메뉴 건너뛰기




Volumn 77, Issue 6, 2014, Pages 839-845

Measuring thrombin generation as a tool for predicting hemostatic potential and transfusion requirements following trauma

Author keywords

Coagulopathy; Thrombin; Trauma

Indexed keywords

THROMBIN;

EID: 84918550182     PISSN: 21630755     EISSN: 21630763     Source Type: Journal    
DOI: 10.1097/TA.0000000000000348     Document Type: Conference Paper
Times cited : (68)

References (40)
  • 1
    • 0028909841 scopus 로고
    • Epidemiology of trauma deaths: A reassessment
    • PubMed PMID: 7869433
    • Sauaia A, Moore FA, Moore EE, Moser KS, Brennan R, Read RA, et al. Epidemiology of trauma deaths: a reassessment. J Trauma. 1995;38(2): 185-193. PubMed PMID: 7869433.
    • (1995) J Trauma , vol.38 , Issue.2 , pp. 185-193
    • Sauaia, A.1    Moore, F.A.2    Moore, E.E.3    Moser, K.S.4    Brennan, R.5    Read, R.A.6
  • 2
    • 77949783052 scopus 로고    scopus 로고
    • Management of trauma-induced coagulopathy: Trends and practices
    • PubMed PMID: 20977127. Epub 2010/10/28. eng
    • D'Angelo MR, Dutton RP. Management of trauma-induced coagulopathy: trends and practices. AANA J. 2010;78(1):35-40. PubMed PMID: 20977127. Epub 2010/10/28. eng.
    • (2010) AANA J , vol.78 , Issue.1 , pp. 35-40
    • D'Angelo, M.R.1    Dutton, R.P.2
  • 3
    • 79952114098 scopus 로고    scopus 로고
    • Trauma induced coagulopathy
    • PubMed PMID: 20397610
    • Brohi K. Trauma induced coagulopathy. J R Army Med Corps. 2009;155(4): 320-322. PubMed PMID: 20397610.
    • (2009) J R Army Med Corps , vol.155 , Issue.4 , pp. 320-322
    • Brohi, K.1
  • 4
    • 43449134118 scopus 로고    scopus 로고
    • Acute coagulopathy of trauma: Hypoperfusion induces systemic anticoagulation and hyperfibrinolysis
    • discussion 1217. PubMed PMID: 18469643. Epub 2008/05/13. eng
    • Brohi K, Cohen MJ, Ganter MT, Schultz MJ, LeviM, Mackersie RC, et al. Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis. J Trauma. 2008;64(5):1211-1217; discussion 1217. PubMed PMID: 18469643. Epub 2008/05/13. eng.
    • (2008) J Trauma , vol.64 , Issue.5 , pp. 1211-1217
    • Brohi, K.1    Cohen, M.J.2    Ganter, M.T.3    Schultz, M.J.4    Levim Mackersie, R.C.5
  • 5
    • 0010514587 scopus 로고
    • Coagulation and fibrinolysis in injured patients
    • PubMed PMID: 14103515. Pubmed Central PMCID 480663
    • Innes D, Sevitt S. Coagulation and fibrinolysis in injured patients. J Clin Pathol. 1964;17:1-13. PubMed PMID: 14103515. Pubmed Central PMCID: 480663.
    • (1964) J Clin Pathol , vol.17 , pp. 1-13
    • Innes, D.1    Sevitt, S.2
  • 6
    • 0015387609 scopus 로고
    • Coagulopathy after major combat injury: Occurrence, management, and pathophysiology
    • PubMed PMID: 5077085. Pubmed Central PMCID 1355312
    • McNamara JJ, Burran EL, Stremple JF, Molot MD. Coagulopathy after major combat injury: occurrence, management, and pathophysiology. Ann Surg. 1972;176(2):243-246. PubMed PMID: 5077085. Pubmed Central PMCID: 1355312.
