    • S. Walrand K. R. Short M. L. Bigelow A. J. Sweatt S. M. Hutson K. S. Nair 2008 Functional impact of high protein intake on healthy elderly people Am J Physiol Endocrinol Metab 295 E921 928 1:CAS:528:DC%2BD1cXht1ymtbzK 10.1152/ajpendo.90536.2008 18697911
    • (2008) Am J Physiol Endocrinol Metab , vol.295 , pp. 921-928
    • Walrand, S.1    Short, K.R.2    Bigelow, M.L.3    Sweatt, A.J.4    Hutson, S.M.5    Nair, K.S.6
  • 39
    • 53249087926 scopus 로고    scopus 로고
    • Whey protein ingestion in elderly persons results in greater muscle protein accrual than ingestion of its constituent essential amino acid content
    • 1:CAS:528:DC%2BD1cXht1egtLnF 10.1016/j.nutres.2008.06.007 19083472
    • C. S. Katsanos D. L. Chinkes D. Paddon-Jones X. J. Zhang A. Aarsland R. R. Wolfe 2008 Whey protein ingestion in elderly persons results in greater muscle protein accrual than ingestion of its constituent essential amino acid content Nutr Res 28 651 658 1:CAS:528:DC%2BD1cXht1egtLnF 10.1016/j.nutres.2008. 06.007 19083472
    • (2008) Nutr Res , vol.28 , pp. 651-658
    • Katsanos, C.S.1    Chinkes, D.L.2    Paddon-Jones, D.3    Zhang, X.J.4    Aarsland, A.5    Wolfe, R.R.6
  • 40
    • 31544472848 scopus 로고    scopus 로고
    • Differential stimulation of muscle protein synthesis in elderly humans following isocaloric ingestion of amino acids or whey protein
    • DOI 10.1016/j.exger.2005.10.006, PII S0531556505002548
    • D. Paddon-Jones M. Sheffield-Moore C. S. Katsanos X. J. Zhang R. R. Wolfe 2006 Differential stimulation of muscle protein synthesis in elderly humans following isocaloric ingestion of amino acids or whey protein Exp Gerontol 41 215 219 1:CAS:528:DC%2BD28XhtVCqtbg%3D 10.1016/j.exger.2005.10.006 16310330 (Pubitemid 43165694)
    • (2006) Experimental Gerontology , vol.41 , Issue.2 , pp. 215-219
    • Paddon-Jones, D.1    Sheffield-Moore, M.2    Katsanos, C.S.3    Zhang, X.-J.4    Wolfe, R.R.5
  • 41
    • 0026217043 scopus 로고
    • Ornithine alpha-ketoglutarate in nutritional support
    • 1:STN:280:DyaK383gvVGitw%3D%3D 1804465
    • L. Cynober 1991 Ornithine alpha-ketoglutarate in nutritional support Nutrition 7 313 322 1:STN:280:DyaK383gvVGitw%3D%3D 1804465
    • (1991) Nutrition , vol.7 , pp. 313-322
    • Cynober, L.1
  • 42
    • 0022520991 scopus 로고
    • Characteristics of a glutamine carrier in skeletal muscle have important consequences for nitrogen loss in injury, infection, and chronic disease
    • 1:CAS:528:DyaL2sXjtV2ntw%3D%3D 10.1016/S0140-6736(86)92617-6 2877174
    • M. J. Rennie H. S. Hundal P. Babij P. MacLennan P. M. Taylor P. W. Watt M. M. Jepson D. J. Millward 1986 Characteristics of a glutamine carrier in skeletal muscle have important consequences for nitrogen loss in injury, infection, and chronic disease Lancet 2 1008 1012 1:CAS:528:DyaL2sXjtV2ntw%3D%3D 10.1016/S0140-6736(86)92617-6 2877174
    • (1986) Lancet , vol.2 , pp. 1008-1012
    • Rennie, M.J.1    Hundal, H.S.2    Babij, P.3    MacLennan, P.4    Taylor, P.M.5    Watt, P.W.6    Jepson, M.M.7    Millward, D.J.8
  • 43
    • 0024411070 scopus 로고
    • Glutamine and ornithine-α-ketoglutarate but not branched-chain amino acids reduce the loss of muscle glutamine after surgical trauma
    • DOI 10.1016/0026-0495(89)90144-3
    • J. Wernerman F. Hammarkvist M. R. Ali E. Vinnars 1989 Glutamine and ornithine-alpha-ketoglutarate but not branched-chain amino acids reduce the loss of muscle glutamine after surgical trauma Metabolism 38 63 66 1:CAS:528:DyaL1MXlslartLg%3D 10.1016/0026-0495(89)90144-3 2503684 (Pubitemid 19207466)
    • (1989) Metabolism: Clinical and Experimental , vol.38 , Issue.8 SUPPL. 1 , pp. 63-66
    • Wernerman, J.1    Hammarkvist, F.2    Ali, M.R.3    Vinnars, E.4
  • 44
