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Volumn 31, Issue 4, 2012, Pages 527-534

RUNX3 acts as a tumor suppressor in breast cancer by targeting estrogen receptor α

Author keywords

Breast cancer; Degradation; ERa; RUNX3; Tumor suppressor

Indexed keywords

AGAR; ESTROGEN; ESTROGEN RECEPTOR ALPHA; TRANSCRIPTION FACTOR RUNX3;

EID: 84856213379     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2011.252     Document Type: Article
Times cited : (65)

References (28)
  • 1
    • 0035995602 scopus 로고    scopus 로고
    • The role of oestrogen and progesterone receptors in human mammary development and tumorigenesis
    • DOI 10.1186/bcr452
    • Anderson E. (2002). The role of oestrogen and progesterone receptors in human mammary development and tumorigenesis. Breast Cancer Res 4: 197-201. (Pubitemid 34918998)
    • (2002) Breast Cancer Research , vol.4 , Issue.5 , pp. 197-201
    • Anderson, E.1
  • 4
    • 34347262483 scopus 로고    scopus 로고
    • Differential regulation of estrogen receptor α turnover and transactivation by Mdm2 and stress-inducing agents
    • DOI 10.1158/0008-5472.CAN-07-0967
    • Duong V, Boulle N, Daujat S, Chauvet J, Bonnet S, Neel H et al. (2007). Differential regulation of estrogen receptor alpha turnover and transactivation by Mdm2 and stress-inducing agents. Cancer Res 67: 5513-5521. (Pubitemid 46997293)
    • (2007) Cancer Research , vol.67 , Issue.11 , pp. 5513-5521
    • Duong, V.1    Boulle, N.2    Daujat, S.3    Chauvet, J.4    Bonnet, S.5    Neel, H.6    Cavailles, V.7
  • 5
    • 0029807308 scopus 로고    scopus 로고
    • Identification of amino acids in the hormone binding domain of the human estrogen receptor important in estrogen binding
    • DOI 10.1074/jbc.271.33.20053
    • Ekena K, Weis KE, Katzenellenbogen JA, Katzenellenbogen BS. (1996). Identification of amino acids in the hormone binding domain of the human estrogen receptor important in estrogen binding. J Biol Chem 271: 20053-20059. (Pubitemid 26281755)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.33 , pp. 20053-20059
    • Ekena, K.1    Weis, K.E.2    Katzenellenbogen, J.A.3    Katzenellenbogen, B.S.4
  • 6
    • 8344241132 scopus 로고    scopus 로고
    • Inhibiting proteasomal proteolysis sustains estrogen receptor-α activation
    • DOI 10.1210/me.2004-0164
    • Fan M, Nakshatri H, Nephew K.P. (2004). Inhibiting proteasomal proteolysis sustains estrogen receptor-alpha activation. Mol Endocrinol 18: 2603-2615. (Pubitemid 39482052)
    • (2004) Molecular Endocrinology , vol.18 , Issue.11 , pp. 2603-2615
    • Fan, M.1    Nakshatri, H.2    Nephew, K.P.3
  • 7
    • 13444272959 scopus 로고    scopus 로고
    • Deregulated estrogen receptor α expression in mammary epithelial cells of transgenic mice results in the development of ductal carcinoma In situ
    • Frech MS, Halama ED, Tilli MT, Singh B, Gunther EJ, Chodosh LA et al. (2005). Deregulated estrogen receptor alpha expression in mammary epithelial cells of transgenic mice results in the development of ductal carcinoma in situ. Cancer Res 65: 681-685. (Pubitemid 40216421)
    • (2005) Cancer Research , vol.65 , Issue.3 , pp. 681-685
    • Frech, M.S.1    Halama, E.D.2    Tilli, M.T.3    Singh, B.4    Gunther, E.J.5    Chodosh, L.A.6    Flaws, J.A.7    Furth, P.A.8
  • 8
    • 62249151768 scopus 로고    scopus 로고
    • Runx3 expression in gastrointestinal tract epithelium: Resolving the controversy