    • (1972) Ann Surg , vol.176 , Issue.2 , pp. 243-246
    • McNamara, J.J.1    Burran, E.L.2    Stremple, J.F.3    Molot, M.D.4
  • 7
    • 0014497258 scopus 로고
    • Coagulation disorders in combat casualties. I. Acute changes after wounding. Ii. Effects of massive transfusion. 3. Post-resuscitative changes
    • PubMed PMID: 5774736. PubmedCentral PMCID 1387454
    • Simmons RL, Collins JA, Heisterkamp CA, Mills DE, Andren R, Phillips LL. Coagulation disorders in combat casualties. I. Acute changes after wounding. II. Effects of massive transfusion. 3. Post-resuscitative changes. Ann Surg. 1969;169(4):455-482. PubMedPMID: 5774736. PubmedCentral PMCID: 1387454.
    • (1969) Ann Surg , vol.169 , Issue.4 , pp. 455-482
    • Simmons, R.L.1    Collins, J.A.2    Heisterkamp, C.A.3    Mills, D.E.4    Andren, R.5    Phillips, L.L.6
  • 8
    • 40849126406 scopus 로고    scopus 로고
    • Thrombin generation, fibrin clot formation and hemostasis
    • PubMed PMID: 18282807. Pubmed Central PMCID 2408736
    • Wolberg AS, Campbell RA. Thrombin generation, fibrin clot formation and hemostasis. Transfus Apher Sci. 2008;38(1):15-23. PubMed PMID: 18282807. Pubmed Central PMCID: 2408736.
    • (2008) Transfus Apher Sci , vol.38 , Issue.1 , pp. 15-23
    • Wolberg, A.S.1    Campbell, R.A.2
  • 9
    • 33644821104 scopus 로고    scopus 로고
    • What does it take to make the perfect clot?
    • PubMed PMID: 16254201
    • Monroe DM, Hoffman M. What does it take to make the perfect clot? Arterioscler ThrombVasc Biol. 2006;26(1):41-48. PubMed PMID: 16254201.
    • (2006) Arterioscler ThrombVasc Biol , vol.26 , Issue.1 , pp. 41-48
    • Monroe, D.M.1    Hoffman, M.2
  • 10
    • 34047229067 scopus 로고    scopus 로고
    • Thrombin generation and fibrin clot structure
    • PubMed PMID: 17208341
    • Wolberg AS. Thrombin generation and fibrin clot structure. Blood Rev. 2007;21(3):131-142. PubMed PMID: 17208341.
    • (2007) Blood Rev , vol.21 , Issue.3 , pp. 131-142
    • Wolberg, A.S.1
  • 12
    • 44349188657 scopus 로고    scopus 로고
    • New advances in the therapeutic and laboratory management of patients with haemophilia and inhibitors
    • PubMed PMID: 18494689
    • Dargaud Y, Lambert T, Trossaert M. New advances in the therapeutic and laboratory management of patients with haemophilia and inhibitors. Haemophilia. 2008;14(Suppl 4):20-27. PubMed PMID: 18494689.
    • (2008) Haemophilia , vol.14 , pp. 20-27
    • Dargaud, Y.1    Lambert, T.2    Trossaert, M.3
  • 13
    • 71849117107 scopus 로고    scopus 로고
    • Thrombin generation in trauma patients
    • PubMed PMID: 19682336
    • Dunbar NM, Chandler WL. Thrombin generation in trauma patients. Transfusion. 2009;49(12):2652-2660. PubMed PMID: 19682336.
    • (2009) Transfusion , vol.49 , Issue.12 , pp. 2652-2660
    • Dunbar, N.M.1    Chandler, W.L.2
  • 14
    • 84865482138 scopus 로고    scopus 로고
    • Admission rapid thrombelastography can replace conventional coagulation tests in the emergency department: Experience with 1974 consecutive trauma patients
    • PubMed# PMID: 22868371
    • Holcomb JB, Minei KM, Scerbo ML, Radwan ZA, Wade CE, Kozar RA, et al. Admission rapid thrombelastography can replace conventional coagulation tests in the emergency department: experience with 1974 consecutive trauma patients. Ann Surg. 2012;256(3):476-486. PubMed PMID: 22868371.