    • 0023472110 scopus 로고
    • Ornithine-alpha-ketoglutarate improves skeletal muscle protein synthesis as assessed by ribosome analysis and nitrogen use after surgery
    • 1:STN:280:DyaL1c%2FkvVKitw%3D%3D 10.1097/00000658-198711000-00020 3118827
    • J. Wernerman F. Hammarqvist A. von der Decken E. Vinnars 1987 Ornithine-alpha-ketoglutarate improves skeletal muscle protein synthesis as assessed by ribosome analysis and nitrogen use after surgery Ann Surg 206 674 678 1:STN:280:DyaL1c%2FkvVKitw%3D%3D 10.1097/00000658-198711000-00020 3118827
    • (1987) Ann Surg , vol.206 , pp. 674-678
    • Wernerman, J.1    Hammarqvist, F.2    Von Der Decken, A.3    Vinnars, E.4
  • 45
    • 0025308131 scopus 로고
    • Analogues to glutamine in clinical practice
    • 1:STN:280:DC%2BD28vhsFGrtw%3D%3D 10.1016/0261-5614(90)90078-7 16837324
    • J. Wernerman F. Hammarqvist A. von der Decken E. Vinnars 1990 Analogues to glutamine in clinical practice Clin Nutr 9 41 43 1:STN:280: DC%2BD28vhsFGrtw%3D%3D 10.1016/0261-5614(90)90078-7 16837324
    • (1990) Clin Nutr , vol.9 , pp. 41-43
    • Wernerman, J.1    Hammarqvist, F.2    Von Der Decken, A.3    Vinnars, E.4
  • 46
    • 0033489873 scopus 로고    scopus 로고
    • Glutamine and the immune system
    • 1:CAS:528:DyaK1MXnslaqtLw%3D 10.1007/BF01366922 10582122
    • P. C. Calder P. Yaqoob 1999 Glutamine and the immune system Amino Acids 17 227 241 1:CAS:528:DyaK1MXnslaqtLw%3D 10.1007/BF01366922 10582122
    • (1999) Amino Acids , vol.17 , pp. 227-241
    • Calder, P.C.1    Yaqoob, P.2
  • 47
    • 0025357122 scopus 로고
    • Glutamine metabolism in human lymphocytes
    • 1:STN:280:DC%2BD28vhsFGrsA%3D%3D 10.1016/0261-5614(90)90075-4 16837321
    • P. Schauder 1990 Glutamine metabolism in human lymphocytes Clin Nutr 9 36 37 1:STN:280:DC%2BD28vhsFGrsA%3D%3D 10.1016/0261-5614(90)90075-4 16837321
    • (1990) Clin Nutr , vol.9 , pp. 36-37
    • Schauder, P.1
  • 48
    • 0025914681 scopus 로고
    • Glutamine: A key substrate for the splanchnic bed
    • 1:CAS:528:DyaK3MXlsFOlsbw%3D 10.1146/annurev.nu.11.070191.001441 1892702
    • W. W. Souba 1991 Glutamine: a key substrate for the splanchnic bed Annu Rev Nutr 11 285 308 1:CAS:528:DyaK3MXlsFOlsbw%3D 10.1146/annurev.nu.11.070191. 001441 1892702
    • (1991) Annu Rev Nutr , vol.11 , pp. 285-308
    • Souba, W.W.1
  • 49
    • 0023252168 scopus 로고
    • A positive relationship between protein synthetic rate and intracellular glutamine concentration in perfused rat skeletal muscle
    • DOI 10.1016/0014-5793(87)80139-4
    • P. A. MacLennan R. A. Brown M. J. Rennie 1987 A positive relationship between protein synthetic rate and intracellular glutamine concentration in perfused rat skeletal muscle FEBS Lett 215 187 191 1:CAS:528:DyaL2sXktVCru7o%3D 10.1016/0014-5793(87)80139-4 2883028 (Pubitemid 17099161)
    • (1987) FEBS Letters , vol.215 , Issue.1 , pp. 187-191
    • MacLennan, P.A.1    Brown, R.A.2    Rennie, M.J.3
  • 50
    • 0037303876 scopus 로고    scopus 로고
    • Glutamine deprivation facilitates tumour necrosis factor induced bacterial translocation in Caco-2 cells by depletion of enterocyte fuel substrate
    • DOI 10.1136/gut.52.2.224
    • E. C. Clark S. D. Patel P. R. Chadwick G. Warhurst A. Curry G. L. Carlson 2003 Glutamine deprivation facilitates tumour necrosis factor induced bacterial translocation in Caco-2 cells by depletion of enterocyte fuel substrate Gut 52 224 230 1:CAS:528:DC%2BD3sXhtlShs7w%3D 10.1136/gut.52.2.224 12524404 (Pubitemid 36115063)
    • (2003) Gut , vol.52 , Issue.2 , pp. 224-230
    • Clark, E.C.1    Patel, S.D.2    Chadwick, P.R.3    Warhurst, G.4    Curry, A.5    Carlson, G.L.6
  • 51
    • 0029795778 scopus 로고    scopus 로고
    • OKG, glutamine, arginine and so on: Nutrients or drugs?
