Molecular mechanism of inhibitory aryl hydrocarbon receptor - Estrogen receptor/Sp1 cross talk in breast cancer cells

Molecular Endocrinology

Volumn 20, Issue 9, 2006, Pages 2199-2214

  Khan, Shaheen ^a   Barhoumi, Rola ^b   Burghardt, Robert ^b   Liu, Shengxi ^c   Kim, Kyounghyun ^d   Safe, Stephen ^a,c  

^a TEXAS A AND M UNIVERSITY   (United States)

^b TEXAS A AND M UNIVERSITY   (United States)

^c TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

^d NONE

Author keywords

[No Author keywords available]

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; AROMATIC HYDROCARBON RECEPTOR; ASPARTATE CARBAMOYLTRANSFERASE; CARBAMOYL PHOSPHATE SYNTHASE; DIHYDROOROTASE; ESTRADIOL; ESTROGEN RECEPTOR; ESTROGEN RECEPTOR ALPHA; TRANSCRIPTION FACTOR SP1;

ARTICLE; BREAST CANCER; CANCER CELL; DRUG EFFECT; GENE ACTIVATION; GENE ACTIVITY; GENE EXPRESSION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION;

ANIMALS; ASPARTATE CARBAMOYLTRANSFERASE; BREAST NEOPLASMS; CARBAMOYL-PHOSPHATE SYNTHASE (GLUTAMINE-HYDROLYZING); CELL LINE; CERCOPITHECUS AETHIOPS; CYTOCHROME P-450 CYP1A1; DIHYDROOROTASE; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; FLUORESCENCE RESONANCE ENERGY TRANSFER; GENE EXPRESSION; GENES, REPORTER; HUMANS; LIGANDS; MUTATION; PROMOTER REGIONS (GENETICS); RECEPTORS, ARYL HYDROCARBON; SP1 TRANSCRIPTION FACTOR; TETRACHLORODIBENZODIOXIN;

EID: 33747820887     PISSN: 08888809     EISSN: 08888809     Source Type: Journal    
DOI: 10.1210/me.2006-0100     Document Type: Article

References (54)

