Dysregulation of Notch and ERα signaling in AhR-/- male mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 113, Issue 42, 2016, Pages 11883-11888

  Huang, Bo ^a   Butler, Ryan ^a   Miao, Yifei ^a   Dai, Yubing ^a   Wu, Wanfu ^a   Su, Wen ^a   Fujii Kuriyama, Yoshiaki ^b   Warner, Margaret ^a   Gustafsson, Jan Åke ^a,c  

^a University of Houston   (United States)

^b UNIVERSITY OF TOKYO   (Japan)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Aryl hydrocarbon receptor; Germ cell apoptosis; Low fertility; Mammary gland; Testosterone

Indexed keywords

ANDROGEN RECEPTOR; AROMATASE; ESTROGEN; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; NOTCH RECEPTOR; NOTCH1 RECEPTOR; NOTCH3 RECEPTOR; TRANSCRIPTION FACTOR HES 1; AHR PROTEIN, MOUSE; AROMATIC HYDROCARBON RECEPTOR; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; BIOLOGICAL MARKER; PROGESTERONE RECEPTOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; FEMALE; GERM CELL; MALE; MALE INFERTILITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SPERMATID; SPERMATOCYTE; TESTIS; ANIMAL; DEFICIENCY; FERTILITY; GENE DELETION; GENE EXPRESSION; GENETICS; GROWTH, DEVELOPMENT AND AGING; IMMUNOHISTOCHEMISTRY; KNOCKOUT MOUSE; METABOLISM; UDDER;

ANIMALS; APOPTOSIS; AROMATASE; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BIOMARKERS; CELL PROLIFERATION; ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; FEMALE; FERTILITY; GENE DELETION; GENE EXPRESSION; GERM CELLS; IMMUNOHISTOCHEMISTRY; MALE; MAMMARY GLANDS, ANIMAL; MICE; MICE, KNOCKOUT; RECEPTORS, ANDROGEN; RECEPTORS, ARYL HYDROCARBON; RECEPTORS, NOTCH; RECEPTORS, PROGESTERONE; SIGNAL TRANSDUCTION; SPERMATOCYTES; TESTIS;

EID: 84991648837     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1613269113     Document Type: Article

References (38)

