Temporal proteomics of NGF-TrkA signaling identifies an inhibitory role for the E3 ligase Cbl-b in neuroblastoma cell differentiation

Science Signaling

Volumn 8, Issue 374, 2015, Pages

  Emdal, Kristina B ^a   Pedersen, Anna Kathrine ^a   Bekker Jensen, Dorte B ^a   Tsafou, Kalliopi P ^a   Horn, Heiko ^a   Lindner, Sven ^b   Schulte, Johannes H ^b,c,d   Eggert, Angelika ^b,c,d   Jensen, Lars J ^a   Francavilla, Chiara ^a   Olsen, Jesper V ^a  

^a University of Copenhagen   (Denmark)

^b UNIVERSITY HOSPITAL ESSEN   (Germany)

^c CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^d GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CBL B PROTEIN; CBL PROTEIN; CYCLOHEXIMIDE; DUAL SPECIFICITY PHOSPHATASE 4; INTERACTOME; MITOGEN ACTIVATED PROTEIN KINASE; NERVE GROWTH FACTOR; PHOSPHOPROTEOME; PROTEIN KINASE B; PROTEIN KINASE WNK2; PROTEIN TYROSINE KINASE A; PROTEOME; SPROUTY 4 PROTEIN; SPROUTY PROTEIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG; CBLB PROTEIN, HUMAN; NGF PROTEIN, HUMAN; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; CELL DIFFERENTIATION; CELL LYSATE; CELL STIMULATION; COMPARATIVE STUDY; CONTROLLED STUDY; DOWN REGULATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; ISOTOPE LABELING; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; NERVE CELL DIFFERENTIATION; NERVE FIBER GROWTH; NEUROBLASTOMA CELL; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN SYNTHESIS; PROTEOMICS; QUANTITATIVE ANALYSIS; SIGNAL TRANSDUCTION; TANDEM MASS SPECTROMETRY; UBIQUITINATION; WESTERN BLOTTING; GENETICS; METABOLISM; NEURITE; NEUROBLASTOMA; PATHOLOGY; TUMOR CELL LINE;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; CELL DIFFERENTIATION; CELL LINE, TUMOR; HUMANS; MAP KINASE SIGNALING SYSTEM; NERVE GROWTH FACTOR; NEURITES; NEUROBLASTOMA; PROTO-ONCOGENE PROTEINS C-CBL; RECEPTOR, TRKA;

EID: 84928733586     PISSN: 19450877     EISSN: 19379145     Source Type: Journal    
DOI: 10.1126/scisignal.2005769     Document Type: Article

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