1. Clark JH 1998 Female reproduction and toxicology of estrogens. In: Korach KS, ed. Reproductive and developmental toxicology. New York: Marcel Dekker; 259-275
2. Turner RT, Riggs BL, Spelsberg TC 1994 Skeletal effects of estrogen. Endocr Rev 15:275-300
3. Couse JF, Korach KS 1999 Estrogen receptor null mice: what have we learned and where will they lead us? Endocr Rev 20:358-417
4. Krege JH, Hodgin JB, Couse JF, Enmark E, Warner M, Mahler JF, Sar M, Korach KS, Gustafsson JA, Smithies O 1998 Generation and reproductive phenotypes of mice lacking estrogen receptor β. Proc Natl Acad Sci USA 95:15677-15682
5. Chow J, Tobias JH, Colston KW 1992 Estrogen maintains trabecular bone volume in rats not only by suppression of bone resorption but also by stimulation of bone formation. J Clin Invest 89:74-78
6. Farhat MY, Lavigne MC, Ramwell PW 1996 The vascular protective effects of estrogen. FASEB J 10:615-624
7. Clemons M, Goss P 2001 Estrogen and the risk of breast cancer. N Engl J Med 344:276-285
8. Hulka BS, Liu ET, Lininger RA 1994 Steroid hormones and risk of breast cancer. Cancer 74:1111-1124
9. MacGregor JI, Jordan VC 1998 Basic guide to the mechanisms of antiestrogen action. Pharmacol Rev 50:151-196
10. Jordan VC 2003 Antiestrogens and selective estrogen receptor modulators as multifunctional medicines. 1. Receptor interactions. J Med Chem 46:883-908
11. Jordan VC 2003 Antiestrogens and selective estrogen receptor modulators as multifunctional medicines. 2. Clinical considerations and new agents. J Med Chem 46:1081-1111
12. Clarke R, Leonessa F, Welch JN, Skaar TC 2001 Cellular and molecular pharmacology of antiestrogen action and resistance. Pharmacol Rev 53:25-71
13. Safe S 2005 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related environmental antiestrogens: characterization and mechanism of action. In: Naz RK, ed. Endocrine disruptors. 2nd ed. Boca Raton, FL: CRC Press; 249-287
14. Safe S, McDougal A, Gupta MS, Ramamoorthy K 2001 Selective Ah receptor modulators (SAhRMs): progress towards development of a new class of inhibitors of breast cancer growth. J Women's Cancer 3:37-45
15. McDougal A, Wormke M, Calvin J, Safe S 2001 Tamoxifen-induced antitumorigenic/antiestrogenic action synergized by a selective Ah receptor modulator. Cancer Res 61:3901-3907
16. Krishnan V, Porter W, Santostefano M, Wang X, Safe S 1995 Molecular mechanism of inhibition of estrogen-induced cathepsin D gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in MCF-7 cells. Mol Cell Biol 15:6710-6719
17. Harper N, Wang X, Liu H, Safe S 1994 Inhibition of estrogen-induced progesterone receptor in MCF-7 human breast cancer cells by aryl hydrocarbon (Ah) receptor agonists. Mol Cell Endocrinol 104:47-55
18. Zacharewski TR, Bondy KL, McDonell P, Wu ZF 1994 Antiestrogenic effects of 2,3,7,8-tetrachlorodibenzo-pdioxin on 17β-estradiol-induced pS2 expression. Cancer Res 54:2707-2713
19. Lu Y-F, Sun G, Wang X, Safe S 1996 Inhibition of prolactin receptor gene expression by 2,3,7,8-tetrachlorodibenzo-p-dioxin in MCF-7 human breast cancer cells. Arch Biochem Biophys 332:35-40
20. Gillesby B, Santostefano M, Porter W, Wu ZF, Safe S, Zacharewski T 1997 Identification of a motif within the 5′-regulatory region on pS2 which is responsible for Ap1 binding and TCDD-mediated suppression. Biochemistry 36:6080-6089
21. Porter W, Wang F, Duan R, Qin C, Castro-Rivera E, Safe S 2001 Transcriptional activation of heat shock protein 27 gene expression by 17β-estradiol and modulation by antiestrogens and aryl hydrocarbon receptor agonists: estrogenic activity of ICI 164,384. J Mol Endocrinol 26:31-42
22. Wang W, Smith R, Safe S 1998 Aryl hydrocarbon receptor-mediated antiestrogenicity in MCF-7 cells: modulation of hormone-induced cell cycle enzymes. Arch Biochem Biophys 356:239-248
23. Duan R, Porter W, Samudio I, Vyhlidal C, Kladde M, Safe S 1999 Transcriptional activation of c-fos protooncogene by 17β-estradiol: mechanism of aryl hydrocarbon receptor-mediated inhibition. Mol Endocrinol 13:1511-1521
24. Wormke M, Stoner M, Saville B, Safe S 2000 Crosstalk between estrogen receptor α and the aryl hydrocarbon receptor in breast cancer cells involves unidirectional activation of proteosomes. FEBS Lett 478:109-112
25. Wormke M, Stoner M, Saville B, Walker K, Abdelrahim M, Burghardt R, Safe S 2003 The aryl hydrocarbon receptor mediates degradation of the estrogen receptor α through activation of proteasomes. Mol Cell Biol 23:1843-1855
26. Khan S, Abdelrahim M, Samudio I, Safe S 2003 Estrogen receptor/Sp1 complexes are required for induction of CAD gene expression by 17β-estradiol in breast cancer cells. Endocrinology 144:2325-2335
27. Abdelrahim M, Samudio I, Smith R, Burghardt R, Safe S 2002 Small inhibitory RNA duplexes for Sp1 mRNA block basal and estrogen-induced gene expression and cell cycle progression in MCF-7 breast cancer cells. J Biol Chem 277:28815-28822
28. Safe S, Kim K 2004 Nuclear receptor-mediated transactivation through interaction with Sp proteins. Prog Nucleic Acid Res Mol Biol 77:1-36
