Hypofunctional TrkA Accounts for the Absence of Pain Sensitization in the African Naked Mole-Rat

Cell Reports

Volumn 17, Issue 3, 2016, Pages 748-758

  Omerbašić, Damir ^a   Smith, Ewan St J ^a,b   Moroni, Mirko ^a   Homfeld, Johanna ^a   Eigenbrod, Ole ^a   Bennett, Nigel C ^c   Reznick, Jane ^a   Faulkes, Chris G ^d   Selbach, Matthias ^a   Lewin, Gary R ^a,e  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^c UNIVERSITY OF PRETORIA   (South Africa)

^d QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

^e CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

calcium imaging; capsaicin receptor; electrophysiology; hyperalgesia; nerve growth factor; nociceptor development; receptor kinase signaling; sensitization; transcriptome assembly

Indexed keywords

PROTEIN TYROSINE KINASE A; VANILLOID RECEPTOR 1; NERVE GROWTH FACTOR; VANILLOID RECEPTOR;

ADULT; AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CHO CELL LINE; CONTROLLED STUDY; FEMALE; HETEROCEPHALUS; HYPERALGESIA; MOLECULAR BIOLOGY; MOUSE; NONHUMAN; PAIN; PAIN RECEPTOR; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEOMICS; QUANTITATIVE ANALYSIS; RAT; SENSITIZATION; SENSORY NERVE CELL; SIGNAL TRANSDUCTION; ANIMAL; CHANNEL GATING; CHEMISTRY; DRUG EFFECTS; HEK293 CELL LINE; HUMAN; METABOLISM; MOLE RAT; NERVE CELL; PATHOLOGY; PATHOPHYSIOLOGY; SPINAL GANGLION;

ANIMALS; GANGLIA, SPINAL; HEK293 CELLS; HUMANS; ION CHANNEL GATING; MOLE RATS; NERVE GROWTH FACTOR; NEURONS; NOCICEPTORS; PAIN; PROTEIN DOMAINS; PROTEOMICS; RECEPTOR, TRKA; TRPV CATION CHANNELS;

EID: 84992191727     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2016.09.035     Document Type: Article

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