Disruption of aryl hydrocarbon receptor (AhR) induces regression of the seminal vesicle in aged male mice

Sexual Development

Volumn 2, Issue 1, 2008, Pages 1-11

  Baba, T ^a   Shima, Y ^a   Owaki, A ^a   Mimura, J ^b   Oshima, M ^b   Fujii Kuriyama, Y ^b,c   Morohashi, K I ^a,c  

^a NATIONAL INSTITUTE FOR BASIC BIOLOGY   (Japan)

^b UNIVERSITY OF TSUKUBA   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

3 Hsd; AhR( )males; Aryl hydrocarbon receptor (AhR); Mice; Seminal vesicle regression; Testes; Testosterone

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; HYDROXYSTEROID DEHYDROGENASE; STEROIDOGENIC ACUTE REGULATORY PROTEIN; TESTOSTERONE;

AGED; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EPIDIDYMIS; FERTILITY; KNOCKOUT MOUSE; LEYDIG CELL; MALE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REPRODUCTION; SEMINAL VESICLE DISEASE; SEMINAL VESICLE REGRESSION; SPERMATOZOON COUNT; TESTOSTERONE BLOOD LEVEL;

3-HYDROXYSTEROID DEHYDROGENASES; AGING; ANIMALS; BLOTTING, WESTERN; FEMALE; IMMUNOHISTOCHEMISTRY; LEYDIG CELLS; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; OLIGOSPERMIA; PHOSPHOPROTEINS; RECEPTORS, ARYL HYDROCARBON; REPRODUCTION; SEMINAL VESICLES; TESTOSTERONE;

ANIMALIA; MUS;

EID: 42349100629     PISSN: 16615425     EISSN: 16615433     Source Type: Journal    
DOI: 10.1159/000117714     Document Type: Article

References (39)