29. Klinge CM, Bowers JL, Kulakosky PC, Kamboj KK, Swanson HI 1999 The aryl hydrocarbon receptor (AHR)/AHR nuclear translocator (ARNT) heterodimer interacts with naturally occurring estrogen response elements. Mol Cell Endocrinol 157:105-119
30. Kobayashi A, Sogawa K, Fujii-Kuriyama Y 1996 Cooperative interaction between AhR·Arnt and Sp1 for the drug-inducible expression of CYP1A1 gene. J Biol Chem 271:12310-12316
31. Wang F, Hoivik D, Pollenz R, Safe S 1998 Functional and physical interactions between the estrogen receptor-Sp1 and the nuclear aryl hydrocarbon receptor complexes. Nucleic Acids Res 26:3044-3052
32. Tamrazi A, Carlson KE, Daniels JR, Hurth KM, Katzenellenbogen JA 2002 Estrogen receptor dimerization: ligand binding regulates dimer affinity and dimer dissociation rate. Mol Endocrinol 16:2706-2719
33. Bai Y, Giguere V 2003 Isoform-selective interactions between estrogen receptors and steroid receptor coactivators promoted by estradiol and ErbB-2 signaling in living cells. Mol Endocrinol 17:589-599
34. Llopis J, Westin S, Ricote M, Wang Z, Cho CY, Kurokawa R, Mullen TM, Rose DW, Rosenfeld MG, Tsien RY, Glass CK, Wang J 2000 Ligand-dependent interactions of coactivators steroid receptor coactivator-1 and peroxisome proliferator-activated receptor binding protein with nuclear hormone receptors can be imaged in live cells and are required for transcription. Proc Natl Acad Sci USA 97:4363-4368
35. Weatherman RV, Chang CY, Clegg NJ, Carroll DC, Day RN, Baxter JD, McDonnell DP, Scanlan TS, Schaufele F 2002 Ligand-selective interactions of ER detected in living cells by fluorescence resonance energy transfer. Mol Endocrinol 16:487-496
36. Kim K, Barhoumi R, Burghardt R, Safe S 2005 Analysis of estrogen receptor α-Sp1 interactions in breast cancer cells by fluorescence resonance energy transfer. Mol Endocrinol 19:843-854
37. Beischlag TV, Perdew GH 2005 ERα-AHR-ARNT protein-protein interactions mediate estradiol-dependent transrepression of dioxin-inducible gene transcription. J Biol Chem 280:21607-21611
38. Matthews J, Wihlen B, Thomsen J, Gustafsson JA 2005 Aryl hydrocarbon receptor-mediated transcription: ligand-dependent recruitment of estrogen receptor α to 2,3,7,8-tetrachlorodibenzo-p-dioxin-responsive promoters. Mol Cell Biol 25:5317-5328
39. Berry M, Nunez A-M, Chambon P 1989 Estrogen-responsive element of the human pS2 gene is an imperfectly palindromic sequence. Proc Natl Acad Sci USA 86:1218-1222
40. Shang Y, Hu X, DiRenzo J, Lazar MA, Brown M 2000 Cofactor dynamics and sufficiency in estrogen receptor-regulated transcription. Cell 103:843-852
41. Shao W, Halachmi S, Brown M 2002 ERAP140, a conserved tissue-specific nuclear receptor coactivator. Mol Cell Biol 22:3358-3372
42. Metivier R, Penot G, Hubner MR, Reid G, Brand H, Kos M, Gannon F 2003 Estrogen receptor-α directs ordered, cyclical, and combinatorial recruitment of cofactors on a natural target promoter. Cell 115:751-763
43. Acevedo ML, Lee KC, Stender JD, Katzenellenbogen BS, Kraus WL 2004 Selective recognition of distinct classes of coactivators by a ligand-inducible activation domain. Mol Cell 13:725-738
44. Krieg AJ, Krieg SA, Ahn BS, Shapiro DJ 2004 Interplay between estrogen response element sequence and ligands controls in vivo binding of estrogen receptor to regulated genes. J Biol Chem 279:5025-5034
45. Kumar V, Chambon P 1988 The estrogen receptor binds tightly to its responsive element as a ligand-induced homodimer. Cell 55:145-156
46. O'Malley BW 2005 A life-long search for the molecular pathways of steroid hormone action. Mol Endocrinol 19:1402-1411
47. Cowley SM, Hoare S, Mosselman S, Parker MG 1997 Estrogen receptors α and β form heterodimers on DNA. J Biol Chem 272:19858-19862
48. Pace P, Taylor J, Suntharalingam S, Coombes RC, Ali S 1997 Human estrogen receptor β binds DNA in a manner similar to and dimerizes with estrogen receptor α. J Biol Chem 272:25832-25838
49. Paech K, Webb P, Kuiper GG, Nilsson S, Gustafsson J, Kushner PJ, Scanlan TS 1997 Differential ligand activation of estrogen receptors ERα and ERβ at AP1 sites. Science 277:1508-1510
50. Safe S, Wormke M 2003 Inhibitory aryl hydrocarbon-estrogen receptor a crosstalk and mechanisms of action. Chem Res Toxicol 16:807-816
51. 3. Cancer Res 47:21-25
52. Muller P, Kietz S, Gustafsson JA, Strom 2002 A The anti-estrogenic effect of all-trans-retinoic acid on the breast cancer cell line MCF-7 is dependent on HES-1 expression. J Biol Chem 277:28376-28379
53. Ohtake F, Takeyama K, Matsumoto T, Kitagawa H, Yamamoto Y, Nohara K, Tohyama C, Krust A, Mimura J, Chambon P, Yanagisawa J, Fujii-Kuriyama Y, Kato S 2003 Modulation of oestrogen receptor signalling by association with the activated dioxin receptor. Nature 423:545-550
54. Hoivik D, Willett K, Wilson C, Safe S 1997 Estrogen does not inhibit 2,3,7,8-tetraclorodibenzo-p-dioxin-mediated effects in MCF-7 and Hepa 1c1c7 cells. J Biol Chem 272:30270-30274