1. Ema M, et al. (1992) cDNA cloning and structure of mouse putative Ah receptor. Biochem Biophys Res Commun 184(1):246-253.
2. Burbach KM, Poland A, Bradfield CA (1992) Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor. Proc Natl Acad Sci USA 89(17):8185-8189.
3. Bock KW, Köhle C (2009) The mammalian aryl hydrocarbon (Ah) receptor: From mediator of dioxin toxicity toward physiological functions in skin and liver. Biol Chem 390(12):1225-1235.
4. Stevens EA, Mezrich JD, Bradfield CA (2009) The aryl hydrocarbon receptor: A perspective on potential roles in the immune system. Immunology 127(3):299-311.
5. Gonzalez FJ, Fernandez-Salguero P (1998) The aryl hydrocarbon receptor: Studies using the AHR-null mice. Drug Metab Dispos 26(12):1194-1198.
6. Khan S, et al. (2006) Molecular mechanism of inhibitory aryl hydrocarbon receptor-estrogen receptor/Sp1 cross talk in breast cancer cells. Mol Endocrinol 20(9):2199-2214.
7. Matthews J, Gustafsson JA (2006) Estrogen receptor and aryl hydrocarbon receptor signaling pathways. Nucl Recept Signal 4:e016.
8. Vogel CF, et al. (2014) Cross-talk between aryl hydrocarbon receptor and the inflammatory response: A role for nuclear factor-κB. J Biol Chem 289(3):1866-1875.
9. Wu Y, Baumgarten SC, Zhou P, Stocco C (2013) Testosterone-dependent interaction between androgen receptor and aryl hydrocarbon receptor induces liver receptor homolog 1 expression in rat granulosa cells. Mol Cell Biol 33(15):2817-2828.
10. Baba T, et al. (2005) Intrinsic function of the aryl hydrocarbon (dioxin) receptor as a key factor in female reproduction. Mol Cell Biol 25(22):10040-10051.
11. Baba T, et al. (2008) Disruption of aryl hydrocarbon receptor (AhR) induces regression of the seminal vesicle in aged male mice. Sex Dev 2(1):1-11.
12. Li X, et al. (2006) Transgenic mice expressing p450 aromatase as a model for male infertility associated with chronic inflammation in the testis. Endocrinology 147(3):1271-1277.
13. Liu D, et al. (1998) Cyclin A1 is required for meiosis in the male mouse. Nat Genet 20(4):377-380.
14. Murta D, et al. (2014) In vivo notch signaling blockade induces abnormal spermatogenesis in the mouse. PLoS One 9(11):e113365.
15. Thomsen JS, Kietz S, Ström A, Gustafsson JA (2004) HES-1, a novel target gene for the aryl hydrocarbon receptor. Mol Pharmacol 65(1):165-171.
16. Sofikitis N, et al. (2008) Hormonal regulation of spermatogenesis and spermiogenesis. J Steroid Biochem Mol Biol 109(3-5):323-330.
17. Shaha C, Tripathi R, Mishra DP (2010) Male germ cell apoptosis: Regulation and biology. Philos Trans R Soc Lond B Biol Sci 365(1546):1501-1515.
18. Kim JM, Ghosh SR, Weil AC, Zirkin BR (2001) Caspase-3 and caspase-activated deoxyribonuclease are associated with testicular germ cell apoptosis resulting from reduced intratesticular testosterone. Endocrinology 142(9):3809-3816.
19. Li X, et al. (2002) Mammary gland development in transgenic male mice expressing human P450 aromatase. Endocrinology 143(10):4074-4083.
20. Gill K, Kirma N, Tekmal RR (2001) Overexpression of aromatase in transgenic male mice results in the induction of gynecomastia and other biochemical changes in mammary glands. J Steroid Biochem Mol Biol 77(1):13-18.
21. Rotter V, et al. (1993) Mice with reduced levels of p53 protein exhibit the testicular giant-cell degenerative syndrome. Proc Natl Acad Sci USA 90(19):9075-9079.
22. Hansen DA, Esakky P, Drury A, Lamb L, Moley KH (2014) The aryl hydrocarbon receptor is important for proper seminiferous tubule architecture and sperm development in mice. Biol Reprod 90(1):8.
23. Andersson ER, Sandberg R, Lendahl U (2011) Notch signaling: Simplicity in design, versatility in function. Development 138(17):3593-3612.
24. Al Qassabi SS, Al-Harthi SM, Al-Osali ME (2015) Mixed gynecomastia. Saudi Med J 36(9):1115-1117.
25. Hushka LJ, Williams JS, Greenlee WF (1998) Characterization of 2,3,7,8-tetrachlorodibenzofuran-dependent suppression and AH receptor pathway gene expression in the developing mouse mammary gland. Toxicol Appl Pharmacol 152(1):200-210.
26. Sternlicht MD, Kouros-Mehr H, Lu P, Werb Z (2006) Hormonal and local control of mammary branching morphogenesis. Differentiation 74(7):365-381.
27. Brisken C, O'Malley B (2010) Hormone action in the mammary gland. Cold Spring Harb Perspect Biol 2(12):a003178.
28. Antal MC, Krust A, Chambon P, Mark M (2008) Sterility and absence of histopathological defects in nonreproductive organs of a mouse ERbeta-null mutant. Proc Natl Acad Sci USA 105(7):2433-2438.
29. Förster C, et al. (2002) Involvement of estrogen receptor beta in terminal differentiation of mammary gland epithelium. Proc Natl Acad Sci USA 99(24):15578-15583.
30. Zhou Q, et al. (2002) Localization of androgen and estrogen receptors in adult male mouse reproductive tract. J Androl 23(6):870-881.
31. Mäkinen S, et al. (2001) Localization of oestrogen receptors alpha and beta in human testis. Mol Hum Reprod 7(6):497-503.
32. Mimura J, et al. (1997) Loss of teratogenic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the Ah (dioxin) receptor. Genes Cells 2(10):645-654.
33. Shimizu Y, et al. (2000) Benzo[a]pyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor. Proc Natl Acad Sci USA 97(2):779-782.
34. Plante I, Stewart MK, Laird DW (2011) Evaluation of mammary gland development and function in mouse models. J Vis Exp (53):2828.
35. Huang B, et al. (2012) RUNX3 acts as a tumor suppressor in breast cancer by targeting estrogen receptor α. Oncogene 31(4):527-534.
36. Jeong JH, et al. (2010) The gene for aromatase, a rate-limiting enzyme for local estrogen biosynthesis, is a downstream target gene of Runx2 in skeletal tissues. Mol Cell Biol 30(10):2365-2375.
37. Huang B, et al. (2014) Differential expression of estrogen receptor α, β1, and β2 in lobular and ductal breast cancer. Proc Natl Acad Sci USA 111(5):1933-1938.
38. Jensen EC (2013) Quantitative analysis of histological staining and fluorescence using ImageJ. Anat Rec (Hoboken) 296(3):378-381.