The proportion of regulatory T cells in patients with rheumatoid arthritis: A meta-Analysis

PLoS ONE

Volumn 11, Issue 9, 2016, Pages

  Morita, Takayoshi ^a,b   Shima, Yoshihito ^a   Wing, James Badger ^b   Sakaguchi, Shimon ^b,c   Ogata, Atsushi ^a,d   Kumanogoh, Atsushi ^a  

^a OSAKA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d OSAKA POLICE HOSPITAL   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; CORTICOSTEROID; METHOTREXATE; RHEUMATOID FACTOR; TOCILIZUMAB; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; IL2RA PROTEIN, HUMAN; INTERLEUKIN 2 RECEPTOR ALPHA;

ARTICLE; BLOOD; CASE CONTROL STUDY; CASE STUDY; CD25+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; DAS28; DISEASE DURATION; ERYTHROCYTE SEDIMENTATION RATE; FOXP3+ T LYMPHOCYTE; HUMAN; MEASUREMENT ACCURACY; PATHOGENESIS; QUALITY CONTROL; REGULATORY T LYMPHOCYTE; RHEUMATOID ARTHRITIS; SYNOVIAL FLUID; SYSTEMATIC REVIEW; CD4 LYMPHOCYTE COUNT; CLASSIFICATION; CYTOLOGY; IMMUNOLOGY; META ANALYSIS; METABOLISM; PATHOLOGY;

ARTHRITIS, RHEUMATOID; CD4 LYMPHOCYTE COUNT; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; SYNOVIAL FLUID; T-LYMPHOCYTES, REGULATORY;

EID: 84991624946     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0162306     Document Type: Article

References (64)