    • Ito K, Inoue KI, Bae SC, Ito Y. (2009). Runx3 expression in gastrointestinal tract epithelium: resolving the controversy. Oncogene 28: 1379-1384.
    • (2009) Oncogene , vol.28 , pp. 1379-1384
    • Ito, K.1    Inoue, K.I.2    Bae, S.C.3    Ito, Y.4
  • 9
  • 10
    • 2942659322 scopus 로고    scopus 로고
    • Oncogenic potential of the RUNX gene family: 'Overview'
    • DOI 10.1038/sj.onc.1207755
    • Ito Y. (2004). Oncogenic potential of the RUNX gene family: 'overview'. Oncogene 23: 4198-4208. (Pubitemid 38765135)
    • (2004) Oncogene , vol.23 , Issue.24 , pp. 4198-4208
    • Ito, Y.1
  • 11
    • 77950598697 scopus 로고    scopus 로고
    • Estrogens, regulation of p53 and breast cancer risk: A balancing act
    • Jerry DJ, Dunphy KA, Hagen MJ. (2010). Estrogens, regulation of p53 and breast cancer risk: a balancing act. Cell Mol Life Sci 67: 1017-1023.
    • (2010) Cell Mol Life Sci , vol.67 , pp. 1017-1023
    • Jerry, D.J.1    Dunphy, K.A.2    Hagen, M.J.3
  • 12
    • 46349102935 scopus 로고    scopus 로고
    • Expression of RUNX3 gene, methylation status and clinicopathological significance in breast cancer and breast cancer cell lines
    • DOI 10.1159/000132385
    • Jiang Y, Tong D, Lou G, Zhang Y, Geng J. (2008). Expression of RUNX3 gene, methylation status and clinicopathological significance in breast cancer and breast cancer cell lines. Pathobiology 75: 244-251. (Pubitemid 351918429)
    • (2008) Pathobiology , vol.75 , Issue.4 , pp. 244-251
    • Jiang, Y.1    Tong, D.2    Lou, G.3    Zhang, Y.4    Geng, J.5
  • 13
    • 0034466972 scopus 로고    scopus 로고
    • Estrogen receptor alpha and estrogen receptor beta: Regulation by selective estrogen receptor modulators and importance in breast cancer
    • DOI 10.1186/bcr78
    • Katzenellenbogen BS, Katzenellenbogen JA. (2000). Estrogen receptor transcription and transactivation: estrogen receptor alpha and estrogen receptor beta: regulation by selective estrogen receptor modulators and importance in breast cancer. Breast Cancer Res 2: 335-344. (Pubitemid 32223616)
    • (2000) Breast Cancer Research , vol.2 , Issue.5 , pp. 335-344
    • Katzenellenbogen, B.S.1    Katzenellenbogen, J.A.2
  • 14
    • 0028179150 scopus 로고
    • Estrogen receptor expression of benign breast epithelium and its association with breast cancer
    • Khan SA, Rogers MA, Obando JA, Tamsen A. (1994). Estrogen receptor expression of benign breast epithelium and its association with breast cancer. Cancer Res 54: 993-997.
    • (1994) Cancer Res , vol.54 , pp. 993-997
    • Khan, S.A.1    Rogers, M.A.2    Obando, J.A.3    Tamsen, A.4
  • 15
    • 40349102278 scopus 로고    scopus 로고
    • Estrogen regulation of mammary gland development and breast cancer: Amphiregulin takes center stage
    • LaMarca HL, Rosen JM. (2007). Estrogen regulation of mammary gland development and breast cancer: amphiregulin takes center stage. Breast Cancer Res 9: 304-306.
    • (2007) Breast Cancer Res , vol.9 , pp. 304-306
    • Lamarca, H.L.1    Rosen, J.M.2
  • 17
    • 0033638393 scopus 로고    scopus 로고
    • The 26S proteasome is required for estrogen receptor-alpha and coactivator turnover and for efficient estrogen receptor-alpha transactivation
    • Lonard DM, Nawaz Z, Smith CL, O'Malley BW. (2000). The 26S proteasome is required for estrogen receptor-alpha and coactivator turnover and for efficient estrogen receptor-alpha transactivation. Mol Cell 5: 939-948.
    • (2000) Mol Cell , vol.5 , pp. 939-948