    • (2012) Ann Surg , vol.256 , Issue.3 , pp. 476-486
    • Holcomb, J.B.1    Minei, K.M.2    Scerbo, M.L.3    Radwan, Z.A.4    Wade, C.E.5    Kozar, R.A.6
  • 15
    • 80051772129 scopus 로고    scopus 로고
    • Rapid thrombelastography delivers real-time results that predict transfusion within 1 hour of admission
    • discussion 414-417. PubMed PMID: 21825945
    • Cotton BA, Faz G, Hatch QM, Radwan ZA, Podbielski J, Wade C, et al. Rapid thrombelastography delivers real-time results that predict transfusion within 1 hour of admission. J Trauma. 2011;71(2):407-414; discussion 414-417. PubMed PMID: 21825945.
    • (2011) J Trauma , vol.71 , Issue.2 , pp. 407-414
    • Cotton, B.A.1    Faz, G.2    Hatch, Q.M.3    Radwan, Z.A.4    Podbielski, J.5    Wade, C.6
  • 16
    • 67649220075 scopus 로고    scopus 로고
    • Predefined massive transfusion protocols are associated with a reduction in organ failure and postinjury complications
    • discussion 48-49. PubMed PMID: 19131804
    • Cotton BA, Au BK, Nunez TC, Gunter OL, Robertson AM, Young PP. Predefined massive transfusion protocols are associated with a reduction in organ failure and postinjury complications. J Trauma. 2009;66(1):41-48; discussion 48-49. PubMed PMID: 19131804.
    • (2009) J Trauma , vol.66 , Issue.1 , pp. 41-48
    • Cotton, B.A.1    Au, B.K.2    Nunez, T.C.3    Gunter, O.L.4    Robertson, A.M.5    Young, P.P.6
  • 17
    • 84872069750 scopus 로고    scopus 로고
    • Defining when to initiatemassive transfusion: A validation study of individual massive transfusion triggers in prommtt patients
    • 67-68; discussion 66-67. PubMed PMID 23271078
    • Callcut RA, Cotton BA, Muskat P, Fox EE, Wade CE, Holcomb JB, et al. Defining when to initiatemassive transfusion: a validation study of individual massive transfusion triggers in PROMMTT patients. J Trauma Acute Care Surg. 2013;74(1):59-65, 67-68; discussion 66-67. PubMedPMID: 23271078.
    • (2013) J Trauma Acute Care Surg , vol.74 , Issue.1 , pp. 59-65
    • Callcut, R.A.1    Cotton, B.A.2    Muskat, P.3    Fox, E.E.4    Wade, C.E.5    Holcomb, J.B.6
  • 18
    • 80052519077 scopus 로고    scopus 로고
    • Massive transfusion protocols for patients with substantial hemorrhage
    • PubMed PMID: 21664104. Pubmed Central PMCID 3176940
    • Young PP, Cotton BA, Goodnough LT. Massive transfusion protocols for patients with substantial hemorrhage. Transfus Med Rev. 2011;25(4): 293-303. PubMed PMID: 21664104. Pubmed Central PMCID: 3176940.
    • (2011) Transfus Med Rev , vol.25 , Issue.4 , pp. 293-303
    • Young, P.P.1    Cotton, B.A.2    Goodnough, L.T.3
  • 19
    • 84880402299 scopus 로고    scopus 로고
    • Early resuscitation intensity as a surrogate for bleeding severity and early mortality in the prommtt study
    • PubMed PMID: 23778506. Pubmed Central PMCID 3744217
    • Rahbar E, Fox EE, del Junco DJ, Harvin JA, Holcomb JB,Wade CE, et al. Early resuscitation intensity as a surrogate for bleeding severity and early mortality in the PROMMTT study. J Trauma Acute Care Surg. 2013;75(1Suppl 1):S16-S23. PubMed PMID: 23778506. Pubmed Central PMCID: 3744217.