    • 1:STN:280:DC%2BD28vitV2htA%3D%3D 10.1016/S0261-5614(96)80247-0 16844040
    • L. Cynober 1996 OKG, glutamine, arginine and so on: nutrients or drugs? Clin Nutr 15 214 215 1:STN:280:DC%2BD28vitV2htA%3D%3D 10.1016/S0261-5614(96) 80247-0 16844040
    • (1996) Clin Nutr , vol.15 , pp. 214-215
    • Cynober, L.1
  • 52
    • 0033840204 scopus 로고    scopus 로고
    • Involvement of glutamine, arginine, and polyamines in the action of ornithine alpha-ketoglutarate on macrophage functions in stressed rats
    • 1:CAS:528:DC%2BD3cXktFWmsbs%3D 10857856
    • C. Moinard F. Caldefie S. Walrand C. Felgines M. P. Vasson L. Cynober 2000 Involvement of glutamine, arginine, and polyamines in the action of ornithine alpha-ketoglutarate on macrophage functions in stressed rats J Leukoc Biol 67 834 840 1:CAS:528:DC%2BD3cXktFWmsbs%3D 10857856
    • (2000) J Leukoc Biol , vol.67 , pp. 834-840
    • Moinard, C.1    Caldefie, F.2    Walrand, S.3    Felgines, C.4    Vasson, M.P.5    Cynober, L.6
  • 53
    • 0036185146 scopus 로고    scopus 로고
    • Effects of ornithine 2-oxoglutarate on neutrophils in stressed rats: Evidence for the involvement of nitric oxide and polyamines
    • DOI 10.1042/CS20010162
    • C. Moinard F. Caldefie S. Walrand A. Tridon J. Chassagne M. P. Vasson L. Cynober 2002 Effects of ornithine 2-oxoglutarate on neutrophils in stressed rats: evidence for the involvement of nitric oxide and polyamines Clin Sci (Lond) 102 287 295 1:CAS:528:DC%2BD38XislSnurw%3D 10.1042/CS20010162 (Pubitemid 34214391)
    • (2002) Clinical Science , vol.102 , Issue.3 , pp. 287-295
    • Moinard, C.1    Caldefie, F.2    Walrand, S.3    Tridon, A.4    Chassagne, J.5    Vasson, M.-P.6    Cynober, L.7
  • 54
    • 0032838402 scopus 로고    scopus 로고
    • Phagocyte functions in stressed rats: Comparison of modulation by glutamine, arginine and ornithine 2-oxoglutarate
    • DOI 10.1042/CS19980418
    • C. Moinard B. Chauveau S. Walrand C. Felgines J. Chassagne F. Caldefie L. A. Cynober M. P. Vasson 1999 Phagocyte functions in stressed rats: comparison of modulation by glutamine, arginine and ornithine 2-oxoglutarate Clin Sci (Lond) 97 59 65 1:CAS:528:DyaK1MXltFyjurw%3D 10.1042/CS19980418 (Pubitemid 29353895)
    • (1999) Clinical Science , vol.97 , Issue.1 , pp. 59-65
    • Moinard, C.1    Chauveau, B.2    Walrand, S.3    Felgines, C.4    Chassagne, J.5    Caldefie, F.6    Cynober, L.A.7    Vasson, M.-P.8
  • 55
    • 0020045422 scopus 로고
    • Changes of plasma amino acids in cirrhotics treated with ornithine salts
    • 1:STN:280:DyaL387otV2mug%3D%3D 10.1159/000176540 7073242
    • R. Molimard C. Charpentier F. Lemonnier 1982 [Changes of plasma amino acids in cirrhotics treated with ornithine salts] Ann Nutr Metab 26 25 36 1:STN:280:DyaL387otV2mug%3D%3D 10.1159/000176540 7073242
    • (1982) Ann Nutr Metab , vol.26 , pp. 25-36
    • Molimard, R.1    Charpentier, C.2    Lemonnier, F.3
  • 56
    • 0028985857 scopus 로고
    • Metabolism of ornithine, alpha-ketoglutarate and arginine in isolated perfused rat liver
    • 10.1079/BJN19950025 7718542
    • J. P. De Bandt L. Cynober S. K. Lim C. Coudray-Lucas R. Poupon J. Giboudeau 1995 Metabolism of ornithine, alpha-ketoglutarate and arginine in isolated perfused rat liver Br J Nutr 73 227 239 10.1079/BJN19950025 7718542
