Haemostatic function and biomarkers of endothelial damage before and after platelet transfusion in patients with acute myeloid leukaemia

Transfusion Medicine

Volumn 25, Issue 3, 2015, Pages 174-183

  Larsen, A M ^a   Leinoe E B ^b   Johansson, P I ^b   Larsen, R ^c   Wantzin, P ^a   Birgens, H ^a   Ostrowski, S R ^b  

^a Mental Health Services CPH   (Denmark)

^b Rigshospitalet   (Denmark)

^c HILLERØD HOSPITAL   (Denmark)

Author keywords

Acute myeloid leukaemia; Endothelium; Haemostasis; Platelet transfusion

Indexed keywords

BIOLOGICAL MARKER; HEMOGLOBIN; SYNDECAN 1; THROMBOMODULIN; TRANSFORMING GROWTH FACTOR BETA; CD40 LIGAND; TUMOR MARKER;

ACUTE MYELOBLASTIC LEUKEMIA; ADULT; ARTICLE; BLOOD; BLOOD BANK; BLOOD CLOTTING TEST; BLOOD DONOR; BLOOD SAMPLING; CELL DAMAGE; CLINICAL ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; FEMALE; HEMOGLOBIN BLOOD LEVEL; HEMOSTASIS; HUMAN; HUMAN CELL; IMMUNE RESPONSE; INFLAMMATION; LEUKOCYTE COUNT; MALE; MIDDLE AGED; SENSITIVITY ANALYSIS; THROMBOCYTE ACTIVATION; THROMBOCYTE AGGREGATION; THROMBOCYTE COUNT; THROMBOCYTE FUNCTION; THROMBOCYTE TRANSFUSION; THROMBOELASTOGRAPHY; AGED; CLINICAL TRIAL; INJURIES; LEUKEMIA, MYELOID, ACUTE; METABOLISM; MULTICENTER STUDY; VASCULAR ENDOTHELIUM;

AGED; BIOMARKERS, TUMOR; CD40 LIGAND; ENDOTHELIUM, VASCULAR; FEMALE; HEMOSTASIS; HUMANS; LEUKEMIA, MYELOID, ACUTE; MALE; MIDDLE AGED; PLATELET TRANSFUSION;

EID: 84937024106     PISSN: 09587578     EISSN: 13653148     Source Type: Journal    
DOI: 10.1111/tme.12209     Document Type: Article

References (30)