    • (2013) J Trauma Acute Care Surg , vol.75 , Issue.1 , pp. S16-S23
    • Rahbar, E.1    Fox, E.E.2    Del Junco, D.J.3    Harvin, J.A.4    Holcomb, J.B.5    Wade, C.E.6
  • 20
    • 0031832408 scopus 로고    scopus 로고
    • Significant correlations between tissue factor and thrombin markers in trauma and septic patients with disseminated intravascular coagulation
    • PubMed PMID: 9657433
    • Gando S, Nanzaki S, Sasaki S, Kemmotsu O. Significant correlations between tissue factor and thrombin markers in trauma and septic patients with disseminated intravascular coagulation. Thromb Haemost. 1998;79(6): 1111-1115. PubMed PMID: 9657433.
    • (1998) Thromb Haemost , vol.79 , Issue.6 , pp. 1111-1115
    • Gando, S.1    Nanzaki, S.2    Sasaki, S.3    Kemmotsu, O.4
  • 21
    • 77954522283 scopus 로고    scopus 로고
    • Procoagulant activity in trauma patients
    • PubMed PMID: 20551272
    • Chandler WL. Procoagulant activity in trauma patients. Am J Clin Pathol. 2010;134(1):90-96. PubMed PMID: 20551272.
    • (2010) Am J Clin Pathol , vol.134 , Issue.1 , pp. 90-96
    • Chandler, W.L.1
  • 22
    • 70449556913 scopus 로고    scopus 로고
    • Effects of tissue factor, thrombomodulin and elevated clotting factor levels on thrombin generation in the calibrated automated thrombogram
    • PubMed PMID: 19888532. Pubmed Central PMCID 2904819
    • Machlus KR, Colby EA, Wu JR, Koch GG, Key NS, Wolberg AS. Effects of tissue factor, thrombomodulin and elevated clotting factor levels on thrombin generation in the calibrated automated thrombogram. Thromb Haemost. 2009;102(5):936-944. PubMed PMID: 19888532. Pubmed Central PMCID: 2904819.
    • (2009) Thromb Haemost , vol.102 , Issue.5 , pp. 936-944
    • Machlus, K.R.1    Colby, E.A.2    Wu, J.R.3    Koch, G.G.4    Key, N.S.5    Wolberg, A.S.6
  • 23
    • 79958796259 scopus 로고    scopus 로고
    • Pathophysiology of early trauma-induced coagulopathy: Emerging evidence for hemodilution and coagulation factor depletion
    • PubMed PMID 21460741. Pubmed Central PMCID 3131448
    • Shaz BH, Winkler AM, James AB, Hillyer CD, MacLeod JB. Pathophysiology of early trauma-induced coagulopathy: emerging evidence for hemodilution and coagulation factor depletion. J Trauma. 2011;70(6): 1401-1407. PubMedPMID: 21460741. Pubmed Central PMCID: 3131448.
    • (2011) J Trauma , vol.70 , Issue.6 , pp. 1401-1407
    • Shaz, B.H.1    Winkler, A.M.2    James, A.B.3    Hillyer, C.D.4    Macleod, J.B.5
  • 24
    • 37649010712 scopus 로고    scopus 로고
    • Coagulation factors and the protein c system as determinants of thrombin generation in a normal population
    • PubMed PMID: 17988231
    • Dielis AW, Castoldi E, Spronk HM, van Oerle R, Hamulyak K, Ten Cate H, et al. Coagulation factors and the protein C system as determinants of thrombin generation in a normal population. J Thromb Haemost. 2008;6(1): 125-131. PubMed PMID: 17988231.