    • (1995) Br J Nutr , vol.73 , pp. 227-239
    • De Bandt, J.P.1    Cynober, L.2    Lim, S.K.3    Coudray-Lucas, C.4    Poupon, R.5    Giboudeau, J.6
  • 57
    • 0027481821 scopus 로고
    • Metabolic interaction between ornithine and alpha-ketoglutarate as a basis for the action of ornithine alpha-ketoglutarate
    • 1:CAS:528:DyaK3sXlsFyqtb0%3D 10.1016/0261-5614(93)90150-3 16843281
    • L. Cynober 1993 Metabolic interaction between ornithine and alpha-ketoglutarate as a basis for the action of ornithine alpha-ketoglutarate Clin Nutr 12 54 56 1:CAS:528:DyaK3sXlsFyqtb0%3D 10.1016/0261-5614(93)90150-3 16843281
    • (1993) Clin Nutr , vol.12 , pp. 54-56
    • Cynober, L.1
  • 58
    • 0036763526 scopus 로고    scopus 로고
    • The mechanism of action of ornithine alpha-ketaoglutarate and its role in clinical nutrition
    • 1:CAS:528:DC%2BD3sXkvVKrsA%3D%3D
    • D. Cardenas T. Le Bricon L. Cynober 2002 The mechanism of action of ornithine alpha-ketaoglutarate and its role in clinical nutrition Nutr Clin Metabol 16 151 163 1:CAS:528:DC%2BD3sXkvVKrsA%3D%3D
    • (2002) Nutr Clin Metabol , vol.16 , pp. 151-163
    • Cardenas, D.1    Le Bricon, T.2    Cynober, L.3
  • 59
    • 0037222253 scopus 로고    scopus 로고
    • Use of ornithine α-ketoglutarate in clinical nutrition of elderly patients
    • DOI 10.1016/S0899-9007(02)00849-3, PII S0899900702008493
    • F. Blonde-Cynober C. Aussel L. Cynober 2003 Use of ornithine alpha-ketoglutarate in clinical nutrition of elderly patients Nutrition 19 73 75 1:CAS:528:DC%2BD38XpvVahsL4%3D 10.1016/S0899-9007(02)00849-3 12507647 (Pubitemid 36044494)
    • (2003) Nutrition , vol.19 , Issue.1 , pp. 73-75
    • Blonde-Cynober, F.1    Aussel, C.2    Cynober, L.3
  • 60
    • 0031968638 scopus 로고    scopus 로고
    • A randomized controlled trial of the influence of the mode of enteral ornithine alpha-ketoglutarate administration in burn patients
    • 9482764
    • J. P. De Bandt C. Coudray-Lucas N. Lioret S. K. Lim R. Saizy J. Giboudeau L. Cynober 1998 A randomized controlled trial of the influence of the mode of enteral ornithine alpha-ketoglutarate administration in burn patients J Nutr 128 563 569 9482764
    • (1998) J Nutr , vol.128 , pp. 563-569
    • De Bandt, J.P.1    Coudray-Lucas, C.2    Lioret, N.3    Lim, S.K.4    Saizy, R.5    Giboudeau, J.6    Cynober, L.7
  • 61
    • 0033917350 scopus 로고    scopus 로고
    • Ornithine alpha-ketoglutarate improves wound healing in severe burn patients: A prospective randomized double-blind trial versus isonitrogenous controls
    • 1:STN:280:DC%2BD3czks1Kksw%3D%3D 10.1097/00003246-200006000-00012 10890617
    • C. Coudray-Lucas H. Le Bever L. Cynober J. P. De Bandt H. Carsin 2000 Ornithine alpha-ketoglutarate improves wound healing in severe burn patients: a prospective randomized double-blind trial versus isonitrogenous controls Crit Care Med 28 1772 1776 1:STN:280:DC%2BD3czks1Kksw%3D%3D 10.1097/00003246- 200006000-00012 10890617
    • (2000) Crit Care Med , vol.28 , pp. 1772-1776
    • Coudray-Lucas, C.1    Le Bever, H.2    Cynober, L.3    De Bandt, J.P.4    Carsin, H.5
  • 62
    • 0021996748 scopus 로고
