Sympathoadrenal activation and endotheliopathy are drivers of hypocoagulability and hyperfibrinolysis in trauma: A prospective observational study of 404 severely injured patients

Journal of Trauma and Acute Care Surgery

Volumn 82, Issue 2, 2017, Pages 293-301

  Ostrowski, Sisse R ^a   Henriksen, Hanne H ^a   Stensballe, Jakob ^a   Gybel Brask, Mikkel ^a   Cardenas, Jessica C ^b   Baer, Lisa A ^b   Cotton, Bryan A ^b   Holcomb, John B ^b   Wade, Charles E ^b   Johansson, Pär I ^a,b  

^a Rigshospitalet   (Denmark)

^b UNIVERSITY OF TEXAS MEDICAL SCHOOL   (United States)

Author keywords

catecholamines; coagulopathy; endotheliopathy; Endothelium; trauma

Indexed keywords

ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; EPINEPHRINE; NORADRENALIN; SYNDECAN 1; THROMBOMODULIN; VASCULAR ENDOTHELIAL CADHERIN; BIOLOGICAL MARKER;

ADRENALIN BLOOD LEVEL; ADULT; ARTICLE; AUTONOMIC NERVOUS SYSTEM FUNCTION; BLOOD CLOTTING DISORDER; BLUNT TRAUMA; CELL JUNCTION; CONTROLLED STUDY; EMERGENCY HEALTH SERVICE; ENDOTHELIAL DYSFUNCTION; ENDOTHELIOPATHY; ENDOTHELIUM CELL; ERYTHROCYTE TRANSFUSION; FEMALE; FIBRINOLYSIS; GLYCOCALYX; HEMOSTASIS; HOSPITAL ADMISSION; HUMAN; HYPERFIBRINOLYSIS; HYPOCOAGULABILITY; INJURY; INJURY SCALE; INJURY SEVERITY; MAJOR CLINICAL STUDY; MALE; MORTALITY; NUCLEOSOME; OBSERVATIONAL STUDY; PARTIAL THROMBOPLASTIN TIME; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTHROMBIN TIME; RAPID THROMBELASTOGRAPHY; SYMPATHOADRENAL ACTIVATION; THROMBOELASTOGRAPH; THROMBOELASTOGRAPHY; ADRENAL GLAND; ADRENERGIC SYSTEM; BLOOD; BLOOD COAGULATION DISORDERS; COMPLICATION; HOSPITAL MORTALITY; INNERVATION; MIDDLE AGED; PATHOLOGY; PATHOPHYSIOLOGY; PHYSIOLOGY; PROGNOSIS; VASCULAR ENDOTHELIUM;

ADRENAL GLANDS; ADULT; BIOMARKERS; BLOOD COAGULATION DISORDERS; ENDOTHELIUM, VASCULAR; FEMALE; FIBRINOLYSIS; HOSPITAL MORTALITY; HUMANS; INJURY SEVERITY SCORE; MALE; MIDDLE AGED; PROGNOSIS; PROSPECTIVE STUDIES; SYMPATHETIC NERVOUS SYSTEM; THROMBELASTOGRAPHY; TRAUMA CENTERS; WOUNDS, NONPENETRATING;

EID: 84992315777     PISSN: 21630755     EISSN: 21630763     Source Type: Journal    
DOI: 10.1097/TA.0000000000001304     Document Type: Article

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