    • (2008) J Thromb Haemost , vol.6 , Issue.1 , pp. 125-131
    • Dielis, A.W.1    Castoldi, E.2    Spronk, H.M.3    Van Oerle, R.4    Hamulyak, K.5    Ten Cate, H.6
  • 25
    • 43749099671 scopus 로고    scopus 로고
    • Influence of coagulation factors and tissue factor concentration on the thrombin generation test in plasma
    • PubMed PMID: 18392335
    • Duchemin J, Pan-Petesch B, Arnaud B, Blouch MT, Abgrall JF. Influence of coagulation factors and tissue factor concentration on the thrombin generation test in plasma. Thromb Haemost. 2008;99(4):767-773. PubMed PMID: 18392335.
    • (2008) Thromb Haemost , vol.99 , Issue.4 , pp. 767-773
    • Duchemin, J.1    Pan-Petesch, B.2    Arnaud, B.3    Blouch, M.T.4    Abgrall, J.F.5
  • 26
    • 34247568437 scopus 로고    scopus 로고
    • Acute traumatic coagulopathy: Initiated by hypoperfusion: Modulated through the protein c pathway?
    • PubMed PMID: 17457176. Pubmed Central PMCID 1877079
    • Brohi K, Cohen MJ, Ganter MT, Matthay MA, Mackersie RC, Pittet JF. Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway? Ann Surg. 2007;245(5):812-818. PubMed PMID: 17457176. Pubmed Central PMCID: 1877079.
    • (2007) Ann Surg , vol.245 , Issue.5 , pp. 812-818
    • Brohi, K.1    Cohen, M.J.2    Ganter, M.T.3    Matthay, M.A.4    Mackersie, R.C.5    Pittet, J.F.6
  • 27
    • 84855826297 scopus 로고    scopus 로고
    • Critical role of activated protein c in early coagulopathy and later organ failure, infection and death in trauma patients
    • PubMed PMID: 22133894. Pubmed Central PMCID: PMC3549308. Epub 2011/12/03. eng
    • Cohen MJ, Call M, Nelson M, Calfee CS, Esmon CT, Brohi K, et al. Critical role of activated protein C in early coagulopathy and later organ failure, infection and death in trauma patients. Ann Surg. 2012;255(2):379-385. PubMed PMID: 22133894. Pubmed Central PMCID: PMC3549308. Epub 2011/12/03. eng.
    • (2012) Ann Surg , vol.255 , Issue.2 , pp. 379-385
    • Cohen, M.J.1    Call, M.2    Nelson, M.3    Calfee, C.S.4    Esmon, C.T.5    Brohi, K.6
  • 28
    • 38949185037 scopus 로고    scopus 로고
    • Early coagulopathy after traumatic brain injury: The role of hypoperfusion and the protein c pathway
    • discussion 1261-1262. PubMed PMID: 18212647
    • Cohen MJ, Brohi K, Ganter MT, Manley GT, Mackersie RC, Pittet JF. Early coagulopathy after traumatic brain injury: the role of hypoperfusion and the protein C pathway. J Trauma. 2007;63(6):1254-1261; discussion 1261-1262. PubMed PMID: 18212647.
    • (2007) J Trauma , vol.63 , Issue.6 , pp. 1254-1261
    • Cohen, M.J.1    Brohi, K.2    Ganter, M.T.3    Manley, G.T.4    Mackersie, R.C.5    Pittet, J.F.6
  • 29
    • 81455154774 scopus 로고    scopus 로고
    • Clotting factor deficiency in early trauma-Associated coagulopathy
    • PubMed PMID: 22071999. Pubmed Central PMCID: PMC3241929. Epub 2011/12/17. eng
    • Rizoli SB, Scarpelini S, Callum J, Nascimento B, Mann KG, Pinto R, et al. Clotting factor deficiency in early trauma-Associated coagulopathy.JTrauma. 2011;71(5 Suppl 1):S427-S434. PubMed PMID: 22071999. Pubmed Central PMCID: PMC3241929. Epub 2011/12/17. eng.