    • Nitrogen sparing effect of ornicetil® in the immediate postoperative state. Clinical biochemistry and nitrogen balance
    • DOI 10.1016/0261-5614(85)90037-8
    • U. Leander P. Furst K. Vesterberg E. Vinnars 1985 Nitrogen sparing effect of Ornicetil in the immediate postoperative state clinical biochemistry and nitrogen balance Clin Nutr 4 43 51 1:STN:280:DC%2BD1cvgsFCqsQ%3D%3D 10.1016/0261-5614(85)90037-8 16831703 (Pubitemid 15105862)
    • (1985) Clinical Nutrition , vol.4 , Issue.1 , pp. 43-51
    • Leander, U.1    Furst, P.2    Vesterberg, K.3    Vinnars, E.4
  • 63
    • 0021397731 scopus 로고
    • Effects of ornithine alpha-ketoglutarate on the nutritional state of intensive-care patients]
    • 1:STN:280:DyaL2M7ltFahtA%3D%3D 6442191
    • J. M. Demarcq M. Delbar G. Trochu J. J. Crignon 1984 Effects of ornithine alpha-ketoglutarate on the nutritional state of intensive-care patients] Cah Anesthesiol 32 229 232 1:STN:280:DyaL2M7ltFahtA%3D%3D 6442191
    • (1984) Cah Anesthesiol , vol.32 , pp. 229-232
    • Demarcq, J.M.1    Delbar, M.2    Trochu, G.3    Crignon, J.J.4
  • 64
    • 0033429655 scopus 로고    scopus 로고
    • Substrate fuel kinetics in enterally fed trauma patients supplemented with ornithine alpha ketoglutarate
    • 1:CAS:528:DyaK1MXmsFOhsrs%3D 10.1016/S0261-5614(99)80072-7 10578020
    • M. Jeevanandam S. R. Petersen 1999 Substrate fuel kinetics in enterally fed trauma patients supplemented with ornithine alpha ketoglutarate Clin Nutr 18 209 217 1:CAS:528:DyaK1MXmsFOhsrs%3D 10.1016/S0261-5614(99)80072-7 10578020
    • (1999) Clin Nutr , vol.18 , pp. 209-217
    • Jeevanandam, M.1    Petersen, S.R.2
  • 65
    • 70349146296 scopus 로고    scopus 로고
    • Protein and energy supplementation in elderly people at risk from malnutrition
    • CD003288
    • Milne, A. C., Potter, J., Vivanti, A., and Avenell, A. (2009) Protein and energy supplementation in elderly people at risk from malnutrition. Cochrane Database Syst Rev, CD003288
    • (2009) Cochrane Database Syst Rev
    • Milne, A.C.1    Potter, J.2    Vivanti, A.3    Avenell, A.4
  • 66
    • 0028966099 scopus 로고
    • Acute renutrition by cyclic enteral nutrition in elderly and younger patients
    • 1:STN:280:DyaK2M7kslegsw%3D%3D 10.1001/jama.273.8.638 7844874
    • X. Hebuterne J. F. Broussard P. Rampal 1995 Acute renutrition by cyclic enteral nutrition in elderly and younger patients Jama 273 638 643 1:STN:280:DyaK2M7kslegsw%3D%3D 10.1001/jama.273.8.638 7844874
    • (1995) Jama , vol.273 , pp. 638-643
    • Hebuterne, X.1    Broussard, J.F.2    Rampal, P.3
  • 67
    • 0031424728 scopus 로고    scopus 로고
    • Effects of refeeding by cyclic enteral nutrition on body composition: Comparative study of elderly and younger patients
    • DOI 10.1016/S0261-5614(97)80013-1
    • X. Hebuterne S. Schneider J. L. Peroux P. Rampal 1997 Effects of refeeding by cyclic enteral nutrition on body composition: comparative study of elderly and younger patients Clin Nutr 16 283 289 1:STN:280: DC%2BD28vitV2qtA%3D%3D 10.1016/S0261-5614(97)80013-1 16844610 (Pubitemid 28065969)
    • (1997) Clinical Nutrition , vol.16 , Issue.6 , pp. 283-289
    • Hebuterne, X.1    Schneider, S.2    Peroux, J.-L.3    Rampal, P.4