1. Lee DM, Weinblatt ME. Rheumatoid arthritis.Lancet 2001; 358:903-11. PMID: 11567728.
2. ManicourtDH, Triki R, Fukuda K, Devogelaer JP, Nagant de Deuxchaisnes C, Thonar EJ. Levels of circulating tumor necrosis factor-α and interleukin-6 in patients with rheumatoid arthritis.Arthritis Rheum 1993; 36:490-9. PMID: 8457224.
3. van Hamburg JP, Asmawidjaja PS, Davelaar N, Mus AM, Colin EM, Hazes JM, et al. Th17 cells, but not Th1 cells, from patients with early rheumatoid arthritisare potent inducers of matrix metalloproteinases and proinflammatory cytokines upon synovial fibroblast interaction, including autocrine interleukin-17A production. Arthritis Rheum 2011; 63:73-83. PMID: 20954258 doi:10.1002/art.30093.
4. Ito Y, Hashimoto M, Hirota K, Ohkura N, Morikawa H, Nishikawa H, et al. Detection of T cell responses to a ubiquitous cellular protein in autoimmune disease. Science 2014; 346:363-8. PMID: 25324392doi:10.1126/science.1259077.
5. Sakaguchi S, Yamaguchi T, Nomura T, Ono M. Regulatory T cells and immune tolerance. Cell 2008; 133:775-87. PMID: 18510923 doi:10.1016/j.cell.2008.05.009.
6. Hori S, Nomura T, Sakaguchi S. Control of regulatoryT cell development by the transcription factor Foxp3. Science 2003; 299:1057-61. PMID: 12522256.
7. Wildin R, Smyk-Pearson S, Filipovich A. Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome. J Med Gene 2002; 39:527-545. PMID: 12161590.
8. Zhu J, Chen XY, Li LB, Yu XT, Zhou Y, Yang WJ, et al. Electroacupuncture attenuates collageninduced arthritis in rats through vasoactive intestinal peptide signalling-dependent re-establishment of the regulatory T cell/T-helper 17 cell balance. Acupunct Med 2015; 33:305-11. PMID: 25979865doi:10.1136/acupmed-2014-010732.
9. + cell depletion hastens the onset of severe disease in collagen-induced arthritis.Arthritis Rheum 2003; 48:1452-60. PMID: 12746920.
10. + regulatoryT cells. Arthritis Rheum 2005; 52:2212-21. PMID: 15986351.
11. Paradowska-Gorycka A, Jurkowska M, Felis-Giemza A, Romanowska-Próchnicka K, Manczak M, Maslinski S, et al. Genetic polymorphisms of Foxp3 in patients with rheumatoid arthritis.J Rheumatol. 2015; 42:170-80. PMID: 25448791 doi:10.3899/jrheum.131381.
12. Wing K, Yamaguchi T, Sakaguchi S. Cell-Autonomous and -non-Autonomous roles of CTLA-4 in immune regulation. Trends Immunol 2011; 32:428-433. PMID: 21723783 doi:10.1016/j.it.2011.06.002.
13. Shi F, Liu J, Li Y. The effect of CTLA-4 A49G polymorphism on rheumatoid arthritis risk:a meta-Analysis. Diagn Pathol 2014; 9:157. PMID: 25128482 doi:10.1186/s13000-014-0157-0.
14. hi T-regulatory cells. BLOOD 2015; 108:253-61. PMID: 16537805.
15. Kimura A, Kishimoto T. IL-6: Regulator of Treg/Th17 balance. Eur J Immunol 2010; 40:1830-5. PMID: 20583029 doi:10.1002/eji.201040391.
16. Sakaguchi S, Sakaguchi N, Asano M, Itoh M, Toda M. Immunologic self-Tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of selftolerance causes various autoimmune diseases. J Immunol 1995; 155:1151-64. PMID: 7636184.
17. Lastovicka J. The phenotypic markers of CD4+ CD25+ T regulatory lymphocytes. Res Immunol 2013; 2013:119348.
18. Miyara M, Yoshioka Y, Kitoh A, Shima T, Wing K, Niwa A, et al. Functional delineation and differentiation dynamics of human CD4+ T cells expressing the FoxP3 transcription factor. Immunity 2009; 30:899-911. PMID: 19464196 doi:10.1016/j.immuni.2009.03.019.
19. OCEBM Levels of EvidenceWorking Group. The Oxford 2011 levels of evidence. Oxford: Oxford Centre for Evidence-Based Medicine. Available at http://www.cebm.net/ocebm-levels-of-evidence/.
20. Wells GA, Shea B, O'Connell D, Peterson J, Welch V, Losos M, et al. The Newcastle-Ottawa Scale (NOS) for assessing the quality if nonrandomized studies in meta-Analyses. Available at http://www.ohri.ca/programs/clinical-epidemiology/oxford.asp.
21. Moher D, Liberati A, Tetzlaff J, Altman DG; PRISMA Group. Preferred reportingitems for systematic reviews and meta-Analyses: The PRISMA statement. PLoS Med 2009; 6:e1000097. doi:10.1371/journal.pmed.1000097 PMID: 19621072.
22. Der Simonian R, Kacker R. Random-effects model for meta-Analysis of clinical trials: An update. Contemp Clin Trials 2007; 28:105-14. PMID: 16807131.
23. Higgins JPT, Thompson SG. Quantifying heterogeneity in a meta-Analysis. Stat Med 2002; 21:1539- 58. PMID: 12111919.