1. Apelseth, T.O., Bruserud, O., Wentzel-Larsen, T. & Hervig, T. (2010) Therapeutic efficacy of platelet transfusion in patients with acute leukemia: an evaluation of methods. Transfusion, 50, 766-775.
2. Apelseth, T.O., Hervig, T., Wentzel-Larsen, T., Petersen, K., Reikvam, H. & Bruserud, Ø. (2011) A prospective observational study of the effect of platelet transfusions on levels of platelet-derived cytokines, chemokines and interleukins in acute leukaemia patients with severe chemotherapy-induced cytopenia. European Cytokine Network, 22, 52-62.
3. Aslam, R., Speck, E.R., Kim, M., Freedman, J. & Semple, J.W. (2008) Transfusion-related immunomodulation by platelets is dependent on their expression of MHC class I molecules and is independent of white cells. Transfusion, 48, 1778-1786.
4. Blann, A.D. (2000) Endothelial cell activation, injury, damage and dysfunction: separate entities or mutual terms? Blood Coagulation & Fibrinolysis, 11, 623-630.
5. Blumberg, N., Gettings, K.F., Turner, C., Heal, J.M. & Phipps, R.P. (2006) An association of soluble CD40 ligand (CD154) with adverse reactions to platelet transfusions. Transfusion, 46, 1813-1821.
6. Blumberg, N., Phipps, R.P., Kaufman, J. & Heal, J.M. (2014) The causes and treatment of reactions to platelet transfusions. Transfusion, 58, 96.
7. Cognasse, F., Boussoulade, F., Chavarin, P., Acquart, S., Fabrigli, P., Lamy, B. & Garraud, O. (2006) Release of potential immunomodulatory factors during platelet storage. Transfusion, 46, 1184-1189.
8. Estcourt, L.J., Stanworth, S.J., Harrison, P., Powter, G., McClure, M., Murphy, M.F. & Mumford, A.D. (2014) Prospective observational cohort study of the association between thromboelastometry, coagulation and platelet parameters and bleeding in patients with haematological malignancies - the ATHENA study. British Journal of Haematology, 166, 581-591.
9. Geiger, T.L. (2008) Transfusion-associated immune modulation: a reason to TRIM platelet transfusions? Transfusion, 48, 1772-1773.
10. Haemoscope Corporation, Niles, IL, USA (2004) Guide to Functional Fibrinogen, 1-35.
11. Henn, V., Slupsky, J., Gräfe, M., Ioannis Anagnostopoulos, R.F., Kroczek, R.A. & Müller-Berghaus, G. (1998) CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells. Nature, 676, 591-594.
12. Hug, V., Keating, M., McCredie, K., Hester, J., Bodey, G.P. & Freireich, E.J. (1983) Clinical course and response to treatment of patients with acute myelogenous leukemia presenting with a high leukocyte count. Cancer, 52, 773-779.
13. Keir, A.K., McPhee, A.J., Andersen, C.C. & Stark, M.J. (2013) Plasma cytokines and markers of endothelial activation increase after packed red blood cell transfusion in the preterm infant. Pediatric Research, 73, 75-79.
14. Larsen, A.M., Leinoe, E.B., Johansson, P.I., Birgens, H. & Ostrowski, S.R. (2013) High syndecan-1 levels in acute myeloid leukemia are associated with bleeding, thrombocytopathy, endothelial cell damage, and leukocytosis. Leukemia Research, 37, 777-783.
15. Leinoe, E.B., Hoffmann, M.H., Kjaersgaard, E., Nielsen, J.D., Bergmann, O.J., Klausen, T.W. & Johnsen, H.E. (2005) Prediction of haemorrhage in the early stage of acute myeloid leukaemia by flow cytometric analysis of platelet function. British Journal of Haematology, 128, 526-532.
16. Nachman, R.L. & Rafii, S. (2008) Platelets, petechiae, and preservation of the vascular wall. The New England Journal of Medicine, 359, 1261-1270.
17. Ostrowski, S.R. & Johansson, P.I. (2011) Rethinking platelet function: thrombocytopenia induced immunodeficiency in critical illness. Medical Hypotheses, 77, 798-802.
18. Ostrowski, S.R., Bochsen, L., Salado-Jimena, J.A., Ullum, H., Reynaerts, I., Goodrich, R.P. & Johansson, P.I. (2010) In vitro cell quality of buffy coat platelets in additive solution treated with pathogen reduction technology. Transfusion, 50, 2210-2219.
19. Ostrowski, S.R., Berg, R.M.G., Windeløv, N.A., Meyer, M.A.S., Plovsing, R.R., Møller, K. & Johansson, P.I. (2013) Coagulopathy, catecholamines, and biomarkers of endothelial damage in experimental human endotoxemia and in patients with severe sepsis : a prospective study. Journal of Critical Care, 28, 586-596.
20. Phipps, R.P., Kaufman, J. & Blumberg, N. (2001) Platelet derived CD154 (CD40 ligand) and febrile responses to transfusion. The Lancet, 357, 2023-2024.
21. Rebulla, P., Finazzi, G., Marangoni, F. et al. (1997) The threshold for prophylactic platelet transfusions in adults with acute myeloid leukemia. New England Journal of Medicine, 337, 1870-1875.
22. Reitsma, S., Slaaf, D.W., Vink, H., van, Zandvoort, M.A. & oude Egbrink, M.G. (2007) The endothelial glycocalyx: composition, functions, and visualization. Pflügers Archiv: European Journal of Physiology, 454, 345-359.
23. Roeloffzen, W.W.H., Kluin-Nelemans, H.C., Mulder, A.B. & de, Wolf, J.T. (2010) Thrombocytopenia affects plasmatic coagulation as measured by thrombelastography. Blood Coagulation & Fibrinolysis, 21, 389-397.
24. Semple, J.W., Italiano, J.E. & Freedman, J. (2011) Platelets and the immune continuum. Nature Reviews Immunology, 11, 264-274.
25. Stanworth, S., Hyde, C., Heddle, N., Rebulla, P., Brunskill, S. & Murphy, M.F. (2004) Prophylactic platelet transfusion for haemorrhage after chemotherapy and stem cell transplantation. Cochrane Database of Systematic Reviews, 4.
26. Stanworth, S.J., Estcourt, L.J., Powter, G. et al. (2013) A no-prophylaxis platelet-transfusion strategy for hematologic cancers. New England Journal of Medicine, 368, 1771-1780.
27. Urner, M., Herrmann, I.K., Buddeberg, F. et al. (2012) Effects of blood products on inflammatory response in endothelial cells in vitro. PLoS One, 7, e33403.
28. Wandt, H., Schaefer-Eckart, K., Wendelin, K. et al. (2012) Therapeutic platelet transfusion versus routine prophylactic transfusion in patients with haematological malignancies: an open-label, multicentre, randomised study. Lancet, 380, 1309-1316.
29. Webert, K., Cook, R.J., Sigouin, C.S., Rebulla, P. & Heddle, N.M. (2006) The risk of bleeding in thrombocytopenic patients with acute myeloid leukemia. Haematologica, 91, 1530-1537.
30. Yellin, M.J., Brett, J., Baum, D., Matsushima, A., Szabolcs, M., Stern, D. & Chess, L. (1995) Functional interactions of the T cells with endothelial cells: the role of CD40L-CD40-mediated signals. Journal of Experimental Medicine, 182, 1857-1864.