    • (2011) JTrauma , vol.71 , Issue.5 , pp. S427-S434
    • Rizoli, S.B.1    Scarpelini, S.2    Callum, J.3    Nascimento, B.4    Mann, K.G.5    Pinto, R.6
  • 30
    • 81455159200 scopus 로고    scopus 로고
    • Hypoperfusion in severely injured trauma patients is associated with reduced coagulation factor activity
    • PubMed PMID: 22072000
    • Jansen JO, Scarpelini S, Pinto R, Tien HC, Callum J, Rizoli SB. Hypoperfusion in severely injured trauma patients is associated with reduced coagulation factor activity. J Trauma. 2011;71(5 Suppl 1):S435-S440. PubMed PMID: 22072000.
    • (2011) J Trauma , vol.71 , Issue.5 , pp. S435-S440
    • Jansen, J.O.1    Scarpelini, S.2    Pinto, R.3    Tien, H.C.4    Callum, J.5    Rizoli, S.B.6
  • 31
    • 84892186993 scopus 로고    scopus 로고
    • Activity of factor vii in patients with isolated blunt traumatic brain injury: Association with coagulopathy and progressive hemorrhagic injury
    • PubMed PMID: 24368365
    • Wu X, Du Z, Yu J, Sun Y, Pei B, Lu X, et al. Activity of factor VII in patients with isolated blunt traumatic brain injury: association with coagulopathy and progressive hemorrhagic injury. J Trauma Acute Care Surg. 2014;76(1): 114-120. PubMed PMID: 24368365.
    • (2014) J Trauma Acute Care Surg , vol.76 , Issue.1 , pp. 114-120
    • Wu, X.1    Du, Z.2    Yu, J.3    Sun, Y.4    Pei, B.5    Lu, X.6
  • 32
    • 84864242336 scopus 로고    scopus 로고
    • Endothelial glycocalyx degradation induces endogenous heparinization in patients with severe injury and early traumatic coagulopathy
    • PubMed PMID: 22743373
    • Ostrowski SR, Johansson PI. Endothelial glycocalyx degradation induces endogenous heparinization in patients with severe injury and early traumatic coagulopathy. J Trauma Acute Care Surg. 2012;73(1):60-66. PubMed PMID: 22743373.
    • (2012) J Trauma Acute Care Surg , vol.73 , Issue.1 , pp. 60-66
    • Ostrowski, S.R.1    Johansson, P.I.2
  • 33
    • 84894453966 scopus 로고    scopus 로고
    • Plasma colloid osmotic pressure is an early indicator of injury and hemorrhagic shock
    • Rahbar E, Baer LA, Cotton BA, Holcomb JB, Wade CE. Plasma colloid osmotic pressure is an early indicator of injury and hemorrhagic shock. Shock. 2014;41:181-187.
    • (2014) Shock , vol.41 , pp. 181-187
    • Rahbar, E.1    Baer, L.A.2    Cotton, B.A.3    Holcomb, J.B.4    Wade, C.E.5
  • 34
    • 79958106996 scopus 로고    scopus 로고
    • Plasma restoration of endothelial glycocalyx in a rodent model of hemorrhagic shock
    • PubMed PMID: 21346161. Pubmed Central PMCID 3102787
    • Kozar RA, Peng Z, Zhang R, Holcomb JB, Pati S, Park P, et al. Plasma restoration of endothelial glycocalyx in a rodent model of hemorrhagic shock. Anesth Analg. 2011;112(6):1289-1295. PubMed PMID: 21346161. Pubmed Central PMCID: 3102787.