  • 68
    • 0026562671 scopus 로고
    • The effect of age on the caloric requirement of malnourished individuals
    • 1:STN:280:DyaK387pslGnsQ%3D%3D 1550059
    • H. M. Shizgal M. F. Martin Z. Gimmon 1992 The effect of age on the caloric requirement of malnourished individuals Am J Clin Nutr 55 783 789 1:STN:280:DyaK387pslGnsQ%3D%3D 1550059
    • (1992) Am J Clin Nutr , vol.55 , pp. 783-789
    • Shizgal, H.M.1    Martin, M.F.2    Gimmon, Z.3
  • 69
    • 0002549837 scopus 로고
    • Value of ornithine-ketoglutarate for nutritional support in convalescent, malnourished elderly subjects
    • Debry, G., and T, P. (1995) Value of ornithine-ketoglutarate for nutritional support in convalescent, malnourished elderly subjects. Facts and Research in Gerontology, 165-176
    • (1995) Facts and Research in Gerontology , pp. 165-176
    • Debry, G.1    T, P.2
  • 70
    • 0028283767 scopus 로고
    • A two-centre, randomized, double-blind trial of ornithine oxoglutarate in 194 elderly, ambulatory, convalescent subjects
    • 1:STN:280:DyaK2M%2Fmslehuw%3D%3D 10.1093/ageing/23.4.303 7976777
    • P. Brocker B. Vellas J. L. Albarede T. Poynard 1994 A two-centre, randomized, double-blind trial of ornithine oxoglutarate in 194 elderly, ambulatory, convalescent subjects Age Ageing 23 303 306 1:STN:280: DyaK2M%2Fmslehuw%3D%3D 10.1093/ageing/23.4.303 7976777
    • (1994) Age Ageing , vol.23 , pp. 303-306
    • Brocker, P.1    Vellas, B.2    Albarede, J.L.3    Poynard, T.4
  • 71
    • 0021081675 scopus 로고
    • Impact de l'alpha cétoglutarate d'ornithine sur la dénutrition des sujets âgés en pratique ambulatoire
    • C. Baes Y. Bridoux A. Delory B. Mielcarek M. Vaconsin 1983 Impact de l'alpha cétoglutarate d'ornithine sur la dénutrition des sujets âgés en pratique ambulatoire Gaz. Med. France 90 4047 4049
    • (1983) Gaz. Med. France , vol.90 , pp. 4047-4049
    • Baes, C.1    Bridoux, Y.2    Delory, A.3    Mielcarek, B.4    Vaconsin, M.5
  • 72
    • 70349471703 scopus 로고
    • Comparaison en double aveugle des effets de l'oxoglurate d'ornithine sur le comportement alimentaire des sujets âgés
    • J. Mettetal Y. Wolmarck P. Berthaux 1990 Comparaison en double aveugle des effets de l'oxoglurate d'ornithine sur le comportement alimentaire des sujets âgés Rev. Gériatr. 15 353 355
    • (1990) Rev. Gériatr. , vol.15 , pp. 353-355
    • Mettetal, J.1    Wolmarck, Y.2    Berthaux, P.3
  • 73
    • 33847338909 scopus 로고    scopus 로고
    • Effect of ornithine α-ketoglutarate on glutamine pools in burn injury: Evidence of component interaction
    • DOI 10.1007/s00134-006-0511-0
    • L. Cynober E. Lasnier J. Le Boucher A. Jardel C. Coudray-Lucas 2007 Effect of ornithine alpha-ketoglutarate on glutamine pools in burn injury: evidence of component interaction Intensive Care Med 33 538 541 1:CAS:528:DC%2BD1cXhtFSgtrjO 10.1007/s00134-006-0511-0 17235510 (Pubitemid 46333844)
    • (2007) Intensive Care Medicine , vol.33 , Issue.3 , pp. 538-541
    • Cynober, L.1    Lasnier, E.2    Le Boucher, J.3    Jardel, A.4    Coudray-Lucas, C.5
  • 76
    • 57149135353 scopus 로고    scopus 로고
    • La citrulline module la synthèse protéique musculaire chez le rat âgé dénutri via l'activation de S6R et de P70S6kinase1