24. Kanda Y. Investigation of the freely available easy-To-use software "EZR" for medical statistics. Bone Marrow Transplant 2013; 48:452-8. PMID: 23208313 doi:10.1038/bmt.2012.244.
25. + cells in peripheral blood and synovial fuluid of patients with rheumatoid arthritis.J Immunol Res. 2015; 2015:729654. PMID: 26090498 doi:10.1155/2015/729654.
26. + T regulatory cells in Rheumatoid arthritisand the imbalance of the Treg/TH17 cytokine axis. Egypt Rheum, 2015; 37:7-15.
27. Gaafar T, Farid R, Raafat H, Bayoumi F, Gerges B, Rasheed D. The TH17/Treg imbalance in rheumatoid arthritisand relation to disease activity. J Clin Cell Immunol, 2015; 6:381.
28. Daïen CI, Gailhac S, Audo R, Mura T, Hahne M, Combe B, et al. High levels of natural killer cells are associated with response to tocilizumab in patients with sever rheumatolid arthritis.Rheumatology (Oxford) 2015; 54:601-8. PMID: 25231180.
29. Cribbs AP, Kennedy A, Penn H, Read JE, Amjadi P, Green P, et al. Treg cell function in rheumatoid arthritis is compromised by CTLA-4 promoter methylation resulting in a failure to activate the indoleamine 2, 3-dioxygenase pathway. Arthritis Rheum 2014; 66:2344-54. PMID: 24891289.
30. Moradi B, Schnatzer P, Hagmann S, Rosshirt N, GotterbarmT, Kretzer JP, et al. CD4+CD25+/high- CD127low/- regulatoryT cells are enriched in rheumatoid arthritisand osteoarthritis joints-Analysis of frequency and phenotype in synovial membrane, synovial fluid and peripheral blood. Arthritis Res Ter 2014; 16:R97. PMID: 24742142.
31. + central memory subset are decreased in peripheral blood from patients with rheumatoid arthritis.Biochem Biophys Res Commun 2013; 438:778-83. PMID: 23747721 doi:10.1016/j.bbrc.2013.05.120.
32. Guggino G, Giardina A, Ferrante A, Giardina G, Schinocca C, Sireci G, et al. The in vitro addition of methotrexate and/or methylprednisolone determines peripheral reduction in Th17 and expansion of conventional Treg and of IL-10 producing Th17 lymphocytes in patients with early rheumatoid arthritis. Rheumatol Int. 2015; 35:171-5. PMID: 24792332 doi:10.1007/s00296-014-3030-2.
33. Ji L, Geng Y, ZhouW, Zhang Z. A study on relationship among apoptosis rates, number of peripheralT cell subtypes and disease activity in rheumatoid arthritis. Int J Rheum Dis 2013. PMID: 24618356.
34. Gao S, Hao B, Yang XF, Chen WQ. Decreased CD200R expression on monocyte-derived macrophages correlates with Th17/Treg imbalance and disease activity in rheumatoid arthritis patients. Inflamm Res 2014; 63:441-50. PMID: 24496593 doi:10.1007/s00011-014-0716-6.
35. Nie H, Zheng Y, Li R, Guo TB, He D, Fang L, et al. Phosphorylation of FOXP3 controls regulatoryT cell function and is inhibited by TNF-α in rheumatoid arthritis.Nat Med 2013; 19:322-30. PMID: 23396208 doi:10.1038/nm.3085.
36. Abazaa N, EL-kabarityb RH, Abo-Shadyb RA. Deficient or abundant but unable to fight? Estimation of circulating FoxP3+ T regulatorycells and their counteracting FoxP3- in rheumatoid arthritisand correlation with disease activity. Egypt Rheum 2013; 35:185-92.
37. Kim JR, Chae JN, Kim SH, Ha JS. Subpopulations of regulatory T cells in rheumatoid arthritis, systemic lupus erythematosus, and Behcet's disease. J Korean Med Sci 2012; 27:1009-13. PMID: 22969245 doi:10.3346/jkms.2012.27.9.1009.
38. Niu Q, Cai B, Huang ZC, Shi YY, Wang LL. Disturbed Th17/Treg balance in patients with rheumatoid arthritis.Rheumatol Int 2012; 32:2731-6. PMID: 21809006 doi:10.1007/s00296-011-1984-x.
39. Chen J, Li J, Gao H, Wang C, Luo J, Lv Z, et al. Comprehensive evaluation of different T-helper cell subsets differentiation and function in rheumatoid arthritis.J Biomed Biotechnol 2012; 2012:535361. PMID: 23091349 doi:10.1155/2012/535361.
40. Chen R, Tao Y, Qiu K, HuangW, Huang C, Li J. Association of circulating Treg cells with disease activity in patients with rheumatoid arthritis. J South Med Univ 2012; 32:886-9. PMID: 22699077.
41. -T cells by regulatoryT cells in patients with rheumatoid arthritis.J Clin Immunol 2011; 31:1112-9. PMID: 21732015 doi:10.1007/s10875-011-9559-x.
42. Furuzawa-Carballeda J, Lima G, Jakez-Ocampo J, Llorente L. Indoleamine 2, 3-dioxygenase-expressing peripheral cells in rheumatoid arthritisand systemic lupus erythematosus: A cross-sectional study. Eur J Clin Invest 2011; 41:1037-46. PMID: 21366559 doi:10.1111/j.1365-2362.2011.02491.x.