    • Lonard, D.M.1    Nawaz, Z.2    Smith, C.L.3    O'malley, B.W.4
  • 19
    • 0037351881 scopus 로고    scopus 로고
    • Cyclic, proteasome-mediated turnover of unliganded and liganded ERα on responsive promoters is an integral feature of estrogen signaling
    • DOI 10.1016/S1097-2765(03)00090-X
    • Reid G, Hubner MR, Metivier R, Brand H, Denger S, Manu D et al. (2003). Cyclic, proteasome-mediated turnover of unliganded and liganded ERalpha on responsive promoters is an integral feature of estrogen signaling. Mol Cell 11: 695-707. (Pubitemid 36385123)
    • (2003) Molecular Cell , vol.11 , Issue.3 , pp. 695-707
    • Reid, G.1    Hubner, M.R.2    Metivier, R.3    Brand, H.4    Denger, S.5    Manu, D.6    Beaudouin, J.7    Ellenberg, J.8    Gannon, F.9
  • 20
    • 53049084384 scopus 로고    scopus 로고
    • Loss of Runx3 affects ovulation and estrogen-induced endometrial cell proliferation in female mice
    • Sakuma A, Fukamachi H, Ito K, Ito Y, Takeuchi S, Takahashi S. (2008). Loss of Runx3 affects ovulation and estrogen-induced endometrial cell proliferation in female mice. Mol Reprod Dev 75: 1653-1661.
    • (2008) Mol Reprod Dev , vol.75 , pp. 1653-1661
    • Sakuma, A.1    Fukamachi, H.2    Ito, K.3    Ito, Y.4    Takeuchi, S.5    Takahashi, S.6
  • 22
    • 58049221118 scopus 로고    scopus 로고
    • RUNX3 inactivation by frequent promoter hypermethylation and protein mislocalization constitute an early event in breast cancer progression
    • Subramaniam MM, Chan JY, Soong R, Ito K, Ito Y, Yeoh KG et al. (2009a). RUNX3 inactivation by frequent promoter hypermethylation and protein mislocalization constitute an early event in breast cancer progression. Breast Cancer Res Treat 113: 113-121.
    • (2009) Breast Cancer Res Treat , vol.113 , pp. 113-121
    • Subramaniam, M.M.1    Chan, J.Y.2    Soong, R.3    Ito, K.4    Ito, Y.5    Yeoh, K.G.6
  • 25
    • 33646189483 scopus 로고    scopus 로고
    • RUNX3 cooperates with FoxO3a to induce apoptosis in gastric cancer cells
    • DOI 10.1074/jbc.M512151200
    • Yamamura Y, Lee WL, Inoue K, Ida H, Ito Y. (2006). RUNX3 cooperates with FoxO3a to induce apoptosis in gastric cancer cells. J Biol Chem 281: 5267-5276. (Pubitemid 43847791)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.8 , pp. 5267-5276
    • Yamamura, Y.1    Wei, L.L.2    Inoue, K.-I.3    Ida, H.4    Ito, Y.5
  • 26
    • 66149089133 scopus 로고    scopus 로고
    • PDLIM2 suppresses human T-cell leukemia virus type i Tax-mediated tumorigenesis by targeting Tax into the nuclear matrix for proteasomal degradation
    • Yan P, Fu J, Qu Z, Li S, Tanaka T, Grusby MJ et al. (2009). PDLIM2 suppresses human T-cell leukemia virus type I Tax-mediated tumorigenesis by targeting Tax into the nuclear matrix for proteasomal degradation. Blood 113: 4370-4380.
    • (2009) Blood , vol.113 , pp. 4370-4380
    • Yan, P.1    Fu, J.2    Qu, Z.3    Li, S.4    Tanaka, T.5    Grusby, M.J.6
  • 28
    • 0141927384 scopus 로고    scopus 로고
    • Tissue microarray study for classification of breast tumors
    • DOI 10.1016/j.lfs.2003.05.006
    • Zhang DH, Salto-Tellez M, Chiu LL, Shen L, Koay ES. (2003). Tissue microarray study for classification of breast tumors. Life Sci 73: 3189-3199. (Pubitemid 37237573)
    • (2003) Life Sciences , vol.73 , Issue.25 , pp. 3189-3199
    • Zhang, D.-H.1    Salto-Tellez, M.2    Chiu, L.-L.3    Shen, L.4    Koay, E.S.-C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.