1. Baba T, Mimura J, Nakamura N, Harada N, Yamamoto M, Morohashi K, Fujii-Kuriyama Y: Intrinsic function of the aryl hydrocarbon (dioxin) receptor as a key factor in female reproduction. Mol Cell Biol 25:10040-10051 (2005).
2. Bell DR, Clode S, Fan MQ, Fernandes A, Foster PM, et al: Toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the developing male Wistar(Han) rat. II: Chronic dosing causes developmental delay. Toxicol Sci 99:224-233 (2007).
3. Brown NM, Manzolillo PA, Zhang JX, Wang J, Lamartiniere CA: Prenatal TCDD and predisposition to mammary cancer in the rat. Carcinogenesis 19:1623-1629 (1998).
4. Burbach KM, Poland A, Bradfield CA: Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor. Proc Natl Acad Sci USA 89:8185-8189 (1992).
5. Cederroth CR, Schaad O, Descombes P, Chambon P, Vassalli JD, Nef S: Estrogen receptor alpha is a major contributor to estrogen-mediated fetal testis dysgenesis and cryptorchidism. Endocrinology 148:5507-5519 (2007).
6. Cooke PS, Young P, Cunha GR: Androgen receptor expression in developing male reproductive organs. Endocrinology 128:2867-2873 (1991).
7. Cunha GR: Epithelio-mesenchymal interactions in primordial gland structures which become responsive to androgenic stimulation. Anat Rec 172:179-195 (1972).
8. Curtis Hewitt S, Goulding EH, Eddy EM, Korach KS: Studies using the estrogen receptor alpha knockout uterus demonstrate that implantation but not decidualization-associated signaling is estrogen dependent. Biol Reprod 67:1268-1277 (2002).
9. De Gendt K, Swinnen JV, Saunders PT, Schoonjans L, Dewerchin M, et al: A Sertoli cell-selective knockout of the androgen receptor causes spermatogenic arrest in meiosis. Proc Natl Acad Sci USA 101:1327-1332 (2004).
10. Dupont E, Zhao HF, Rheaume E, Simard J, Luu-The V, Labrie F, Pelletier G: Localization of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4-isomerase in rat gonads and adrenal glands by immunocytochemistry and in situ hybridization. Endocrinology 127:1394-1403 (1990).
11. Dupont S, Krust A, Gansmuller A, Dierich A, Chambon P, Mark M: Effect of single and compound knockouts of estrogen receptors alpha (ERalpha) and beta (ERbeta) on mouse reproductive phenotypes. Development 127:4277-4291 (2000).
12. Elferink CJ, Ge NL, Levine A: Maximal aryl hydrocarbon receptor activity depends on an interaction with the retinoblastoma protein. Mol Pharmacol 59:664-673 (2001).
13. Elizondo G, Fernandez-Salguero P, Sheikh MS, Kim GY, Fornace AJ, Lee KS, Gonzalez FJ: Altered cell cycle control at the G(2)/M phases in aryl hydrocarbon receptor-null embryo fibroblast. Mol Pharmacol 57:1056-1063 (2000).
14. Ema M, Sogawa K, Watanabe N, Chujoh Y, Matsushita N, et al: cDNA cloning and structure of mouse putative Ah receptor. Biochem Biophys Res Commun 184:246-253 (1992).
15. Fisher CR, Graves KH, Parlow AF, Simpson ER: Characterization of mice deficient in aromatase (ArKO) because of targeted disruption of the cyp19 gene. Proc Natl Acad Sci USA 95:6965-6970 (1998).
16. Fujisawa-Sehara A, Sogawa K, Yamane M, Fujii-Kuriyama Y: Characterization of xenobiotic responsive elements upstream from the drug-metabolizing cytochrome P-450c gene: a similarity to glucocorticoid regulatory elements. Nucleic Acids Res 15:4179-4191 (1987).
17. Ge NL, Elferink CJ: A direct interaction between the aryl hydrocarbon receptor and retinoblastoma protein. Linking dioxin signaling to the cell cycle. J Biol Chem 273:22708-22713 (1998).
18. Gibbons A: Dioxin tied to endometriosis. Science 262:1373 (1993).
19. Gray LE Jr, Kelce WR, Monosson E, Ostby JS, Birnbaum LS: Exposure to TCDD during development permanently alters reproductive function in male Long Evans rats and hamsters: reduced ejaculated and epididymal sperm numbers and sex accessory gland weights in offspring with normal androgenic status. Toxicol Appl Pharmacol 131:108-118 (1995).
20. Hahn ME: Aryl hydrocarbon receptors: diversity and evolution. Chem Biol Interact 141:131-160 (2002).
21. Hankinson O: The aryl hydrocarbon receptor complex. Annu Rev Pharmacol Toxicol 35:307-340 (1995).
22. Kolluri SK, Weiss C, Koff A, Gottlicher M: p27(Kip1) induction and inhibition of proliferation by the intracellular Ah receptor in developing thymus and hepatoma cells. Genes Dev 13:1742-1753 (1999).
23. Lahvis GP, Pyzalski RW, Glover E, Pitot HC, McElwee MK, Bradfield CA: The aryl hydrocarbon receptor is required for developmental closure of the ductus venosus in the neonatal mouse. Mol Pharmacol 67:714-720 (2005).
24. Lin TM, Ko K, Moore RW, Simanainen U, Oberley TD, Peterson RE: Effects of aryl hydrocarbon receptor null mutation and in utero and lactational 2,3,7,8-tetrachlorodibenzop-dioxin exposure on prostate and seminal vesicle development in C57BL/6 mice. Toxicol Sci 68:479-487 (2002).
25. Lynch JP, Lala DS, Peluso JJ, Luo W, Parker KL, White BA: Steroidogenic factor 1, an orphan nuclear receptor, regulates the expression of the rat aromatase gene in gonadal tissues. Mol Endocrinol 7:776-786 (1993).
26. Ma Q, Whitlock JP Jr: The aromatic hydrocarbon receptor modulates the Hepa 1c1c7 cell cycle and differentiated state independently of dioxin. Mol Cell Biol 16:2144-2150 (1996).
27. Mimura J, Fujii-Kuriyama Y: Functional role of AhR in the expression of toxic effects by TCDD. Biochim Biophys Acta 1619:263-268 (2003).
28. Mimura J, Yamashita K, Nakamura K, Morita M, Takagi TN, et al: Loss of teratogenic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the Ah (dioxin) receptor. Genes Cells 2:645-654 (1997).
29. Morohashi K, Zanger UM, Honda S, Hara M, Waterman MR, Omura T: Activation of CYP11A and CYP11B gene promoters by the steroidogenic cell-specific transcription factor, Ad4BP. Mol Endocrinol 7:1196-1204 (1993).
30. Morohashi K, Iida H, Nomura M, Hatano O, Honda S, et al: Functional difference between Ad4BP and ELP, and their distributions in steroidogenic tissues. Mol Endocrinol 8:643-653 (1994).
31. Neubauer B, Blume C, Cricco R, Greiner J, Mawhinney M: Comparative effects and mechanisms of castration, estrogen anti-androgen, and anti-estrogen-induced regression of accessory sex organ epithelium and muscle. Invest Urol 18:229-234 (1981).
32. Poland A, Knutson JC: 2,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity. Annu Rev Pharmacol Toxicol 22:517-554 (1982).
33. Poland A, Glover E, Kende AS: Stereospecific, high affinity binding of 2,3,7,8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of aryl hydrocarbon hydroxylase. J Biol Chem 251:4936-4946 (1976).
34. Puga A, Barnes SJ, Dalton TP, Chang C, Knudsen ES, Maier MA: Aromatic hydrocarbon receptor interaction with the retinoblastoma protein potentiates repression of E2F-dependent transcription and cell cycle arrest. J Biol Chem 275:2943-2950 (2000).
35. Schultz R, Suominen J, Varre T, Hakovirta H, Parvinen M, Toppari J, Pelto-Huikko M: Expression of aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator messenger ribonucleic acids and proteins in rat and human testis. Endocrinology 144:767-776 (2003).
36. Sherr CJ, Roberts JM: CDK inhibitors: positive and negative regulators of G1-phase progression. Genes Dev 13:1501-1512 (1999).
37. Shimizu Y, Nakatsuru Y, Ichinose M, Takahashi Y, Kume H, et al: Benzo[a]pyrene carcinogenicity is lost in mice lacking the aryl hydrocarbon receptor. Proc Natl Acad Sci USA 97:779-782 (2000).
38. Sommer RJ, Ippolito DL, Peterson RE: In utero and lactational exposure of the male Holtzman rat to 2,3,7,8-tetrachlorodibenzop-dioxin: decreased epididymal and ejaculated sperm numbers without alterations in sperm transit rate. Toxicol Appl Pharmacol 140:146-153 (1996).
39. Vinggaard AM, Nellemann C, Dalgaard M, Jorgensen EB, Andersen HR: Antiandrogenic effects in vitro and in vivo of the fungicide prochloraz. Toxicol Sci 69:344-353 (2002).