    • C. Moinard S. Le Plenier C. Perret L. Cynober 2007 La citrulline module la synthèse protéique musculaire chez le rat âgé dénutri via l'activation de S6R et de P70S6kinase1 Nutr Clin Metabol 21 S32 33
    • (2007) Nutr Clin Metabol , vol.21 , pp. 32-33
    • Moinard, C.1    Le Plenier, S.2    Perret, C.3    Cynober, L.4
  • 78
    • 0035142258 scopus 로고    scopus 로고
    • Effect of glutamine supplementation of the diet on tissue protein synthesis rate of glucocorticoid-treated rats
    • DOI 10.1016/S0899-9007(00)00505-0, PII S0899900700005050
    • J. J. Boza M. Turini D. Moennoz F. Montigon J. Vuichoud N. Gueissaz G. Gremaud E. Pouteau C. Piguet-Welsch P. A. Finot O. Ballevre 2001 Effect of glutamine supplementation of the diet on tissue protein synthesis rate of glucocorticoid-treated rats Nutrition 17 35 40 1:CAS:528:DC%2BD3MXhsVyktbw%3D 10.1016/S0899-9007(00)00505-0 11165886 (Pubitemid 32114329)
    • (2001) Nutrition , vol.17 , Issue.1 , pp. 35-40
    • Boza, J.J.1    Turini, M.2    Moennoz, D.3    Montigon, F.4    Vuichoud, J.5    Gueissaz, N.6    Gremaud, G.7    Pouteau, E.8    Piguet-Welsch, C.9    Finot, P.A.10    Ballevre, O.11
  • 79
    • 33646267446 scopus 로고    scopus 로고
    • Insulin resistance of muscle protein metabolism in aging
    • 1:CAS:528:DC%2BD28XjtlKisLo%3D 16464955
    • B. B. Rasmussen S. Fujita R. R. Wolfe B. Mittendorfer M. Roy V. L. Rowe E. Volpi 2006 Insulin resistance of muscle protein metabolism in aging Faseb J 20 768 769 1:CAS:528:DC%2BD28XjtlKisLo%3D 16464955
    • (2006) Faseb J , vol.20 , pp. 768-769
    • Rasmussen, B.B.1    Fujita, S.2    Wolfe, R.R.3    Mittendorfer, B.4    Roy, M.5    Rowe, V.L.6    Volpi, E.7
  • 80
    • 33847699009 scopus 로고    scopus 로고
    • Oxygen exchange in muscle of young and old rats: Muscle-vascular- pulmonary coupling
    • DOI 10.1113/expphysiol.2006.036764
    • D. C. Poole L. F. Ferreira 2007 Oxygen exchange in muscle of young and old rats: muscle-vascular-pulmonary coupling Exp Physiol 92 341 346 1:CAS:528:DC%2BD2sXkvFegs7k%3D 10.1113/expphysiol.2006.036764 17185349 (Pubitemid 46376324)
    • (2007) Experimental Physiology , vol.92 , Issue.2 , pp. 341-346
    • Poole, D.C.1    Ferreira, L.F.2
  • 81
    • 14844330782 scopus 로고    scopus 로고
    • Effects of aging on microvascular oxygen pressures in rat skeletal muscle
    • DOI 10.1016/j.resp.2004.12.009
    • B. J. Behnke M. D. Delp P. J. Dougherty T. I. Musch D. C. Poole 2005 Effects of aging on microvascular oxygen pressures in rat skeletal muscle Respir Physiol Neurobiol 146 259 268 10.1016/j.resp.2004.12.009 15766914 (Pubitemid 40349096)
    • (2005) Respiratory Physiology and Neurobiology , vol.146 , Issue.2-3 , pp. 259-268
    • Behnke, B.J.1    Delp, M.D.2    Dougherty, P.J.3    Musch, T.I.4    Poole, D.C.5
  • 82
    • 33645837065 scopus 로고    scopus 로고
    • Vasodilation and vascular control in contracting muscle of the aging human
    • 1:CAS:528:DC%2BD28XjtlKqtb4%3D 10.1080/10739680600618967 16611597
    • D. N. Proctor B. A. Parker 2006 Vasodilation and vascular control in contracting muscle of the aging human Microcirculation 13 315 327 1:CAS:528:DC%2BD28XjtlKqtb4%3D 10.1080/10739680600618967 16611597