43. Loza MJ, Anderson AS, O'Rourke KS, Wood J, Khan IU. T-cell specific defect in expression of the NTPDase CD39 as a biomarker for lupus. Cell Immunol 2011; 271:110-7. PMID: 21763644 doi:10.1016/j.cellimm.2011.06.010.
44. Tang TT, Song Y, Ding YJ, Liao YH, Yu X, Du R et al. Atorvastatin upregulates regulatory T cells and reduces clinical disease activity in patients with rheumatoid arthritis.J Lipid Res 2011; 52:1023-32. PMID: 21368320 doi:10.1194/jlr.M010876.
45. Chen MH, ChenWS, Lee H, Tsai CY, Chou CT. Inverse correlation of programmed death 1 (PD-1) expression in T cells to the spinal radiologic changes in Taiwanese patients with ankylosing spondylitis. Clin Rheumatol 2011; 20:1181-7. PMID: 21547439.
46. Ursaciuc C, Surcel M, CiotaruD, Dobre M, Pirvu IR, Munteanu AN et al. Regulatory T cells and Th1/Th2 cytokines as immunodiagnosis keys in systemic autoimmune diseases. Roum Arch Microbiol Immunol 2010; 69:79-84. PMID: 21235134.
47. Al-Shukaili A, AlKaabi J, Al-GafriS, Hassan B, Al-Muneeri A. Quantification of CD4+ CD25+ regulatory T cells in peripheral blood of patients with systemic lupus erythematosus and rheumatoid arthritis. Open Autoimmun J 2009; 1:5-9.
48. Sempere-Ortells JM, Perez-Garcia V, Marin-Alberca G, Peris-Pertusa A, Benito JM, Marco FM, et al. Quantification and phenotype of regulatoryT cells in rheumatoid arthritisaccording to disease activity score-28.Autoimmunity 2009; 42:636-45. PMID: 19886735 doi:10.3109/08916930903061491.
49. Hung ZX, Cheng BR, Li TW, Lu YM, Gu JR, Han XY, et al. Study on expressions of CD25 and CD127 in CD4+ peripheral T lymphocytes of patients with rheumatoid arthritis.Nat Med J China 2009; 89;2476-80. PMID: 20137434.
50. high T cell numbers are enriched in the peripheral blood of patients with rheumatoid arthritis. Cell Immunol 2008; 253:92-101. PMID: 18649874 doi:10.1016/j.cellimm.2008.05.007.
51. + regulatory T Cells, which suppress T cell response in rheumatoid arthritispatients. Immune Netw 2007; 7:124-32.
52. +T regulatoryT cells during acute and remission stages in rheumatoid arthritis patients. J Microbiol Immunol Infect 2007; 40:419-27. PMID: 17932602.
53. +T cells with distinct chemokine receptors in synovial fluid of patients with active rheumatoid arthritis. Scand J Rheumatol 2007; 36:428-33. PMID: 18092263.
54. +rgulatoryT cells in patients with rheumatoid arthritis.Nihon Rinsho Meneki Gakkai Kaishi. 2006; 29:37-42. [Published in Japanese] PMID: 16505601.
55. +T cells with the phenotypic and functional characteristics of regulatory T cells are enriched in the synovial fluid of patients with rheumatoid arthritis. Clin Exp Immunol 2005; 140:360-7. PMID: 15807863.
56. Seddiki N, Santner-Nanan B, MartinsonJ, Zaunders J, Sasson S, Landay A et al. Expression of interleukin (IL)-2 and IL-7 receptors discriminates between human regulatoryand activated T cells. J Exp Med 2006; 203:1693-700. PMID: 16818676.
57. + regulatoryT cells in the human immune system. Nat Rev Immunol 2010; 10:490-500. PMID: 20559327 doi:10.1038/nri2785.
58. Curiel TJ, Coukos G, Zou L, Alvarez X, Cheng P, Mottram P, et al. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nat. Med. 2004; 10:942-949. PMID: 15322536.
59. Yurchenko E, Tritt M, Hay V, Shevach EM, Belkaid Y, Piccirillo CA. CCR5-dependent homing of naturally occurringCD4 regulatoryT cells to sites of Leishmania major infection favors pathogen persistence. J. Exp. Med. 2006; 203:2451-2460. PMID: 17015634.
60. Green AM, Mattila JT, Bigbee CL, Bongers KS, Lin PL, Flynn JL. CD4(+) regulatoryT cells in a cynomolgus macaque model of Mycobacterium tuberculosis infection. J Infect Dis. 2010; 202:533-41. PMID: 20617900 doi:10.1086/654896.
61. David B, Eirini G, Hannah L, Lucy RW. Synovial regulatory T cells occupy adscrete TCR niche in human arthritisand require local signals to stabilize FOXP3 protein expression. J. Immunol, 2015; 195:5616-24. PMID: 26561546 doi:10.4049/jimmunol.1500391.
62. Yadav M, Stephan S, Bluestone JA. Peripherally induced Tregs-role in immune homeostasis and autoimmunity. Front Immunol, 2013; 4:232. PMID: 23966994 doi:10.3389/fimmu.2013.00232.
63. hi T-regulatory cells. Blood, 2007; 108:253-261. PMID: 16537805.
64. + regulatoryT cells are enriched in inflamed joints of patients with chronic rheumatic disease. Arthritis Res Ther, 2004; 6: R335-46. PMID: 15225369.