    • (2011) Anesth Analg , vol.112 , Issue.6 , pp. 1289-1295
    • Kozar, R.A.1    Peng, Z.2    Zhang, R.3    Holcomb, J.B.4    Pati, S.5    Park, P.6
  • 35
    • 0027567887 scopus 로고
    • Structure-function relationships of the thrombin-thrombomodulin interaction
    • PubMed PMID: 8388351
    • Sadler JE, Lentz SR, Sheehan JP, Tsiang M, Wu Q. Structure-function relationships of the thrombin-thrombomodulin interaction. Haemostasis. 1993;23(Suppl 1):183-193. PubMed PMID: 8388351.
    • (1993) Haemostasis , vol.23 , pp. 183-193
    • Sadler, J.E.1    Lentz, S.R.2    Sheehan, J.P.3    Tsiang, M.4    Wu, Q.5
  • 37
    • 84883579679 scopus 로고    scopus 로고
    • Normal prothrombinase activity, increased systemic thrombin activity, and lower antithrombin levels in patients with disseminated intravascular coagulation at an early phase of trauma: Comparison with acute coagulopathy of trauma-shock
    • PubMed PMID: 23684364
    • Yanagida Y, Gando S, Sawamura A, Hayakawa M, Uegaki S, Kubota N, et al. Normal prothrombinase activity, increased systemic thrombin activity, and lower antithrombin levels in patients with disseminated intravascular coagulation at an early phase of trauma: comparison with acute coagulopathy of trauma-shock. Surgery. 2013;154(1):48-57. PubMed PMID: 23684364.
    • (2013) Surgery , vol.154 , Issue.1 , pp. 48-57
    • Yanagida, Y.1    Gando, S.2    Sawamura, A.3    Hayakawa, M.4    Uegaki, S.5    Kubota, N.6
  • 38
    • 38349104987 scopus 로고    scopus 로고
    • Increased thrombin generation and fibrinogen level after therapeutic plasma transfusion: Relation to bleeding
    • PubMed PMID: 18217136
    • Schols SE, van der Meijden PE, van Oerle R, Curvers J, Heemskerk JW, van Pampus EC. Increased thrombin generation and fibrinogen level after therapeutic plasma transfusion: relation to bleeding. Thromb Haemost. 2008;99(1):64-70. PubMed PMID: 18217136.
    • (2008) Thromb Haemost , vol.99 , Issue.1 , pp. 64-70
    • Schols, S.E.1    Van Der Meijden, P.E.2    Van Oerle, R.3    Curvers, J.4    Heemskerk, J.W.5    Van Pampus, E.C.6
  • 39
    • 84877864702 scopus 로고    scopus 로고
    • Thrombin generation capacity of prothrombin complex concentrate in an in vitro dilutional model
    • PubMed PMID: 23696866. Pubmed Central PMCID 3656958
    • Grottke O, Rossaint R, Henskens Y, van Oerle R, Ten Cate H, Spronk HM. Thrombin generation capacity of prothrombin complex concentrate in an in vitro dilutional model. PloS One. 2013;8(5):e64100. PubMed PMID: 23696866. Pubmed Central PMCID: 3656958.
    • (2013) PloS One , vol.8 , Issue.5 , pp. e64100
    • Grottke, O.1    Rossaint, R.2    Henskens, Y.3    Van Oerle, R.4    Ten Cate, H.5    Spronk, H.M.6
  • 40
    • 84872094662 scopus 로고    scopus 로고
    • Prothrombin complex concentrate: An effective therapy in reversing the coagulopathy of traumatic brain injury
    • PubMed PMID: 23271101
    • Joseph B, Hadjizacharia P, Aziz H, Kulvatunyou N, Tang A, Pandit V, et al. Prothrombin complex concentrate: an effective therapy in reversing the coagulopathy of traumatic brain injury. J Trauma Acute Care Surg. 2013; 74(1):248-253. PubMed PMID: 23271101.
    • (2013) J Trauma Acute Care Surg , vol.74 , Issue.1 , pp. 248-253
    • Joseph, B.1    Hadjizacharia, P.2    Aziz, H.3    Kulvatunyou, N.4    Tang, A.5    Pandit, V.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.