    • (2006) Microcirculation , vol.13 , pp. 315-327
    • Proctor, D.N.1    Parker, B.A.2
  • 83
    • 0034124224 scopus 로고    scopus 로고
    • Interactions between nitric oxide and endothelin in the regulation of vascular tone of human resistance vessels in vivo
    • 1:CAS:528:DC%2BD3cXksVCntrs%3D 10856270
    • C. Cardillo C. M. Kilcoyne R. O. Cannon 3rd J. A. Panza 2000 Interactions between nitric oxide and endothelin in the regulation of vascular tone of human resistance vessels in vivo Hypertension 35 1237 1241 1:CAS:528: DC%2BD3cXksVCntrs%3D 10856270
    • (2000) Hypertension , vol.35 , pp. 1237-1241
    • Cardillo, C.1    Kilcoyne, C.M.2    Cannon III, R.O.3    Panza, J.A.4
  • 84
    • 0028113927 scopus 로고
    • Nitric oxide release accounts for insulin's vascular effects in humans
    • 1:CAS:528:DyaK2MXisFWgsrY%3D 10.1172/JCI117621 7989610
    • U. Scherrer D. Randin P. Vollenweider L. Vollenweider P. Nicod 1994 Nitric oxide release accounts for insulin's vascular effects in humans J Clin Invest 94 2511 2515 1:CAS:528:DyaK2MXisFWgsrY%3D 10.1172/JCI117621 7989610
    • (1994) J Clin Invest , vol.94 , pp. 2511-2515
    • Scherrer, U.1    Randin, D.2    Vollenweider, P.3    Vollenweider, L.4    Nicod, P.5
  • 85
    • 0028030813 scopus 로고
    • Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release
    • 1:CAS:528:DyaK2cXlslWjsLY%3D 10.1172/JCI117433 8083357
    • H. O. Steinberg G. Brechtel A. Johnson N. Fineberg A. D. Baron 1994 Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent. A novel action of insulin to increase nitric oxide release J Clin Invest 94 1172 1179 1:CAS:528:DyaK2cXlslWjsLY%3D 10.1172/JCI117433 8083357
    • (1994) J Clin Invest , vol.94 , pp. 1172-1179
    • Steinberg, H.O.1    Brechtel, G.2    Johnson, A.3    Fineberg, N.4    Baron, A.D.5
  • 86
    • 0029070893 scopus 로고
    • Insulin-mediated increase in blood flow is impaired in the elderly
    • 1:CAS:528:DyaK2MXmtFOms7c%3D 10.1210/jc.80.6.1899 7775638
    • G. S. Meneilly T. Elliot M. Bryer-Ash J. S. Floras 1995 Insulin-mediated increase in blood flow is impaired in the elderly J Clin Endocrinol Metab 80 1899 1903 1:CAS:528:DyaK2MXmtFOms7c%3D 10.1210/jc.80.6.1899 7775638
    • (1995) J Clin Endocrinol Metab , vol.80 , pp. 1899-1903
    • Meneilly, G.S.1    Elliot, T.2    Bryer-Ash, M.3    Floras, J.S.4
  • 87
    • 18744407265 scopus 로고    scopus 로고
    • Does dietary ornithine α-ketoglutarate supplementation protect the liver against ischemia-reperfusion injury?
    • DOI 10.1016/j.clnu.2004.12.002, PII S0261561404002110
    • H. Schuster M. C. Blanc C. Genthon P. Therond D. Bonnefont-Rousselot A. Le Tourneau J. P. De Bandt L. Cynober 2005 Does dietary ornithine alpha-ketoglutarate supplementation protect the liver against ischemia-reperfusion injury? Clin Nutr 24 375 384 1:CAS:528:DC%2BD2MXkt1Ckurw%3D 10.1016/j.clnu.2004.12.002 15896423 (Pubitemid 40668423)
    • (2005) Clinical Nutrition , vol.24 , Issue.3 , pp. 375-384
    • Schuster, H.1    Blanc, M.-C.2    Genthon, C.3    Therond, P.4    Bonnefont-Rousselot, D.5    Le Tourneau, A.6    De Bandt, J.-P.7    Cynober, L.8


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.